-
1
-
-
0021681351
-
Microtubule-associated proteins connect microtubules and neurofilaments in vitro
-
Aamodt EJ, Williams RC Jr. 1984. Microtubule-associated proteins connect microtubules and neurofilaments in vitro. Biochemistry 23: 6023-6031.
-
(1984)
Biochemistry
, vol.23
, pp. 6023-6031
-
-
Aamodt, E.J.1
Williams Jr., R.C.2
-
2
-
-
0034730759
-
Nonsaturable binding indicates clustering of tau on the microtubule surface in a paired helical filament-like conformation
-
Ackmann M, Wiech H, Mandelkow E. 2000. Nonsaturable binding indicates clustering of tau on the microtubule surface in a paired helical filament-like conformation. J Biol Chem 275: 30335-30343.
-
(2000)
J Biol Chem
, vol.275
, pp. 30335-30343
-
-
Ackmann, M.1
Wiech, H.2
Mandelkow, E.3
-
3
-
-
72149125838
-
The transcellular spread of cytosolic amyloids, prions, and prionoids
-
Aguzzi A, Rajendran L. 2009. The transcellular spread of cytosolic amyloids, prions, and prionoids. Neuron 64: 783-790.
-
(2009)
Neuron
, vol.64
, pp. 783-790
-
-
Aguzzi, A.1
Rajendran, L.2
-
4
-
-
22544457646
-
Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation
-
Ahn JS, Radhakrishnan ML, Mapelli M, Choi S, Tidor B, Cuny GD, Musacchio A, Yeh LA, Kosik KS. 2005. Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. Chem Biol 12: 811-823.
-
(2005)
Chem Biol
, vol.12
, pp. 811-823
-
-
Ahn, J.S.1
Radhakrishnan, M.L.2
Mapelli, M.3
Choi, S.4
Tidor, B.5
Cuny, G.D.6
Musacchio, A.7
Yeh, L.A.8
Kosik, K.S.9
-
5
-
-
0037166943
-
MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments
-
Al-Bassam J, Ozer RS, Safer D, Halpain S, Milligan RA. 2002. MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments. J Cell Biol 157: 1187-1196.
-
(2002)
J Cell Biol
, vol.157
, pp. 1187-1196
-
-
Al-Bassam, J.1
Ozer, R.S.2
Safer, D.3
Halpain, S.4
Milligan, R.A.5
-
6
-
-
39049193314
-
Misregulation of tau alternative splicing in neurodegeneration and dementia
-
Andreadis A. 2006. Misregulation of tau alternative splicing in neurodegeneration and dementia. Prog Mol Subcell Biol 44: 89-107.
-
(2006)
Prog Mol Subcell Biol
, vol.44
, pp. 89-107
-
-
Andreadis, A.1
-
7
-
-
0036798495
-
Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules
-
Aronov S, Aranda G, Behar L, Ginzburg I. 2002. Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules. J Cell Sci 115: 3817-3827.
-
(2002)
J Cell Sci
, vol.115
, pp. 3817-3827
-
-
Aronov, S.1
Aranda, G.2
Behar, L.3
Ginzburg, I.4
-
8
-
-
56749104288
-
Inclusion-body myositis: Muscle-fiber molecular pathology and possible pathogenic significance of its similarity to Alzheimer's and Parkinson's disease brains
-
Askanas V, Engel WK. 2008. Inclusion-body myositis: Muscle-fiber molecular pathology and possible pathogenic significance of its similarity to Alzheimer's and Parkinson's disease brains. Acta Neuropathol 116: 583-595.
-
(2008)
Acta Neuropathol
, vol.116
, pp. 583-595
-
-
Askanas, V.1
Engel, W.K.2
-
9
-
-
0346120162
-
Slow axonal transport and the genesis of neuronal morphology
-
Baas PW, Buster DW. 2004. Slow axonal transport and the genesis of neuronal morphology. J Neurobiol 58: 3-17.
-
(2004)
J Neurobiol
, vol.58
, pp. 3-17
-
-
Baas, P.W.1
Buster, D.W.2
-
10
-
-
34548036227
-
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
-
Ballatore C, Lee VM, Trojanowski JQ. 2007. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci 8: 663-672.
