Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 45, 2008, Pages 17278-17283

  Amaro, Rommie E ^a   Schnaufer, Achim ^b   Interthal, Heidrun ^c   Hold, Wim ^c,d   Stuart, Kenneth D ^b,c   McCammon, J Andrew ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

African sleeping sickness; Molecular dynamics; Receptor flexibility; Relaxed complex scheme; RNA ligase

Indexed keywords

1 AMINO 4 (3 (AMINOSULFONYL)ANILINO) 9,10 DIOXO ,10 DIHYDRO 2 ANTHRACENESULFONIC ACID; 3 ((4 (ETHYLAMINO)PHENYL)DIAZENYL) 4,5 DIHYDROXY 2,7 NAPHTHALENEDISULFONIC ACID; 3 ((5 CHLORO 2 HYDROXYPHENYL)DIAZENYL) 4,5 DIHYDROXY 2,7 NAPHTHALENEDISULFONIC ACID; 3 HYDROXY 4 ((1 HYDROXY 2 NAPHTHYL)DIAZENYL) 7 (HYDROXY(OXIDO)AINO 1 NAPHTHALENESULFONIC ACID; 4,5 DIHYDROXY 3 (1 NAPHTHYLDIAZENYL) 2,7 NAPHTHALENEDISULFONIC ACID; ANTIPROTOZOAL AGENT; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RNA LIGASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIOPHAGE; BINDING AFFINITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG MECHANISM; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA EDITING; TRYPANOSOMA BRUCEI;

ANIMALS; CARBON-OXYGEN LIGASES; COMPUTATIONAL BIOLOGY; DNA LIGASES; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MITOCHONDRIAL PROTEINS; MOLECULAR STRUCTURE; RNA EDITING; RNA LIGASE (ATP); TRYPANOSOMA BRUCEI BRUCEI; VIRAL PROTEINS;

PROTOZOA; TRYPANOSOMA BRUCEI; TRYPANOSOMATIDAE;

EID: 56249134213     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0805820105     Document Type: Article

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