-
2
-
-
33749234216
-
Drugs, their targets and the nature and number of drug targets
-
Imming, P., Sinning, C. & Meyer, A. Drugs, their targets and the nature and number of drug targets. Nat. Rev. Drug Discov. 5, 821-834 (2006).
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, pp. 821-834
-
-
Imming, P.1
Sinning, C.2
Meyer, A.3
-
3
-
-
33751547539
-
How many drug targets are there?
-
Overington, J.P., Bissan, A. & Hopkins, A. How many drug targets are there? Nat. Rev. Drug Discov. 5, 993-996 (2006).
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, pp. 993-996
-
-
Overington, J.P.1
Bissan, A.2
Hopkins, A.3
-
4
-
-
29144531173
-
The druggable genome: An update
-
Russ, A.P. & Lampel, S. The druggable genome: an update. Drug Discov. Today 10, 1607-1610 (2005).
-
(2005)
Drug Discov. Today
, vol.10
, pp. 1607-1610
-
-
Russ, A.P.1
Lampel, S.2
-
5
-
-
0037404094
-
Stategic trends in the drug industry
-
Drews, J. Stategic trends in the drug industry. Drug Discov. Today 8, 411-420 (2003).
-
(2003)
Drug Discov. Today
, vol.8
, pp. 411-420
-
-
Drews, J.1
-
6
-
-
0742305866
-
Network biology: Understanding the cell's functional organization
-
Barabasi, A.L. & Oltvai, Z.N. Network biology: understanding the cell's functional organization. Nat. Rev. Genet. 5, 101-113 (2004).
-
(2004)
Nat. Rev. Genet
, vol.5
, pp. 101-113
-
-
Barabasi, A.L.1
Oltvai, Z.N.2
-
7
-
-
3042848952
-
Evidence for dynamically organized modularity in the yeast protein-protein interaction network
-
Han, J.-D. et al. Evidence for dynamically organized modularity in the yeast protein-protein interaction network. Nature 430, 88-93 (2004).
-
(2004)
Nature
, vol.430
, pp. 88-93
-
-
Han, J.-D.1
-
8
-
-
0035799707
-
Lethality and centrality in protein networks
-
Jeong, H., Mason, S., Barabasi, A.-L. & Oltvai, Z. Lethality and centrality in protein networks. Nature 411, 41-42 (2001).
-
(2001)
Nature
, vol.411
, pp. 41-42
-
-
Jeong, H.1
Mason, S.2
Barabasi, A.-L.3
Oltvai, Z.4
-
9
-
-
14844311241
-
Interactome modeling
-
Vidal, M. Interactome modeling. FEBS Lett. 579, 1834-1838 (2005).
-
(2005)
FEBS Lett
, vol.579
, pp. 1834-1838
-
-
Vidal, M.1
-
10
-
-
34547140875
-
The human disease network
-
Goh, K.I. et al. The human disease network. Proc. Natl. Acad. Sci. USA 104, 8685-8690 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 8685-8690
-
-
Goh, K.I.1
-
11
-
-
0035865078
-
Human disease genes
-
Jimenez-Sanchez, G., Childs, B. & Valle, D. Human disease genes. Nature 409, 853-855 (2001).
-
(2001)
Nature
, vol.409
, pp. 853-855
-
-
Jimenez-Sanchez, G.1
Childs, B.2
Valle, D.3
-
12
-
-
0035895515
-
Dissecting human disease in the postgenomic era
-
Peltonen, L. & McKusick, V. Dissecting human disease in the postgenomic era. Science 291, 1224-1229 (2001).
-
(2001)
Science
, vol.291
, pp. 1224-1229
-
-
Peltonen, L.1
McKusick, V.2
-
13
-
-
33644876210
-
Drugbank: A comprehensive resource for in silico drug discovery and exploration
-
Wishart, D.S. et al. Drugbank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 34, D668-D672 (2006).
-
(2006)
Nucleic Acids Res
, vol.34
-
-
Wishart, D.S.1
-
14
-
-
33746156959
-
Global mapping of pharmacological space
-
Paolini, G.V., Shapland, R.H., van Hoorn, W.P., Mason, J.S. & Hopkins, A.L. Global mapping of pharmacological space. Nat. Biotechnol. 24, 805-815 (2006).
