A side effect resource to capture phenotypic effects of drugs

Molecular Systems Biology

Volumn 6, Issue , 2010, Pages

  Kuhn, Michael ^a,d   Campillos, Monica ^a   Letunic, Ivica ^a   Jensen, Lars Juhl ^a,b   Bork, Peer ^a,c  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b University of Copenhagen   (Denmark)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Adverse drug reactions; Database; Drugs; Human phenotypes; Side effects

Indexed keywords

PLACEBO; DRUG;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG CLASSIFICATION; DRUG INFORMATION; DRUG RESEARCH; HUMAN; PHENOTYPE; POSTMARKETING SURVEILLANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; CHEMISTRY; DATA BASE; DATA MINING; DRUG SURVEILLANCE PROGRAM; DRUG THERAPY; INTERNET; RISK ASSESSMENT; STRUCTURE ACTIVITY RELATION;

ADVERSE DRUG REACTION REPORTING SYSTEMS; DATA MINING; DATABASES AS TOPIC; DRUG THERAPY; HUMANS; INTERNET; PHARMACEUTICAL PREPARATIONS; PHENOTYPE; RISK ASSESSMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 76149120425     PISSN: 17444292     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2009.98     Document Type: Article

References (16)

1. Ashburn TT, Thor KB (2004) Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov 3: 673-683
2. Barsky AJ, Saintfort R, Rogers MP, Borus JF (2002) Nonspecific medication side effects and the nocebo phenomenon. JAMA 287: 622-627
3. Bender A, Scheiber J, Glick M, Davies JW, Azzaoui K, Hamon J, Urban L, Whitebread S, Jenkins JL (2007) Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure. Chem Med Chem 2: 861-873
4. Campillos M, Kuhn M, Gavin AC, Jensen LJ, Bork P (2008) Drug target identification using side-effect similarity. Science 321: 263-266
5. Fliri AF, LogingWT, Volkmann RA (2007) Analysis of system structurefunction relationships. Chem Med Chem 2: 1774-1782
6. Krejsa CM, Horvath D, Rogalski SL, Penzotti JE, Mao B, Barbosa F, Migeon JC (2003) Predicting ADME properties and side effects: the BioPrint approach. Curr Opin Drug Discov Devel 6: 470-480
7. Kuhn M, Campillos M, González P, Jensen LJ, Bork P (2008) Large-scale prediction of drug-target relationships. FEBS Lett 582: 1283-1290
8. Liebler DC, Guengerich FP (2005) Elucidating mechanisms of drug-induced toxicity. Nat Rev Drug Discov 4: 410-420
9. Liu T, Lin Y,Wen X, Jorissen RN, Gilson MK (2007) BindingDB: a webaccessible database of experimentally determined protein-ligand binding affinities. Nucleic Acids Res 35: D198-D201
10. Lue TF (2000) Erectile dysfunction. N Engl J Med 342: 1802-1813
11. Pafilis E, O'Donoghue SI, Jensen LJ, Horn H, Kuhn M, Brown NP, Schneider R (2009) Reflect: augmented browsing for the life scientist. Nat Biotechnol 27: 508-510
12. Roth B, KroezeW, Patel S, Lopez E (2000) The multiplicity of serotonin receptors: uselessly diverse molecules or an embarrassment of riches? Neuroscientist 6: 252-262
13. Seiler KP, George GA, Happ MP, Bodycombe NE, Carrinski HA, Norton S, Brudz S, Sullivan JP, Muhlich J, Serrano M, Ferraiolo P, Tolliday NJ, Schreiber SL, Clemons PA (2008) ChemBank: a small-molecule screening and cheminformatics resource database. Nucleic Acids Res 36: D351-D359
14. Shiri R, Koskimaki J, Hakkinen J, Auvinen A, Tammela TL, HakamaM (2007) Cardiovascular drug use and the incidence of erectile dysfunction. Int J Impot Res 19: 208-212
15. Wheeler DL, Barrett T, Benson DA, Bryant SH, Canese K, Chetvernin V, Church DM, DiCuccio M, Edgar R, Federhen S, Geer LY, Kapustin Y, Khovayko O, Landsman D, Lipman DJ, Madden TL, Maglott DR, Ostell J, Miller V, Pruitt KD et al (2007) Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 35: D5-12
16. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008) DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res 36: D901-D906