-
1
-
-
77952270920
-
Cardiovascular friendly natural products: A promising approach in the management of CVD
-
Shukla S. K.; Gupta S.; Ojha S. K.; Sharma S. B. Cardiovascular friendly natural products: a promising approach in the management of CVD. Nat. Prod. Res., 2010, 24, 873-98.
-
(2010)
Nat. Prod. Res.
, vol.24
, pp. 873-898
-
-
Shukla, S.K.1
Gupta, S.2
Ojha, S.K.3
Sharma, S.B.4
-
2
-
-
39149098194
-
Natural products as leads to anticancer drugs
-
Gordaliza M. Natural products as leads to anticancer drugs. Clin. Transl. Oncol., 2007, 9, 767-76.
-
(2007)
Clin. Transl. Oncol.
, vol.9
, pp. 767-776
-
-
Gordaliza, M.1
-
3
-
-
63149118507
-
Ready for a comeback of natural products in oncology
-
Bailly C. Ready for a comeback of natural products in oncology. Biochem. Pharmacol., 2009, 77, 1447-57.
-
(2009)
Biochem. Pharmacol.
, vol.77
, pp. 1447-1457
-
-
Bailly, C.1
-
4
-
-
70350448473
-
Antibiotics: Natural products essential to human health
-
Demain A. L. Antibiotics: Natural products essential to human health. Med. Res. Rev., 2009, 29, 821-42.
-
(2009)
Med. Res. Rev.
, vol.29
, pp. 821-842
-
-
Demain, A.L.1
-
5
-
-
14644436385
-
Biodiversity: A continuing source of novel drug leads
-
DOI 10.1351/pac200577010007
-
Cragg G. M.; Newman D. J. Biodiversity: A continuing source of novel drug leads. Pure Appl. Chem., 2005, 77, 7-24. (Pubitemid 40321875)
-
(2005)
Pure and Applied Chemistry
, vol.77
, Issue.1
, pp. 7-24
-
-
Cragg, G.M.1
Newman, D.J.2
-
6
-
-
44249098800
-
Natural products to drugs: Natural product-derived compounds in clinical trials
-
DOI 10.1039/b514294f
-
Butler M. S. Natural products to drugs: natural product-derived compounds in clinical trials. Nat. Prod. Rep., 2008, 25, 475-516. (Pubitemid 351725315)
-
(2008)
Natural Product Reports
, vol.25
, Issue.3
, pp. 475-516
-
-
Butler, M.S.1
-
7
-
-
79952081834
-
The medicinal potential of promising marine macrolides with anticancer activity
-
Qi Y.; Ma S. The Medicinal Potential of Promising Marine Macrolides with Anticancer Activity. ChemMedChem, 2011, 6, 399-409.
-
(2011)
ChemMedChem
, vol.6
, pp. 399-409
-
-
Qi, Y.1
Ma, S.2
-
8
-
-
62149117325
-
Discovery of natural product anticancer agents from biodiverse organisms
-
Kinghorn A. D.; Chin Y. W.; Swanson S. M. Discovery of natural product anticancer agents from biodiverse organisms. Curr. Opin. Drug Disc., 2009, 12, 189-96.
-
(2009)
Curr. Opin. Drug Disc.
, vol.12
, pp. 189-196
-
-
Kinghorn, A.D.1
Chin, Y.W.2
Swanson, S.M.3
-
10
-
-
67650675111
-
Impact of natural products on developing new anti-cancer agents
-
Cragg G. M.; Grothaus P. G.; Newman D. J. Impact of Natural Products on Developing New Anti-Cancer Agents. Chem. Rev., 2009, 109, 3012-43.
-
(2009)
Chem. Rev.
, vol.109
, pp. 3012-3043
-
-
Cragg, G.M.1
Grothaus, P.G.2
Newman, D.J.3
-
11
-
-
34247109045
-
Natural products as sources of new drugs over the last 25 years
-
DOI 10.1021/np068054v
-
Newman D. J.; Cragg G. M. Natural Products as Sources of New Drugs over the Last 25 Years. J.Nat. Prod., 2007, 70, 461-77. (Pubitemid 46595760)
-
(2007)
Journal of Natural Products
, vol.70
, Issue.3
, pp. 461-477
-
-
Newman, D.J.1
Cragg, G.M.2
-
12
-
-
52049109838
-
Natural products in drug discovery
-
Harvey A. L. Natural products in drug discovery. Drug Discovery Today, 2008, 13, 894-901.
-
(2008)
Drug Discovery Today
, vol.13
, pp. 894-901
-
-
Harvey, A.L.1
-
13
-
-
44949134801
-
The impact of natural products upon modern drug discovery
-
Ganesan A. The impact of natural products upon modern drug discovery. Curr. Opin. Chem. Biol., 2008, 12, 306-17.
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, pp. 306-317
-
-
Ganesan, A.1
-
14
-
-
61849148824
-
Natural products and drug discovery
-
Ji H. F.; Li X. J.; Zhang H. Y. Natural products and drug discovery. EMBO Rep., 2009, 10, 194-200.
-
(2009)
EMBO Rep.
, vol.10
, pp. 194-200
-
-
Ji, H.F.1
Li, X.J.2
Zhang, H.Y.3
-
16
-
-
77955014467
-
Natural products as chemical probes
-
Carlson E. E. Natural products as chemical probes. ACS Chem. Biol., 2010, 5, 639-53.
-
(2010)
ACS Chem. Biol.
, vol.5
, pp. 639-653
-
-
Carlson, E.E.1
-
17
-
-
0031730097
-
Drug target validation and identification of secondary drug target effects using DNA microarrays
-
DOI 10.1038/3282
-
Marton M. J.; DeRisi J. L.; Bennett H. A.; Iyer V. R.; Meyer M. R.; Roberts C. J.; Stoughton R.; Burchard J.; Slade D.; Dai H. Drug target validation and identification of secondary drug target effects using DNA microarrays. Nat. Med., 1998, 4, 1293-301. (Pubitemid 28512111)
-
(1998)
Nature Medicine
, vol.4
, Issue.11
, pp. 1293-1301
-
-
Marton, M.J.1
Derisi, J.L.2
Bennett, H.A.3
Iyer, V.R.4
Meyer, M.R.5
Roberts, C.J.6
Stoughton, R.7
Burchard, J.8
Slade, D.9
Dai, H.10
Bassett Jr., D.E.11
Hartwell, L.H.12
Brown, P.O.13
Friend, S.H.14
-
19
-
-
11144346764
-
The promise of genomics to identify novel therapeutic targets
-
DOI 10.1517/14728222.8.6.587
-
Orth A. P.; Batalov S.; Perrone M.; Chanda S. K. The promise of genomics to identify novel therapeutic targets. Expert Opin. Ther. Tar., 2004, 8, 587-96. (Pubitemid 40028368)
-
(2004)
Expert Opinion on Therapeutic Targets
, vol.8
, Issue.6
, pp. 587-596
-
-
Orth, A.P.1
Batalov, S.2
Perrone, M.3
Chanda, S.K.4
-
20
-
-
18944387166
-
Staphylococcus aureus: The search for novel targets
-
DOI 10.1016/S1359-6446(05)03432-X, PII S135964460503432X
-
Garcia-Lara J.; Masalha M.; Foster S. J. Staphylococcus aureus: the search for novel targets. Drug Discov. Today, 2005, 10, 643-51. (Pubitemid 40704772)
-
(2005)
Drug Discovery Today
, vol.10
, Issue.9
, pp. 643-651
-
-
Garcia-Lara, J.1
Masalha, M.2
Foster, S.J.3
-
21
-
-
65049086286
-
Genomics: Applications in mechanism elucidation
-
Gresham V.; McLeod H. L. Genomics: Applications in mechanism elucidation. Adv. Drug Delver. Rev., 2009, 61, 369-74.
-
(2009)
Adv. Drug Delver. Rev.
, vol.61
, pp. 369-374
-
-
Gresham, V.1
McLeod, H.L.2
-
22
-
-
33646572869
-
A functional genomics approach to the mode of action of apratoxin A
-
DOI 10.1038/nchembio769, PII NCHEMBIO769
-
Luesch H.; Chanda S. K.; Raya R. M.; DeJesus P. D.; Orth A. P.; Walker J. R.; Belmonte J. C. I.; Schultz P. G. A functional genomics approach to the mode of action of apratoxin A. Nat. Chem. Biol., 2006, 2, 158-67. (Pubitemid 44323868)
-
(2006)
Nature Chemical Biology
, vol.2
, Issue.3
, pp. 158-167
-
-
Luesch, H.1
Chanda, S.K.2
Raya, R.M.3
DeJesus, P.D.4
Orth, A.P.5
Walker, J.R.6
Izpisua Belmonte, J.C.7
Schultz, P.G.8
-
23
-
-
1842532337
-
Chemogenomics: An emerging strategy for rapid target and drug discovery
-
DOI 10.1038/nrg1317
-
Bredel M.; Jacoby E. Chemogenomics: an emerging strategy for rapid target and drug discovery. Nat. Rev. Genet., 2004, 5, 262-75. (Pubitemid 38435622)
-
(2004)
Nature Reviews Genetics
, vol.5
, Issue.4
, pp. 262-275
-
-
Bredel, M.1
Jacoby, E.2
-
24
-
-
34250621337
-
Chemical genetics: Elucidating biological systems with small-molecule compounds
-
DOI 10.1038/sj.jid.5700853, PII 5700853
-
Kawasumi M.; Nghiem P. Chemical genetics: elucidating biological systems with small-molecule compounds. J. Invest. Dermatol., 2007, 127, 1577-84. (Pubitemid 46933419)
-
(2007)
Journal of Investigative Dermatology
, vol.127
, Issue.7
, pp. 1577-1584
-
-
Kawasumi, M.1
Nghiem, P.2
-
25
-
-
34249986315
-
Chemogenomics approaches to novel target discovery
-
DOI 10.1586/14789450.4.3.411
-
Gaither L. A. Chemogenomics approaches to novel target discovery. Expert Rev. Proteomic, 2007, 4, 411-19. (Pubitemid 46890078)
-
(2007)
Expert Review of Proteomics
, vol.4
, Issue.3
, pp. 411-419
-
-
Gaither, L.A.1
-
26
-
-
35949000935
-
Tagged small molecule library approach for facilitated chemical genetics
-
Ahn Y. H.; Chang Y. T. Tagged small molecule library approach for facilitated chemical genetics. Acc. Chem. Res., 2007, 40, 1025-33.
-
(2007)
Acc. Chem. Res.
, vol.40
, pp. 1025-1033
-
-
Ahn, Y.H.1
Chang, Y.T.2
-
27
-
-
2642573570
-
Genetic and genomic approaches to identify and study the targets of bioactive small molecules
-
DOI 10.1016/j.chembiol.2003.08.011, PII S1074552104001188
-
Zheng X. S.; Chan T. F.; Zhou H. H. Genetic and genomic approaches to identify and study the targets of bioactive small molecules. Chem. Biol., 2004, 11, 609-18. (Pubitemid 38708830)
-
(2004)
Chemistry and Biology
, vol.11
, Issue.5
, pp. 609-618
-
-
Zheng, X.S.1
Chan, T.-F.2
Zhou, H.H.3
-
28
-
-
47649093352
-
An integrated platform of genomic assays reveals small-molecule bioactivities
-
Hoon S.; Smith A. M.; Wallace I. M.; Suresh S.; Miranda M.; Fung E.; Proctor M.; Shokat K. M.; Zhang C.; Davis R. W. An integrated platform of genomic assays reveals small-molecule bioactivities. Nat. Chem. Biol., 2008, 4, 498-506.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 498-506
-
-
Hoon, S.1
Smith, A.M.2
Wallace, I.M.3
Suresh, S.4
Miranda, M.5
Fung, E.6
Proctor, M.7
Shokat, K.M.8
Zhang, C.9
Davis, R.W.10
-
29
-
-
33749335282
-
The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease
-
DOI 10.1126/science.1132939
-
Lamb J.; Crawford E. D.; Peck D.; Modell J. W.; Blat I. C.; Wrobel M. J.; Lerner J.; Brunet J. P.; Subramanian A.; Ross K. N. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science, 2006, 313, 1929-35. (Pubitemid 44497995)
-
(2006)
Science
, vol.313
, Issue.5795
, pp. 1929-1935
-
-
Lamb, J.1
Crawford, E.D.2
Peck, D.3
Modell, J.W.4
Blat, I.C.5
Wrobel, M.J.6
Lerner, J.7
Brunet, J.-P.8
Subramanian, A.9
Ross, K.N.10
Reich, M.11
Hieronymus, H.12
Wei, G.13
Armstrong, S.A.14
Haggarty, S.J.15
Clemons, P.A.16
Wei, R.17
Carr, S.A.18
Lander, E.S.19
Golub, T.R.20
more..
