Inhibition of eukaryotic translation initiation by the marine natural product pateamine A

Molecular Cell

Volumn 20, Issue 5, 2005, Pages 709-722

  Low, Woon Kai ^a   Dang, Yongjun ^a   Schneider Poetsch, Tilman ^a   Shi, Zonggao ^a   Choi, Nam Song ^b   Merrick, William C ^c   Romo, Daniel ^b   Liu, Jun O ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; INITIATION FACTOR; INITIATION FACTOR 4A; INITIATION FACTOR 4B; INITIATION FACTOR 4E; INITIATION FACTOR 4G; MESSENGER RNA; PATEAMINE A; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER INHIBITION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; EUKARYOTE; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOLECULAR PROBE; PROTEIN BINDING; TRANSLATION INITIATION;

EPOXY COMPOUNDS; EUKARYOTIC CELLS; EUKARYOTIC INITIATION FACTOR-4A; EUKARYOTIC INITIATION FACTOR-4G; EUKARYOTIC INITIATION FACTORS; HELA CELLS; HUMANS; MACROLIDES; MOLECULAR STRUCTURE; PROTEIN BIOSYNTHESIS; THIAZOLES;

EUKARYOTA;

EID: 28444448743     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2005.10.008     Document Type: Article

References (48)

1. M. Altmann, P.P. Muller, B. Wittmer, F. Ruchti, S. Lanker, and H. Trachsel A Saccharomyces cerevisiae homologue of mammalian translation initiation factor 4B contributes to RNA helicase activity EMBO J. 12 1993 3997 4003
2. D.D. Anthony, and W.C. Merrick Analysis of 40 S and 80 S complexes with mRNA as measured by sucrose density gradients and primer extension inhibition J. Biol. Chem. 267 1992 1554 1562
3. M.-E. Bordeleau, J. Matthews, J.M. Wojnar, L. Lindqvist, O. Novac, E. Jankowsky, N. Sonenberg, P. Northcote, P. Teesdale-Spittle, and J. Pelletier Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation Proc. Natl. Acad. Sci. USA 102 2005 10460 10465
4. J.M. Caruthers, E.R. Johnson, and D.B. McKay Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase Proc. Natl. Acad. Sci. USA 97 2000 13080 13085
5. R. Coppolecchia, P. Buser, A. Stotz, and P. Linder A new yeast translation initiation factor suppresses a mutation in the eIF-4A RNA helicase EMBO J. 12 1993 4005 4011
6. G. Fischer, B. Wittmann-Liebold, K. Lang, T. Kiefhaber, and F.X. Schmid Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins Nature 337 1989 476 478
7. N. Gilks, N. Kedersha, M. Ayodele, L. Shen, G. Stoecklin, L.M. Dember, and P. Anderson Stress granule assembly is mediated by prion-like aggregation of TIA-1 Mol. Biol. Cell 15 2004 5383 5398
8. A.C. Gingras, B. Raught, and N. Sonenberg eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation Annu. Rev. Biochem. 68 1999 913 963
9. E.C. Griffith, Z. Su, B.E. Turk, S. Chen, Y.-W. Chang, Z. Wu, K. Biemann, and J.O. Liu Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin Chem. Biol. 4 1997 461 471
10. J.A. Grifo, R.D. Abramson, C.A. Satler, and W.C. Merrick RNA-stimulated ATPase activity of eukaryotic initiation factors J. Biol. Chem. 259 1984 8648 8654
11. M.W. Harding, A. Galat, D.E. Uehling, and S.L. Schreiber A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase Nature 341 1989 758 760
12. J. Heitman, N.R. Movva, and M.N. Hall Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast Science 253 1991 905 909
13. S.L. Hunt, J.J. Hsuan, N. Totty, and R.J. Jackson Unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA Genes Dev. 13 1999 437 448
14. L.D. Kapp, and J.R. Lorsch The molecular mechanics of eukaryotic translation Annu. Rev. Biochem. 73 2004 657 704
15. L. Katz, and G.W. Ashley Translation and protein synthesis: macrolides Chem. Rev. 105 2005 499 528
16. N. Kedersha, and P. Anderson Stress granules: sites of mRNA triage that regulate mRNA stability and translatability Biochem. Soc. Trans. 30 2002 963 969
17. N. Kedersha, S. Chen, N. Gilks, W. Li, I.J. Miller, J. Stahl, and P. Anderson Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules Mol. Biol. Cell 13 2002 195 210
18. N.L. Korneeva, E.A. First, C.A. Benoit, and R.E. Rhoads Interaction between the NH2-terminal domain of eIF4A and the central domain of eIF4G modulates RNA-stimulated ATPase activity J. Biol. Chem. 280 2005 1872 1881
19. J. Liu FK506 and cyclosporin, molecular probes for studying intracellular signal transduction Immunol. Today 14 1993 290 296
20. J. Liu, J.D. Farmer, W.S. Lane, J. Friedman, I. Weissman, and S.L. Schreiber Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes Cell 66 1991 807 815
21. J.R. Lorsch, and D. Herschlag DEAD box protein eIF4A. 1. A minimal kinetic and thermodynamic framework reveals coupled binding of RNA and nucleotide Biochemistry 37 1998 2180 2193
