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Volumn 40, Issue 10, 2007, Pages 1025-1033

Tagged small molecule library approach for facilitated chemical genetics

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; BRAIN; DNA MICROARRAY; EYE; GENETICS; MELANOCYTE; METABOLISM; PHENOTYPE; PIGMENTATION; PRENATAL DEVELOPMENT; ZEBRA FISH;

EID: 35949000935     PISSN: 00014842     EISSN: None     Source Type: Journal    
DOI: 10.1021/ar700030k     Document Type: Article
Times cited : (26)

References (53)
  • 1
    • 0026343121 scopus 로고
    • 25 Years of Cell-Cycle Genetics
    • Hartwell, L. H. 25 Years of Cell-Cycle Genetics. Genetics 1991, 129, 975-980.
    • (1991) Genetics , vol.129 , pp. 975-980
    • Hartwell, L.H.1
  • 2
    • 0031731989 scopus 로고    scopus 로고
    • Genetics of programmed cell death in C. elegans: Past, present and future
    • Metzstein, M. M.; Stanfield, G. M.; Horvitz, H. R. Genetics of programmed cell death in C. elegans: Past, present and future. Trends Genet. 1998, 14, 410-416.
    • (1998) Trends Genet , vol.14 , pp. 410-416
    • Metzstein, M.M.1    Stanfield, G.M.2    Horvitz, H.R.3
  • 3
    • 0034332931 scopus 로고    scopus 로고
    • Frontiers in chemical genetics
    • Stockwell, B. R. Frontiers in chemical genetics. Trends Biotechnol. 2000, 18, 449-455.
    • (2000) Trends Biotechnol , vol.18 , pp. 449-455
    • Stockwell, B.R.1
  • 4
    • 33745726644 scopus 로고    scopus 로고
    • Chemical genetics
    • Walsh, D. P.; Chang, Y. T. Chemical genetics. Chem. Rev. 2006, 106, 2476-2530.
    • (2006) Chem. Rev , vol.106 , pp. 2476-2530
    • Walsh, D.P.1    Chang, Y.T.2
  • 5
    • 0036250571 scopus 로고    scopus 로고
    • From sequence to phenotype: Reverse genetics in Drosophila melanogaster
    • Adams, M. D.; Sekelsky, J. J. From sequence to phenotype: Reverse genetics in Drosophila melanogaster. Nat. Rev. Genet. 2002, 3, 189-198.
    • (2002) Nat. Rev. Genet , vol.3 , pp. 189-198
    • Adams, M.D.1    Sekelsky, J.J.2
  • 6
    • 0031710509 scopus 로고    scopus 로고
    • Chemical genetics resulting from a passion for synthetic organic chemistry
    • Schreiber, S. L. Chemical genetics resulting from a passion for synthetic organic chemistry. Bioorg. Med. Chem. 1998, 6, 1127-1152.
    • (1998) Bioorg. Med. Chem , vol.6 , pp. 1127-1152
    • Schreiber, S.L.1
  • 7
    • 0037305949 scopus 로고    scopus 로고
    • Forward chemical genetics: Progress and obstacles on the path to a new pharmacopoeia
    • Lokey, R. S. Forward chemical genetics: Progress and obstacles on the path to a new pharmacopoeia. Curr. Opin. Chem. Biol. 2003, 7, 91-96.
    • (2003) Curr. Opin. Chem. Biol , vol.7 , pp. 91-96
    • Lokey, R.S.1
  • 8
    • 0033178766 scopus 로고    scopus 로고
    • Chemical genetics: Exploring and controlling cellular processes with chemical probes
    • Crews, C. M.; Splittgerber, U. Chemical genetics: Exploring and controlling cellular processes with chemical probes. Trends Biochem. Sci. 1999, 24, 317-320.
    • (1999) Trends Biochem. Sci , vol.24 , pp. 317-320
    • Crews, C.M.1    Splittgerber, U.2
  • 10
    • 0036669959 scopus 로고    scopus 로고
    • Using small molecules to study big questions in cellular microbiology
    • Ward, G. E.; Carey, K. L.; Westwood, N. J. Using small molecules to study big questions in cellular microbiology. Cell. Microbiol. 2002, 4, 471-482.