-
30
-
-
59649109178
-
Identifying network of drug mode of action by gene expression profiling
-
Iorio F.; Tagliaferri R.; Bernardo D. Identifying network of drug mode of action by gene expression profiling. J. Comput. Biol., 2009, 16, 241-51.
-
(2009)
J. Comput. Biol.
, vol.16
, pp. 241-251
-
-
Iorio, F.1
Tagliaferri, R.2
Bernardo, D.3
-
31
-
-
33845876254
-
The Connectivity Map: A new tool for biomedical research
-
DOI 10.1038/nrc2044, PII NRC2044
-
Lamb J. The Connectivity Map: a new tool for biomedical research. Nat. Rev. Cancer, 2007, 7, 54-60. (Pubitemid 46020847)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.1
, pp. 54-60
-
-
Lamb, J.1
-
32
-
-
33646353201
-
Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A
-
Bordeleau M. E.; Mori A.; Oberer M.; Lindqvist L.; Chard L. S.; Higa T.; Belsham G. J.; Wagner G.; Tanaka J.; Pelletier J. Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A. Nat. Chem. Biol., 2006, 2, 213-20.
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 213-220
-
-
Bordeleau, M.E.1
Mori, A.2
Oberer, M.3
Lindqvist, L.4
Chard, L.S.5
Higa, T.6
Belsham, G.J.7
Wagner, G.8
Tanaka, J.9
Pelletier, J.10
-
33
-
-
67650281479
-
Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting
-
Fisch K. M.; Gurgui C.; Heycke N.; van der Sar S. A.; Anderson S. A.; Webb V. L.; Taudien S.; Platzer M.; Rubio B. K.; Robinson S. J. Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting. Nat. Chem. Biol., 2009, 5, 494-501.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 494-501
-
-
Fisch, K.M.1
Gurgui, C.2
Heycke, N.3
Van Der Sar, S.A.4
Anderson, S.A.5
Webb, V.L.6
Taudien, S.7
Platzer, M.8
Rubio, B.K.9
Robinson, S.J.10
-
34
-
-
77953810135
-
Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling
-
Nishimura S.; Arita Y.; Honda M.; Iwamoto K.; Matsuyama A.; Shirai A.; Kawasaki H.; Kakeya H.; Kobayashi T.; Matsunaga S. Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling. Nat. Chem. Biol., 2010, 6:, 516-26.
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 516-526
-
-
Nishimura, S.1
Arita, Y.2
Honda, M.3
Iwamoto, K.4
Matsuyama, A.5
Shirai, A.6
Kawasaki, H.7
Kakeya, H.8
Kobayashi, T.9
Matsunaga, S.10
-
35
-
-
34247142390
-
Neopeltolide, a macrolide from a lithistid sponge of the family neopeltidae
-
DOI 10.1021/np060597h
-
Wright A. E.; Botelho J. C.; Guzmán E.; Harmody D.; Linley P.; McCarthy P. J.; Pitts T. P.; Pomponi S. A.; Reed J. K. Neopeltolide, a Macrolide from a Lithistid Sponge of the Family Neopeltidae. J. Nat. Prod., 2007, 70, 412-16. (Pubitemid 46595749)
-
(2007)
Journal of Natural Products
, vol.70
, Issue.3
, pp. 412-416
-
-
Wright, A.E.1
Botelho, J.C.2
Guzman, E.3
Harmody, D.4
Linley, P.5
McCarthy, P.J.6
Pitts, T.P.7
Pomponi, S.A.8
Reed, J.K.9
-
36
-
-
45549099845
-
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide
-
DOI 10.1038/nchembio.94, PII NCHEMBIO94
-
Ulanovskaya O. A.; Janjic J.; Suzuki M.; Sabharwal S. S.; Schumacker P. T.; Kron S. J.; Kozmin S. A. Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide. Nat. Chem. Biol., 2008, 4, 418-24. (Pubitemid 351860551)
-
(2008)
Nature Chemical Biology
, vol.4
, Issue.7
, pp. 418-424
-
-
Ulanovskaya, O.A.1
Janjic, J.2
Suzuki, M.3
Sabharwal, S.S.4
Schumacker, P.T.5
Kron, S.J.6
Kozmin, S.A.7
-
37
-
-
45749140448
-
Unraveling a molecular target of macrolides
-
DOI 10.1038/nchembio0708-388, PII NCHEMBIO0708388
-
Altmann K. H.; Carreira E. M. Unraveling a molecular target of macrolides. Nat. Chem. Biol., 2008, 4, 388-89. (Pubitemid 351863595)
-
(2008)
Nature Chemical Biology
, vol.4
, Issue.7
, pp. 388-389
-
-
Altmann, K.-H.1
Carreira, E.M.2
-
38
-
-
35048856423
-
Simultaneous arming and structure/activity studies of natural products employing O-H insertions: An expedient and versatile strategy for natural products-based chemical genetics
-
DOI 10.1021/ja0733686
-
Peddibhotla S.; Dang Y.; Liu J. O.; Romo D. Simultaneous arming and structure/activity studies of natural products employing OH insertions: An expedient and versatile strategy for natural products-based chemical genetics. J. Am. Chem. Soc., 2007, 129, 12222-31. (Pubitemid 47556858)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.40
, pp. 12222-12231
-
-
Peddibhotla, S.1
Dang, Y.2
Liu, J.O.3
Romo, D.4
-
39
-
-
33846524839
-
Proteomic approaches in drug discovery
-
DOI 10.1016/j.ddtec.2006.10.001, PII S1740674906000709
-
Veenstra T. D. Proteomic approaches in drug discovery. Drug Discov. Today, 2007, 3, 433-40. (Pubitemid 46158386)
-
(2006)
Drug Discovery Today: Technologies
, vol.3
, Issue.4
, pp. 433-440
-
-
Veenstra, T.D.1
-
40
-
-
77954464041
-
Proteomics: A pragmatic perspective
-
Mallick P.; Kuster B. Proteomics: a pragmatic perspective. Nat. Biotechnol., 2010, 28, 695-709.
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 695-709
-
-
Mallick, P.1
Kuster, B.2
-
41
-
-
40849130043
-
Proteomic methods for drug target discovery
-
Sleno L.; Emili A. Proteomic methods for drug target discovery. Curr. Opin. Chem. Biol., 2008, 12, 46-54.
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, pp. 46-54
-
-
Sleno, L.1
Emili, A.2
-
42
-
-
57649153125
-
Difference gel electrophoresis
-
Timms J. F.; Cramer R. Difference gel electrophoresis. Proteomics, 2008, 8, 4886-97.
-
(2008)
Proteomics
, vol.8
, pp. 4886-4897
-
-
Timms, J.F.1
Cramer, R.2
-
43
-
-
33646192904
-
Involvement of protein kinase C and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma
-
Ha W.; Wu P.; Kok T.; Leung K.; Mak N.; Yue P.; Ngai S.; Tsai S.; Wong R. Involvement of protein kinase C and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma. Int. J. Biochem. Cell Biol., 2006, 38, 1393-401.
-
(2006)
Int. J. Biochem. Cell Biol.
, vol.38
, pp. 1393-1401
-
-
Ha, W.1
Wu, P.2
Kok, T.3
Leung, K.4
Mak, N.5
Yue, P.6
Ngai, S.7
Tsai, S.8
Wong, R.9
-
44
-
-
33749024778
-
Involvement of multitargets in paeoniflorin-induced preconditioning
-
DOI 10.1124/jpet.106.104380
-
Chen D.; Xiao L.; Cai X.; Zeng R.; Zhu X. Involvement of multitargets in paeoniflorin-induced preconditioning. J. Pharmacol. Exp. Ther., 2006, 319, 165-80. (Pubitemid 44455121)
-
(2006)
Journal of Pharmacology and Experimental Therapeutics
, vol.319
, Issue.1
, pp. 165-180
-
-
Chen, D.-M.1
Xiao, L.2
Cai, X.3
Zeng, R.4
Zhu, X.-Z.5
-
45
-
-
33646251378
-
Proteomic approach to study the cytotoxicity of dioscin (saponin)
-
Wang Y.; Cheung Y.; Yang Z.; Chiu J.; Che C.; He Q. Proteomic approach to study the cytotoxicity of dioscin (saponin). Proteomics, 2006, 6, 2422-32.
-
(2006)
Proteomics
, vol.6
, pp. 2422-2432
-
-
Wang, Y.1
Cheung, Y.2
Yang, Z.3
Chiu, J.4
Che, C.5
He, Q.6
-
46
-
-
38049075602
-
Dioscin (Saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: A proteomic-based study
-
Wang Y.; Che C.; Chiu J.; He Q. Dioscin (Saponin)-Induced Generation of Reactive Oxygen Species through Mitochondria Dysfunction: A Proteomic-Based Study. J. Proteome Res., 2007, 6, 4703-10.
-
(2007)
J. Proteome Res.
, vol.6
, pp. 4703-4710
-
-
Wang, Y.1
Che, C.2
Chiu, J.3
He, Q.4
-
47
-
-
43849085358
-
Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network
-
DOI 10.1074/mcp.M700259-MCP200
-
Yue Q.; Cao Z.; Guan S.; Liu X.; Tao L.; Wu W.; Li Y.; Yang P.; Liu X.; Guo D. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol. Cell. Proteomics, 2008, 7, 949-61. (Pubitemid 351737094)
-
(2008)
Molecular and Cellular Proteomics
, vol.7
, Issue.5
, pp. 949-961
-
-
Yue, Q.-X.1
Cao, Z.-W.2
Guan, S.-H.3
Liu, X.-H.4
Tao, L.5
Wu, W.-Y.6
Li, Y.-X.7
Yang, P.-Y.8
Liu, X.9
Guo, D.-A.10
-
48
-
-
60349092524
-
Proteomic identification of molecular targets of gambogic acid: Role of stathmin in hepatocellular carcinoma
-
Wang X.; Chen Y.; Han Q.; Chan C.; Wang H.; Liu Z.; Cheng C.; Yew D.; Lin M.; He M. Proteomic identification of molecular targets of gambogic acid: Role of stathmin in hepatocellular carcinoma. Proteomics, 2009, 9, 242-53.
