[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A 4 hydrolase

Cancer Research

Volumn 69, Issue 13, 2009, Pages 5584-5591

  Jeong, Chul Ho ^a   Bode, Ann M ^a   Pugliese, Angelo ^a   Cho, Yong Yeon ^a   Kim, Hong Gyum ^a   Shim, Jung Hyun ^a   Jeon, Young Jin ^a,b   Li, Honglin ^c,d   Jiang, Hualiang ^c,d   Dong, Zigang ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Chosun University   (South Korea)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^d EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

(6) GINGEROL; LEUKOTRIENE A4 HYDROLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER PREVENTION; CELL STRAIN HCT116; CHEMOPROPHYLAXIS; COLORECTAL CANCER; CONTROLLED STUDY; DRUG BINDING; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR VOLUME; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CATECHOLS; CELL DIVISION; CELL LINE, TUMOR; COLONIC NEOPLASMS; COLORECTAL NEOPLASMS; EPOXIDE HYDROLASES; FATTY ALCOHOLS; FEMALE; GINGER; HCT116 CELLS; HUMANS; MALE; MICE; MICE, NUDE; MODELS, MOLECULAR; PROTEIN CONFORMATION;

EID: 67650422597     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-0491     Document Type: Article

References (35)

1. Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003;3:768-80.
2. Surh Y. Molecular mechanisms of chemopreventive effects of selectedd ietary andme dicinal phenolic substances. Mutat Res 1999;428:305-27.
3. Bode AM, Ma WY, Surh YJ, Dong Z. Inhibition of epidermal growth factor-induced cell transformation andactivator protein 1 activation by [6]-gingerol. Cancer Res 2001;61:850-3.
4. Kim SO, Kundu JK, Shin YK, et al. [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulatedmouse skin. Oncogene 2005;24:2558-67.
5. Kim EC, Min JK, Kim TY, et al. [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Biochem Biophys Res Commun 2005;335:300-8.
6. Lee HS, Seo EY, Kang NE, Kim WK. [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. J Nutr Biochem 2008;19:313-9.
7. Suzuki F, Kobayashi M, Komatsu Y, Kato A, Pollard RB. Keishi-ka-kei-to, a traditional Chinese herbal medicine, inhibits pulmonary metastasis of B16 melanoma. Anticancer Res 1997;17:873-8.
8. Samuelsson B, Dahlen SE, Lindgren JA, Rouzer CA, Serhan CN. Leukotrienes andlipo xins: structures, biosynthesis, andbiological effects. Science 1987;237:1171-6.
9. Funk CD. Prostaglandins and leukotrienes: advances in eicosanoidbiolog y. Science 2001;294:1871-5.
10. Fabre JE, Goulet JL, Riche E, et al. Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo. J Clin Invest 2002;109:1373-80.
11. Avis I, Hong SH, Martinez A, et al. Five-lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid-interactions. FASEB J 2001;15:2007-9.
12. Moody TW, Leyton J, Martinez A, Hong S, Malkinson A, Mulshine JL. Lipoxygenase inhibitors prevent lung carcinogenesis and inhibit non-small cell lung cancer growth. Exp Lung Res 1998;24:617-28.
13. Goulet JL, Snouwaert JN, Latour AM, Coffman TM, Koller BH. Altered inflammatory responses in leukotriene-deficient mice. Proc Natl Acad Sci U S A 1994;91:12852-6.
14. Gunning WT, Kramer PM, Steele VE, Pereira MA. Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice. Cancer Res 2002;62:4199-201.
15. 4 hydrolase as a target for cancer prevention and therapy. Curr Cancer Drug Targets 2004;4:267-83.
16. 4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes. J Biol Chem 1991;266:1375-8.
17. 4 hydrolase in rat andhuman esophageal adenocarcinomas and inhibitory effects of bestatin. J Natl Cancer Inst 2003;95:1053-61.
18. 4 hydrolase expression in PEL cells is regulated at the transcriptional level andlead s to increased-leukotriene B4 production. J Immunol 2006;176:7051-61.
19. 4 hydrolase, a bifunctional enzyme in inflammation. Nat Struct Biol 2001;8:131-5.
20. Gao Z, Li H, Zhang H, et al. PDTD: a web-accessible protein database for drug target identification. BMC Bioinformatics 2008;9:104.
21. Aktan F, Henness S, Tran VH, Duke CC, Roufogalis BD, Ammit AJ. Gingerol metabolite anda synthetic analogue Capsarol inhibit macrophage NF-κB-mediated iNOS gene expression andenzym e activity. Planta Med 2006;72:727-34.
22. Li H, Gao Z, Kang L, et al. TarFisDock: a web server for identifying drug targets with docking approach. Nucleic Acids Res 2006;34:W219-24.
23. Li H, Li C, Gui C, et al. GAsDock: a new approach for rapidflexible docking basedon an improved multipopulation genetic algorithm. Bioorg Med Chem Lett 2004;14:4671-6.
24. Ewing TJ, Makino S, Skillman AG, Kuntz ID. DOCK 4.0: search strategies for automatedmole cular docking of flexible molecule databases. J Comput Aided Mol Des 2001;15:411-28.
25. Arber N, Levin B. Chemoprevention of colorectal cancer: ready for routine use? Curr Top Med Chem 2005;5:517-25.
26. Schrödinger Suite 2006 QM-polarized ligand docking protocol. New York: Schrödinger, LLC; p. 2005. Glide version 4.0; Jaguar version 6.5; QSite version 4.0.
27. 4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates. J Biol Chem 2004;279:27376-82.
28. Freedman VH, Shin SI. Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium. Cell 1974;3:355-9.
29. 4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms. J Biol Chem 2002;277:1398-404.
30. 4) hydrolase as potential anti-inflammatory agents. Curr Pharm Des 2001;7:163-79.
31. Dreyling KW, Hoppe U, Peskar BA, Morgenroth K, Kozuschek W, Peskar BM. Leukotriene synthesis by human gastrointestinal tissues. Biochim Biophys Acta 1986;878:184-93.
32. Bortuzzo C, Hanif R, Kashfi K, Staiano-Coico L, Shiff SJ, Rigas B. The effect of leukotrienes B andselected HETEs on the proliferation of colon cancer cells. Biochim Biophys Acta 1996;1300:240-6.
33. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
34. 4 hydrolase: a critical role of glutamic acid-296 for the binding of bestatin. Biochem J 2000;345 Pt 3:621-5.
35. Park KK, Chun KS, Lee JM, Lee SS, Surh YJ. Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Lett 1998;129:139-44.