Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network

Molecular and Cellular Proteomics

Volumn 7, Issue 5, 2008, Pages 949-961

  Yue, Qing Xi ^a   Cao, Zhi Wei ^b   Guan, Shu Hong ^a   Liu, Xiao Hui ^c   Tao, Lin ^b   Wu, Wan Ying ^a   Li, Yi Xue ^b   Yang, Peng Yuan ^c   Liu, Xuan ^a   Guo, De An ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHANGHAI CENTER FOR BIOINFORMATION TECHNOLOGY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE B; CORE PROTEIN; CYTOKERATIN 1; CYTOKERATIN 19; DNA; EPHRIN RECEPTOR A7; GANODERIC ACID D; GANODERMA LUCIDUM EXTRACT; INITIATION FACTOR 5A; LIPOCORTIN 5; SPERMIDINE SYNTHASE; TRITERPENE; UBIQUINOL CYTOCHROME C REDUCTASE; ANTINEOPLASTIC AGENT; PROTEIN 14 3 3; PROTEOME;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; COMPUTER MODEL; COMPUTER PROGRAM; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG IDENTIFICATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; FEMALE; FLOW CYTOMETRY; FUNCTIONAL PROTEOMICS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; STRUCTURE ANALYSIS; SURFACE PLASMON RESONANCE; TARGET CELL; TWO DIMENSIONAL GEL ELECTROPHORESIS; UTERINE CERVIX CARCINOMA; WESTERN BLOTTING; CELL CYCLE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; HELA CELL; MASS SPECTROMETRY; METABOLISM; PROTEIN SYNTHESIS; PROTEOMICS;

GANODERMA; GANODERMA LUCIDUM;

14-3-3 PROTEINS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL SURVIVAL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HELA CELLS; HUMANS; PROTEIN BIOSYNTHESIS; PROTEOME; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRITERPENES;

EID: 43849085358     PISSN: 15359476     EISSN: None     Source Type: Journal    
DOI: 10.1074/mcp.M700259-MCP200     Document Type: Article

References (61)

