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Volumn 11, Issue 5, 2004, Pages 609-618

Genetic and genomic approaches to identify and study the targets of bioactive small molecules

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL PRODUCT; DRUG RECEPTOR;

EID: 2642573570     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2003.08.011     Document Type: Review
Times cited : (57)

References (68)
  • 1
    • 0038299000 scopus 로고    scopus 로고
    • Sirolimus: Its discovery, biological properties, and mechanism of action
    • Sehgal S. Sirolimus. its discovery, biological properties, and mechanism of action Transplant. Proc. 35:2003;S7-S14
    • (2003) Transplant. Proc. , vol.35
    • Sehgal, S.1
  • 3
    • 0030905166 scopus 로고    scopus 로고
    • Target of rapamycin proteins and their kinase activities are required for meiosis
    • Zheng X.F., Schreiber S.L. Target of rapamycin proteins and their kinase activities are required for meiosis. Proc. Natl. Acad. Sci. USA. 94:1997;3070-3075
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3070-3075
    • Zheng, X.F.1    Schreiber, S.L.2
  • 4
    • 0037135626 scopus 로고    scopus 로고
    • The ceramide-centric universe of lipid mediated cell regulation: Stress encounters of the lipid kind
    • Hannun Y.A., Obeid L.M. The ceramide-centric universe of lipid mediated cell regulation. stress encounters of the lipid kind J. Biol. Chem. 277:2002;25847-25850
    • (2002) J. Biol. Chem. , vol.277 , pp. 25847-25850
    • Hannun, Y.A.1    Obeid, L.M.2
  • 5
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin a and FKBP-FK506 complexes
    • Liu J., Farmer J.D., Lane W.S., Friedman J., Weissman I., Schreiber S.L. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 66:1991;807-815
    • (1991) Cell , vol.66 , pp. 807-815
    • Liu, J.1    Farmer, J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 6
    • 0035951849 scopus 로고    scopus 로고
    • Calcium, calcineurin, and the control of transcription
    • Crabtree G.R. Calcium, calcineurin, and the control of transcription. J. Biol. Chem. 276:2001;2313-2316
    • (2001) J. Biol. Chem. , vol.276 , pp. 2313-2316
    • Crabtree, G.R.1
  • 8
    • 0034678033 scopus 로고    scopus 로고
    • Target-oriented and diversity-oriented organic synthesis in drug discovery
    • Schreiber S. Target-oriented and diversity-oriented organic synthesis in drug discovery. Science. 287:2000;1964-1969
    • (2000) Science , vol.287 , pp. 1964-1969
    • Schreiber, S.1
  • 9
    • 0033080348 scopus 로고    scopus 로고
    • High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications
    • Stockwell B.R., Haggarty S.J., Schreiber S.L. High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications. Chem. Biol. 6:1999;71-83
    • (1999) Chem. Biol. , vol.6 , pp. 71-83
    • Stockwell, B.R.1    Haggarty, S.J.2    Schreiber, S.L.3
  • 10
    • 0033615357 scopus 로고    scopus 로고
    • Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen
    • Mayer T.U., Kapoor T.M., Haggarty S.J., King R.W., Schreiber S.L., Mitchison T.J. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 286:1999;971-974
    • (1999) Science , vol.286 , pp. 971-974
    • Mayer, T.U.1    Kapoor, T.M.2    Haggarty, S.J.3    King, R.W.4    Schreiber, S.L.5    Mitchison, T.J.6
  • 11
    • 0029824170 scopus 로고    scopus 로고
    • A three-hybrid system for detecting small ligand-protein receptor interactions
    • Licitra E.J., Liu J.O. A three-hybrid system for detecting small ligand-protein receptor interactions. Proc. Natl. Acad. Sci. USA. 93:1996;12817-12821
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 12817-12821
    • Licitra, E.J.1    Liu, J.O.2
  • 12
    • 0033178766 scopus 로고    scopus 로고
    • Chemical genetics: Exploring and controlling cellular processes with chemical probes
    • Crews C.M., Splittgerber U. Chemical genetics. exploring and controlling cellular processes with chemical probes Trends Biochem. Sci. 24:1999;317-320
