Activation of Shaker potassium channels: II. Kinetics of the V2 mutant channel

Journal of General Physiology

Volumn 111, Issue 2, 1998, Pages 295-311

  Schoppa, N E ^a,b   Sigworth, F J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Gating current; Ion channel; Kinetic model; Patch clamp; Single channel current

Indexed keywords

POTASSIUM CHANNEL;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHANNEL GATING; NONHUMAN; PATCH CLAMP; TRANSPORT KINETICS; XENOPUS LAEVIS;

ANIMALS; BIOTRANSFORMATION; ELECTROPHYSIOLOGY; ION CHANNEL GATING; ION CHANNELS; KINETICS; MEMBRANE POTENTIALS; MICE; MICE, NEUROLOGIC MUTANTS; MODELS, BIOLOGICAL; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; XENOPUS LAEVIS;

EID: 0031952460     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.111.2.295     Document Type: Article

References (21)

1. Auld, V.J., A.L. Goldin, D.S. Krafte, W. Catterall, H.A. Lester, N. Davidson, and R. Dunn. 1990. A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel. Proc. Natl. Acad. Sci. USA. 87: 323-327.
2. + channel. J. Membr. Biol. 157:215-230.
3. + channels: II. The components of gating currents and a model of channel activation. Biophys. J. 66:1011-1021.
4. Cole, K.S., and J.W. Moore. 1960. Potassium ion current in the squid giant axon: dynamic characteristic. Biophys. J. 1:1-14.
5. + channel. J. Gen. Physiol. 108:195-206.
6. Hoshi, T., W.N. Zagotta, and R.W. Aldrich. 1990. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science. 250:533-538.
7. Hoshi, T., W.N. Zagotta, and R.W. Aldrich. 1994. Shaker potassium channel gating. I: Transitions near the open state. J. Gen. Physiol. 103:249-278.
8. Kavanaugh, M.P., R.S. Hurst, J. Yakel, M.D. Varnum, J.P. Adelman, and R.A. North. 1992. Multiple subunits of a voltage-dependent potassium channel contribute to the binding site for tetraethyl-ammonium. Neuron. 8:493-497.
9. Li, M., N. Unwin, K.A. Stauffer, Y.N. Jan, and L.Y. Jan. 1994. Images of purified Shaker potassium channels. Curr. Biol. 4:110-115.
10. + channels. Neuron. 7:327-336.
11. MacKinnon, R. 1991. Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature. 350:232-235.
12. McCormack, K., J.T. Campanelli, M. Ramaswami, M.K. Mathew, M.A. Tanouye, L.E. Iverson, and B. Rudy. 1989. Leucine-zipper motif update. Nature. 340:103.
13. + channels during gating and assembly. Biophys. J. 65:1740-1748.
14. + channels. Proc. Natl. Acad. Sci. USA. 88:2931-2935.
15. Schoppa, N.E., K. McCormack, M.A. Tanuoye, and F.J. Sigworth. 1992. The size of gating charge in wild-type and mutant Shaker potassium channels. Science. 255:1712-1715.
16. Schoppa, N.E., and F.J. Sigworth. 1998a. Activation of Shaker potassium channels. I. Characterization of voltage-dependent transitions. J. Gen. Physiol. 111:271-294.
17. Schoppa, N.E., and F.J. Sigworth. 1998b. Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels. J. Gen. Physiol. 111:313-342.
18. Sigworth, F.J. 1994. Voltage gating of ion channels. Q. Rev. Biophys. 27:1-40.
19. Stühmer, W., F. Conti, M. Stocker, O. Pongs, and S.H. Heinemann. 1991. Gating currents of inactivating and non-inactivating potassium channels expressed in Xenopus oocytes. Pflügers Archiv Eur. J. Physiol. 418:423-429.
20. Zagotta, W.N., T. Hoshi, and R.W. Aldrich. 1994b. Shaker potassium channel gating. III. Evaluation of kinetic models for activation. J. Gen. Physiol. 103:321-362.
21. Zagotta, W.N., T. Hoshi, J. Dittman, and R.W. Aldrich. 1994a. Shaker potassium channel gating. II. Transitions in the activation pathway. J. Gen. Physiol. 103:279-319.