1. Yuri, T. K. (1999) Update from Asia. Asian studies on cancer chemoprevention. Ann. N. Y. Acad. Sci. 889, 157-192
2. Sliva, D. (2004) Cellular and physiological effects of Ganoderma lucidum (Reishi). Mini-Rev. Med. Chem. 4, 873-879
3. Yuen, J. W., and Gohel, M. D. (2005) Anticancer effects of Ganoderma lucidum: a review of scientific evidence. Nutr. Cancer 53, 11-17
4. Sliva, D. (2006) Ganoderma lucidum in cancer research. Leuk. Res. 30, 767-768
5. Yeung, W. H., Lu, Q. L., Zhang, Q., and Go, V. L. W. (2004) Chemical and biochemical basis of the potential anti-tumor properties of Ganoderma lucidum. Curr. Top. Nutraceutical Res. 2, 67-77
6. Lin, S. B., Li, C. H., Lee, S. S., and Kan, L. S. (2003) Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. Life Sci. 72, 2381-2390
7. Yang, H. L. (2005) Ganoderic acid produced from submerged culture of Ganoderma lucidum induces cell cycle arrest and cytotoxicity in human hepatoma cell line BEL7402. Biotechnol. Lett. 27, 835-838
8. Kimura, Y., Taniguchi, M., and Baba, K. (2002) Antitumor and antimetastatic effects on liver triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of active substance. Anticancer Res. 22, 3309-3318
9. Min, B. S., Gao, J. J., Nakamura, N., and Hattori, M. (2000) Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells. Chem. Pharm. Bull. 48, 1026-1033
10. Wang, X. M., Yang, M., Guan, S. H., Liu, R. X., Xia, J. M., Bi, K. S., and Guo, D. A. (2006) Quantitative determination of six major triterpenoids in Ganoderma lucidum and related species by high performance liquid chromatography. J. Pharm. Biomed. Anal. 41, 838-844
11. Komoda, Y., Nakamura, H., Ishihara, S., Uchida, M., Kohda, H., and Yamasaki, K. (1985) Structures of new terpenoid constituents of Ganoderma lucidum (Fr.) Karst (Polyporaceae). Chem. Pharm. Bull. 33, 4829-4835
12. Liu, X., Fan, X. L., Zhao, Y., Luo, G. R., Li, X. P., Li. R., and Le, W. D. (2005) Estrogen provides neuroprotection against activated microglia-induced dopaminergic neuronal injury through both estrogen receptor-α and estrogen receptor-β in microglia. J. Neurosci. Res. 81, 653-665
13. Liu, X., and Zhu, X. Z. (1999) Roles of p53, c-Myc, Bcl-2, Bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor. Brain Res. Mol. Brain Res. 71, 210-216
14. Roberts, K., Bhatia, K., Stanton, P., and Lord, R. (2004) Proteomic analysis of selected prognostic factors of breast cancer. Proteomics 4, 784-792
15. Garfin, D., and Heerdt, L. (2001) 2-D Electrophoresis for Proteomics: a Methods and Product Manual, pp. 25-27, Bio-Rad Laboratories, Richmond, CA
16. Shen, H., Cheng, G., Fan, H., Zhang, J., Zhang, X., Lu, H., Liu, C., Sun, F., Jin, H., Xu, X., Xu, G., Wang, S., Fang, C., Bao, H., Wang, Y., Wang, J., Zhong, H., Yu, Z., Liu, Y., Tang, Z., and Yang, P. (2006) Expressed proteome analysis of human hepatocellular carcinoma in nude mice (LCI-D20) with high metastasis potential. Proteomics 6, 528-537
17. Chen, Y. Z, and Zhi, D. G. (2001) Ligand-protein inverse docking and its potential use in the computer search of protein targets of a small molecule. Proteins 43, 217-226
18. Ye, F., Zhang, Z. S., Luo, H. B., Shen, J. H., Chen, K. X., Shen, X., and Jiang, H. L. (2006) The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARγ: bioassay with molecular modeling simulation. Chembiochem 7, 74-82
19. Chen, S., Chen, L. L., Tan, J. Z., Chen, J., Du, L., Sun, T., Shen, J. H., Chen, K. X., Jiang, H. L., and Shen, X. (2005) Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. J. Biol. Chem. 280, 164-173
20. Chaurasia, G., Iqbal, Y., Hanig, C., Herzel, H., Wanker, E. E., and Futschik, M. E. (2007) UniHI: an entry gate to the human protein interactome. Nucleic Acids Res. 35, D590-DD594
21. Klein, P., and Ravi, R. A (1995) Nearly best-possible approximation algorithm for node-weighted Steiner trees. J. Algorithms 19, 104-115
