Effect of cysteine substitutions on the topology of the S4 segment of the Shaker potassium channel: Implications for molecular models of gating

Journal of Physiology

Volumn 521, Issue 2, 1999, Pages 315-326

  Wang, M H ^a   Yusaf, S P ^a   Elliott, D J S ^a   Wray, D ^a   Sivaprasadarao, A ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROMERCURIBENZENESULFONIC ACID; CYSTEINE; POTASSIUM; POTASSIUM CHANNEL; ARGININE; ISOLEUCINE; LEUCINE; MUTANT PROTEIN; SERINE; SHAKER POTASSIUM CHANNEL; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DEPOLARIZATION; ELECTRIC POTENTIAL; MEMBRANE STEADY POTENTIAL; MOLECULAR MODEL; NONHUMAN; OOCYTE; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; XENOPUS; BIOENGINEERING; CELL MEMBRANE STEADY POTENTIAL; MUTATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REACTION TIME;

EID: 0033433966     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1999.00315.x     Document Type: Article

References (25)

1. + channel. Neuron 16, 1169-1177.
2. + channel gating. Neuron 20, 1283-1294.
3. + channels: II. The components of gating currents and a model of channel activation. Biophysical Journal 66, 1011-1021.
4. BEZANILLA, F. & STEFANI, E. (1994). Voltage-dependent gating of ionic channels. Annual Review of Biophysics and Biomolecular Structure 23, 819-846.
5. + channel with fluorescence. Neuron 19, 1127-1140.
6. + conduction and selectivity. Science 280, 69-77.
7. + channels in open, closed and inactivated conformations. Journal of Structural Biology 121, 263-284.
8. HILLE, B. (1992). Ionic Channels of Excitable Membranes. Sinauer Associates, Sunderland, MA, USA.
9. + channel. Journal of General Physiology 108, 195-206.
10. HOSHI, T., ZAGOTTA, W. N. & ALDRICH, R. W. (1990). Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250, 533-538.
11. JAN, L. Y. & JAN, Y. N. (1997). Cloned potassium channels from eukaryotes and prokaryotes. Annual Review of Neuroscience 20, 91-123.
12. + channel S4. Neuron 16, 387-397.
13. + channel. Neuron 14, 1293-1301.
14. PAPAZIAN, D. M., TIMPE, L. C., JAN, Y. N. & JAN, L. Y. (1991). Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence. Nature 349, 305-310.
15. SCHOPPA, N. E., MCCORMACK, K., TANOUYE, M. A. & SIGWORTH, F. J. (1992). The size of gating charge in wild-type and mutant potassium channels. Science 255, 1712-1715.
16. + channel. Neuron 16, 1159-1167.
17. SIGWORTH, F. J. (1994). Voltage gating of ion channels. Quarterly Reviews of Biophysics 27, 1-40.
18. SMITH-MAXWELL, C. J., LEDWELL, J. L. & ALDRICH, R. W. (1998). Uncharged S4 residues and cooperativity in voltage-dependent potassium channel activation. Journal of General Physiology 111, 421-439.
19. + channel. Neuron 19, 1319-1327.
20. + channel subunits. Biophysical Journal 72, 1489-1500.
21. TYTGAT, J. & HESS, P. (1992). Evidence of cooperative interactions in potassium channel gating. Nature 359, 420-423.
22. YANG, N., GEORGE, A. L. J. & HORN, R. (1996). Molecular basis of charge movement in voltage-gated sodium channels. Neuron 16, 113-122.
23. YELLEN, G. (1998). The moving parts of voltage-gated ion channels. Quarterly Reviews of Biophysics 31, 239-295.
24. + channel allows inactivation to be modulated by metal binding. Biophysical Journal 66, 1068-1075.
25. YUSAF, S. P., WRAY, D. & SIVAPRASADARAO, A. (1996). Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel. Pflügers Archiv 433, 91-97.