    • (2002) Cell. Microbiol , vol.4 , pp. 471-482
    • Ward, G.E.1    Carey, K.L.2    Westwood, N.J.3
  • 11
    • 0034331004 scopus 로고    scopus 로고
    • Chemical genetics: Ligand-based discovery of gene function
    • Stockwell, B. R. Chemical genetics: Ligand-based discovery of gene function. Nat. Rev. Genet. 2000, 1, 116-125.
    • (2000) Nat. Rev. Genet , vol.1 , pp. 116-125
    • Stockwell, B.R.1
  • 12
    • 0036462476 scopus 로고    scopus 로고
    • Chemical genomics in the global study of protein functions
    • Zheng, X. F. S.; Chan, T. F. Chemical genomics in the global study of protein functions. Drug Discovery Today 2002, 7, 197-205.
    • (2002) Drug Discovery Today , vol.7 , pp. 197-205
    • Zheng, X.F.S.1    Chan, T.F.2
  • 13
    • 2642553258 scopus 로고    scopus 로고
    • Target identification in chemical genetics: The (often) missing link
    • Burdine, L.; Kodadek, T. Target identification in chemical genetics: The (often) missing link. Chem. Biol. 2004, 11, 593-597.
    • (2004) Chem. Biol , vol.11 , pp. 593-597
    • Burdine, L.1    Kodadek, T.2
  • 14
    • 0040111705 scopus 로고    scopus 로고
    • Bivalent inhibitors of protein tyrosine kinases
    • Profit, A. A.; Lee, T. R.; Lawrence, D. S. Bivalent inhibitors of protein tyrosine kinases. J. Am. Chem. Soc. 1999, 121, 280-283.
    • (1999) J. Am. Chem. Soc , vol.121 , pp. 280-283
    • Profit, A.A.1    Lee, T.R.2    Lawrence, D.S.3
  • 15
    • 0034646370 scopus 로고    scopus 로고
    • Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors
    • Maly, D. J.; Choong, I. C.; Ellman, J. A. Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 2419-2424.
    • (2000) Proc. Natl. Acad. Sci. U.S.A , vol.97 , pp. 2419-2424
    • Maly, D.J.1    Choong, I.C.2    Ellman, J.A.3
  • 17
    • 0033951038 scopus 로고    scopus 로고
    • Using photolabile ligands in drug discovery and development
    • Dorman, G.; Prestwich, G. D. Using photolabile ligands in drug discovery and development. Trends Biotechnol. 2000, 18, 64-77.
    • (2000) Trends Biotechnol , vol.18 , pp. 64-77
    • Dorman, G.1    Prestwich, G.D.2
  • 18
    • 0030878873 scopus 로고    scopus 로고
    • Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen
    • Liberies, S. D.; Diver, S. T.; Austin, D. J.; Schreiber, S. L. Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen. Proc. Natl. Acad. Sei. U.S.A. 1997, 94, 7825-7830.
    • (1997) Proc. Natl. Acad. Sei. U.S.A , vol.94 , pp. 7825-7830
    • Liberies, S.D.1    Diver, S.T.2    Austin, D.J.3    Schreiber, S.L.4
  • 19
    • 2642520581 scopus 로고    scopus 로고
    • Chemical dimerizers and three-hybrid systems: Scanning the proteome for targets of organic small molecules
    • Kley, N. Chemical dimerizers and three-hybrid systems: Scanning the proteome for targets of organic small molecules. Chem. Biol. 2004, 11, 599-608.
    • (2004) Chem. Biol , vol.11 , pp. 599-608
    • Kley, N.1
  • 21
    • 0025776523 scopus 로고
    • Targets for Cell-Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
    • Heitman, J.; Movva, N. R.; Hall, M. N. Targets for Cell-Cycle Arrest by the Immunosuppressant Rapamycin in Yeast. Science 1991, 253, 905-909.
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 22
    • 2642573570 scopus 로고    scopus 로고
    • Genetic and genomic approaches to identify and study the targets of bioactive small molecules
    • Zheng, X. F. S.; Chan, T. F.; Zhou, H. H. Genetic and genomic approaches to identify and study the targets of bioactive small molecules. Chem. Biol. 2004, 11, 609-618.
    • (2004) Chem. Biol , vol.11 , pp. 609-618
    • Zheng, X.F.S.1    Chan, T.F.2    Zhou, H.H.3
  • 23
    • 0038506175 scopus 로고    scopus 로고
    • A small molecule suppressor of FK506 that targets the mitochondria and modulates ionic balance in Saccharomyces cerevisiae
    • Butcher, R. A.; Schreiber, S. L. A small molecule suppressor of FK506 that targets the mitochondria and modulates ionic balance in Saccharomyces cerevisiae. Chem. Biol. 2003, 10, 521-531.
