-
1
-
-
0038299000
-
Sirolimus: Its discovery, biological properties, and mechanism of action
-
Sehgal S. Sirolimus. its discovery, biological properties, and mechanism of action Transplant. Proc. 35:2003;S7-S14
-
(2003)
Transplant. Proc.
, vol.35
-
-
Sehgal, S.1
-
2
-
-
0030021524
-
TOR controls translation initiation and early G1 progression in yeast
-
Barbet N.C., Schneider U., Helliwell S.B., Stansfield I., Tuite M.F., Hall M.N. TOR controls translation initiation and early G1 progression in yeast. Mol. Biol. Cell. 7:1996;25-42
-
(1996)
Mol. Biol. Cell
, vol.7
, pp. 25-42
-
-
Barbet, N.C.1
Schneider, U.2
Helliwell, S.B.3
Stansfield, I.4
Tuite, M.F.5
Hall, M.N.6
-
3
-
-
0030905166
-
Target of rapamycin proteins and their kinase activities are required for meiosis
-
Zheng X.F., Schreiber S.L. Target of rapamycin proteins and their kinase activities are required for meiosis. Proc. Natl. Acad. Sci. USA. 94:1997;3070-3075
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 3070-3075
-
-
Zheng, X.F.1
Schreiber, S.L.2
-
4
-
-
0037135626
-
The ceramide-centric universe of lipid mediated cell regulation: Stress encounters of the lipid kind
-
Hannun Y.A., Obeid L.M. The ceramide-centric universe of lipid mediated cell regulation. stress encounters of the lipid kind J. Biol. Chem. 277:2002;25847-25850
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 25847-25850
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
5
-
-
0025893168
-
Calcineurin is a common target of cyclophilin-cyclosporin a and FKBP-FK506 complexes
-
Liu J., Farmer J.D., Lane W.S., Friedman J., Weissman I., Schreiber S.L. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 66:1991;807-815
-
(1991)
Cell
, vol.66
, pp. 807-815
-
-
Liu, J.1
Farmer, J.D.2
Lane, W.S.3
Friedman, J.4
Weissman, I.5
Schreiber, S.L.6
-
6
-
-
0035951849
-
Calcium, calcineurin, and the control of transcription
-
Crabtree G.R. Calcium, calcineurin, and the control of transcription. J. Biol. Chem. 276:2001;2313-2316
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 2313-2316
-
-
Crabtree, G.R.1
-
8
-
-
0034678033
-
Target-oriented and diversity-oriented organic synthesis in drug discovery
-
Schreiber S. Target-oriented and diversity-oriented organic synthesis in drug discovery. Science. 287:2000;1964-1969
-
(2000)
Science
, vol.287
, pp. 1964-1969
-
-
Schreiber, S.1
-
9
-
-
0033080348
-
High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications
-
Stockwell B.R., Haggarty S.J., Schreiber S.L. High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications. Chem. Biol. 6:1999;71-83
-
(1999)
Chem. Biol.
, vol.6
, pp. 71-83
-
-
Stockwell, B.R.1
Haggarty, S.J.2
Schreiber, S.L.3
-
10
-
-
0033615357
-
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen
-
Mayer T.U., Kapoor T.M., Haggarty S.J., King R.W., Schreiber S.L., Mitchison T.J. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 286:1999;971-974
-
(1999)
Science
, vol.286
, pp. 971-974
-
-
Mayer, T.U.1
Kapoor, T.M.2
Haggarty, S.J.3
King, R.W.4
Schreiber, S.L.5
Mitchison, T.J.6
-
11
-
-
0029824170
-
A three-hybrid system for detecting small ligand-protein receptor interactions
-
Licitra E.J., Liu J.O. A three-hybrid system for detecting small ligand-protein receptor interactions. Proc. Natl. Acad. Sci. USA. 93:1996;12817-12821
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 12817-12821
-
-
Licitra, E.J.1
Liu, J.O.2
-
12
-
-
0033178766
-
Chemical genetics: Exploring and controlling cellular processes with chemical probes
-
Crews C.M., Splittgerber U. Chemical genetics. exploring and controlling cellular processes with chemical probes Trends Biochem. Sci. 24:1999;317-320
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 317-320
-
-
Crews, C.M.1
Splittgerber, U.2
-
13
-
-
0034331004
-
Chemical genetics: Ligand-based discovery of gene function
-
Stockwell B.R. Chemical genetics. ligand-based discovery of gene function Nat. Rev. Genet. 1:2000;116-125
-
(2000)
Nat. Rev. Genet.