22. Gardino, A. K., Smerdonb, S. J., and Yaffe, M. B. (2006) Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: A comparison of the X-ray crystal structures of all human 14-3-3 isoforms. Semin. Cancer Biol. 16, 173-182
23. Park, M. H. (2006) The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A). J. Biochem. (Tokyo) 139, 161-169
24. Muller, C. I., Kumagai, T., O'Kelly, J., Seeram, N. P., Heber, D., and Koeffler, H. P. (2006) Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells. Leuk. Res. 30, 841-848
25. Jiang, J., Slivova, V., Valachovicova, T., Harvey, K., and Sliva, D. (2004) Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. Int. J. Oncol. 24, 1093-1100
26. Hu, H., Ahn, N. S., Yang, X., Lee, Y. S., and Kang, K. S. (2002) Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Int. J. Cancer 102, 250-253
27. Lu, Q. Y., Jin, Y. S., Zhang, Q., Zhang, Z., Heber, D., Go, V. L., Li, F. P., and Rao, J. Y. (2004) Ganoderma lucidum extracts inhibit growth and induce actin polymerization in bladder cancer cells in vitro. Cancer Lett. 216, 9-20
28. Jiang, J., Slivova, V., Harvey, K., Valachovicova, T., and Sliva, D. (2004) Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-κB signaling. Nutr. Cancer 49, 209-216
29. Tzivion, G., Gupta, V. S., Kaplun, L., and Balan, V. (2006) 14-3-3 proteins as potential oncogenes. Semin. Cancer Biol. 16, 203-213
30. Hermeking, H., and Benzinger, A. (2006) 14-3-3 proteins in cell cycle regulation. Semin. Cancer Biol. 16, 183-192
31. Masters, S. C., and Fu, H. (2001) 14-3-3 proteins mediate an essential anti-apoptotic signal. J. Biol. Chem. 276, 45193-45200
32. Jao, D. L., and Chen, K. Y. (2002) Subcellular localization of the hypusine-containing eukaryotic initiation factor 5A by immunofluorescent staining and green fluorescent protein tagging. J. Cell. Biochem. 86, 590-600
33. Park, M. H., Lee, Y. B., and Joe, Y. A. (1997) Hypusine is essential for eukaryotic cell proliferation. Biol. Signals 6, 115-123
34. Nishimura, K., Murozumi, K., Shirahata, K., Park, M. H., Kashiwagi, K., and Igarashi, K. (2005) Independent roles of eIF5A and polyamines in cell proliferation. Biochem. J. 385, 779-785
35. Caraglia, M., Budillon, A., Vitale, G., Lupoli, G., Tagliaferri, P., and Abbruzzese, A. (2000) Modulation of molecular mechanisms involved in protein synthesis machinery as a new tool for the control of cell proliferation. Eur. J. Biochem. 267, 3919-3936
36. Caraglia, M., Marra, M., Giuberti, G., D'Alessandro, A. M., Budillon, A., del Prete, S., Lentini, A., Beninati, S., and Abbruzzese, A. (2001) The role of eukaryotic initiation factor 5A in the control of cell proliferation and apoptosis. Amino Acids 20, 91-104
37. Kang, H. A., and Hershey, J. W. B. (1994) Effect of initiation factor eIF-5A depletion on protein synthesis and proliferation of Saccharomyces cerevisiae. J. Biol. Chem. 269, 3934-3940
38. Kenis, H., van Genderen, H., Bennaghmouch, A., Rinia, H.A., Frederik, P., Narula, J., Hofstra, L., and Reutelingsperger, C. P. (2004) Cell surface-expressed phosphatidylserine and annexin A5 open a novel portal of cell entry. J. Biol. Chem. 279, 52623-52629
39. Hayes, M. J., and Moss, S. E. (2004) Annexins and disease. Biochem. Biophys. Res. Commun. 322, 1166-1170
40. Bastian, B. C. (1997) Annexins in cancer and autoimmune diseases. CMLS Cell. Mol. Life Sci. 53, 554-556
41. Dooley, T. P., Reddy, S. P., Wilborn, T. W., and Davis, R. L. (2003) Biomarkers of human cutaneous squamous cell carcinoma from tissues and cell lines identified by DNA microarrays and qRT-PCR. Biochem. Biophys. Res. Commun. 306, 1026-1036
42. Mulla, A., Christian, H. C., Solito, E., Mendoza, N., Morris, J. F., and Buckingham, J. C. (2004) Expression, subcellular localization and phosphorylation status of annexins 1 and 5 in human pituitary adenomas and a growth hormone-secreting carcinoma. Clin. Endocrinol. (Oxf.) 60, 107-119
