Mechanistic insight into human ether-à-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain

Journal of Biological Chemistry

Volumn 286, Issue 8, 2011, Pages 6184-6191

  Muskett, Frederick W ^a   Thouta, Samrat ^a   Thomson, Steven J ^a   Bowen, Alexander ^a   Stansfeld, Phillip J ^b   Mitcheson, John S ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIPATHIC; CARDIAC ACTION POTENTIAL; CYCLIC NUCLEOTIDE BINDING DOMAIN; ELECTROPHYSIOLOGICAL STUDIES; LONG QT SYNDROME; MOLECULAR MODELING STUDIES; NMR STRUCTURES; OPEN CONFORMATION; POSITIVELY CHARGED; REPOLARIZATION; SOLUTION STRUCTURES; STRUCTURAL ELEMENTS; TIME COURSE;

AMINO ACIDS; ELECTROPHYSIOLOGY; ETHERS; GENES; MUTAGENESIS; ORGANIC COMPOUNDS;

NUCLEOTIDES;

CYCLIC NUCLEOTIDE; POTASSIUM CHANNEL HERG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CYTOPLASM; MOLECULAR MODEL; MUTAGENESIS; NONHUMAN; NUCLEOTIDE BINDING SITE; OOCYTE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; XENOPUS LAEVIS;

AMINO ACID SUBSTITUTION; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; ION CHANNEL GATING; MODELS, MOLECULAR; MUTAGENESIS; MUTATION, MISSENSE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, TERTIARY;

EID: 79953175625     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.199364     Document Type: Article

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