-
(2009)
Proteomics
, vol.9
, pp. 242-253
-
-
Wang, X.1
Chen, Y.2
Han, Q.3
Chan, C.4
Wang, H.5
Liu, Z.6
Cheng, C.7
Yew, D.8
Lin, M.9
He, M.10
-
49
-
-
34748916981
-
Quantitative mass spectrometry in proteomics: A critical review
-
DOI 10.1007/s00216-007-1486-6, Proteomics/Molecular Imaging
-
Bantscheff M.; Schirle M.; Sweetman G.; Rick J.; Kuster B. Quantitative mass spectrometry in proteomics: a critical review. Anal. Bioanal. Chem., 2007, 389, 1017-31. (Pubitemid 47482251)
-
(2007)
Analytical and Bioanalytical Chemistry
, vol.389
, Issue.4
, pp. 1017-1031
-
-
Bantscheff, M.1
Schirle, M.2
Sweetman, G.3
Rick, J.4
Kuster, B.5
-
50
-
-
69249136243
-
Target profiling of small molecules by chemical proteomics
-
Rix U.; Superti-Furga G. Target profiling of small molecules by chemical proteomics. Nat. Chem. Biol., 2008, 5, 616-24.
-
(2008)
Nat. Chem. Biol.
, vol.5
, pp. 616-624
-
-
Rix, U.1
Superti-Furga, G.2
-
51
-
-
40649095957
-
Quantitative proteomics using stable isotope labeling with amino acids in cell culture
-
DOI 10.1038/nprot.2008.2, PII NPROT.2008.2
-
Harsha H.; Molina H.; Pandey A. Quantitative proteomics using stable isotope labeling with amino acids in cell culture. Nat. Protoc., 2008, 3, 505-16. (Pubitemid 351372235)
-
(2008)
Nature Protocols
, vol.3
, Issue.3
, pp. 505-516
-
-
Harsha, H.C.1
Molina, H.2
Pandey, A.3
-
52
-
-
0032875697
-
Quantitative analysis of complex protein mixtures using isotope-coded affinity tags
-
DOI 10.1038/13690
-
Gygil S. P.; Rist B.; Gerber S. A.; Turecek F.; Gelb M. H.; Aebersold R. Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat. Biotechnol., 1999, 17, 994-99. (Pubitemid 29474856)
-
(1999)
Nature Biotechnology
, vol.17
, Issue.10
, pp. 994-999
-
-
Gygi, S.P.1
Rist, B.2
Gerber, S.A.3
Turecek, F.4
Gelb, M.H.5
Aebersold, R.6
-
53
-
-
33847174067
-
Protein labeling by iTRAQ: A new tool for quantitative mass spectrometry in proteome research
-
DOI 10.1002/pmic.200600422
-
Wiese S.; Reidegeld K. A.; Meyer H. E.; Warscheid B. Protein labeling by iTRAQ: a new tool for quantitative mass spectrometry in proteome research. Proteomics, 2007, 7, 340-50. (Pubitemid 46293976)
-
(2007)
Proteomics
, vol.7
, Issue.3
, pp. 340-350
-
-
Wiese, S.1
Reidegeld, K.A.2
Meyer, H.E.3
Warscheid, B.4
-
54
-
-
34948875686
-
Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
-
DOI 10.1038/nbt1328, PII NBT1328
-
Bantscheff M.; Eberhard D.; Abraham Y.; Bastuck S.; Boesche M.; Hobson S.; Mathieson T.; Perrin J.; Raida M.; Rau C. Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat. Biotechnol., 2007, 25, 1035-44. (Pubitemid 47517638)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.9
, pp. 1035-1044
-
-
Bantscheff, M.1
Eberhard, D.2
Abraham, Y.3
Bastuck, S.4
Boesche, M.5
Hobson, S.6
Mathieson, T.7
Perrin, J.8
Raida, M.9
Rau, C.10
Reader, V.11
Sweetman, G.12
Bauer, A.13
Bouwmeester, T.14
Hopf, C.15
Kruse, U.16
Neubauer, G.17
Ramsden, N.18
Rick, J.19
Kuster, B.20
Drewes, G.21
more..
-
55
-
-
77954610415
-
Combined comparative and chemical proteomics on the mechanisms of levotetrahydropalmatine-induced antinociception in the formalin test
-
Wang C.; Zhou J.; Wang S.; Ye M.; Jiang C.; Fan G.; Zou H. Combined comparative and chemical proteomics on the mechanisms of levotetrahydropalmatine-induced antinociception in the formalin test. J. Proteome Res., 2010, 9, 3225-34.
-
(2010)
J. Proteome Res.
, vol.9
, pp. 3225-3234
-
-
Wang, C.1
Zhou, J.2
Wang, S.3
Ye, M.4
Jiang, C.5
Fan, G.6
Zou, H.7
-
56
-
-
63849172494
-
Identifying the proteins to which smallmolecule probes and drugs bind in cells
-
Ong S. E.; Schenone M.; Margolin A. A.; Li X.; Do K.; Doud M. K.; Mani D.; Kuai L.; Wang X.; Wood J. L. Identifying the proteins to which smallmolecule probes and drugs bind in cells. Proc. Natl. Acad. Sci. U. S. A., 2009, 106, 4617-22.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 4617-4622
-
-
Ong, S.E.1
Schenone, M.2
Margolin, A.A.3
Li, X.4
Do, K.5
Doud, M.K.6
Mani, D.7
Kuai, L.8
Wang, X.9
Wood, J.L.10
-
57
-
-
33947725496
-
Preparation of a biochip on porous silicon and application for label-free detection of small molecule-protein interactions
-
DOI 10.1002/rcm.2944
-
Hu L.; Xu S.; Pan C.; Zou H.; Jiang G. Preparation of a biochip on porous silicon and application for label-free detection of small molecule-protein interactions. Rapid Commun. Mass Spectrom., 2007, 21, 1277-81. (Pubitemid 46506582)
-
(2007)
Rapid Communications in Mass Spectrometry
, vol.21
, Issue.7
, pp. 1277-1281
-
-
Hu, L.1
Xu, S.2
Pan, C.3
Zou, H.4
Jiang, G.5
-
59
-
-
9344247454
-
Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips
-
DOI 10.1073/pnas.0407117101
-
Huang J.; Zhu H.; Haggarty S. J.; Spring D. R.; Hwang H.; Jin F.; Snyder M.; Schreiber S. L. Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc. Natl. Acad. Sci. U. S. A., 2004, 101, 16594-99. (Pubitemid 39557758)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.47
, pp. 16594-16599
-
-
Huang, J.1
Zhu, H.2
Haggarty, S.J.3
Spring, D.R.4
Hwang, H.5
Jin, F.6
Snyder, M.7
Schreiber, S.L.8
-
61
-
-
1542290057
-
A three-hybrid approach to scanning the proteome for targets of small molecule kinase inhibitors
-
DOI 10.1016/S1074-5521(04)00029-8, PII S1074552104000298
-
Becker F.; Murthi K.; Smith C.; Come J.; Costa-Roldán N.; Kaufmann C.; Hanke U.; Degenhart C.; Baumann S.; Wallner W. A three-hybrid approach to scanning the proteome for targets of small molecule kinase inhibitors. Chem. Biol., 2004, 11, 211-23. (Pubitemid 38300291)
-
(2004)
Chemistry and Biology
, vol.11
, Issue.2
, pp. 211-223
-
-
Becker, F.1
Murthi, K.2
Smith, C.3
Come, J.4
Costa-Roldan, N.5
Kaufmann, C.6
Hanke, U.7
Degenhart, C.8
Baumann, S.9
Wallner, W.10
Huber, A.11
Dedier, S.12
Dill, S.13
Kinsman, D.14
Hediger, M.15
Bockovich, N.16
Meier-Ewert, S.17
Kluge, A.F.18
Kley, N.19
-
63
-
-
5444253443
-
2+/calmodulin function
-
DOI 10.1016/j.chembiol.2004.08.015, PII S1074552104002509
-
Shim J. S.; Lee J.; Park H. J.; Park S. J.; Kwon H. J. A new curcumin derivative, HBC, interferes with the cell cycle progression of colon cancer cells via antagonization of the Ca2+/calmodulin function. Chem. Biol., 2004, 11, 1455-63. (Pubitemid 39351381)
-
(2004)
Chemistry and Biology
, vol.11
, Issue.10
, pp. 1455-1463
-
-
Shim, J.S.1
Lee, J.2
Park, H.-J.3
Park, S.-J.4
Kwon, H.J.5
-
64
-
-
0026346182
-
Using protein affinity chromatography to probe structure of protein machines
-
Formosa T.; Barry J.; Alberts B.; Greenblatt J. Using protein affinity chromatography to probe structure of protein machines. Methods Enzymol., 1991, 208, 24-45.
-
(1991)
Methods Enzymol.
, vol.208
, pp. 24-45
-
-
Formosa, T.1
Barry, J.2
Alberts, B.3
Greenblatt, J.4
-
65
-
-
67650708399
-
Small-molecule affinity chromatography coupled mass spectrometry for drug target deconvolution
-
Saxena C.; Higgs R. E.; Zhen E.; Hale J. E. Small-molecule affinity chromatography coupled mass spectrometry for drug target deconvolution. Expert Opin. Drug Dis., 2009, 4, 701-14.
-
(2009)
Expert Opin. Drug Dis.
, vol.4
, pp. 701-714
-
-
Saxena, C.1
Higgs, R.E.2
Zhen, E.3
Hale, J.E.4
-
66
-
-
45749158648
-
Identification of the cellular targets of bioactive small organic molecules using affinity reagents
-
Leslie B. J.; Hergenrother P. J. Identification of the cellular targets of bioactive small organic molecules using affinity reagents. Chem. Soc. Rev., 2008, 37, 1347-60.
-
(2008)
Chem. Soc. Rev.
, vol.37
, pp. 1347-1360
-
-
Leslie, B.J.1
Hergenrother, P.J.2
-
67
-
-
73849090207
-
Identification and characterization of molecular targets of natural products by mass spectrometry
-
Cheng K. W.; Wong C. C.; Wang M.; He Q. Y.; Chen F. Identification and characterization of molecular targets of natural products by mass spectrometry. Mass Spectrom. Rev., 2010, 29, 126-55.
-
(2010)
Mass Spectrom. Rev.
, vol.29
, pp. 126-155
-
-
Cheng, K.W.1
Wong, C.C.2
Wang, M.3
He, Q.Y.4
Chen, F.5
-
68
-
-
77950493758
-
Natural products and their biological targets: Proteomic and metabolomic labeling strategies
-
Bttcher T.; Pitscheider M.; Sieber S. A. Natural products and their biological targets: proteomic and metabolomic labeling strategies. Angew. Chem. Int. Ed., 2010, 49, 2680-98.
-
(2010)
Angew. Chem. Int. Ed.
, vol.49
, pp. 2680-2698
-
-
Bttcher, T.1
Pitscheider, M.2
Sieber, S.A.3
-
69
-
-
35748983210
-
Target deconvolution strategies in drug discovery
-
DOI 10.1038/nrd2410, PII NRD2410
-
Terstappen G.; Schlüpen C.; Raggiaschi R.; Gaviraghi G. Target deconvolution strategies in drug discovery. Nat. Rev. Drug Disc., 2007, 6, 891-903. (Pubitemid 350042397)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.11
, pp. 891-903
-
-
Terstappen, G.C.1
Schlupen, C.2
Raggiaschi, R.3
Gaviraghi, G.4
-
70
-
-
45749110640
-
Small-molecule microarrays as tools in ligand discovery
-
Vegas A. J.; Fuller J. H.; Koehler A. N. Small-molecule microarrays as tools in ligand discovery. Chem. Soc. Rev., 2008, 37, 1385-94.
-
(2008)
Chem. Soc. Rev.
