Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 47, 2004, Pages 16594-16599

  Huang, Jing ^a,d   Zhu, Heng ^c,e   Haggarty, Stephen J ^b   Spring, David R ^a,f   Hwang, Heejun ^d   Jin, Fulai ^d   Snyder, Michael ^c   Schreiber, Stuart L ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b HARVARD UNIVERSITY   (United States)

^c YALE UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Diabetes; Drug discovery; Drug target identification; Proteomics

Indexed keywords

PROTEOME; TARGET OF RAPAMYCIN KINASE;

ARTICLE; BIOTINYLATION; CANCER; CHEMICAL GENETICS; DIABETES MELLITUS; DRUG TARGETING; GENETIC SCREENING; GROWTH INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TARGETING; PROTEOMICS; SACCHAROMYCES CEREVISIAE; STARVATION; TUMOR SUPPRESSOR GENE;

HUMANS; JURKAT CELLS; MODELS, BIOLOGICAL; PROTEIN ARRAY ANALYSIS; PROTEIN KINASES; PROTEOMICS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; SIROLIMUS;

EUKARYOTA; MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 9344247454     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0407117101     Document Type: Article

References (32)

1. DeRisi, J. L., Iyer, V. R. & Brown, P. O. (1997) Science 278, 680-686.
2. Hartwell, L. H., Hopfield, J. J., Leibler, S. & Murray, A. W. (1999) Nature 402, C47-C52.
3. Hughes, T. R., Marton, M. J., Jones, A. R., Roberts, C. J., Stoughton, R., Armour, C. D., Bennett, H. A., Coffey, E., Dai, H., He, Y. D., et al. (2000) Cell 102, 109-126.
4. Bishop, A. C., Ubersax, J. A., Petsch, D. T., Matheos, D. P., Gray, N. S., Blethrow, J., Shimizu, E., Tsien, J. Z., Schultz, P. G., Rose, M. D., et al. (2000) Nature 407, 395-401.
5. Ideker, T., Thorsson, V., Ranish, J. A., Christmas, R., Buhler, J., Eng, J. K., Bumgarner, R., Goodlett, D. R., Aebersold, R. & Hood, L. (2001) Science 292, 929-934.
6. Lee, T. I., Rinaldi, N. J., Robert, F., Odom, D. T., Bar-Joseph, Z., Gerber, G. K., Hannett, N. M., Harbison, C. T., Thompson, C. M., Simon, I., et al. (2002) Science 298, 799-804.
7. Giaever, G., Chu, A. M., Ni, L., Connelly, C., Riles, L., Veronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., Andre, B., et al. (2002) Nature 418, 387-391.
8. Phizicky, E., Bastiaens, P. I., Zhu, H., Snyder, M. & Fields, S. (2003) Nature 422, 208-215.
9. Wohlschlegel, J. A. & Yates, J. R. (2003) Nature 425, 671-672.
10. Mayer, T. U., Kapoor, T. M., Haggarty, S. J., King, R. W., Schreiber, S. L. & Mitchison, T. J. (1999) Science 286, 971-974.
11. Komarov, P. G., Komarova, E. A., Kondratov, R. V., Christov-Tselkov, K., Coon, J. S., Chernov, M. V. & Gudkov, A. V. (1999) Science 285, 1733-1737.
12. Garber, K. (2001) J. Natl. Cancer Inst. 93, 1517-1519.
13. Keith, C. T. & Schreiber, S. L. (1995) Science 270, 50-51.
14. Jacinto, E. & Hall, M. N. (2003) Nat. Rev. Mol. Cell Biol. 4, 117-126.
15. Zhu, H., Bilgin, M., Bangham, R., Hall, D., Casamayor, A., Bertone, P., Lan, N., Jansen, R., Bidlingmaier, S., Houfek, T., et al. (2001) Science 293, 2101-2105.
16. Thomas, G. & Hall, M. N. (1997) Curr. Opin. Cell Biol. 9, 782-787.
17. Hardwick, J. S., Kuruvilla, F. G., Tong, J. K., Shamji, A. F. & Schreiber, S. L. (1999) Proc. Natl. Acad. Sci. USA 96, 14866-14870.
18. Cardenas, M. E., Cutler, N. S., Lorenz, M. C., Di Como, C. J. & Heitman, J. (1999) Genes Dev. 13, 3271-3279.
19. Beck, T. & Hall, M. N. (1999) Nature 402, 689-692.
20. Peng, T., Golub, T. R. & Sabatini, D. M. (2002) Mol. Cell. Biol. 22, 5575-5584.
21. Heymont, J., Berenfeld, L., Collins, J., Kaganovich, A., Maynes, B., Moulin, A., Ratskovskaya, I., Poon, P. P., Johnston, G. C., Kamenetsky, M., et al. (2000) Proc. Natl. Acad. Sci. USA 97, 12672-12677.
22. Maehama, T. & Dixon, J. E. (1998) J. Biol. Chem. 273, 13375-13378.
23. Myers, M. P., Pass, I., Batty, I. H., Van der Kaay, J., Stolarov, J. P., Hemmings, B. A., Wigler, M. H., Downes, C. P. & Tonks, N. K. (1998) Proc. Natl. Acad. Sci. USA 95, 13513-13518.
24. Bickle, M., Delley, P. A., Schmidt, A. & Hall, M. N. (1998) EMBO J. 17, 2235-2245.
25. Schmelzle, T., Beck, T., Martin, D. E. & Hall, M. N. (2004) Mol. Cell. Biol. 24, 338-351.
26. Heitman, J., Mowa, N. R. & Hall, M. N. (1991) Science 253, 905-909.
27. Kim, D. H. & Sabatini, D. M. (2004) Curr. Top. Microbiol. Immunol. 279, 259-270.
28. Granot, D. & Snyder, M. (1991) Proc. Natl. Acad. Sci. USA 88, 5724-5728.
29. Mills, G. B., Lu, Y. & Kohn, E. C. (2001) Proc. Natl. Acad. Sci. USA 98, 10031-10033.
30. Neshat, M. S., Mellinghoff, I. K., Tran, C., Stiles, B., Thomas, G., Petersen, R., Frost, P., Gibbons, J. J., Wu, H. & Sawyers, C. L. (2001) Proc. Natl. Acad. Sci. USA 98, 10314-10319.
31. Podsypanina, K., Lee, R. T., Politis, C., Hennessy, I., Crane, A., Puc, J., Neshat, M., Wang, H., Yang, L., Gibbons, J., et al. (2001) Proc. Natl. Acad. Sci. USA 98, 10320-10325.
32. Huang, S. & Houghton, P. J. (2001) Drug Resist. Update 4, 378-391.