Sesterterpenes as tubulin tyrosine ligase inhibitors. First insight of structure-activity relationships and discovery of new lead

Journal of Medicinal Chemistry

Volumn 52, Issue 12, 2009, Pages 3814-3828

  Dal Piaz, Fabrizio ^a   Vassallo, Antonio ^a   Lepore, Laura ^a   Tosco, Alessandra ^a   Bader, Ammar ^b   De Tommasi, Nunziatina ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b AL ZAYTOONAH UNIVERSITY OF JORDAN   (Jordan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; LIGASE; LIGASE INHIBITOR; PLANT EXTRACT; SALVIA DOMINICA EXTRACT; SESTERTERPENE; TUBULIN TYROSINE LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PEPTIDE SYNTHASES; PROTEOMICS; SALVIA; SESTERTERPENES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

EID: 67549128952     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801637f     Document Type: Article

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