Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel

Journal of Physiology

Volumn 493, Issue 3, 1996, Pages 635-642

  Schönherr, Roland ^a   Heinemann, Stefan H ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CESIUM ION; LITHIUM ION; POTASSIUM CHANNEL; POTASSIUM ION; SODIUM ION;

ARTICLE; GENETIC TRANSFECTION; HUMAN; NONHUMAN; OOCYTE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; XENOPUS;

EID: 0030054878     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1996.sp021410     Document Type: Article

References (18)

1. 2+ and modulated by cAMP. Nature 365, 445-448
2. CURRAN, M. E., SPLAWSKI, I, TIMOTHY, K. W., VINCENT, G. M., GREEN, E. D. & KEATING, M. T. (1995). A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80, 795-803.
3. + pores. Pflügers Archiv 422, 354-363.
4. + channels to intracellular spermine. FEBS Letters 356, 199-203.
5. + channels. Science 266, 1068-1072.
6. HOSHI, T., ZAGOTTA, W. N. & ALDRICH, R. W. (1990). Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250, 533-538.
7. + channels: Effects of alterations in the carboxy-terminal region. Neuron 7, 547-556.
8. LÓPEZ-BARNEO, J., HOSHI, T., HEINEMANN, S. H. & ALDRICH, R. W. (1993). Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors and Channels 1, 61-71.
9. LUDWIG, J., TERLAU, H., WUNDER, F., BRÜGGEMANN, A., PARDO, L. A., MARQUARDT, A., STÜHMER, W. & PONGS, O. (1994). Functional expression of a rat homologue of the voltage gated ether á-go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart. EMBO Journal 13, 4451-4458.
10. + channel. Proceedings of the National Academy of Sciences of the USA 89, 2466-2470.
11. Kr potassium channel. Cell 81, 299-307.
12. SCHLIEF, T, SCHÖNHERR, R. & HEINEMANN, S. H. (1996). Modification of C-type inactivating Shaker potassium channels by chloramine-T. Pflügers Archiv 431, 483-493.
13. SMITH, P. L., BAUKROWITZ, T. & YELLEN, G. (1996). The inward rectification mechanism of the HERG cardiac potassium channel. Nature 379, 833-836.
14. STÜHMER, W., TERLAU, H. & HEINEMANN, S. H. (1992). Two electrode and patch clamp recording from Xenopus oocytes. In Practical Electrophysiological Methods, ed. KETTENMANN, H. & GRANTYN, R., pp. 121-125. Wiley-Liss, New York.
15. TRUDEAU, M. C., WARMKE, J. W., GANETZKY, B. & ROBERTSON, G. A. (1995). HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 269, 92-95.
16. VILLARROEL, A., HERLITZE, S., KOENEN, M. & SAKMANN, B. (1991). Location of a threonine residue in the alpha-subunit M2 trans-membrane segment that determines the ion flow through the acetylcholine receptor. Proceedings of the Royal Society of London B 243, 69-74.
17. WARMKE, J. W., DRYSDALE, R. & GANETZKY, B. (1991). A distinct potassium channel polypeptide encoded by the Drosophila eag locus. Science 252, 1560-1562.
18. WARMKE, J. W. & GANETZKY, B. (1994). A family of potassium channel genes related to eag in Drosophila and mammals. Proceedings of the National Academy of Sciences of the USA 91, 3438-3442.