43. Karube, A., Shidara, Y., Hayasaka, K., Maki, M., and Tanaka, T. (1995) Suppression of calphobindin I (CPB I) production in carcinoma of uterine cervix and endometrium. Gynecol. Oncol. 58, 295-300
44. Guzman-Aranguez, A., Olma, N., Turnay, J., Lecona, E., Perez-Ramos, P., Lopez de Silanes, I., and Lizarbe, M. A. (2006) Differentiation of human colon adenocarcinoma cells alters the expression and intracellular localization of annexins A1, A2, and A5. J. Cell. Biochem. 94, 178-193
45. Wang, J., Kataoka, H., Suzuki, M., Sato, N., Nakumura, R., Tao, H., Maruyama, K., Isogaki, J., Kanaoka, S., Ihara, M., Tanaka, M., Kanamori, M., Nakamura, I., Shinmura, K., and Sugimura, H. (2005) Downregulation of EphA7 by hypermethylation in colorectal cancer. Oncogene 24, 5637-5647
46. Nonn, L., Berggren, M., and Powis, G. (2003) Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis. Mol. Cancer Res. 1, 682-689.
47. Siligardi, G., Hu, B., Panaretou, B., Piper, P. W., Piper, P. W., Pearl, L. H., and Prodromou, C. (2004) Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle. J. Biol. Chem. 279, 51989-51998
48. Gonzalez-Santiago, L., Alfonso, P., Suarez, Y., Nunez, A., Garcia-Fernandez, L. F., Alvarez, E., Munoz, A., and Casal, J. I. (2007) Proteomic analysis of the resistance to Aplidin in human cancer cells. J. Proteome Res. 6, 1286-1294
49. Varona, A., Blanco, L., Lopez, J. I., Gil, J., Agirregoitia, E., Irazusta, J., and Larrinaga, G. (2007) Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma. Am. J. Physiol. 292, F780-F788
50. Odgren, P. R., Toukatly, G., Bangs, P. L., Gilmore, R., and Fey, E. G. (1996) Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains. J. Cell Sci. 109, 2253-2264
51. Navet, R., Mathy, G., Douette, P., Dobson, R. L., Leprince, P., De Pauw, E., Sluse-Goffart, C., and Sluse, F. E. (2007) Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation. J. Proteome Res. 6, 25-33
52. Green, R. A., Wollman, R., and Kaplan, K. B. (2005) APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment. Mol. Biol. Cell 16, 4609-4622
53. Kline-Smith, S. L., and Walczak, C. E. (2004) Mitotic spindle assembly and chromosome segregation: refocusing on microtubule dynamics. Mol. Cell 15, 317-327
54. Timauer, J. S., Grego, S., Salmon, E. D., and Mitchison, T. J. (2002) EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. Mol. Biol. Cell 13, 3614-3626
55. Chu, P. G., and Weiss, L. M. (2002) Keratin expression in human tissues and neoplasms. Histopathology 41, 365-366
56. Yuan, C. C., Huang, T. S., Ng, H. T., Liu, R. S., Hung, M. W., and Tsai, L. C. (1998) Elevated cytokeratin-19 expression associated with apoptotic resistance and malignant progression of human cervical carcinoma. Apoptosis 3, 161-169
57. Yuan, C. C., Huang, H. C., Tsai, L. C., Ng, H. T., and Huang, T. S. (1997) Cytokeratin-19 associated with apoptosis and chemosensitivity in human cervical cancer cells. Apoptosis 2, 101-105
58. 2+-binding protein, interacts with ryanodine receptor-1 in rabbit skeletal sarcoplasmic reticulum. Biochem. Biophys. Res. Commun. 343, 34-42
59. Ding, S. J., Li, Y., Shao, X. X., Zhou, H., Zeng, R., Tang, Z. Y., and Xia, Q. C. (2004) Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials. Proteomics 4, 982-994
60. Wu, W., Tang, X., Hu, W., Lotan, R., Hong, W. K., and Mao, L. (2002) Identification and validation of metastasis-associated proteins in head and neck cancer cell lines by two-dimensional electrophoresis and mass spectrometry. Clin. Exp. Metastasis 19, 319-326
61. Guan, S. H., Yang, M., Liu, X., Xia, J. M., Wang, X. M., Jin, H., and Guo, D. A. (2006) Two new lanostanoid triterpenes from the fruit body of Ganoderma lucidum - the major component of SunRecome®. Nat. Prod. Commun. 1, 177-181