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 317-320
    • Crews, C.M.1    Splittgerber, U.2
  • 13
    • 0034331004 scopus 로고    scopus 로고
    • Chemical genetics: Ligand-based discovery of gene function
    • Stockwell B.R. Chemical genetics. ligand-based discovery of gene function Nat. Rev. Genet. 1:2000;116-125
    • (2000) Nat. Rev. Genet. , vol.1 , pp. 116-125
    • Stockwell, B.R.1
  • 14
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman J., Movva N.R., Hall M.N. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science. 253:1991;905-909
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 16
    • 0027311858 scopus 로고
    • Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
    • Kunz J., Henriquez R., Schneider U., Deuter-Reinhard M., Movva N.R., Hall M.N. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell. 73:1993;585-596
    • (1993) Cell , vol.73 , pp. 585-596
    • Kunz, J.1    Henriquez, R.2    Schneider, U.3    Deuter-Reinhard, M.4    Movva, N.R.5    Hall, M.N.6
  • 18
    • 0028239893 scopus 로고
    • RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin dependent fashion and is homologous to yeast tors
    • Sabatini D.M., Erdjument-Bromage H., Lui M., Tempst P., Snyder S.H. RAFT1. a mammalian protein that binds to FKBP12 in a rapamycin dependent fashion and is homologous to yeast tors Cell. 78:1994;35-43
    • (1994) Cell , vol.78 , pp. 35-43
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Lui, M.3    Tempst, P.4    Snyder, S.H.5
  • 19
    • 0029071264 scopus 로고
    • TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin
    • Zheng X.F., Florentino D., Chen J., Crabtree G.R., Schreiber S.L. TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell. 82:1995;121-130
    • (1995) Cell , vol.82 , pp. 121-130
    • Zheng, X.F.1    Florentino, D.2    Chen, J.3    Crabtree, G.R.4    Schreiber, S.L.5
  • 20
    • 0029055145 scopus 로고
    • Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue
    • Chen J., Zheng X.F., Brown E.J., Schreiber S.L. Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin- associated protein and characterization of a critical serine residue. Proc. Natl. Acad. Sci. USA. 92:1995;4947-4951
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4947-4951
    • Chen, J.1    Zheng, X.F.2    Brown, E.J.3    Schreiber, S.L.4
  • 21
    • 0035991851 scopus 로고    scopus 로고
    • PCR-based ordered genomic libraries: A new approach to drug target identification for streptococcus pneumoniae
    • Belanger A.E., Lai A., Brackman M.A., LeBlanc D.J. PCR-based ordered genomic libraries. a new approach to drug target identification for streptococcus pneumoniae Antimicrob. Agents Chemother. 46:2002;2507-2512
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 2507-2512
    • Belanger, A.E.1    Lai, A.2    Brackman, M.A.3    Leblanc, D.J.4
  • 22
    • 0343130542 scopus 로고    scopus 로고
    • Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast
    • Sun Y., Taniguchi R., Tanoue D., Yamaji T., Takematsu H., Mori K., Fujita T., Kawasaki T., Kozutsumi Y. Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. Mol. Cell. Biol. 20:2000;4411-4419
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4411-4419
    • Sun, Y.1    Taniguchi, R.2    Tanoue, D.3    Yamaji, T.4    Takematsu, H.5    Mori, K.6    Fujita, T.7    Kawasaki, T.8    Kozutsumi, Y.9
  • 23
    • 0035803482 scopus 로고    scopus 로고
    • Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast
    • Friant S., Lombardi R., Schmelzle T., Hall M.N., Riezman H. Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. EMBO J. 20:2001;6783-6792
    • (2001) EMBO J. , vol.20 , pp. 6783-6792
    • Friant, S.1    Lombardi, R.2    Schmelzle, T.3    Hall, M.N.4    Riezman, H.5
  • 24
    • 0029932598 scopus 로고    scopus 로고
    • A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p