-
(2007)
Nat Rev Neurosci
, vol.8
, pp. 663-672
-
-
Ballatore, C.1
Lee, V.M.2
Trojanowski, J.Q.3
-
11
-
-
0034718571
-
Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias
-
Barghorn S, Zheng-Fischhofer Q, Ackmann M, Biernat J, von Bergen M, Mandelkow EM, Mandelkow E. 2000. Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias. Biochemistry 39: 11714-11721.
-
(2000)
Biochemistry
, vol.39
, pp. 11714-11721
-
-
Barghorn, S.1
Zheng-Fischhofer, Q.2
Ackmann, M.3
Biernat, J.4
von Bergen, M.5
Mandelkow, E.M.6
Mandelkow, E.7
-
12
-
-
1042288284
-
Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on β-structure in the core domain
-
Barghorn S, Davies P, MandelkowE. 2004. Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on β-structure in the core domain. Biochemistry 43: 1694-1703.
-
(2004)
Biochemistry
, vol.43
, pp. 1694-1703
-
-
Barghorn, S.1
Davies, P.2
Mandelkow, E.3
-
13
-
-
0023875705
-
2+/calmodulin-dependent protein kinase II
-
2+/calmodulin-dependent protein kinase II. J Biol Chem 263: 5876-5883.
-
(1988)
J Biol Chem
, vol.263
, pp. 5876-5883
-
-
Baudier, J.1
Cole, R.D.2
-
14
-
-
0023190008
-
Comparison of S100b protein with calmodulin: Interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C
-
Baudier J, Mochly-Rosen D, Newton A, Lee SH, Koshland DE Jr, Cole RD. 1987. Comparison of S100b protein with calmodulin: Interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C. Biochemistry 26: 2886-2893.
-
(1987)
Biochemistry
, vol.26
, pp. 2886-2893
-
-
Baudier, J.1
Mochly-Rosen, D.2
Newton, A.3
Lee, S.H.4
Koshland Jr., D.E.5
Cole, R.D.6
-
15
-
-
53149103944
-
Truncated Tau with the Fynbinding domain and without the microtubule-binding domain hinders the myelinating capacity of an oligodendrocyte cell line
-
Belkadi A, LoPresti P. 2008. Truncated Tau with the Fynbinding domain and without the microtubule-binding domain hinders the myelinating capacity of an oligodendrocyte cell line. J Neurochem 107: 351-360.
-
(2008)
J Neurochem
, vol.107
, pp. 351-360
-
-
Belkadi, A.1
LoPresti, P.2
-
16
-
-
0042307302
-
Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-β structure
-
Berriman J, Serpell LC, Oberg KA, Fink AL, Goedert M, Crowther RA. 2003. Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-β structure. Proc Natl Acad Sci 100: 9034-9038.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 9034-9038
-
-
Berriman, J.1
Serpell, L.C.2
Oberg, K.A.3
Fink, A.L.4
Goedert, M.5
Crowther, R.A.6
-
17
-
-
27444437758
-
Disease-related modifications in tau affect the interaction between Fyn and Tau
-
Bhaskar K, Yen SH, Lee G. 2005. Disease-related modifications in tau affect the interaction between Fyn and Tau. J Biol Chem 280: 35119-35125.
-
(2005)
J Biol Chem
, vol.280
, pp. 35119-35125
-
-
Bhaskar, K.1
Yen, S.H.2
Lee, G.3
-
18
-
-
0026551711
-
The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region
-
Biernat J, Mandelkow EM, Schroter C, Lichtenberg-Kraag B, Steiner B, Berling B, Meyer H, Mercken M, Vandermeeren A, Goedert M, et al. 1992. The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region. EMBO J 11: 1593-1597.
-
(1992)
EMBO J
, vol.11
, pp. 1593-1597
-
-
Biernat, J.1
Mandelkow, E.M.2
Schroter, C.3
Lichtenberg-Kraag, B.4
Steiner, B.5
Berling, B.6
Meyer, H.7
Mercken, M.8
Vandermeeren, A.9
Goedert, M.10
-
19
-
-
0027338266
-
Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
-
Biernat J, Gustke N, Drewes G, Mandelkow EM, Mandelkow E. 1993. Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding. Neuron 11: 153-163.