, vol.1
, pp. 116-125
-
-
Stockwell, B.R.1
-
14
-
-
0025776523
-
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
-
Heitman J., Movva N.R., Hall M.N. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science. 253:1991;905-909
-
(1991)
Science
, vol.253
, pp. 905-909
-
-
Heitman, J.1
Movva, N.R.2
Hall, M.N.3
-
15
-
-
0027382875
-
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity
-
Cafferkey R., Young P.R., McLaughlin M.M., Bergsma D.J., Koltin Y., Sathe G.M., Faucette L., Eng W.K., Johnson R.K., Livi G.P. Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. Mol. Cell. Biol. 13:1993;6012-6023
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 6012-6023
-
-
Cafferkey, R.1
Young, P.R.2
McLaughlin, M.M.3
Bergsma, D.J.4
Koltin, Y.5
Sathe, G.M.6
Faucette, L.7
Eng, W.K.8
Johnson, R.K.9
Livi, G.P.10
-
16
-
-
0027311858
-
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
-
Kunz J., Henriquez R., Schneider U., Deuter-Reinhard M., Movva N.R., Hall M.N. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell. 73:1993;585-596
-
(1993)
Cell
, vol.73
, pp. 585-596
-
-
Kunz, J.1
Henriquez, R.2
Schneider, U.3
Deuter-Reinhard, M.4
Movva, N.R.5
Hall, M.N.6
-
17
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
Brown E.J., Albers M.W., Shin T.B., Ichikawa K., Keith C.T., Lane W.S., Schreiber S.L. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature. 369:1994;756-758
-
(1994)
Nature
, vol.369
, pp. 756-758
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
Ichikawa, K.4
Keith, C.T.5
Lane, W.S.6
Schreiber, S.L.7
-
18
-
-
0028239893
-
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin dependent fashion and is homologous to yeast tors
-
Sabatini D.M., Erdjument-Bromage H., Lui M., Tempst P., Snyder S.H. RAFT1. a mammalian protein that binds to FKBP12 in a rapamycin dependent fashion and is homologous to yeast tors Cell. 78:1994;35-43
-
(1994)
Cell
, vol.78
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
Tempst, P.4
Snyder, S.H.5
-
19
-
-
0029071264
-
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin
-
Zheng X.F., Florentino D., Chen J., Crabtree G.R., Schreiber S.L. TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell. 82:1995;121-130
-
(1995)
Cell
, vol.82
, pp. 121-130
-
-
Zheng, X.F.1
Florentino, D.2
Chen, J.3
Crabtree, G.R.4
Schreiber, S.L.5
-
20
-
-
0029055145
-
Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue
-
Chen J., Zheng X.F., Brown E.J., Schreiber S.L. Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin- associated protein and characterization of a critical serine residue. Proc. Natl. Acad. Sci. USA. 92:1995;4947-4951
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 4947-4951
-
-
Chen, J.1
Zheng, X.F.2
Brown, E.J.3
Schreiber, S.L.4
-
21
-
-
0035991851
-
PCR-based ordered genomic libraries: A new approach to drug target identification for streptococcus pneumoniae
-
Belanger A.E., Lai A., Brackman M.A., LeBlanc D.J. PCR-based ordered genomic libraries. a new approach to drug target identification for streptococcus pneumoniae Antimicrob. Agents Chemother. 46:2002;2507-2512
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 2507-2512
-
-
Belanger, A.E.1
Lai, A.2
Brackman, M.A.3
Leblanc, D.J.4
-
22
-
-
0343130542
-
Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast
-
Sun Y., Taniguchi R., Tanoue D., Yamaji T., Takematsu H., Mori K., Fujita T., Kawasaki T., Kozutsumi Y. Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. Mol. Cell. Biol. 20:2000;4411-4419
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 4411-4419
-
-
Sun, Y.1
Taniguchi, R.2
Tanoue, D.3
Yamaji, T.4
Takematsu, H.5
Mori, K.6
Fujita, T.7
Kawasaki, T.8
Kozutsumi, Y.9
-
23
-
-
0035803482
-
Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast
-
Friant S., Lombardi R., Schmelzle T., Hall M.N., Riezman H. Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. EMBO J. 20:2001;6783-6792
-
(2001)
EMBO J.