    • Taunton J., Hassig C.A., Schreiber S.L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science. 272:1996;408-411
    • (1996) Science , vol.272 , pp. 408-411
    • Taunton, J.1    Hassig, C.A.2    Schreiber, S.L.3
  • 25
    • 0031007189 scopus 로고    scopus 로고
    • Histone deacetylase activity is required for full transcriptional repression by mSin3A
    • Hassig C.A., Fleischer T.C., Billin A.N., Schreiber S.L., Ayer D.E. Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell. 89:1997;341-347
    • (1997) Cell , vol.89 , pp. 341-347
    • Hassig, C.A.1    Fleischer, T.C.2    Billin, A.N.3    Schreiber, S.L.4    Ayer, D.E.5
  • 26
    • 0031682217 scopus 로고    scopus 로고
    • Camptothecin and taxol: Discovery to clinic
    • Wall M. Camptothecin and taxol. discovery to clinic Med. Res. Rev. 18:1998;299-314
    • (1998) Med. Res. Rev. , vol.18 , pp. 299-314
    • Wall, M.1
  • 27
    • 0022340594 scopus 로고
    • Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
    • Hsiang Y.H., Hertzberg R., Hecht S., Liu L.F. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem. 260:1985;14873-14878
    • (1985) J. Biol. Chem. , vol.260 , pp. 14873-14878
    • Hsiang, Y.H.1    Hertzberg, R.2    Hecht, S.3    Liu, L.F.4
  • 28
    • 0023924786 scopus 로고
    • Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin
    • Hsiang Y.H., Liu L.F. Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res. 48:1988;1722-1726
    • (1988) Cancer Res. , vol.48 , pp. 1722-1726
    • Hsiang, Y.H.1    Liu, L.F.2
  • 29
    • 0000536643 scopus 로고
    • DNA topoisomerase-targeting antitumor drugs can be studied in yeast
    • Nitiss J., Wang J.C. DNA topoisomerase-targeting antitumor drugs can be studied in yeast. Proc. Natl. Acad. Sci. USA. 85:1988;7501-7505
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 7501-7505
    • Nitiss, J.1    Wang, J.C.2
  • 30
    • 0027381388 scopus 로고
    • Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants
    • Knab A.M., Fertala J., Bjornsti M.A. Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants. J. Biol. Chem. 268:1993;22322-22330
    • (1993) J. Biol. Chem. , vol.268 , pp. 22322-22330
    • Knab, A.M.1    Fertala, J.2    Bjornsti, M.A.3
  • 31
    • 0029842109 scopus 로고    scopus 로고
    • Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
    • Choi J., Chen J., Schreiber S.L., Clardy J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science. 273:1996;239-242
    • (1996) Science , vol.273 , pp. 239-242
    • Choi, J.1    Chen, J.2    Schreiber, S.L.3    Clardy, J.4
  • 33
    • 0025989238 scopus 로고
    • Multiple targets for brefeldin a
    • Pelham H. Multiple targets for brefeldin A. Cell. 67:1991;449-451
    • (1991) Cell , vol.67 , pp. 449-451
    • Pelham, H.1
  • 34
    • 0026677375 scopus 로고
    • Brefeldin a inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein
    • Donaldson J.G., Finazzi D., Klausner R.D. Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein. Nature. 360:1992;350-352
    • (1992) Nature , vol.360 , pp. 350-352
    • Donaldson, J.G.1    Finazzi, D.2    Klausner, R.D.3
  • 35
    • 0026746713 scopus 로고
    • Inhibition by brefeldin a of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF
    • Helms J.B., Rothman J.E. Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF. Nature. 360:1992;352-354
    • (1992) Nature , vol.360 , pp. 352-354
    • Helms, J.B.1    Rothman, J.E.2
  • 36
    • 0002955384 scopus 로고    scopus 로고
    • Brefeldin a acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: Involvement of specific residues of the Sec7 domain
    • Peyroche A., Antonny B., Robineau S., Acker J., Cherfils J., Jackson C.L. Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex. involvement of specific residues of the Sec7 domain Mol. Cell. 3:1999;275-285
    • (1999) Mol. Cell , vol.3 , pp. 275-285
    • Peyroche, A.1    Antonny, B.2    Robineau, S.3    Acker, J.4    Cherfils, J.5    Jackson, C.L.6
  • 37