, vol.37
, pp. 1385-1394
-
-
Vegas, A.J.1
Fuller, J.H.2
Koehler, A.N.3
-
71
-
-
24744437350
-
Roscovitine targets, protein kinases and pyridoxal kinase
-
DOI 10.1074/jbc.M500806200
-
Bach S.; Knockaert M.; Reinhardt J.; Lozach O.; Schmitt S.; Baratte B.; Koken M.; Coburn S.; Tang L.; Jiang T. Roscovitine targets, protein kinases and pyridoxal kinase. J. Biol. Chem., 2005, 280, 31208-19. (Pubitemid 41291858)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.35
, pp. 31208-31219
-
-
Bach, S.1
Knockaert, M.2
Reinhardt, J.3
Lozach, O.4
Schmitt, S.5
Baratte, B.6
Koken, M.7
Coburn, S.P.8
Tang, L.9
Jiang, T.10
Liang, D.-C.11
Galons, H.12
Dierick, J.-F.13
Pinna, L.A.14
Meggio, F.15
Totzke, F.16
Schachtele, C.17
Lerman, A.S.18
Carnero, A.19
Wan, Y.20
Gray, N.21
Meijer, L.22
more..
-
72
-
-
34250627652
-
Small-molecule synergist of the Wnt/β-catenin signaling pathway
-
DOI 10.1073/pnas.0702136104
-
Zhang Q.; Major M.; Takanashi S.; Camp N.; Nishiya N.; Peters E.; Ginsberg M.; Jian X.; Randazzo P.; Schultz P. Small-molecule synergist of the Wnt/β-catenin signaling pathway. Proc. Natl. Acad. Sci. U.S.A., 2007, 104, 7444-48. (Pubitemid 47185925)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.18
, pp. 7444-7448
-
-
Zhang, Q.1
Major, M.B.2
Takanashi, S.3
Camp, N.D.4
Nishiya, N.5
Peters, E.C.6
Ginsberg, M.H.7
Schultz, P.G.8
Moon, R.T.9
Ding, S.10
-
73
-
-
50149114458
-
The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase i
-
Makoto K.; Hideo O.; Kaori H.; Naoki Kanoh; Makoto Muroi; Naoshi Dohmae; Masamichi Takami; Mitsuhiro Kitagawa; Yushi Futamura; Masaya Imoto; Osada H. The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I. Proc. Natl. Acad. Sci. U. S. A., 2008, 105, 11691-96.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 11691-11696
-
-
Makoto, K.1
Hideo, O.2
Kaori, H.3
Kanoh, N.4
Muroi, M.5
Dohmae, N.6
Takami, M.7
Kitagawa, M.8
Futamura, Y.9
Imoto, M.10
Osada, H.11
-
74
-
-
17844362208
-
Dissection of melanogenesis with small molecules identifies prohibitin as a regulator
-
DOI 10.1016/j.chembiol.2005.02.014
-
Snyder J.; Hall A.; Ni-Komatsu L.; Khersonsky S.; Chang Y.; Orlow S. Dissection of melanogenesis with small molecules identifies prohibitin as a regulator. Chem. Biol., 2005, 12, 477-84. (Pubitemid 40588923)
-
(2005)
Chemistry and Biology
, vol.12
, Issue.4
, pp. 477-484
-
-
Snyder, J.R.1
Hall, A.2
Ni-Komatsu, L.3
Khersonsky, S.M.4
Chang, Y.-T.5
Orlow, S.J.6
-
75
-
-
0038371369
-
Quantitative chemical proteomics for identifying candidate drug targets
-
DOI 10.1021/ac026196y
-
Oda Y.; Owa T.; Sato T.; Boucher B.; Daniels S.; Yamanaka H.; Shinohara Y.; Yokoi A.; Kuromitsu J.; Nagasu T. Quantitative chemical proteomics for identifying candidate drug targets. Anal. Chem, 2003, 75, 2159-65. (Pubitemid 36542358)
-
(2003)
Analytical Chemistry
, vol.75
, Issue.9
, pp. 2159-2165
-
-
Oda, Y.1
Owa, T.2
Sato, T.3
Boucher, B.4
Daniels, S.5
Yamanaka, H.6
Shinohara, Y.7
Yokoi, A.8
Kuromitsu, J.9
Nagasu, T.10
-
76
-
-
33847788820
-
Diazonamide toxins reveal an unexpected function for ornithine δ-amino transferase in mitotic cell division
-
DOI 10.1073/pnas.0610832104
-
Wang G.; Shang L.; Burgett A.; Harran P.; Wang X. Diazonamide toxins reveal an unexpected function for ornithine δ-amino transferase in mitotic cell division. Proc. Natl. Acad. Sci. U.S.A., 2007, 104, 2068-73. (Pubitemid 46391353)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.7
, pp. 2068-2073
-
-
Wang, G.1
Shang, L.2
Burgett, A.W.G.3
Harran, P.G.4
Wang, X.5
-
77
-
-
33846681655
-
Polyproline-rod approach to isolating protein targets of bioactive small molecules: Isolation of a new target of indomethacin
-
DOI 10.1021/ja0655643
-
Sato S.; Kwon Y.; Kamisuki S.; Srivastava N.; Mao Q.; Kawazoe Y.; Uesugi M. Polyproline-Rod Approach to Isolating Protein Targets of Bioactive Small Molecules: Isolation of a New Target of Indomethacin. J. Am. Chem. Soc., 2007, 129, 873-80. (Pubitemid 46188236)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.4
, pp. 873-880
-
-
Sato, S.-I.1
Kwon, Y.2
Kamisuki, S.3
Srivastava, N.4
Mao, Q.5
Kawazoe, Y.6
Uesugi, M.7
-
78
-
-
4344587136
-
-
Emami K.; Nguyen C.; Ma H.; Kim D.; Jeong K.; Eguchi M.; Moon R.; Teo J.; Oh S.; Kim H. A small molecule inhibitor of β-catenin/CREB-binding protein transcription. Proc. Natl. Acad. Sci. U.S.A., 2004, 101, 12682-87.
-
(2004)
A Small Molecule Inhibitor of β-catenin/CREB-binding Protein Transcription. Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 12682-12687
-
-
Emami, K.1
Nguyen, C.2
Ma, H.3
Kim, D.4
Jeong, K.5
Eguchi, M.6
Moon, R.7
Teo, J.8
Oh, S.9
Kim, H.10
-
79
-
-
33646052014
-
A versatile method of identifying specific binding proteins on affinity resins
-
Yamamoto K.; Yamazaki A.; Takeuchi M.; Tanaka A. A versatile method of identifying specific binding proteins on affinity resins. Anal. Biochem., 2006, 352, 15-23.
-
(2006)
Anal. Biochem.
, vol.352
, pp. 15-23
-
-
Yamamoto, K.1
Yamazaki, A.2
Takeuchi, M.3
Tanaka, A.4
-
80
-
-
36448960196
-
The natural product avrainvillamide binds to the oncoprotein nucleophosmin
-
DOI 10.1021/ja075327f
-
Wulff J. E.; Siegrist R.; Myers A. G. The natural product avrainvillamide binds to the oncoprotein nucleophosmin. J. Am. Chem. Soc., 2007, 129, 14444-51. (Pubitemid 350171471)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.46
, pp. 14444-14451
-
-
Wulff, J.E.1
Siegrist, R.2
Myers, A.G.3
-
81
-
-
67549128952
-
Sesterterpenes as Tubulin Tyrosine Ligase Inhibitors. First Insight of Structure Activity Relationships and Discovery of New Lead
-
Dal Piaz F.; Vassallo A.; Lepore L.; Tosco A.; Bader A.; De Tommasi N. Sesterterpenes as Tubulin Tyrosine Ligase Inhibitors. First Insight of Structure Activity Relationships and Discovery of New Lead. J. Med. Chem., 2009, 52, 327-29.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 327-329
-
-
Dal Piaz, F.1
Vassallo, A.2
Lepore, L.3
Tosco, A.4
Bader, A.5
De Tommasi, N.6
-
82
-
-
70350522204
-
Selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines
-
Clerc J.; Florea B. I.; Kraus M.; Groll M.; Huber R.; Bachmann A. S.; Dudler R.; Driessen C.; Overkleeft H. S.; Kaiser M. Syringolin A Selectively Labels the 20 S Proteasome in Murine EL4 and Wild-Type and Bortezomib-Adapted Leukaemic Cell Lines. ChemBioChem, 2009, 10, 2638-43.
-
(2009)
ChemBioChem
, vol.10
, pp. 2638-2643
-
-
Clerc, J.1
Florea, B.I.2
Kraus, M.3
Groll, M.4
Huber, R.5
Bachmann, A.S.6
Dudler, R.7
Driessen, C.8
Overkleeft, H.S.9
Kaiser, M.10
Syringolin, A.11
-
83
-
-
76049084586
-
Target identification using drug affinity responsive target stability (DARTS)
-
Lomenick B.; Hao R.; Jonai N.; Chin R. M.; Aghajan M.; Warburton S.; Wang J.; Wu R. P.; Gomez F.; Loo J. A. Target identification using drug affinity responsive target stability (DARTS). Proc. Natl. Acad. Sci. U. S. A., 2009, 106, 21984-89.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 21984-21989
-
-
Lomenick, B.1
Hao, R.2
Jonai, N.3
Chin, R.M.4
Aghajan, M.5
Warburton, S.6
Wang, J.7
Wu, R.P.8
Gomez, F.9
Loo, J.A.10
-
84
-
-
47249089015
-
Synthesis and cytotoxicity of aurilide analogs
-
Suenaga K.; Kajiwara S.; Kuribayashi S.; Handa T.; Kigoshi H. Synthesis and cytotoxicity of aurilide analogs. Bioorg. Med. Chem. Lett., 2008, 18, 3902-05.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 3902-3905
-
-
Suenaga, K.1
Kajiwara, S.2
Kuribayashi, S.3
Handa, T.4
Kigoshi, H.5
-
86
-
-
39449112660
-
Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria
-
DOI 10.1101/gad.460708
-
Merkwirth C.; Dargazanli S.; Tatsuta T.; Geimer S.; Lwer B.; Wunderlich F. T.; von Kleist-Retzow J. C.; Waisman A.; Westermann B.; Langer T. Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria. Genes Dev., 2008, 22, 476-88. (Pubitemid 351272755)
-
(2008)
Genes and Development
, vol.22
, Issue.4
, pp. 476-488
-
-
Merkwirth, C.1
Dargazanli, S.2
Tatsuta, T.3
Geimer, S.4
Lower, B.5
Wunderlich, F.T.6
Von Kleist-Retzow, J.-C.7
Waisman, A.8
Westermann, B.9
Langer, T.10
-
87
-
-
79251577725
-
Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin
-
Sato S.; Murata A.; Orihara T.; Shirakawa T.; Suenaga K.; Kigoshi H.; Uesugi M. Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin. Chem. Biol., 2011, 18, 131-39.
-
(2011)
Chem. Biol.
, vol.18
, pp. 131-139
-
-
Sato, S.1
Murata, A.2
Orihara, T.3
Shirakawa, T.4
Suenaga, K.5
Kigoshi, H.6
Uesugi, M.7
-
88
-
-
79251571481
-
Prohibitin (g) Cancer: Aurilide and Killing by Opa1-Dependent Cristae Remodeling
-
Semenzato M.; Cogliati S.; Scorrano L. Prohibitin (g) Cancer: Aurilide and Killing by Opa1-Dependent Cristae Remodeling. Chem. Biol., 2011, 18, 8-9.
-
(2011)
Chem. Biol.
, vol.18
, pp. 8-9
-
-
Semenzato, M.1
Cogliati, S.2
Scorrano, L.3
-
89
-
-
78650284389
-
Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli
-
Costa V.; Giacomello M.; Hudec R.; Lopreiato R.; Ermak G.; Lim D.; Malorni W.; Davies K. J. A.; Carafoli E.; Scorrano L. Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO Mol. Med., 2010, 2:, 490-503.
-
(2010)
EMBO Mol. Med.