, vol.20
, pp. 6783-6792
-
-
Friant, S.1
Lombardi, R.2
Schmelzle, T.3
Hall, M.N.4
Riezman, H.5
-
24
-
-
0029932598
-
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p
-
Taunton J., Hassig C.A., Schreiber S.L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science. 272:1996;408-411
-
(1996)
Science
, vol.272
, pp. 408-411
-
-
Taunton, J.1
Hassig, C.A.2
Schreiber, S.L.3
-
25
-
-
0031007189
-
Histone deacetylase activity is required for full transcriptional repression by mSin3A
-
Hassig C.A., Fleischer T.C., Billin A.N., Schreiber S.L., Ayer D.E. Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell. 89:1997;341-347
-
(1997)
Cell
, vol.89
, pp. 341-347
-
-
Hassig, C.A.1
Fleischer, T.C.2
Billin, A.N.3
Schreiber, S.L.4
Ayer, D.E.5
-
26
-
-
0031682217
-
Camptothecin and taxol: Discovery to clinic
-
Wall M. Camptothecin and taxol. discovery to clinic Med. Res. Rev. 18:1998;299-314
-
(1998)
Med. Res. Rev.
, vol.18
, pp. 299-314
-
-
Wall, M.1
-
27
-
-
0022340594
-
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
-
Hsiang Y.H., Hertzberg R., Hecht S., Liu L.F. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem. 260:1985;14873-14878
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 14873-14878
-
-
Hsiang, Y.H.1
Hertzberg, R.2
Hecht, S.3
Liu, L.F.4
-
28
-
-
0023924786
-
Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin
-
Hsiang Y.H., Liu L.F. Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res. 48:1988;1722-1726
-
(1988)
Cancer Res.
, vol.48
, pp. 1722-1726
-
-
Hsiang, Y.H.1
Liu, L.F.2
-
29
-
-
0000536643
-
DNA topoisomerase-targeting antitumor drugs can be studied in yeast
-
Nitiss J., Wang J.C. DNA topoisomerase-targeting antitumor drugs can be studied in yeast. Proc. Natl. Acad. Sci. USA. 85:1988;7501-7505
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 7501-7505
-
-
Nitiss, J.1
Wang, J.C.2
-
30
-
-
0027381388
-
Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants
-
Knab A.M., Fertala J., Bjornsti M.A. Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants. J. Biol. Chem. 268:1993;22322-22330
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 22322-22330
-
-
Knab, A.M.1
Fertala, J.2
Bjornsti, M.A.3
-
31
-
-
0029842109
-
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
-
Choi J., Chen J., Schreiber S.L., Clardy J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science. 273:1996;239-242
-
(1996)
Science
, vol.273
, pp. 239-242
-
-
Choi, J.1
Chen, J.2
Schreiber, S.L.3
Clardy, J.4
-
32
-
-
0029103330
-
Control of p70 s6 kinase by kinase activity of FRAP in vivo
-
Brown E.J., Beal P.A., Keith C.T., Chen J., Shin T.B., Schreiber S.L. Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature. 377:1995;441-446
-
(1995)
Nature
, vol.377
, pp. 441-446
-
-
Brown, E.J.1
Beal, P.A.2
Keith, C.T.3
Chen, J.4
Shin, T.B.5
Schreiber, S.L.6
-
33
-
-
0025989238
-
Multiple targets for brefeldin a
-
Pelham H. Multiple targets for brefeldin A. Cell. 67:1991;449-451
-
(1991)
Cell
, vol.67
, pp. 449-451
-
-
Pelham, H.1
-
34
-
-
0026677375
-
Brefeldin a inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein
-
Donaldson J.G., Finazzi D., Klausner R.D. Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein. Nature. 360:1992;350-352
-
(1992)
Nature
, vol.360
, pp. 350-352
-
-
Donaldson, J.G.1
Finazzi, D.2
Klausner, R.D.3
-
35
-
-
0026746713
-
Inhibition by brefeldin a of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF
-
Helms J.B., Rothman J.E. Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF. Nature. 360:1992;352-354
-
(1992)
Nature
, vol.360
, pp. 352-354
-
-
Helms, J.B.1
Rothman, J.E.2
-
36
-
-
0002955384
-
Brefeldin a acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: Involvement of specific residues of the Sec7 domain
-
Peyroche A., Antonny B., Robineau S., Acker J., Cherfils J., Jackson C.L. Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex. involvement of specific residues of the Sec7 domain Mol. Cell. 3:1999;275-285