    • (2003) Chem. Biol , vol.10 , pp. 521-531
    • Butcher, R.A.1    Schreiber, S.L.2
  • 24
    • 0033579188 scopus 로고    scopus 로고
    • Chemical genetic and genomic approaches reveal a role for copper in specific gene activation
    • Stockwell, B. R.; Hardwick, J. S.; Tong, J. K.; Schreiber, S. L. Chemical genetic and genomic approaches reveal a role for copper in specific gene activation. J. Am. Chem. Soc. 1999, 121, 10662-10663.
    • (1999) J. Am. Chem. Soc , vol.121 , pp. 10662-10663
    • Stockwell, B.R.1    Hardwick, J.S.2    Tong, J.K.3    Schreiber, S.L.4
  • 25
    • 9344247454 scopus 로고    scopus 로고
    • Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips
    • Huang, J.; Zhu, H.; Haggarty, S. J.; Spring, D. R.; Hwang, H.; Jin, F. L.; Snyder, M.; Schreiber, S. L. Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 16594-16599.
    • (2004) Proc. Natl. Acad. Sci. U.S.A , vol.101 , pp. 16594-16599
    • Huang, J.1    Zhu, H.2    Haggarty, S.J.3    Spring, D.R.4    Hwang, H.5    Jin, F.L.6    Snyder, M.7    Schreiber, S.L.8
  • 26
    • 1042287126 scopus 로고    scopus 로고
    • Tagged library approach to chemical genomics and proteomics
    • Mitsopoulos, G.; Walsh, D. P.; Chang, Y. T. Tagged library approach to chemical genomics and proteomics. Curr. Opin. Chem. Biol. 2004, 8, 26-32.
    • (2004) Curr. Opin. Chem. Biol , vol.8 , pp. 26-32
    • Mitsopoulos, G.1    Walsh, D.P.2    Chang, Y.T.3
  • 27
    • 0035801347 scopus 로고    scopus 로고
    • From split-pool libraries to spatially addressable microarrays and its application to functional proteomic profiling
    • Winssinger, N.; Harris, J. L.; Backes, B. J.; Schultz, P. G. From split-pool libraries to spatially addressable microarrays and its application to functional proteomic profiling. Angew. Chem., Int. Ed. 2001, 40, 3152-3155.
    • (2001) Angew. Chem., Int. Ed , vol.40 , pp. 3152-3155
    • Winssinger, N.1    Harris, J.L.2    Backes, B.J.3    Schultz, P.G.4
  • 28
    • 0035957374 scopus 로고    scopus 로고
    • The use of mRNA display to select high-affinity protein-binding peptides
    • Wilson, D. S.; Keefe, A. D.; Szostak, J. W. The use of mRNA display to select high-affinity protein-binding peptides. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 3750-3755.
    • (2001) Proc. Natl. Acad. Sci. U.S.A , vol.98 , pp. 3750-3755
    • Wilson, D.S.1    Keefe, A.D.2    Szostak, J.W.3
  • 29
    • 0037462106 scopus 로고    scopus 로고
    • Speers, A. E.; Adam, G. C.; Cravatt, B. F. Activity-based protein profiling in vivo using a copper(l)-catalyzed azide-alkyne [3+2] cycloaddition. J. Am. Chem. Soc. 2003, 125, 4686-4687.
    • Speers, A. E.; Adam, G. C.; Cravatt, B. F. Activity-based protein profiling in vivo using a copper(l)-catalyzed azide-alkyne [3+2] cycloaddition. J. Am. Chem. Soc. 2003, 125, 4686-4687.
  • 30
    • 4544334518 scopus 로고    scopus 로고
    • Strategies for facilitated forward chemical genetics
    • Khersonsky, S. M.; Chang, Y. T. Strategies for facilitated forward chemical genetics. ChemBioChem 2004, 5, 903-908.
    • (2004) ChemBioChem , vol.5 , pp. 903-908
    • Khersonsky, S.M.1    Chang, Y.T.2
  • 32
    • 0032537027 scopus 로고    scopus 로고
    • Incorporation of carbohydrates and peptides into large triazine-based screening libraries using automated parallel synthesis
    • Gustafson, G. R.; Baldino, C. M.; O'Donnell, M. M. E.; Sheldon, A.; Tarsa, R. J.; Verni, C. J.; Coffen, D. L. Incorporation of carbohydrates and peptides into large triazine-based screening libraries using automated parallel synthesis. Tetrahedron 1998, 54, 4051-4065.