    • 0033574449 scopus 로고    scopus 로고
    • Brefeldin A: The advantage of being uncompetitive
    • Chardin P., McCormick F. Brefeldin A. the advantage of being uncompetitive Cell. 97:1999;153-155
    • (1999) Cell , vol.97 , pp. 153-155
    • Chardin, P.1    McCormick, F.2
  • 38
    • 0037178786 scopus 로고    scopus 로고
    • MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • Kim D., Sarbassov D.D., Ali S., King J., Latek R., Erdjument-Bromage H., Tempst P., Sabatini D. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell. 110:2002;163-175
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.1    Sarbassov, D.D.2    Ali, S.3    King, J.4    Latek, R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.8
  • 40
    • 0033980083 scopus 로고    scopus 로고
    • Bleomycin: New perspectives on the mechanism of action
    • Hecht S. Bleomycin. new perspectives on the mechanism of action J. Nat. Prod. 63:2000;158-168
    • (2000) J. Nat. Prod. , vol.63 , pp. 158-168
    • Hecht, S.1
  • 42
    • 0028265206 scopus 로고
    • Use of Drosophila mutants to distinguish among volatile general anesthetics
    • Campbell D.B., Nash H.A. Use of Drosophila mutants to distinguish among volatile general anesthetics. Proc. Natl. Acad. Sci. USA. 91:1994;2135-2139
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 2135-2139
    • Campbell, D.B.1    Nash, H.A.2
  • 43
    • 0025016343 scopus 로고
    • A genetic study of the anesthetic response: Mutants of Drosophila melanogaster altered in sensitivity to halothane
    • Krishnan K.S., Nash H.A. A genetic study of the anesthetic response. mutants of Drosophila melanogaster altered in sensitivity to halothane Proc. Natl. Acad. Sci. USA. 87:1990;8632-8636
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 8632-8636
    • Krishnan, K.S.1    Nash, H.A.2
  • 46
    • 0033180210 scopus 로고    scopus 로고
    • Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins
    • Choy R.K., Thomas J.H. Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins. Mol. Cell. 4:1999;143-152
    • (1999) Mol. Cell , vol.4 , pp. 143-152
    • Choy, R.K.1    Thomas, J.H.2
  • 47
    • 0037108682 scopus 로고    scopus 로고
    • Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
    • Kenerson H.L., Aicher L.D., True L.D., Yeung R.S. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res. 62:2002;5645-5650
    • (2002) Cancer Res. , vol.62 , pp. 5645-5650
    • Kenerson, H.L.1    Aicher, L.D.2    True, L.D.3    Yeung, R.S.4
  • 48
    • 0032839061 scopus 로고    scopus 로고
    • Cyclooxygenase knockout mice: Models for elucidating isoform-specific functions
    • Langenbach R., Loftin C., Lee C., Tiano H. Cyclooxygenase knockout mice. models for elucidating isoform-specific functions Biochem. Pharmacol. 58:1999;1237-1246
    • (1999) Biochem. Pharmacol. , vol.58 , pp. 1237-1246
    • Langenbach, R.1    Loftin, C.2    Lee, C.3    Tiano, H.4
  • 49
    • 0035967887 scopus 로고    scopus 로고
    • Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature
    • Graef I.A., Chen F., Chen L., Kuo A., Crabtree G.R. Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 105:2001;863-875
    • (2001) Cell , vol.105 , pp. 863-875
    • Graef, I.A.1    Chen, F.2    Chen, L.3    Kuo, A.4    Crabtree, G.R.5
  • 50
    • 0033583076 scopus 로고    scopus 로고
    • Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta
    • Dong L.Q., Zhang R.B., Langlais P., He H., Clark M., Zhu L., Liu F. Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta. J. Biol. Chem. 274:1999;8117-8122
    • (1999) J. Biol. Chem. , vol.274 , pp. 8117-8122
    • Dong, L.Q.1    Zhang, R.B.2    Langlais, P.3    He, H.4    Clark, M.5    Zhu, L.6    Liu, F.7
  • 51
    • 0035113642 scopus 로고    scopus 로고
    • High-throughput reverse genetics: RNAi screens in Caenorhabditis elegans
    • Bargmann, C.I. (2001). High-throughput reverse genetics: RNAi screens in Caenorhabditis elegans. Genome Biol 2, REVIEWS1005.1-1005.3.