-
(2006)
Nat. Biotechnol
, vol.24
, pp. 805-815
-
-
Paolini, G.V.1
Shapland, R.H.2
van Hoorn, W.P.3
Mason, J.S.4
Hopkins, A.L.5
-
15
-
-
4644271084
-
Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia
-
Roth, B.L., Sheffler, D.J. & Kroeze, W.K. Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nat. Rev. Drug Discov. 3, 353-359 (2004).
-
(2004)
Nat. Rev. Drug Discov
, vol.3
, pp. 353-359
-
-
Roth, B.L.1
Sheffler, D.J.2
Kroeze, W.K.3
-
16
-
-
32344446028
-
Can we rationally design promiscuous drugs?
-
Hopkins, A.L., Mason, J.S. & Overington, J.P. Can we rationally design promiscuous drugs? Curr. Opin. Struct. Biol. 16, 127-136 (2006).
-
(2006)
Curr. Opin. Struct. Biol
, vol.16
, pp. 127-136
-
-
Hopkins, A.L.1
Mason, J.S.2
Overington, J.P.3
-
17
-
-
27544446579
-
Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)
-
Mencher, S.K. & Wang, L.G. Promiscuous drugs compared to selective drugs (promiscuity can be a virtue). BMC Clin. Pharmacol. 5, 3 (2005).
-
(2005)
BMC Clin. Pharmacol
, vol.5
, pp. 3
-
-
Mencher, S.K.1
Wang, L.G.2
-
18
-
-
0035395881
-
Scientific collaboration networks. I. Network construction and fundamental results
-
Newman, M.E. Scientific collaboration networks. I. Network construction and fundamental results. Phys. Rev. E 64, 016131 (2001).
-
(2001)
Phys. Rev. E
, vol.64
, pp. 016131
-
-
Newman, M.E.1
-
19
-
-
27144469033
-
Emergent behavior of growing knowledge about molecular interactions
-
Cokol, M., Iossifov, I., Weinreb, C. & Rzhetsky, A. Emergent behavior of growing knowledge about molecular interactions. Nat. Biotechnol. 23, 1243-1247 (2005).
-
(2005)
Nat. Biotechnol
, vol.23
, pp. 1243-1247
-
-
Cokol, M.1
Iossifov, I.2
Weinreb, C.3
Rzhetsky, A.4
-
20
-
-
27144530248
-
Toward a proteome-scale map of the human protein-protein interaction network
-
Rual, J.-F. et al. Toward a proteome-scale map of the human protein-protein interaction network. Nature 437, 1173-1178 (2005).
-
(2005)
Nature
, vol.437
, pp. 1173-1178
-
-
Rual, J.-F.1
-
21
-
-
25144498379
-
A human protein-protein interaction network: A resource for annotating the proteome
-
Stelzl, U. et al. A human protein-protein interaction network: a resource for annotating the proteome. Cell 122, 957-968 (2005).
-
(2005)
Cell
, vol.122
, pp. 957-968
-
-
Stelzl, U.1
-
22
-
-
13444254254
-
The Mouse Genome Database (MGD): From genes to mice-a community resource for mouse biology
-
Eppig, J.T. et al. The Mouse Genome Database (MGD): from genes to mice-a community resource for mouse biology. Nucleic Acids Res. 33, D471-D475 (2005).
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Eppig, J.T.1
-
23
-
-
0033518234
-
From molecular to modular cell biology
-
Hartwell, L.H., Hopfield, J.J., Leibler, S. & Murray, A.W. From molecular to modular cell biology. Nature 402, C47-C52 (1999).
-
(1999)
Nature
, vol.402
-
-
Hartwell, L.H.1
Hopfield, J.J.2
Leibler, S.3
Murray, A.W.4
-
24
-
-
21444445235
-
Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues
-
Ge, X. et al. Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 86, 127-141 (2005).
-
(2005)
Genomics
, vol.86
, pp. 127-141
-
-
Ge, X.1
-
25
-
-
13444266370
-
Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders
-
Hamosh, A., Scott, A.F., Amberger, J.S., Bocchini, C.A. & McKusick, V.A. Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res. 33, D514-D517 (2005).
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Hamosh, A.1
Scott, A.F.2
Amberger, J.S.3
Bocchini, C.A.4
McKusick, V.A.5
-
26
-
-
5044226336
-
Systems biology in drug discovery
-
Butcher, E.C., Berg, E. & Kunkel, E. Systems biology in drug discovery. Nat. Biotechnol. 22, 1253-1259 (2004).