-
(1993)
Neuron
, vol.11
, pp. 153-163
-
-
Biernat, J.1
Gustke, N.2
Drewes, G.3
Mandelkow, E.M.4
Mandelkow, E.5
-
20
-
-
0036854327
-
Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity
-
Biernat J, Wu YZ, Timm T, Zheng-Fischhofer Q, Mandelkow E, Meijer L, Mandelkow EM. 2002. Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. Mol Biol Cell 13: 4013-4028.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 4013-4028
-
-
Biernat, J.1
Wu, Y.Z.2
Timm, T.3
Zheng-Fischhofer, Q.4
Mandelkow, E.5
Meijer, L.6
Mandelkow, E.M.7
-
21
-
-
0022365608
-
The distribution of tau in the mammalian central nervous system
-
Binder LI, Frankfurter A, Rebhun LI. 1985. The distribution of tau in the mammalian central nervous system. J Cell Biol 101: 1371-1378.
-
(1985)
J Cell Biol
, vol.101
, pp. 1371-1378
-
-
Binder, L.I.1
Frankfurter, A.2
Rebhun, L.I.3
-
23
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak H, Braak E. 1991. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82: 239-259.
-
(1991)
Acta Neuropathol
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
24
-
-
0028362458
-
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
-
Braak E, Braak H, Mandelkow EM. 1994. A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol 87: 554-567.
-
(1994)
Acta Neuropathol
, vol.87
, pp. 554-567
-
-
Braak, E.1
Braak, H.2
Mandelkow, E.M.3
-
25
-
-
0028364256
-
Differential effect of phosphorylation and substrate modulation on tau's ability to promote microtubule growth and nucleation
-
Brandt R, Lee G, Teplow DB, Shalloway D, Abdel-Ghany M. 1994. Differential effect of phosphorylation and substrate modulation on tau's ability to promote microtubule growth and nucleation. J Biol Chem 269: 11776-11782.
-
(1994)
J Biol Chem
, vol.269
, pp. 11776-11782
-
-
Brandt, R.1
Lee, G.2
Teplow, D.B.3
Shalloway, D.4
Abdel-Ghany, M.5
-
26
-
-
0028785525
-
Interaction of tau with the neural plasma membrane mediated by tau's aminoterminal projection domain
-
Brandt R, Leger J, Lee G. 1995. Interaction of tau with the neural plasma membrane mediated by tau's aminoterminal projection domain. J Cell Biol 131: 1327-1340.
-
(1995)
J Cell Biol
, vol.131
, pp. 1327-1340
-
-
Brandt, R.1
Leger, J.2
Lee, G.3
-
27
-
-
10944241542
-
Tau alteration and neuronal degeneration in tauopathies: Mechanisms and models
-
Brandt R, Hundelt M, Shahani N. 2005. Tau alteration and neuronal degeneration in tauopathies: Mechanisms and models. Biochim Biophys Acta 1739: 331-354.
-
(2005)
Biochim Biophys Acta
, vol.1739
, pp. 331-354
-
-
Brandt, R.1
Hundelt, M.2
Shahani, N.3
-
30
-
-
0026046950
-
Tau protein binds to microtubules through a flexible array of distributed weak sites
-
Butner KA, Kirschner MW. 1991. Tau protein binds to microtubules through a flexible array of distributed weak sites. J Cell Biol 115: 717-730.
-
(1991)
J Cell Biol
, vol.115
, pp. 717-730
-
-
Butner, K.A.1
Kirschner, M.W.2
-
31
-
-
1442324853
-
In vitro cultured neurons for molecular studies correlating apoptosis with events related to Alzheimer disease
-
Canu N, Calissano P. 2003. In vitro cultured neurons for molecular studies correlating apoptosis with events related to Alzheimer disease. Cerebellum 2: 270-278.
-
(2003)
Cerebellum
, vol.2
, pp. 270-278
-
-
Canu, N.1
Calissano, P.2
-
32
-
-
0034826896
-
Regulation of microtubuleassociated proteins
-
Cassimeris L, Spittle C. 2001. Regulation of microtubuleassociated proteins. Int Rev Cytol 210: 163-226.
-
(2001)
Int Rev Cytol
, vol.210
, pp. 163-226
-
-
Cassimeris, L.1
Spittle, C.2
-
33
-
-
77249177547
-
A role for FKBP52 in Tau protein function
-
Chambraud B, Sardin E, Giustiniani J, Dounane O, Schumacher M, Goedert M, Baulieu EE. 2010. A role for FKBP52 in Tau protein function. Proc Natl Acad Sci 107: 2658-2663.