, vol.2
, pp. 490-503
-
-
Costa, V.1
Giacomello, M.2
Hudec, R.3
Lopreiato, R.4
Ermak, G.5
Lim, D.6
Malorni, W.7
Davies, K.J.A.8
Carafoli, E.9
Scorrano, L.10
-
90
-
-
78651232227
-
MiR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1
-
Wang J. X.; Jiao J. Q.; Li Q.; Long B.; Wang K.; Liu J. P.; Li Y. R.; Li P. F. miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat. Med., 2010, 17, 71-78.
-
(2010)
Nat. Med.
, vol.17
, pp. 71-78
-
-
Wang, J.X.1
Jiao, J.Q.2
Li, Q.3
Long, B.4
Wang, K.5
Liu, J.P.6
Li, Y.R.7
Li, P.F.8
-
92
-
-
50649112213
-
Activity-based protein profiling: From enzyme chemistry to proteomic chemistry
-
Cravatt B.; Wright A.; Kozarich J. Activity-based protein profiling: from enzyme chemistry to proteomic chemistry. Annu. Rev. Biochem., 2008, 77, 383-414.
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 383-414
-
-
Cravatt, B.1
Wright, A.2
Kozarich, J.3
-
93
-
-
1042287130
-
The development and application of methods for activity-based protein profiling
-
DOI 10.1016/j.cbpa.2003.11.004
-
Jessani N.; Cravatt B. The development and application of methods for activity-based protein profiling. Curr. Opin. Chem. Biol., 2004, 8, 54-59. (Pubitemid 38201478)
-
(2004)
Current Opinion in Chemical Biology
, vol.8
, Issue.1
, pp. 54-59
-
-
Jessani, N.1
Cravatt, B.F.2
-
94
-
-
0347087452
-
Chemical Strategies for Activity-Based Proteomics
-
DOI 10.1002/cbic.200300721
-
Speers A.; Cravatt B. Chemical strategies for activity-based proteomics. ChemBioChem, 2004, 5, 41-47. (Pubitemid 38095018)
-
(2004)
ChemBioChem
, vol.5
, Issue.1
, pp. 41-47
-
-
Speers, A.E.1
Cravatt, B.F.2
-
95
-
-
33846807650
-
Tagging and detection strategies for activity-based proteomics
-
DOI 10.1016/j.cbpa.2006.11.030, PII S1367593106001876
-
Sadaghiani A. M.; Verhelst S. H. L.; Bogyo M. Tagging and detection strategies for activity-based proteomics. Curr. Opin. Chem. Biol., 2007, 11, 20-28. (Pubitemid 46216128)
-
(2007)
Current Opinion in Chemical Biology
, vol.11
, Issue.1
, pp. 20-28
-
-
Sadaghiani, A.M.1
Verhelst, S.H.2
Bogyo, M.3
-
96
-
-
35948972522
-
Chemical proteomics identifies unanticipated targets of clinical kinase inhibitors
-
DOI 10.1021/cb700203j
-
Peters E. C.; Gray N. S. Chemical proteomics identifies unanticipated targets of clinical kinase inhibitors. ACS Chem. Biol., 2007, 2, 661-64. (Pubitemid 350066014)
-
(2007)
ACS Chemical Biology
, vol.2
, Issue.10
, pp. 661-664
-
-
Peters, E.C.1
Gray, N.S.2
-
97
-
-
34547789923
-
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases
-
DOI 10.1021/ja073650c
-
Li W.; Blankman J. L.; Cravatt B. F. A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J. Am. Chem. Soc., 2007, 129, 9594-95. (Pubitemid 47237463)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.31
, pp. 9594-9595
-
-
Li, W.1
Blankman, J.L.2
Cravatt, B.F.3
-
98
-
-
46749145391
-
An unbiased evaluation of CK2 inhibitors by chemoproteomics: Characterization of inhibitor effects on CK2 and identification of novel inhibitor targets
-
DOI 10.1074/mcp.M700559-MCP200
-
Duncan J.; Gyenis L.; Lenehan J.; Bretner M.; Graves L.; Haystead T.; Litchfield D. An Unbiased Evaluation of CK2 Inhibitors by Chemoproteomics: Characterization of Inhibitor Effects on CK2 and Identification of Novel Inhibitor Targets. Mol. Cell. Proteomics, 2008, 7, 1077-88. (Pubitemid 351943955)
-
(2008)
Molecular and Cellular Proteomics
, vol.7
, Issue.6
, pp. 1077-1088
-
-
Duncan, J.S.1
Gyenis, L.2
Lenehan, J.3
Bretner, M.4
Graves, L.M.5
Haystead, T.A.6
Litchfield, D.W.7
-
99
-
-
0036051482
-
Chemical approaches for functionally probing the proteome
-
Greenbaum D.; Baruch A.; Hayrapetian L.; Darula Z.; Burlingame A.; Medzihradszky K.; Bogyo M. Chemical Approaches for Functionally Probing the Proteome. Mol. Cell. Proteomics, 2002, 1, 60-68.
-
(2002)
Mol. Cell. Proteomics
, vol.1
, pp. 60-68
-
-
Greenbaum, D.1
Baruch, A.2
Hayrapetian, L.3
Darula, Z.4
Burlingame, A.5
Medzihradszky, K.6
Bogyo, M.7
-
100
-
-
29444460784
-
Activity-based probes that target diverse cysteine protease families
-
Kato D.; Boatright K.; Berger A.; Nazif T.; Blum G.; Ryan C.; Chehade K.; Salvesen G.; Bogyo M. Activity-based probes that target diverse cysteine protease families. Nat. Chem. Biol., 2005, 1, 33-38.
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 33-38
-
-
Kato, D.1
Boatright, K.2
Berger, A.3
Nazif, T.4
Blum, G.5
Ryan, C.6
Chehade, K.7
Salvesen, G.8
Bogyo, M.9
-
101
-
-
33644825565
-
Dynamic imaging of protease activity with fluorescently quenched activity-based probes
-
Blum G.; Mullins S.; Keren K.; Fonovič M.; Jedeszko C.; Rice M.; Sloane B.; Bogyo M. Dynamic imaging of protease activity with fluorescently quenched activity-based probes. Nat. Chem. Biol., 2005, 1, 203-09.
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 203-209
-
-
Blum, G.1
Mullins, S.2
Keren, K.3
Fonovič, M.4
Jedeszko, C.5
Rice, M.6
Sloane, B.7
Bogyo, M.8
-
102
-
-
10744227299
-
Specific and Covalent Targeting of Conjugating and Deconjugating Enzymes of Ubiquitin-Like Proteins
-
DOI 10.1128/MCB.24.1.84-95.2004
-
Hemelaar J.; Borodovsky A.; Kessler B.; Reverter D.; Cook J.; Kolli N.; Gan-Erdene T.; Wilkinson K.; Gill G.; Lima C. Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol. Cell. Biol., 2004, 24, 84-95. (Pubitemid 38010037)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.1
, pp. 84-95
-
-
Hemelaar, J.1
Borodovsky, A.2
Kessler, B.M.3
Reverter, D.4
Cook, J.5
Kolli, N.6
Gan-Erdene, T.7
Wilkinson, K.D.8
Gill, G.9
Lima, C.D.10
Ploegh, H.L.11
Ovaa, H.12
-
103
-
-
13444275087
-
Chemistry-Based Functional Proteomics: Mechanism-Based Activity-Profiling Tools for Ubiquitin and Ubiquitin-like Specific Proteases
-
DOI 10.1021/pr0341080
-
Hemelaar J.; Galardy P.; Borodovsky A.; Kessler B.; Ploegh H.; Ovaa H. Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases. J. Proteome Res., 2004, 3, 268-76. (Pubitemid 38500994)
-
(2004)
Journal of Proteome Research
, vol.3
, Issue.2
, pp. 268-276
-
-
Hemelaar, J.1
Galardy, P.J.2
Borodovsky, A.3
Kessler, B.M.4
Ploegh, H.L.5
Ovaa, H.6
-
104
-
-
21144444663
-
Small-molecule inhibitors and probes for ubiquitin-and ubiquitin-like-specific proteases
-
Borodovsky A.; Ovaa H.; Meester W.; Venanzi E.; Bogyo M.; Hekking B.; Ploegh H.; Kessler B.; Overkleeft H. Small-molecule inhibitors and probes for ubiquitin-and ubiquitin-like-specific proteases. ChemBioChem, 2005, 6, 287-90.
-
(2005)
ChemBioChem
, vol.6
, pp. 287-290
-
-
Borodovsky, A.1
Ovaa, H.2
Meester, W.3
Venanzi, E.4
Bogyo, M.5
Hekking, B.6
Ploegh, H.7
Kessler, B.8
Overkleeft, H.9
-
105
-
-
64349085775
-
Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes
-
Bachovchin D. A.; Brown S. J.; Rosen H.; Cravatt B. F. Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes. Nat. Biotechnol., 2009, 27, 387-94.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 387-394
-
-
Bachovchin, D.A.1
Brown, S.J.2
Rosen, H.3
Cravatt, B.F.4
-
106
-
-
0031171961
-
Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin
-
Griffith E. C.; Su Z.; Turk B. E.; Chen S.; Chang Y. H.; Wu Z.; Biemann K.; Liu J. O. Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Chem. Biol., 1997, 4, 461-71. (Pubitemid 27288711)
-
(1997)
Chemistry and Biology
, vol.4
, Issue.6
, pp. 461-471
-
-
Griffith, E.C.1
Su, Z.2
Turk, B.E.3
Chen, S.4
Chang, Y.-H.5
Wu, Z.6
Biemann, K.7
Liu, J.O.8
-
107
-
-
0033117634
-
The identification of myriocinbinding proteins
-
Chen J. K.; Lane W. S.; Schreiber S. L. The identification of myriocinbinding proteins. Chem. Biol., 1999, 6, 221-35.
-
(1999)
Chem. Biol.
, vol.6
, pp. 221-235
-
-
Chen, J.K.1
Lane, W.S.2
Schreiber, S.L.3
-
109
-
-
5644255983
-
Quality, not quantity: The role of natural products and chemical proteomics in modern drug discovery
-
Piggott A. M.; Karuso P. Quality, not quantity: the role of natural products and chemical proteomics in modern drug discovery. Comb. Chem. High T. Scr., 2004, 7, 607-30. (Pubitemid 39371210)
-
(2004)
Combinatorial Chemistry and High Throughput Screening
, vol.7
, Issue.7
, pp. 607-630
-
-
Piggott, A.M.1
Karuso, P.2
-
110
-
-
23044453692
-
Quality not quantity: The role of marine natural products in drug discovery and reverse chemical proteomics
-
Piggott A. M.; Karuso P. Quality not quantity: the role of marine natural products in drug discovery and reverse chemical proteomics. Mar. Drugs, 2005, 3, 36-63. (Pubitemid 41056618)
-
(2005)
Marine Drugs
, vol.3
, Issue.2
, pp. 36-63
-
-
Piggott, A.M.1
Karuso, P.2
-
111
-
-
84855360379
-
Probing small molecule-protein interactions: A new perspective for functional proteomics
-
Lenz T.; Fischer J. J.; Dreger M. Probing small molecule-protein interactions: A new perspective for functional proteomics. J. Proteomics, 2011, 75, 100-15.
-
(2011)
J. Proteomics
, vol.75
, pp. 100-115
-
-
Lenz, T.1
Fischer, J.J.2
Dreger, M.3
-
112
-
-
75149172947
-
The cAMP Capture Compound Mass Spectrometry as a Novel Tool for Targeting cAMP-binding Proteins
-
Luo Y.; Blex C.; Baessler O.; Glinski M.; Dreger M.; Sefkow M.; Köster H. The cAMP Capture Compound Mass Spectrometry as a Novel Tool for Targeting cAMP-binding Proteins. Mol. Cell. Proteomics, 2009, 8, 2843-56.