    • (2001) Genome Biol , vol.2 , Issue.REVIEWS
    • Bargmann, C.I.1
  • 52
    • 0032883802 scopus 로고    scopus 로고
    • The Berkeley Drosophila genome project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes
    • Spradling A.C., Stern D., Beaton A., Rhem E.J., Laverty T., Mozden N., Misra S., Rubin G.M. The Berkeley Drosophila genome project gene disruption project. single P-element insertions mutating 25% of vital Drosophila genes Genetics. 153:1999;135-177
    • (1999) Genetics , vol.153 , pp. 135-177
    • Spradling, A.C.1    Stern, D.2    Beaton, A.3    Rhem, E.J.4    Laverty, T.5    Mozden, N.6    Misra, S.7    Rubin, G.M.8
  • 54
    • 0034043381 scopus 로고    scopus 로고
    • Genome-wide mutant collections: Toolboxes for functional genomics
    • Coelho P.S., Kumar A., Snyder M. Genome-wide mutant collections. toolboxes for functional genomics Curr. Opin. Microbiol. 3:2000;309-315
    • (2000) Curr. Opin. Microbiol. , vol.3 , pp. 309-315
    • Coelho, P.S.1    Kumar, A.2    Snyder, M.3
  • 55
    • 0036462476 scopus 로고    scopus 로고
    • Chemical genomics in the global study of protein functions
    • Zheng X.F., Chan T.-F. Chemical genomics in the global study of protein functions. Drug Discov. Today. 7:2001;197-205
    • (2001) Drug Discov. Today , vol.7 , pp. 197-205
    • Zheng, X.F.1    Chan, T.-F.2
  • 56
    • 0036194512 scopus 로고    scopus 로고
    • Chemical genomics: A systematic approach in biological research and drug discovery
    • Zheng X.F., Chan T.-F. Chemical genomics. a systematic approach in biological research and drug discovery Curr. Issues Mol. Biol. 4:2001;33-43
    • (2001) Curr. Issues Mol. Biol. , vol.4 , pp. 33-43
    • Zheng, X.F.1    Chan, T.-F.2
  • 57
    • 0034700103 scopus 로고    scopus 로고
    • A chemical genomics approach toward understanding the global functions of TOR
    • Chan T.F., Carvalho J., Riles L., Zheng X.F.S. A chemical genomics approach toward understanding the global functions of TOR. Proc. Natl. Acad. Sci. USA. 97:2000;13227-13232
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13227-13232
    • Chan, T.F.1    Carvalho, J.2    Riles, L.3    Zheng, X.F.S.4
  • 58
    • 0036124292 scopus 로고    scopus 로고
    • High-density cell microarrays for parallel functional determinations
    • Xu C.W. High-density cell microarrays for parallel functional determinations. Genome Res. 12:2002;482-486
    • (2002) Genome Res. , vol.12 , pp. 482-486
    • Xu, C.W.1
  • 59
    • 0029804246 scopus 로고    scopus 로고
    • Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy
    • Shoemaker D.D., Lashkari D.A., Morris D., Mittmann M., Davis R.W. Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy. Nat. Genet. 14:1996;450-456
    • (1996) Nat. Genet. , vol.14 , pp. 450-456
    • Shoemaker, D.D.1    Lashkari, D.A.2    Morris, D.3    Mittmann, M.4    Davis, R.W.5
  • 60
    • 0034659898 scopus 로고    scopus 로고
    • Genomics, gene expression and DNA arrays
    • Lockhart D.J., Winzeler E.A. Genomics, gene expression and DNA arrays. Nature. 405:2000;827-836
    • (2000) Nature , vol.405 , pp. 827-836
    • Lockhart, D.J.1    Winzeler, E.A.2
  • 63
    • 0034710924 scopus 로고    scopus 로고
    • Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks
    • Butte A.J., Tamayo P., Slonim D., Golub T.R., Kohane I.S. Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks. Proc. Natl. Acad. Sci. USA. 97:2000;12182-12186
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12182-12186
    • Butte, A.J.1    Tamayo, P.2    Slonim, D.3    Golub, T.R.4    Kohane, I.S.5
  • 65
    • 0034622925 scopus 로고    scopus 로고
    • Printing proteins as microarrays for high-throughput function determination
    • MacBeath G., Schreiber S.L. Printing proteins as microarrays for high-throughput function determination. Science. 289:2000;1760-1763
    • (2000) Science , vol.289 , pp. 1760-1763
    • MacBeath, G.1    Schreiber, S.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.