-
(1999)
Mol. Cell
, vol.3
, pp. 275-285
-
-
Peyroche, A.1
Antonny, B.2
Robineau, S.3
Acker, J.4
Cherfils, J.5
Jackson, C.L.6
-
37
-
-
0033574449
-
Brefeldin A: The advantage of being uncompetitive
-
Chardin P., McCormick F. Brefeldin A. the advantage of being uncompetitive Cell. 97:1999;153-155
-
(1999)
Cell
, vol.97
, pp. 153-155
-
-
Chardin, P.1
McCormick, F.2
-
38
-
-
0037178786
-
MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim D., Sarbassov D.D., Ali S., King J., Latek R., Erdjument-Bromage H., Tempst P., Sabatini D. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell. 110:2002;163-175
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.1
Sarbassov, D.D.2
Ali, S.3
King, J.4
Latek, R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.8
-
39
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara K., Maruki Y., Long X., Yoshino K., Oshiro N., Hidayat S., Tokunaga C., Avruch J., Yonezawa K. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 110:2002;177-189
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
40
-
-
0033980083
-
Bleomycin: New perspectives on the mechanism of action
-
Hecht S. Bleomycin. new perspectives on the mechanism of action J. Nat. Prod. 63:2000;158-168
-
(2000)
J. Nat. Prod.
, vol.63
, pp. 158-168
-
-
Hecht, S.1
-
41
-
-
0028672617
-
Cell cycle checkpoints, genomic integrity, and cancer
-
Hartwell L., Weinert T., Kadyk L., Garvik B. Cell cycle checkpoints, genomic integrity, and cancer. Cold Spring Harb. Symp. Quant. Biol. 59:1994;259-263
-
(1994)
Cold Spring Harb. Symp. Quant. Biol.
, vol.59
, pp. 259-263
-
-
Hartwell, L.1
Weinert, T.2
Kadyk, L.3
Garvik, B.4
-
42
-
-
0028265206
-
Use of Drosophila mutants to distinguish among volatile general anesthetics
-
Campbell D.B., Nash H.A. Use of Drosophila mutants to distinguish among volatile general anesthetics. Proc. Natl. Acad. Sci. USA. 91:1994;2135-2139
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 2135-2139
-
-
Campbell, D.B.1
Nash, H.A.2
-
43
-
-
0025016343
-
A genetic study of the anesthetic response: Mutants of Drosophila melanogaster altered in sensitivity to halothane
-
Krishnan K.S., Nash H.A. A genetic study of the anesthetic response. mutants of Drosophila melanogaster altered in sensitivity to halothane Proc. Natl. Acad. Sci. USA. 87:1990;8632-8636
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 8632-8636
-
-
Krishnan, K.S.1
Nash, H.A.2
-
44
-
-
0030796102
-
Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans
-
van-Swinderen B., Shook D.R., Ebert R.H., Cherkasova V.A., Johnson T.E., Shmookler-Reis R.J., Crowder C.M. Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA. 94:1997;8232-8237
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 8232-8237
-
-
Van-Swinderen, B.1
Shook, D.R.2
Ebert, R.H.3
Cherkasova, V.A.4
Johnson, T.E.5
Shmookler-Reis, R.J.6
Crowder, C.M.7
-
45
-
-
0034743598
-
Goalpha regulates volatile anesthetic action in Caenorhabditis elegans
-
van Swinderen B., Metz L.B., Shebester L.D., Mendel J.E., Sternberg P.W., Crowder C.M. Goalpha regulates volatile anesthetic action in Caenorhabditis elegans. Genetics. 158:2001;643-655
-
(2001)
Genetics
, vol.158
, pp. 643-655
-
-
Van Swinderen, B.1
Metz, L.B.2
Shebester, L.D.3
Mendel, J.E.4
Sternberg, P.W.5
Crowder, C.M.6
-
46
-
-
0033180210
-
Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins
-
Choy R.K., Thomas J.H. Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins. Mol. Cell. 4:1999;143-152
-
(1999)
Mol. Cell
, vol.4
, pp. 143-152
-
-
Choy, R.K.1
Thomas, J.H.2
-
47
-
-
0037108682
-
Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
-
Kenerson H.L., Aicher L.D., True L.D., Yeung R.S. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res. 62:2002;5645-5650
-
(2002)
Cancer Res.