-
(2009)
Mol. Cell. Proteomics
, vol.8
, pp. 2843-2856
-
-
Luo, Y.1
Blex, C.2
Baessler, O.3
Glinski, M.4
Dreger, M.5
Sefkow, M.6
Köster, H.7
-
113
-
-
74849088596
-
Capture compound mass spectrometry sheds light on the molecular mechanisms of liver toxicity of two Parkinson drugs
-
Fischer J. J.; Michaelis S.; Schrey A. K.; Glinski M.; Dreger M.; Kroll F.; Koester H. Capture compound mass spectrometry sheds light on the molecular mechanisms of liver toxicity of two Parkinson drugs. Toxicol. Sci., 2010, 113, 243-53.
-
(2010)
Toxicol. Sci.
, vol.113
, pp. 243-253
-
-
Fischer, J.J.1
Michaelis, S.2
Schrey, A.K.3
Glinski, M.4
Dreger, M.5
Kroll, F.6
Koester, H.7
-
114
-
-
0026044572
-
Pateamine: A potent cytotoxin from the New Zealand marine sponge mycale Sp
-
Northcote P. T.; Blunt J. W.; Munro M. H. G. Pateamine: a potent cytotoxin from the New Zealand marine sponge, Mycale Sp. Tetrahedron Lett., 1991, 32, 6411-14.
-
(1991)
Tetrahedron Lett.
, vol.32
, pp. 6411-6414
-
-
Northcote, P.T.1
Blunt, J.W.2
Munro, M.H.G.3
-
115
-
-
28444448743
-
Inhibition of eukaryotic translation initiation by the marine natural product pateamine A
-
DOI 10.1016/j.molcel.2005.10.008, PII S1097276505016783
-
Low W. K.; Dang Y.; Schneider-Poetsch T.; Shi Z.; Choi N. S.; Merrick W. C.; Romo D.; Liu J. O. Inhibition of eukaryotic translation initiation by the marine natural product pateamine A. Mol. Cell, 2005, 20, 709-22. (Pubitemid 41740693)
-
(2005)
Molecular Cell
, vol.20
, Issue.5
, pp. 709-722
-
-
Low, W.-K.1
Dang, Y.2
Schneider-Poetsch, T.3
Shi, Z.4
Choi, N.S.5
Merrick, W.C.6
Romo, D.7
Liu, J.O.8
-
116
-
-
23044457401
-
Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation
-
DOI 10.1073/pnas.0504249102
-
Bordeleau M. E.; Matthews J.; Wojnar J. M.; Lindqvist L.; Novac O.; Jankowsky E.; Sonenberg N.; Northcote P.; Teesdale-Spittle P.; Pelletier J. Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proc. Natl. Acad. Sci. U. S. A., 2005, 102, 10460-65. (Pubitemid 41061576)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.30
, pp. 10460-10465
-
-
Bordeleau, M.-E.1
Matthews, J.2
Wojnar, J.M.3
Lindqvist, L.4
Novac, O.5
Jankowsky, E.6
Sonenberg, N.7
Northcote, P.8
Teesdale-Spittle, P.9
Pelletier, J.10
-
117
-
-
33845597429
-
RNA-Mediated Sequestration of the RNA Helicase eIF4A by Pateamine A Inhibits Translation Initiation
-
DOI 10.1016/j.chembiol.2006.10.005, PII S107455210600384X
-
Bordeleau M. E.; Cencic R.; Lindqvist L.; Oberer M.; Northcote P.; Wagner G.; Pelletier J. RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation. Chem. Biol., 2006, 13, 1287-95. (Pubitemid 44932234)
-
(2006)
Chemistry and Biology
, vol.13
, Issue.12
, pp. 1287-1295
-
-
Bordeleau, M.-E.1
Cencic, R.2
Lindqvist, L.3
Oberer, M.4
Northcote, P.5
Wagner, G.6
Pelletier, J.7
-
118
-
-
34250328209
-
Substrate-Dependent Targeting of Eukaryotic Translation Initiation Factor 4A by Pateamine A: Negation of Domain-Linker Regulation of Activity
-
DOI 10.1016/j.chembiol.2007.05.012, PII S1074552107001810
-
Low W. K.; Dang Y.; Bhat S.; Romo D.; Liu J. O. Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: negation of domain-linker regulation of activity. Chem. Biol., 2007, 14, 715-27. (Pubitemid 46920988)
-
(2007)
Chemistry and Biology
, vol.14
, Issue.6
, pp. 715-727
-
-
Low, W.-K.1
Dang, Y.2
Bhat, S.3
Romo, D.4
Liu, J.O.5
-
119
-
-
69949118279
-
Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII
-
Dang Y.; Low W. K.; Xu J.; Gehring N. H.; Dietz H. C.; Romo D.; Liu J. O. Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII. J. Biol. Chem., 2009, 284, 23613-21.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 23613-23621
-
-
Dang, Y.1
Low, W.K.2
Xu, J.3
Gehring, N.H.4
Dietz, H.C.5
Romo, D.6
Liu, J.O.7
-
120
-
-
66849113670
-
Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A
-
Kuznetsov G.; Xu Q.; Rudolph-Owen L.; TenDyke K.; Liu J.; Towle M.; Zhao N.; Marsh J.; Agoulnik S.; Twine N. Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A. Mol. Cancer Ther., 2009, 8, 1250-60.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 1250-1260
-
-
Kuznetsov, G.1
Xu, Q.2
Rudolph-Owen, L.3
Tendyke, K.4
Liu, J.5
Towle, M.6
Zhao, N.7
Marsh, J.8
Agoulnik, S.9
Twine, N.10
-
121
-
-
34548104659
-
Splicing factor SF3b as a target of the antitumor natural product pladienolide
-
DOI 10.1038/nchembio.2007.16, PII NCHEMBIO200716
-
Kotake Y.; Sagane K.; Owa T.; Mimori-Kiyosue Y.; Shimizu H.; Uesugi M.; Ishihama Y.; Iwata M.; Mizui Y. Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat. Chem. Biol., 2007, 3, 570-75. (Pubitemid 47294394)
-
(2007)
Nature Chemical Biology
, vol.3
, Issue.9
, pp. 570-575
-
-
Kotake, Y.1
Sagane, K.2
Owa, T.3
Mimori-Kiyosue, Y.4
Shimizu, H.5
Uesugi, M.6
Ishihama, Y.7
Iwata, M.8
Mizui, Y.9
-
122
-
-
34548095157
-
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
-
DOI 10.1038/nchembio.2007.18, PII NCHEMBIO200718
-
Kaida D.; Motoyoshi H.; Tashiro E.; Nojima T.; Hagiwara M.; Ishigami K.; Watanabe H.; Kitahara T.; Yoshida T.; Nakajima H. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nat. Chem. Biol., 2007, 3, 576-83. (Pubitemid 47294395)
-
(2007)
Nature Chemical Biology
, vol.3
, Issue.9
, pp. 576-583
-
-
Kaida, D.1
Motoyoshi, H.2
Tashiro, E.3
Nojima, T.4
Hagiwara, M.5
Ishigami, K.6
Watanabe, H.7
Kitahara, T.8
Yoshida, T.9
Nakajima, H.10
Tani, T.11
Horinouchi, S.12
Yoshida, M.13
-
123
-
-
79955573435
-
Identification of SAP155 as the Target of GEX1A (Herboxidiene), An Antitumor Natural Product
-
Hasegawa M.; Miura T.; Kuzuya K.; Inoue A.; Ki S. W.; Horinouchi S.; Yoshida T.; Kunoh T.; Koseki K.; Mino K. Identification of SAP155 as the Target of GEX1A (Herboxidiene), An Antitumor Natural Product. ACS Chem. Biol., 2011, 6:, 229-33.
-
(2011)
ACS Chem. Biol.
, vol.6
, pp. 229-233
-
-
Hasegawa, M.1
Miura, T.2
Kuzuya, K.3
Inoue, A.4
Ki, S.W.5
Horinouchi, S.6
Yoshida, T.7
Kunoh, T.8
Koseki, K.9
Mino, K.10
-
124
-
-
79961049732
-
Sudemycins novel small molecule analogues of FR901464, induce alternative gene splicing
-
Fan L.; LAGISETTI C.; Edwards C. C.; Webb T. R.; Potter P. M. Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing. ACS Chem. Biol., 2011, 6, 582-89.
-
(2011)
ACS Chem. Biol.
, vol.6
, pp. 582-589
-
-
Fan, L.1
Lagisetti, C.2
Edwards, C.C.3
Webb, T.R.4
Potter, P.M.5
-
126
-
-
4043121114
-
Computational chemogenomics approaches to systematic knowledge-based drug discovery
-
Mestres J. Computational chemogenomics approaches to systematic knowledge-based drug discovery. Curr. Opin. Drug Disc., 2004, 7, 304-13. (Pubitemid 44120947)
-
(2004)
Current Opinion in Drug Discovery and Development
, vol.7
, Issue.3
, pp. 304-313
-
-
Mestres, J.1
-
127
-
-
33846876695
-
Relating protein pharmacology by ligand chemistry
-
DOI 10.1038/nbt1284, PII NBT1284
-
Keiser M. J.; Roth B. L.; Armbruster B. N.; Ernsberger P.; Irwin J. J.; Shoichet B. K. Relating protein pharmacology by ligand chemistry. Nat. Biotechnol., 2007, 25, 197-206. (Pubitemid 46227119)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.2
, pp. 197-206
-
-
Keiser, M.J.1
Roth, B.L.2
Armbruster, B.N.3
Ernsberger, P.4
Irwin, J.J.5
Shoichet, B.K.6
-
128
-
-
33746042161
-
Integrated in silico tools for exploiting the natural products' bioactivity
-
DOI 10.1055/s-2006-941506
-
Rollinger J.; Langer T.; Stuppner H. Integrated in Silico Tools for Exploiting the Natural Product's Bioactivity. Planta Med., 2006, 72, 671-78. (Pubitemid 44073448)
-
(2006)
Planta Medica
, vol.72
, Issue.8
, pp. 671-678
-
-
Rollinger, J.M.1
Langer, T.2
Stuppner, H.3
-
129
-
-
8544230644
-
GAsDock: A new approach for rapid flexible docking based on an improved multi-population genetic algorithm
-
DOI 10.1016/j.bmcl.2004.06.091, PII S0960894X04008820
-
Li H.; Li C.; Gui C.; Luo X.; Chen K.; Shen J.; Wang X.; Jiang H. GAsDock: a new approach for rapid flexible docking based on an improved multipopulation genetic algorithm. Bioorg. Med. Chem. Lett., 2004, 14, 4671-76. (Pubitemid 39490287)
-
(2004)
Bioorganic and Medicinal Chemistry Letters
, vol.14
, Issue.18
, pp. 4671-4676
-
-
Li, H.1
Li, C.2
Gui, C.3
Luo, X.4
Chen, K.5
Shen, J.6
Wang, X.7
Jiang, H.8
-
130
-
-
40549130652
-
PDTD: A web-accessible protein database for drug target identification
-
Gao Z.; Li H.; Zhang H.; Liu X.; Kang L.; Luo X.; Zhu W.; Chen K.; Wang X.; Jiang H. PDTD: a web-accessible protein database for drug target identification. BMC Bioinformatics 2008, 9, 104.
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 104
-
-
Gao, Z.1
Li, H.2
Zhang, H.3
Liu, X.4
Kang, L.5
Luo, X.6
Zhu, W.7
Chen, K.8
Wang, X.9
Jiang, H.10
-
131
-
-
77954264038
-
PharmMapper server: A web server for potential drug target identification using pharmacophore mapping approach
-
Liu X.; Ouyang S.; Yu B.; Liu Y.; Huang K.; Gong J.; Zheng S.; Li Z.; Li H.; Jiang H. PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach. Nucleic Acids Res., 2010, 38, W609-W14.