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 2658-2663
-
-
Chambraud, B.1
Sardin, E.2
Giustiniani, J.3
Dounane, O.4
Schumacher, M.5
Goedert, M.6
Baulieu, E.E.7
-
34
-
-
0026729767
-
Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons
-
Chen J, Kanai Y, Cowan NJ, Hirokawa N. 1992. Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons. Nature 360: 674-677.
-
(1992)
Nature
, vol.360
, pp. 674-677
-
-
Chen, J.1
Kanai, Y.2
Cowan, N.J.3
Hirokawa, N.4
-
35
-
-
0038152836
-
Anionic micelles and vesicles induce tau fibrillization in vitro
-
Chirita CN, Necula M, Kuret J. 2003. Anionic micelles and vesicles induce tau fibrillization in vitro. J Biol Chem 278: 25644-25650.
-
(2003)
J Biol Chem
, vol.278
, pp. 25644-25650
-
-
Chirita, C.N.1
Necula, M.2
Kuret, J.3
-
36
-
-
17144395539
-
Triggers of full-length tau aggregation: A role for partially folded intermediates
-
Chirita CN, Congdon EE, Yin H, Kuret J. 2005. Triggers of full-length tau aggregation: A role for partially folded intermediates. Biochemistry 44: 5862-5872.
-
(2005)
Biochemistry
, vol.44
, pp. 5862-5872
-
-
Chirita, C.N.1
Congdon, E.E.2
Yin, H.3
Kuret, J.4
-
37
-
-
14544267623
-
14-3-3 Protein mediates phosphorylation of microtubule-associated protein tau by serumand glucocorticoid-induced protein kinase 1
-
Chun J, Kwon T, Lee EJ, Kim CH, Han YS, Hong SK, Hyun S, Kang SS. 2004. 14-3-3 Protein mediates phosphorylation of microtubule-associated protein tau by serumand glucocorticoid-induced protein kinase 1. Mol Cells 18: 360-368.
-
(2004)
Mol Cells
, vol.18
, pp. 360-368
-
-
Chun, J.1
Kwon, T.2
Lee, E.J.3
Kim, C.H.4
Han, Y.S.5
Hong, S.K.6
Hyun, S.7
Kang, S.S.8
-
38
-
-
67650077008
-
Transmission and spreading of tauopathy in transgenic mouse brain
-
Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, et al. 2009. Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol 11: 909-913.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 909-913
-
-
Clavaguera, F.1
Bolmont, T.2
Crowther, R.A.3
Abramowski, D.4
Frank, S.5
Probst, A.6
Fraser, G.7
Stalder, A.K.8
Beibel, M.9
Staufenbiel, M.10
-
39
-
-
0017758306
-
Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly
-
Cleveland DW, Hwo SY, KirschnerMW. 1977a. Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. J Mol Biol 116: 227-247.
-
(1977)
J Mol Biol
, vol.116
, pp. 227-247
-
-
Cleveland, D.W.1
Hwo, S.Y.2
Kirschner, M.W.3
-
40
-
-
0017649032
-
Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin
-
Cleveland DW, Hwo SY, KirschnerMW. 1977b. Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol 116: 207-225.
-
(1977)
J Mol Biol
, vol.116
, pp. 207-225
-
-
Cleveland, D.W.1
Hwo, S.Y.2
Kirschner, M.W.3
-
41
-
-
79953087890
-
The acetylation of tau inhibits its function and promotes pathological tau aggregation
-
Cohen TJ, Guo JL, Hurtado DE, Kwong LK, Mills IP, Trojanowski JQ, Lee VM. 2011. The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nat Commun 2: 252.
-
(2011)
Nat Commun
, vol.2
, pp. 252
-
-
Cohen, T.J.1
Guo, J.L.2
Hurtado, D.E.3
Kwong, L.K.4
Mills, I.P.5
Trojanowski, J.Q.6
Lee, V.M.7
-
42
-
-
0345276572
-
Synaptic slaughter in Alzheimer's disease
-
Coleman PD, Yao PJ. 2003. Synaptic slaughter in Alzheimer's disease. Neurobiol Aging 24: 1023-1027.
-
(2003)
Neurobiol Aging
, vol.24
, pp. 1023-1027
-
-
Coleman, P.D.1
Yao, P.J.2
-
43
-
-
0026507288
-
Primary structure of high molecular weight tau present in the peripheral nervous system
-
Couchie D, Mavilia C, Georgieff IS, Liem RK, Shelanski ML, Nunez J. 1992. Primary structure of high molecular weight tau present in the peripheral nervous system. Proc Natl Acad Sci 89: 4378-4381.