, vol.62
, pp. 5645-5650
-
-
Kenerson, H.L.1
Aicher, L.D.2
True, L.D.3
Yeung, R.S.4
-
48
-
-
0032839061
-
Cyclooxygenase knockout mice: Models for elucidating isoform-specific functions
-
Langenbach R., Loftin C., Lee C., Tiano H. Cyclooxygenase knockout mice. models for elucidating isoform-specific functions Biochem. Pharmacol. 58:1999;1237-1246
-
(1999)
Biochem. Pharmacol.
, vol.58
, pp. 1237-1246
-
-
Langenbach, R.1
Loftin, C.2
Lee, C.3
Tiano, H.4
-
49
-
-
0035967887
-
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature
-
Graef I.A., Chen F., Chen L., Kuo A., Crabtree G.R. Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 105:2001;863-875
-
(2001)
Cell
, vol.105
, pp. 863-875
-
-
Graef, I.A.1
Chen, F.2
Chen, L.3
Kuo, A.4
Crabtree, G.R.5
-
50
-
-
0033583076
-
Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta
-
Dong L.Q., Zhang R.B., Langlais P., He H., Clark M., Zhu L., Liu F. Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta. J. Biol. Chem. 274:1999;8117-8122
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8117-8122
-
-
Dong, L.Q.1
Zhang, R.B.2
Langlais, P.3
He, H.4
Clark, M.5
Zhu, L.6
Liu, F.7
-
51
-
-
0035113642
-
High-throughput reverse genetics: RNAi screens in Caenorhabditis elegans
-
Bargmann, C.I. (2001). High-throughput reverse genetics: RNAi screens in Caenorhabditis elegans. Genome Biol 2, REVIEWS1005.1-1005.3.
-
(2001)
Genome Biol
, vol.2
, Issue.REVIEWS
-
-
Bargmann, C.I.1
-
52
-
-
0032883802
-
The Berkeley Drosophila genome project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes
-
Spradling A.C., Stern D., Beaton A., Rhem E.J., Laverty T., Mozden N., Misra S., Rubin G.M. The Berkeley Drosophila genome project gene disruption project. single P-element insertions mutating 25% of vital Drosophila genes Genetics. 153:1999;135-177
-
(1999)
Genetics
, vol.153
, pp. 135-177
-
-
Spradling, A.C.1
Stern, D.2
Beaton, A.3
Rhem, E.J.4
Laverty, T.5
Mozden, N.6
Misra, S.7
Rubin, G.M.8
-
53
-
-
0033048778
-
Genomic profiling of drug sensitivities via induced haploinsufficiency
-
Giaever G., Shoemaker D.D., Jones T.W., Liang H., Winzeler E.A., Astromoff A., Davis R.W. Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat. Genet. 21:1999;278-283
-
(1999)
Nat. Genet.
, vol.21
, pp. 278-283
-
-
Giaever, G.1
Shoemaker, D.D.2
Jones, T.W.3
Liang, H.4
Winzeler, E.A.5
Astromoff, A.6
Davis, R.W.7
-
54
-
-
0034043381
-
Genome-wide mutant collections: Toolboxes for functional genomics
-
Coelho P.S., Kumar A., Snyder M. Genome-wide mutant collections. toolboxes for functional genomics Curr. Opin. Microbiol. 3:2000;309-315
-
(2000)
Curr. Opin. Microbiol.
, vol.3
, pp. 309-315
-
-
Coelho, P.S.1
Kumar, A.2
Snyder, M.3
-
55
-
-
0036462476
-
Chemical genomics in the global study of protein functions
-
Zheng X.F., Chan T.-F. Chemical genomics in the global study of protein functions. Drug Discov. Today. 7:2001;197-205
-
(2001)
Drug Discov. Today
, vol.7
, pp. 197-205
-
-
Zheng, X.F.1
Chan, T.-F.2
-
56
-
-
0036194512
-
Chemical genomics: A systematic approach in biological research and drug discovery
-
Zheng X.F., Chan T.-F. Chemical genomics. a systematic approach in biological research and drug discovery Curr. Issues Mol. Biol. 4:2001;33-43
-
(2001)
Curr. Issues Mol. Biol.