-
(2010)
Nucleic Acids Res.
, vol.38
-
-
Liu, X.1
Ouyang, S.2
Yu, B.3
Liu, Y.4
Huang, K.5
Gong, J.6
Zheng, S.7
Li, Z.8
Li, H.9
Jiang, H.10
-
132
-
-
33747829590
-
TarFisDock: A web server for identifying drug targets with docking approach
-
DOI 10.1093/nar/gkl114
-
Li H.; Gao Z.; Kang L.; Zhang H.; Yang K.; Yu K.; Luo X.; Zhu W.; Chen K.; Shen J. TarFisDock: a web server for identifying drug targets with docking approach. Nucleic Acids Res., 2006, 34, W219-24. (Pubitemid 44529767)
-
(2006)
Nucleic Acids Research
, vol.34
, Issue.WEB. SERV. ISS.
-
-
Li, H.1
Gao, Z.2
Kang, L.3
Zhang, H.4
Yang, K.5
Yul, K.6
Luo, X.7
Zhu, W.8
Chen, K.9
Shen, J.10
Wang, X.11
Jiang, H.12
-
133
-
-
79959270961
-
Fast and effective identification of the bioactive compounds and their targets from medicinal plants via computational chemical biology approach
-
Zhang S.; Lu W.; Liu X.; Diao Y.; Bai F.; Wang L.; Shan L.; Huang J.; Li H.; Zhang W. Fast and effective identification of the bioactive compounds and their targets from medicinal plants via computational chemical biology approach. Med. Chem. Commun., 2011, 2, 471-77.
-
(2011)
Med. Chem. Commun.
, vol.2
, pp. 471-477
-
-
Zhang, S.1
Lu, W.2
Liu, X.3
Diao, Y.4
Bai, F.5
Wang, L.6
Shan, L.7
Huang, J.8
Li, H.9
Zhang, W.10
-
134
-
-
67650422597
-
[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase
-
Jeong C. H.; Bode A. M.; Pugliese A.; Cho Y. Y.; Kim H. G.; Shim J. H.; Jeon Y. J.; Li H.; Jiang H.; Dong Z. [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer Res., 2009, 69, 5584-91.
-
(2009)
Cancer Res.
, vol.69
, pp. 5584-5591
-
-
Jeong, C.H.1
Bode, A.M.2
Pugliese, A.3
Cho, Y.Y.4
Kim, H.G.5
Shim, J.H.6
Jeon, Y.J.7
Li, H.8
Jiang, H.9
Dong, Z.10
-
135
-
-
77953923379
-
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
-
Alvarez S. E.; Harikumar K. B.; Hait N. C.; Allegood J.; Strub G. M.; Kim E. Y.; Maceyka M.; Jiang H.; Luo C.; Kordula T. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature, 2010, 465, 1084-88.
-
(2010)
Nature
, vol.465
, pp. 1084-1088
-
-
Alvarez, S.E.1
Harikumar, K.B.2
Hait, N.C.3
Allegood, J.4
Strub, G.M.5
Kim, E.Y.6
MacEyka, M.7
Jiang, H.8
Luo, C.9
Kordula, T.10
-
136
-
-
69949113620
-
Regulation of histone acetylation in the nucleus by sphingosine-1- phosphate
-
Hait N.; Allegood J.; Maceyka M.; Strub G.; Harikumar K.; Singh S.; Luo C.; Marmorstein R.; Kordula T.; Milstien S. Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate. Science, 2009, 325, 1254-57.
-
(2009)
Science
, vol.325
, pp. 1254-1257
-
-
Hait, N.1
Allegood, J.2
MacEyka, M.3
Strub, G.4
Harikumar, K.5
Singh, S.6
Luo, C.7
Marmorstein, R.8
Kordula, T.9
Milstien, S.10
-
137
-
-
78649927272
-
Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A4 hydrolase
-
Oi N.; Jeong C. H.; Nadas J.; Cho Y. Y.; Pugliese A.; Bode A. M.; Dong Z. Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A4 hydrolase. Cancer Res., 2010, 70, 9755-64.
-
(2010)
Cancer Res.
, vol.70
, pp. 9755-9764
-
-
Oi, N.1
Jeong, C.H.2
Nadas, J.3
Cho, Y.Y.4
Pugliese, A.5
Bode, A.M.6
Dong, Z.7
-
138
-
-
56249134213
-
Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei
-
Amaro R. E.; Schnaufer A.; Interthal H.; Hol W.; Stuart K. D.; McCammon J. A. Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei. Proc. Natl. Acad. Sci. U. S. A., 2008, 105, 17278-83.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 17278-17283
-
-
Amaro, R.E.1
Schnaufer, A.2
Interthal, H.3
Hol, W.4
Stuart, K.D.5
McCammon, J.A.6
-
139
-
-
50249114683
-
An improved relaxed complex scheme for receptor flexibility in computer-aided drug design
-
Amaro R. E.; Baron R.; McCammon J. A. An improved relaxed complex scheme for receptor flexibility in computer-aided drug design. J. Comput. Aided Mol. Des., 2008, 22, 693-705.
-
(2008)
J. Comput. Aided Mol. Des.
, vol.22
, pp. 693-705
-
-
Amaro, R.E.1
Baron, R.2
McCammon, J.A.3
-
140
-
-
11644261806
-
Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function
-
Morris G. M.; Goodsell D. S.; Halliday R. S.; Huey R.; Hart W. E.; Belew R. K.; Olson A. J. Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. J. Comput. Chem., 1998, 19, 1639-62. (Pubitemid 128590223)
-
(1998)
Journal of Computational Chemistry
, vol.19
, Issue.14
, pp. 1639-1662
-
-
Morris, G.M.1
Goodsell, D.S.2
Halliday, R.S.3
Huey, R.4
Hart, W.E.5
Belew, R.K.6
Olson, A.J.7
-
141
-
-
31544450787
-
Novel procedure for modeling ligand/receptor induced fit effects
-
DOI 10.1021/jm050540c
-
Sherman W.; Day T.; Jacobson M. P.; Friesner R. A.; Farid R. Novel procedure for modeling ligand/receptor induced fit effects. J. Med. Chem., 2006, 49, 534-53. (Pubitemid 43157487)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.2
, pp. 534-553
-
-
Sherman, W.1
Day, T.2
Jacobson, M.P.3
Friesner, R.A.4
Farid, R.5
-
142
-
-
36949009488
-
In silico elucidation of the molecular mechanism defining the adverse effect of selective estrogen receptor modulators
-
Xie L.; Wang J.; Bourne P. E. In silico elucidation of the molecular mechanism defining the adverse effect of selective estrogen receptor modulators. PLoS Comput. Biol., 2007, 3, e217.
-
(2007)
PLoS Comput. Biol.
, vol.3
-
-
Xie, L.1
Wang, J.2
Bourne, P.E.3
-
143
-
-
68249144628
-
Drug discovery using chemical systems biology: Repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis
-
Kinnings S. L.; Liu N.; Buchmeier N.; Tonge P. J.; Xie L.; Bourne P. E. Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis. PLoS Comput. Biol., 2009, 5, e1000423.
-
(2009)
PLoS Comput. Biol.
, vol.5
-
-
Kinnings, S.L.1
Liu, N.2
Buchmeier, N.3
Tonge, P.J.4
Xie, L.5
Bourne, P.E.6
-
144
-
-
79953100964
-
Structure-based systems biology for analyzing off-target binding
-
Xie L.; Bourne P. E. Structure-based systems biology for analyzing off-target binding. Curr. Opin. Struct. Biol., 2011, 21, 189-99.
-
(2011)
Curr. Opin. Struct. Biol.
, vol.21
, pp. 189-199
-
-
Xie, L.1
Bourne, P.E.2
-
145
-
-
46849105028
-
Ensemble-based virtual screening reveals potential novel antiviral compounds for avian influenza neuraminidase
-
DOI 10.1021/jm8001197
-
Cheng L. S.; Amaro R. E.; Xu D.; Li W. W.; Arzberger P. W.; McCammon J. A. Ensemble-based virtual screening reveals potential novel antiviral compounds for avian influenza neuraminidase. J. Med. Chem., 2008, 51, 3878-94. (Pubitemid 351956517)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.13
, pp. 3878-3894
-
-
Cheng, L.S.1
Amaro, R.E.2
Xu, D.3
Li, W.W.4
Arzberger, P.W.5
McCammon, J.A.6
-
146
-
-
37649009919
-
Molecule-pharmacophore superpositioning and pattern matching in computational drug design
-
Wolber G.; Seidel T.; Bendix F.; Langer T. Molecule-pharmacophore superpositioning and pattern matching in computational drug design. Drug Discov. Today, 2008, 13, 23-29.
-
(2008)
Drug Discov. Today
, vol.13
, pp. 23-29
-
-
Wolber, G.1
Seidel, T.2
Bendix, F.3
Langer, T.4
-
147
-
-
33846518797
-
In silico target fishing: Predicting biological targets from chemical structure
-
DOI 10.1016/j.ddtec.2006.12.008, PII S1740674906000813
-
Jenkins J. L.; Bender A.; Davies J. W. In silico target fishing: Predicting biological targets from chemical structure. Drug Discov. Today, 2007, 3, 413-21. (Pubitemid 46158395)
-
(2006)
Drug Discovery Today: Technologies
, vol.3
, Issue.4
, pp. 413-421
-
-
Jenkins, J.L.1
Bender, A.2
Davies, J.W.3
-
148
-
-
34548319111
-
In silico pharmacology for drug discovery: Applications to targets and beyond
-
DOI 10.1038/sj.bjp.0707306, PII 0707306
-
Ekins S.; Mestres J.; Testa B. In silico pharmacology for drug discovery: applications to targets and beyond. Br. J. Pharmacol., 2007, 152, 21-37. (Pubitemid 47339897)
-
(2007)
British Journal of Pharmacology
, vol.152
, Issue.1
, pp. 21-37
-
-
Ekins, S.1
Mestres, J.2
Testa, B.3
-
149
-
-
34548317031
-
Chemogenomic approaches to rational drug design
-
DOI 10.1038/sj.bjp.0707307, PII 0707307
-
Rognan D. Chemogenomic approaches to rational drug design. Br. J. Pharmacol., 2007, 152, 38-52. (Pubitemid 47339898)
-
(2007)
British Journal of Pharmacology
, vol.152
, Issue.1
, pp. 38-52
-
-
Rognan, D.1
-
150
-
-
37249026328
-
Integrating high-content screening and ligand-target prediction to identify mechanism of action
-
DOI 10.1038/nchembio.2007.53, PII NCHEMBIO200753
-
Young D. W.; Bender A.; Hoyt J.; McWhinnie E.; Chirn G. W.; Tao C. Y.; Tallarico J. A.; Labow M.; Jenkins J. L.; Mitchison T. J. Integrating highcontent screening and ligand-target prediction to identify mechanism of action. Nat. Chem. Biol., 2007, 4, 59-68. (Pubitemid 350273652)
-
(2008)
Nature Chemical Biology
, vol.4
, Issue.1
, pp. 59-68
-
-
Young, D.W.1
Bender, A.2
Hoyt, J.3
McWhinnie, E.4
Chirn, G.-W.5
Tao, C.Y.6
Tallarico, J.A.7
Labow, M.8
Jenkins, J.L.9
Mitchison, T.J.10
Feng, Y.11
-
151
-
-
35148838537
-
Drugtarget network
-
Yildirim M. A.; Goh K. I.; Cusick M. E.; Barabsi A. L.; Vidal M. Drugtarget network. Nat. Biotechnol., 2007, 25, 1119-26.