22. J.R. Lorsch, and D. Herschlag DEAD box protein eIF4A. 2. A cycle of nucleotide and RNA-dependent conformational changes Biochemistry 37 1998 2194 2206
23. S. Matsuda, R. Katsumata, T. Okuda, T. Yamamoto, K. Miyazaki, T. Senga, K. Machida, A.A. Thant, S. Nakatsugawa, and M. Hamaguchi Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancer Cancer Res. 60 2000 13 17
24. T. Naranda, W.B. Strong, J. Menaya, B.J. Fabbri, and J.W. Hershey Two structural domains of initiation factor eIF-4B are involved in binding to RNA J. Biol. Chem. 269 1994 14465 14472
25. P.J. Nielsen, and H. Trachsel The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed EMBO J. 7 1988 2097 2105
26. P.T. Northcote, J.W. Blunt, and M.H.G. Munro Pateamine: a potent cytotoxin from the New Zealand marine sponge, Mycale sp Tetrahedron Lett. 32 1991 6411 6414
27. O. Novac, A.S. Guenier, and J. Pelletier Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen Nucleic Acids Res. 32 2004 902 915
28. S. Pestka Inhibitors of Protein Synthesis 1977 Academic Press New York, NY
29. T.V. Pestova, and V.G. Kolupaeva The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection Genes Dev. 16 2002 2906 2922
30. T.V. Pestova, I.N. Shatsky, S.P. Fletcher, R.J. Jackson, and C.U. Hellen A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs Genes Dev. 12 1998 67 83
31. T.V. Pestova, V.G. Kolupaeva, I.B. Lomakin, E.V. Pilipenko, I.N. Shatsky, V.I. Agol, and C.U. Hellen Molecular mechanisms of translation initiation in eukaryotes Proc. Natl. Acad. Sci. USA 98 2001 7029 7036
32. D. Prevot, J.L. Darlix, and T. Ohlmann Conducting the initiation of protein synthesis: the role of eIF4G Biol. Cell. 95 2003 141 156
33. B. Raught, F. Peiretti, A.C. Gingras, M. Livingstone, D. Shahbazian, G.L. Mayeur, R.D. Polakiewicz, N. Sonenberg, and J.W. Hershey Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases EMBO J. 23 2004 1761 1769
34. B.K. Ray, T.G. Lawson, J.C. Kramer, M.H. Cladaras, J.A. Grifo, R.D. Abramson, W.C. Merrick, and R.E. Thach ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors J. Biol. Chem. 260 1985 7651 7658
35. S. Rocak, and P. Linder DEAD-box proteins: the driving forces behind RNA metabolism Nat. Rev. Mol. Cell Biol. 5 2004 232 241
36. G.W. Rogers Jr., W.F. Lima, and W.C. Merrick Further characterization of the helicase activity of eIF4A. Substrate specificity J. Biol. Chem. 276 2001 12598 12608
37. G.W. Rogers Jr., N.J. Richter, W.F. Lima, and W.C. Merrick Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F J. Biol. Chem. 276 2001 30914 30922
38. G.W. Rogers Jr., A.A. Komar, and W.C. Merrick eIF4A: the godfather of the DEAD box helicases Prog. Nucleic Acid Res. Mol. Biol. 72 2002 307 331
39. D. Romo, R.M. Rzasa, H.A. Shea, K. Park, J.M. Langenhan, L. Sun, A. Akhiezer, and J.O. Liu Total synthesis and immunosuppressive activity of (-)-pateamine A and related compounds: implementation of a β-lactam-based macrocyclization J. Am. Chem. Soc. 120 1998 12237 12254
40. D. Romo, N.S. Choi, S. Li, I. Buchler, Z. Shi, and J.O. Liu Evidence for separate binding and scaffolding domains in the immunosuppressive and antitumor marine natural product, pateamine a: design, synthesis, and activity studies leading to a potent simplified derivative J. Am. Chem. Soc. 126 2004 10582 10588
41. F. Rozen, I. Edery, K. Meerovitch, T.E. Dever, W.C. Merrick, and N. Sonenberg Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F Mol. Cell. Biol. 10 1990 1134 1144
42. S.L. Schreiber, and G.R. Crabtree The mechanism of action of cyclosporin A and FK506 Immunol. Today 13 1992 136 142
43. Z.X. Shen, G.Q. Chen, J.H. Ni, X.S. Li, S.M. Xiong, Q.Y. Qiu, J. Zhu, W. Tang, G.L. Sun, and K.Q. Yang Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients Blood 89 1997 3354 3360
44. J.J. Siekierka, S.H. Hung, M. Poe, C.S. Lin, and N.H. Sigal A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin Nature 341 1989 755 757
45. N. Sonenberg, M.A. Morgan, W.C. Merrick, and A.J. Shatkin A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5′-terminal cap in mRNA Proc. Natl. Acad. Sci. USA 75 1978 4843 4847
46. Y.V. Svitkin, A. Pause, A. Haghighat, S. Pyronnet, G. Witherell, G.J. Belsham, and N. Sonenberg The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure RNA 7 2001 382 394
47. D. Vazquez Inhibitors of protein biosynthesis Mol. Biol. Biochem. Biophys. 30 1979 1 312
48. J. Yoder-Hill, A. Pause, N. Sonenberg, and W.C. Merrick The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A J. Biol. Chem. 268 1993 5566 5573