, vol.4
, pp. 33-43
-
-
Zheng, X.F.1
Chan, T.-F.2
-
57
-
-
0034700103
-
A chemical genomics approach toward understanding the global functions of TOR
-
Chan T.F., Carvalho J., Riles L., Zheng X.F.S. A chemical genomics approach toward understanding the global functions of TOR. Proc. Natl. Acad. Sci. USA. 97:2000;13227-13232
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 13227-13232
-
-
Chan, T.F.1
Carvalho, J.2
Riles, L.3
Zheng, X.F.S.4
-
58
-
-
0036124292
-
High-density cell microarrays for parallel functional determinations
-
Xu C.W. High-density cell microarrays for parallel functional determinations. Genome Res. 12:2002;482-486
-
(2002)
Genome Res.
, vol.12
, pp. 482-486
-
-
Xu, C.W.1
-
59
-
-
0029804246
-
Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy
-
Shoemaker D.D., Lashkari D.A., Morris D., Mittmann M., Davis R.W. Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy. Nat. Genet. 14:1996;450-456
-
(1996)
Nat. Genet.
, vol.14
, pp. 450-456
-
-
Shoemaker, D.D.1
Lashkari, D.A.2
Morris, D.3
Mittmann, M.4
Davis, R.W.5
-
60
-
-
0034659898
-
Genomics, gene expression and DNA arrays
-
Lockhart D.J., Winzeler E.A. Genomics, gene expression and DNA arrays. Nature. 405:2000;827-836
-
(2000)
Nature
, vol.405
, pp. 827-836
-
-
Lockhart, D.J.1
Winzeler, E.A.2
-
61
-
-
0031730097
-
Drug target validation and identification of secondary drug target effects using DNA microarrays
-
Marton M.J., DeRisi J.L., Bennett H.A., Iyer V.R., Meyer M.R., Roberts C.J., Stoughton R., Burchard J., Slade D., Dai H., et al. Drug target validation and identification of secondary drug target effects using DNA microarrays. Nat. Med. 4:1998;1293-1301
-
(1998)
Nat. Med.
, vol.4
, pp. 1293-1301
-
-
Marton, M.J.1
Derisi, J.L.2
Bennett, H.A.3
Iyer, V.R.4
Meyer, M.R.5
Roberts, C.J.6
Stoughton, R.7
Burchard, J.8
Slade, D.9
Dai, H.10
-
63
-
-
0034710924
-
Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks
-
Butte A.J., Tamayo P., Slonim D., Golub T.R., Kohane I.S. Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks. Proc. Natl. Acad. Sci. USA. 97:2000;12182-12186
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 12182-12186
-
-
Butte, A.J.1
Tamayo, P.2
Slonim, D.3
Golub, T.R.4
Kohane, I.S.5
-
65
-
-
0034622925
-
Printing proteins as microarrays for high-throughput function determination
-
MacBeath G., Schreiber S.L. Printing proteins as microarrays for high-throughput function determination. Science. 289:2000;1760-1763
-
(2000)
Science
, vol.289
, pp. 1760-1763
-
-
MacBeath, G.1
Schreiber, S.L.2
-
66
-
-
0033768106
-
Analysis of yeast protein kinases using protein chips
-
Zhu H., Klemic J.F., Chang S., Bertone P., Casamayor A., Klemic K.G., Smith D., Gerstein M., Reed M.A., Snyder M. Analysis of yeast protein kinases using protein chips. Nat. Genet. 26:2000;283-289
-
(2000)
Nat. Genet.
, vol.26
, pp. 283-289
-
-
Zhu, H.1
Klemic, J.F.2
Chang, S.3
Bertone, P.4
Casamayor, A.5
Klemic, K.G.6
Smith, D.7
Gerstein, M.8
Reed, M.A.9
Snyder, M.10
-
67
-
-
0033562573
-
Protein microarrays for gene expression and antibody screening
-
Lueking A., Horn M., Eickhoff H., Bussow K., Lehrach H., Walter G. Protein microarrays for gene expression and antibody screening. Anal. Biochem. 270:1999;103-111
-
(1999)
Anal. Biochem.
, vol.270
, pp. 103-111
-
-
Lueking, A.1
Horn, M.2
Eickhoff, H.3
Bussow, K.4
Lehrach, H.5
Walter, G.6
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