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 1119-1126
-
-
Yildirim, M.A.1
Goh, K.I.2
Cusick, M.E.3
Barabsi, A.L.4
Vidal, M.5
-
152
-
-
67049158003
-
Fishing the target of antitubercular compounds: In silico target deconvolution model development and validation
-
Prathipati P.; Ma N. L.; Manjunatha U. H.; Bender A. Fishing the target of antitubercular compounds: in silico target deconvolution model development and validation. J. Proteome Res., 2009, 8, 2788-98.
-
(2009)
J. Proteome Res.
, vol.8
, pp. 2788-2798
-
-
Prathipati, P.1
Ma, N.L.2
Manjunatha, U.H.3
Bender, A.4
-
153
-
-
66749165862
-
Use of ligand based models for protein domains to predict novel molecular targets and applications to triage affinity chromatography data
-
Bender A.; Mikhailov D.; Glick M.; Scheiber J.; Davies J. W.; Cleaver S.; Marshall S.; Tallarico J. A.; Harrington E.; Cornella-Taracido I. Use of Ligand Based Models for Protein Domains To Predict Novel Molecular Targets and Applications To Triage Affinity Chromatography Data. J. Proteome Res., 2009, 8, 2575-85.
-
(2009)
J. Proteome Res.
, vol.8
, pp. 2575-2585
-
-
Bender, A.1
Mikhailov, D.2
Glick, M.3
Scheiber, J.4
Davies, J.W.5
Cleaver, S.6
Marshall, S.7
Tallarico, J.A.8
Harrington, E.9
Cornella-Taracido, I.10
-
154
-
-
45749116266
-
Application of belief theory to similarity data fusion for use in analog searching and lead hopping
-
Muchmore S. W.; Debe D. A.; Metz J. T.; Brown S. P.; Martin Y. C.; Hajduk P. J. Application of belief theory to similarity data fusion for use in analog searching and lead hopping. J. Chem. Inf. model., 2008, 48, 941-48.
-
(2008)
J. Chem. Inf. Model.
, vol.48
, pp. 941-948
-
-
Muchmore, S.W.1
Debe, D.A.2
Metz, J.T.3
Brown, S.P.4
Martin, Y.C.5
Hajduk, P.J.6
-
155
-
-
70449634957
-
Predicting new molecular targets for known drugs
-
Keiser M. J.; Setola V.; Irwin J. J.; Laggner C.; Abbas A. I.; Hufeisen S. J.; Jensen N. H.; Kuijer M. B.; Matos R. C.; Tran T. B. Predicting new molecular targets for known drugs. Nature, 2009, 462, 175-81.
-
(2009)
Nature
, vol.462
, pp. 175-181
-
-
Keiser, M.J.1
Setola, V.2
Irwin, J.J.3
Laggner, C.4
Abbas, A.I.5
Hufeisen, S.J.6
Jensen, N.H.7
Kuijer, M.B.8
Matos, R.C.9
Tran, T.B.10
-
156
-
-
80053906388
-
Chemical structural novelty: On-targets and off-targets
-
Yera E. R.; Cleves A. E.; Jain A. N. Chemical Structural Novelty: On-Targets and Off-Targets. J. Med. Chem., 2011, 54, 6771-85.
-
(2011)
J. Med. Chem.
, vol.54
, pp. 6771-6785
-
-
Yera, E.R.1
Cleves, A.E.2
Jain, A.N.3
-
157
-
-
76149120425
-
A side effect resource to capture phenotypic effects of drugs
-
Kuhn M.; Campillos M.; Letunic I.; Jensen L. J.; Bork P. A side effect resource to capture phenotypic effects of drugs. Mol. Syst. Biol., 2010, 6, 343.
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 343
-
-
Kuhn, M.1
Campillos, M.2
Letunic, I.3
Jensen, L.J.4
Bork, P.5
-
158
-
-
47249146126
-
Drug target identification using side-effect similarity
-
DOI 10.1126/science.1158140
-
Campillos M.; Kuhn M.; Gavin A. C.; Jensen L. J.; Bork P. Drug target identification using side-effect similarity. Science, 2008, 321, 263-66. (Pubitemid 351989100)
-
(2008)
Science
, vol.321
, Issue.5886
, pp. 263-266
-
-
Campillos, M.1
Kuhn, M.2
Gavin, A.-C.3
Jensen, L.J.4
Bork, P.5
-
159
-
-
77955628292
-
Network-based relating pharmacological and genomic spaces for drug target identification
-
Zhao S.; Li S. Network-based relating pharmacological and genomic spaces for drug target identification. PLoS One, 2010, 5, e11764.
-
(2010)
PLoS One
, vol.5
-
-
Zhao, S.1
Li, S.2
-
160
-
-
79952345084
-
Analysis of multiple compound-protein interactions reveals novel bioactive molecules
-
Yabuuchi H.; Niijima S.; Takematsu H.; Ida T.; Hirokawa T.; Hara T.; Ogawa T.; Minowa Y.; Tsujimoto G.; Okuno Y. Analysis of multiple compound-protein interactions reveals novel bioactive molecules. Mol. Syst. Biol., 2011, 7, 472.
-
(2011)
Mol. Syst. Biol.
, vol.7
, pp. 472
-
-
Yabuuchi, H.1
Niijima, S.2
Takematsu, H.3
Ida, T.4
Hirokawa, T.5
Hara, T.6
Ogawa, T.7
Minowa, Y.8
Tsujimoto, G.9
Okuno, Y.10
-
161
-
-
77954197778
-
Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model
-
Yizhak K.; Benyamini T.; Liebermeister W.; Ruppin E.; Shlomi T. Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model. Bioinformatics, 2010, 26, i255-i60.
-
(2010)
Bioinformatics
, vol.26
-
-
Yizhak, K.1
Benyamini, T.2
Liebermeister, W.3
Ruppin, E.4
Shlomi, T.5
-
162
-
-
77954838957
-
Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls
-
Zhang C.; Frias M. A.; Mele A.; Ruggiu M.; Eom T.; Marney C. B.; Wang H.; Licatalosi D. D.; Fak J. J.; Darnell R. B. Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls. Science, 2010, 329, 439-43.
-
(2010)
Science
, vol.329
, pp. 439-443
-
-
Zhang, C.1
Frias, M.A.2
Mele, A.3
Ruggiu, M.4
Eom, T.5
Marney, C.B.6
Wang, H.7
Licatalosi, D.D.8
Fak, J.J.9
Darnell, R.B.10
-
163
-
-
46249128543
-
Identifying functional modules in protein-protein interaction networks: An integrated exact approach
-
Dittrich M. T.; Klau G. W.; Rosenwald A.; Dandekar T.; Muller T. Identifying functional modules in protein-protein interaction networks: an integrated exact approach. Bioinformatics, 2008, 24, i223-i31.
-
(2008)
Bioinformatics
, vol.24
-
-
Dittrich, M.T.1
Klau, G.W.2
Rosenwald, A.3
Dandekar, T.4
Muller, T.5
-
164
-
-
62549145762
-
Toward accurate reconstruction of functional protein networks
-
Yosef N.; Ungar L.; Zalckvar E.; Kimchi A.; Kupiec M.; Ruppin E.; Sharan R. Toward accurate reconstruction of functional protein networks. Mol. Syst. Biol., 2009, 5, 248.
-
(2009)
Mol. Syst. Biol.
, vol.5
, pp. 248
-
-
Yosef, N.1
Ungar, L.2
Zalckvar, E.3
Kimchi, A.4
Kupiec, M.5
Ruppin, E.6
Sharan, R.7
-
165
-
-
43049156566
-
Human metabolic network reconstruction and its impact on drug discovery and development
-
Ma H.; Goryanin I. Human metabolic network reconstruction and its impact on drug discovery and development. Drug Discov. Today, 2008, 13, 402-08.
-
(2008)
Drug Discov. Today
, vol.13
, pp. 402-408
-
-
Ma, H.1
Goryanin, I.2
-
166
-
-
77950493758
-
Natural products and their biological targets: Proteomic and metabolomic labeling strategies
-
Bottcher T.; Pitscheider M.; Sieber S. A. Natural products and their biological targets: proteomic and metabolomic labeling strategies. Angew. Chem. Int. Ed., 2010, 49, 2680-98.
-
(2010)
Angew. Chem. Int. Ed.
, vol.49
, pp. 2680-2698
-
-
Bottcher, T.1
Pitscheider, M.2
Sieber, S.A.3
-
167
-
-
33847377573
-
A robustness-based approach to systems-oriented drug design
-
DOI 10.1038/nrd2195, PII NRD2195
-
Kitano H. A robustness-based approach to systems-oriented drug design. Nat. Rev. Drug Discov., 2007, 5, 202-10. (Pubitemid 46344624)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.3
, pp. 202-210
-
-
Kitano, H.1
-
168
-
-
36448991184
-
Cellular targets of natural products
-
DOI 10.1039/b616808f
-
Dixon N.; Wong L. S.; Geerlings T. H.; Micklefield J. Cellular targets of natural products. Nat. Prod. Rep., 2007, 24, 1288-310. (Pubitemid 350161738)
-
(2007)
Natural Product Reports
, vol.24
, Issue.6
, pp. 1288-1310
-
-
Dixon, N.1
Wong, L.S.2
Geerlings, T.H.3
Micklefield, J.4
-
169
-
-
33751547539
-
How many drug targets are there?
-
DOI 10.1038/nrd2199, PII NRD2199
-
Overington J. P.; Al-Lazikani B.; Hopkins A. L. How many drug targets are there? Nat. Rev. Drug Discov., 2006, 5, 993-96. (Pubitemid 44835126)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.12
, pp. 993-996
-
-
Overington, J.P.1
Al-Lazikani, B.2
Hopkins, A.L.3
-
170
-
-
33750531864
-
Innovative lead discovery strategies for tropical diseases
-
DOI 10.1038/nrd2144, PII NRD2144
-
Nwaka S.; Hudson A. Innovative lead discovery strategies for tropical diseases. Nat. Rev. Drug Discov., 2006, 5, 941-55. (Pubitemid 44660607)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.11
, pp. 941-955
-
-
Nwaka, S.1
Hudson, A.2
-
171
-
-
35148824614
-
Network pharmacology
-
DOI 10.1038/nbt1007-1110, PII NBT10071110
-
Hopkins A. L. Network pharmacology. Nat. Biotechnol., 2007, 25, 1110-11. (Pubitemid 47538107)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.10
, pp. 1110-1111
-
-
Hopkins, A.L.1
-
172
-
-
77955039434
-
Molecular networks for the study of TCM Pharmacology
-
Zhao J.; Jiang P.; Zhang W. Molecular networks for the study of TCM Pharmacology. Brief Bioinform., 2010, 11, 417-30.
-
(2010)
Brief Bioinform.
, vol.11
, pp. 417-430
-
-
Zhao, J.1
Jiang, P.2
Zhang, W.3
-
173
-
-
54249155522
-
Network pharmacology: The next paradigm in drug discovery
-
Hopkins A. L. Network pharmacology: the next paradigm in drug discovery. Nat. Chem. Biol., 2008, 4, 682-90.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 682-690
-
-
Hopkins, A.L.1
-
174
-
-
59349083179
-
Mechanisms of drug combinations: Interaction and network perspectives
-
Jia J.; Zhu F.; Ma X.; Cao Z. W.; Li Y. X.; Chen Y. Z. Mechanisms of drug combinations: interaction and network perspectives. Nat. Rev. Drug Discov., 2009, 8, 111-28.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 111-128
-
-
Jia, J.1
Zhu, F.2
Ma, X.3
Cao, Z.W.4
Li, Y.X.5
Chen, Y.Z.6
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