    • (1998) Tetrahedron , vol.54 , pp. 4051-4065
    • Gustafson, G.R.1    Baldino, C.M.2    O'Donnell, M.M.E.3    Sheldon, A.4    Tarsa, R.J.5    Verni, C.J.6    Coffen, D.L.7
  • 33
    • 0034222020 scopus 로고    scopus 로고
    • Spatially addressed synthesis of amino- and aminooxy-substituted 1,3,5-triazine arrays on polymeric membranes
    • Scharn, D.; Wenschuh, H.; Reineke, U.; Schneider-Mergener, J.; Germeroth, L. Spatially addressed synthesis of amino- and aminooxy-substituted 1,3,5-triazine arrays on polymeric membranes. J. Comb. Chem. 2000, 2, 361-369.
    • (2000) J. Comb. Chem , vol.2 , pp. 361-369
    • Scharn, D.1    Wenschuh, H.2    Reineke, U.3    Schneider-Mergener, J.4    Germeroth, L.5
  • 34
    • 0037009971 scopus 로고    scopus 로고
    • Moon, H. S.; Jacobson, E. M.; Khersonsky, S. M.; Luzung, M. R.; Walsh, D. P.; Xiong, W. N.; Lee, J. W.; Parikh, P. B.; Lam, J. C.; Kang, T. W.; Rosania, G. R.; Schier, A. F.; Chang, Y. T. A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening. J. Am. Chem. Soc. 2002, 124, 11608-11609.
    • Moon, H. S.; Jacobson, E. M.; Khersonsky, S. M.; Luzung, M. R.; Walsh, D. P.; Xiong, W. N.; Lee, J. W.; Parikh, P. B.; Lam, J. C.; Kang, T. W.; Rosania, G. R.; Schier, A. F.; Chang, Y. T. A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening. J. Am. Chem. Soc. 2002, 124, 11608-11609.
  • 37
    • 0034700166 scopus 로고    scopus 로고
    • Small molecule developmental screens reveal the logic and timing of vertebrate development
    • Peterson, R. T.; Link, B. A.; Dowling, J. E.; Schreiber, S. L. Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 12965-12969.
    • (2000) Proc. Natl. Acad. Sci. U.S.A , vol.97 , pp. 12965-12969
    • Peterson, R.T.1    Link, B.A.2    Dowling, J.E.3    Schreiber, S.L.4
  • 38
    • 0142167588 scopus 로고    scopus 로고
    • Zebrafish-based small molecule discovery
    • MacRae, C. A.; Peterson, R. T. Zebrafish-based small molecule discovery. Chem. Biol. 2003, 10, 901-908.
    • (2003) Chem. Biol , vol.10 , pp. 901-908
    • MacRae, C.A.1    Peterson, R.T.2
  • 39
  • 41
    • 0037079077 scopus 로고    scopus 로고
    • Chemical genetics: A small molecule approach to neurobiology
    • Koh, B.; Crews, C. M. Chemical genetics: A small molecule approach to neurobiology. Neuron 2002, 36, 563-566.
    • (2002) Neuron , vol.36 , pp. 563-566
    • Koh, B.1    Crews, C.M.2
  • 42
    • 0037492366 scopus 로고    scopus 로고
    • The platelet as a model for chemical genetics
    • Flaumenhaft, R.; Sim, D. S. The platelet as a model for chemical genetics. Chem. Biol. 2003, 10, 481-486.
    • (2003) Chem. Biol , vol.10 , pp. 481-486
    • Flaumenhaft, R.1    Sim, D.S.2
  • 43
    • 0036909567 scopus 로고    scopus 로고
    • Small molecules, big impact: A history of chemical inhibitors and the cytoskeleton
    • Peterson, J. R.; Mitchison, T. J. Small molecules, big impact: A history of chemical inhibitors and the cytoskeleton. Chem. Biol. 2002, 9, 1275-1285.
    • (2002) Chem. Biol , vol.9 , pp. 1275-1285
    • Peterson, J.R.1    Mitchison, T.J.2
  • 44
    • 3042744026 scopus 로고    scopus 로고
    • A role for chemistry in stem cell biology
    • Ding, S.; Schultz, P. G. A role for chemistry in stem cell biology. Nat. Biotechnol. 2004, 22, 833-840.