-
(2004)
Nat. Biotechnol
, vol.22
, pp. 1253-1259
-
-
Butcher, E.C.1
Berg, E.2
Kunkel, E.3
-
27
-
-
0037441560
-
Fulfilling the promise: Drug discovery in the postgenomic era
-
Chanda, S.K. & Caldwell, J. Fulfilling the promise: drug discovery in the postgenomic era. Drug Discov. Today 8, 168-174 (2003).
-
(2003)
Drug Discov. Today
, vol.8
, pp. 168-174
-
-
Chanda, S.K.1
Caldwell, J.2
-
28
-
-
0042568725
-
Pharmacophylogenomics: Genes, evolution and drug targets
-
Searls, D.B. Pharmacophylogenomics: genes, evolution and drug targets. Nat. Rev. Drug Discov. 2, 613-623 (2003).
-
(2003)
Nat. Rev. Drug Discov
, vol.2
, pp. 613-623
-
-
Searls, D.B.1
-
29
-
-
31144438390
-
Rescuing drug discovery: In vivo systems pathology and systems pharmacology
-
van der Greef, J. & McBurney, R. Rescuing drug discovery: in vivo systems pathology and systems pharmacology. Nat. Rev. Drug Discov. 4, 961-967 (2005).
-
(2005)
Nat. Rev. Drug Discov
, vol.4
, pp. 961-967
-
-
van der Greef, J.1
McBurney, R.2
-
30
-
-
0036596857
-
The impact of pharmacogenetics and pharmacogenomics on drug discovery
-
Lindpaintner, K. The impact of pharmacogenetics and pharmacogenomics on drug discovery. Nat. Rev. Drug Discov. 1, 463-469 (2002).
-
(2002)
Nat. Rev. Drug Discov
, vol.1
, pp. 463-469
-
-
Lindpaintner, K.1
-
31
-
-
0037395605
-
A brief history of novel drug discovery technologies
-
Gershell, L.J. & Atkins, J. A brief history of novel drug discovery technologies. Nat. Rev. Drug Discov. 2, 321-327 (2003).
-
(2003)
Nat. Rev. Drug Discov
, vol.2
, pp. 321-327
-
-
Gershell, L.J.1
Atkins, J.2
-
32
-
-
1542515338
-
A census of human cancer genes
-
Futreal, P.A. et al. A census of human cancer genes. Nat. Rev. Cancer 4, 177-183 (2004).
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 177-183
-
-
Futreal, P.A.1
-
33
-
-
0036635291
-
Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug
-
Capdeville, R., Buchdunger, E., Zimmermann, J. & Matter, A. Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug. Nat. Rev. Drug Discov. 1, 493-502 (2002).
-
(2002)
Nat. Rev. Drug Discov
, vol.1
, pp. 493-502
-
-
Capdeville, R.1
Buchdunger, E.2
Zimmermann, J.3
Matter, A.4
-
34
-
-
2942606066
-
Structure and evolution of transcriptional regulatory networks
-
Babu, M.M., Luscombe, N.M., Aravind, L., Gerstein, M. & Teichmann, S.A. Structure and evolution of transcriptional regulatory networks. Curr. Opin. Struct. Biol. 14, 283-291 (2004).
-
(2004)
Curr. Opin. Struct. Biol
, vol.14
, pp. 283-291
-
-
Babu, M.M.1
Luscombe, N.M.2
Aravind, L.3
Gerstein, M.4
Teichmann, S.A.5
-
35
-
-
0037174671
-
Transcriptional regulatory networks in Saccharomyces cerevisiae
-
Lee, T.-I. et al. Transcriptional regulatory networks in Saccharomyces cerevisiae. Science 298, 799-804 (2002).
-
(2002)
Science
, vol.298
, pp. 799-804
-
-
Lee, T.-I.1
-
36
-
-
29144470990
-
Topology, tinkering and evolution of the human transcription factor network
-
Rodriguez-Caso, C., Medina, M.A. & Sole, R.V. Topology, tinkering and evolution of the human transcription factor network. FEBS J. 272, 6423-6434 (2005).
-
(2005)
FEBS J
, vol.272
, pp. 6423-6434
-
-
Rodriguez-Caso, C.1
Medina, M.A.2
Sole, R.V.3
-
37
-
-
0035823264
-
The small world inside large metabolic networks
-
Wagner, A. & Fell, D.A. The small world inside large metabolic networks. Proc. Biol. Sci. 268, 1803-1810 (2001).
-
(2001)
Proc. Biol. Sci
, vol.268
, pp. 1803-1810
-
-
Wagner, A.1
Fell, D.A.2
|