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Volumn 50, Issue 2, 2001, Pages 301-313

Cellular consequences of HERG mutations in the long QT syndrome: Precursors to sudden cardiac death

Author keywords

Arrhythmia (mechanisms); Computer modelling; K channel; Long QT syndrome; Sudden death; Ventricular arrhythmias

Indexed keywords

ARTICLE; GENE MUTATION; HEART ARRHYTHMIA; HEART DEATH; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; LONG QT SYNDROME; PHENOTYPE; PRIORITY JOURNAL; PROBABILITY; SIMULATION; SUDDEN DEATH; TRANSGENE;

EID: 0035028582     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(00)00293-5     Document Type: Article
Times cited : (157)

References (39)
  • 6
    • 0023162302 scopus 로고
    • Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart
    • (1987) J Physiol , vol.387 , pp. 227-250
    • Shibasaki, T.1
  • 12
    • 0033082093 scopus 로고    scopus 로고
    • Mutations of the S4-S linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes
    • (1999) J Physiol , vol.514 , pp. 667-675
    • Sanguinetti, M.C.1    Xu, Q.P.2
  • 16
    • 0028233422 scopus 로고
    • A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes
    • (1994) Circ Res , vol.74 , pp. 1071-1096
    • Luo, C.H.1    Rudy, Y.2
  • 19
    • 0033527032 scopus 로고    scopus 로고
    • Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia
    • (1999) Nature , vol.400 , pp. 566-569
    • Clancy, C.E.1    Rudy, Y.2
  • 22
    • 0031982513 scopus 로고    scopus 로고
    • Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature
    • (1998) Biophys J , vol.74 , pp. 230-241
    • Zhou, Z.1    Gong, Q.2    Ye, B.3
  • 23
    • 0031733880 scopus 로고    scopus 로고
    • Time course and voltage dependence of expressed HERG current compared with the native rapid delayed rectifier K current during the cardiac ventricular action potential
    • (1998) Pflüger's Arch , vol.436 , pp. 843-853
    • Hancox, J.C.1    Levi, A.J.2    Witchel, H.J.3
  • 31
    • 0028911903 scopus 로고
    • Early afterdepolarizations in cardiac myocytes: Mechanism and rate dependence
    • (1995) Biophys J , vol.68 , pp. 949-964
    • Zeng, J.1    Rudy, Y.2
  • 32
    • 0030614462 scopus 로고    scopus 로고
    • The human delta1261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression
    • (1997) J Biol Chem , vol.272 , pp. 705-708
    • Li, X.1    Xu, J.2    Li, M.3
  • 33
    • 0034646287 scopus 로고    scopus 로고
    • Cellular arrhythmogenic effects of congenital and acquired Long-QT syndrome in the heterogeneous Myocardium
    • (2000) Circulation , vol.101 , pp. 1192-1198
    • Viswanathan, P.1    Rudy, Y.2
  • 34
    • 35649001607 scopus 로고
    • A quantitative description of membrane current and its application to conduction and excitation in nerve
    • (1952) J Physiol , vol.117 , pp. 500-544
    • Hodgkin, A.L.1    Huxely, A.F.2
  • 35
    • 0001248983 scopus 로고    scopus 로고
    • Electrical heterogeneity, the ECG, and cardiac arrhythmias
    • Zipes DP, Jalife J, editors, Cardiac electrophysiology: from cell to bedside, Philidelphia: W.B. Saunders
    • (2000) , pp. 222-238
    • Antzelevitch, C.1    Yan, G.2    Shimuzu, W.3    Burashnikov, P.4
  • 36
    • 0031467877 scopus 로고    scopus 로고
    • Electrophysiological mechanism of the characteristic electrocardiographic morphology of torsade de pointes tachyarrhythmias in the long-QT syndrome: Detailed analysis of ventricular tridimensional activation patterns
    • (1997) Circulation , vol.96 , pp. 4392-4399
    • El-Sherif, N.1    Chinushi, M.2    Caref, E.B.3    Restivo, M.4
  • 39


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.