    • (2004) Nat. Biotechnol , vol.22 , pp. 833-840
    • Ding, S.1    Schultz, P.G.2
  • 45
    • 26944447533 scopus 로고    scopus 로고
    • Chemical genetics and orphan genetic diseases
    • Lunn, M. R.; Stockwell, B. R. Chemical genetics and orphan genetic diseases. Chem. Biol. 2005, 12, 1063-1073.
    • (2005) Chem. Biol , vol.12 , pp. 1063-1073
    • Lunn, M.R.1    Stockwell, B.R.2
  • 46
    • 4644307268 scopus 로고    scopus 로고
    • Identification of compounds that bind mitochondrial F1F0 ATPase by screening a triazine library for correction of albinism
    • Williams, D.; Jung, D. W.; Khersonsky, S. M.; Heidary, N.; Chang, Y. T.; Orlow, S. J. Identification of compounds that bind mitochondrial F1F0 ATPase by screening a triazine library for correction of albinism. Chem. Biol. 2004, 11, 1251-1259.
    • (2004) Chem. Biol , vol.11 , pp. 1251-1259
    • Williams, D.1    Jung, D.W.2    Khersonsky, S.M.3    Heidary, N.4    Chang, Y.T.5    Orlow, S.J.6
  • 47
    • 17844362208 scopus 로고    scopus 로고
    • Dissection of melanogenesis with small molecules identifies prohibitin as a regulator
    • Snyder, J. R.; Hall, A.; Ni-Komatsu, L.; Khersonsky, S. M.; Chang, Y. T.; Orlow, S. J. Dissection of melanogenesis with small molecules identifies prohibitin as a regulator. Chem. Biol. 2005, 12, 477-484.
    • (2005) Chem. Biol , vol.12 , pp. 477-484
    • Snyder, J.R.1    Hall, A.2    Ni-Komatsu, L.3    Khersonsky, S.M.4    Chang, Y.T.5    Orlow, S.J.6
  • 49
    • 0035985173 scopus 로고    scopus 로고
    • Pink-eyed dilution protein controls the processing of tyrosinase
    • Chen, K.; Manga, P.; Orlow, S. J. Pink-eyed dilution protein controls the processing of tyrosinase. MoI. Biol. Cell 2002, 13, 1953-1964.
    • (2002) MoI. Biol. Cell , vol.13 , pp. 1953-1964
    • Chen, K.1    Manga, P.2    Orlow, S.J.3
  • 50
    • 0033199751 scopus 로고    scopus 로고
    • Printing small molecules as microarrays and detecting protein-ligand interactions en masse
    • MacBeath, G.; Koehler, A. N.; Schreiber, S. L. Printing small molecules as microarrays and detecting protein-ligand interactions en masse. J. Am. Chem. Soc. 1999, 121, 7967-7968.
    • (1999) J. Am. Chem. Soc , vol.121 , pp. 7967-7968
    • MacBeath, G.1    Koehler, A.N.2    Schreiber, S.L.3
  • 51
    • 0037061492 scopus 로고    scopus 로고
    • Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays
    • Kuruvilla, F. G.; Shamji, A. F.; Sternson, S. M.; Hergenrother, P. J.; Schreiber, S. L. Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays. Nature 2002, 416, 653-657.
    • (2002) Nature , vol.416 , pp. 653-657
    • Kuruvilla, F.G.1    Shamji, A.F.2    Sternson, S.M.3    Hergenrother, P.J.4    Schreiber, S.L.5
  • 53
    • 9344225707 scopus 로고    scopus 로고
    • Microarrays of tagged combinatorial triazine libraries in the discovery of small-molecule ligands of human IgG
    • Uttamchandani, M.; Walsh, D. P.; Khersonsky, S. M.; Huang, X.; Yao, S. Q.; Chang, Y. T. Microarrays of tagged combinatorial triazine libraries in the discovery of small-molecule ligands of human IgG. J. Comb. Chem. 2004, 6, 862-868.
    • (2004) J. Comb. Chem , vol.6 , pp. 862-868
    • Uttamchandani, M.1    Walsh, D.P.2    Khersonsky, S.M.3    Huang, X.4    Yao, S.Q.5    Chang, Y.T.6


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