-
(1992)
Proc Natl Acad Sci
, vol.89
, pp. 4378-4381
-
-
Couchie, D.1
Mavilia, C.2
Georgieff, I.S.3
Liem, R.K.4
Shelanski, M.L.5
Nunez, J.6
-
44
-
-
0025977281
-
Straight and paired helical filaments in Alzheimer disease have a common structural unit
-
Crowther RA. 1991. Straight and paired helical filaments in Alzheimer disease have a common structural unit. Proc Natl Acad Sci 88: 2288-2292.
-
(1991)
Proc Natl Acad Sci
, vol.88
, pp. 2288-2292
-
-
Crowther, R.A.1
-
45
-
-
0022435132
-
Image reconstruction of the Alzheimer paired helical filament
-
Crowther RA, Wischik CM. 1985. Image reconstruction of the Alzheimer paired helical filament. EMBO J 4: 3661-3665.
-
(1985)
EMBO J
, vol.4
, pp. 3661-3665
-
-
Crowther, R.A.1
Wischik, C.M.2
-
46
-
-
0028121105
-
Assembly of Alzheimer-like filaments from fulllength tau protein
-
Crowther RA, Olesen OF, Smith MJ, Jakes R, Goedert M. 1994. Assembly of Alzheimer-like filaments from fulllength tau protein. FEBS Lett 337: 135-138.
-
(1994)
FEBS Lett
, vol.337
, pp. 135-138
-
-
Crowther, R.A.1
Olesen, O.F.2
Smith, M.J.3
Jakes, R.4
Goedert, M.5
-
47
-
-
0030998758
-
Oxidative stress induces dephosphorylation of tau in rat brain primary neuronal cultures
-
Davis DR, Anderton BH, Brion JP, Reynolds CH, Hanger DP. 1997. Oxidative stress induces dephosphorylation of tau in rat brain primary neuronal cultures. J Neurochem 68: 1590-1597.
-
(1997)
J Neurochem
, vol.68
, pp. 1590-1597
-
-
Davis, D.R.1
Anderton, B.H.2
Brion, J.P.3
Reynolds, C.H.4
Hanger, D.P.5
-
48
-
-
19744382953
-
The MAP2/Tau family of microtubule-associated proteins
-
Dehmelt L, Halpain S. 2005. The MAP2/Tau family of microtubule-associated proteins. Genome Biol 6: 204.
-
(2005)
Genome Biol
, vol.6
, pp. 204
-
-
Dehmelt, L.1
Halpain, S.2
-
49
-
-
33847369469
-
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
-
Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, et al. 2007. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J Clin Invest 117: 648-658.
-
(2007)
J Clin Invest
, vol.117
, pp. 648-658
-
-
Dickey, C.A.1
Kamal, A.2
Lundgren, K.3
Klosak, N.4
Bailey, R.M.5
Dunmore, J.6
Ash, P.7
Shoraka, S.8
Zlatkovic, J.9
Eckman, C.B.10
-
50
-
-
39749165656
-
Differential regulation of dynein and kinesin motor proteins by tau
-
Dixit R, Ross JL, Goldman YE, Holzbaur EL. 2008. Differential regulation of dynein and kinesin motor proteins by tau. Science 319: 1086-1089.
-
(2008)
Science
, vol.319
, pp. 1086-1089
-
-
Dixit, R.1
Ross, J.L.2
Goldman, Y.E.3
Holzbaur, E.L.4
-
52
-
-
0027519666
-
An isoform of microtubule-associated protein 2 (MAP2) containing four repeats of the tubulin-binding motif
-
Doll T, Meichsner M, Riederer BM, Honegger P, Matus A. 1993. An isoform of microtubule-associated protein 2 (MAP2) containing four repeats of the tubulin-binding motif. J Cell Sci 106: 633-639.
-
(1993)
J Cell Sci
, vol.106
, pp. 633-639
-
-
Doll, T.1
Meichsner, M.2
Riederer, B.M.3
Honegger, P.4
Matus, A.5
-
53
-
-
0030969575
-
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption
-
Drewes G, Ebneth A, PreussU, Mandelkow EM, Mandelkow E. 1997. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 89: 297-308.
-
(1997)
Cell
, vol.89
, pp. 297-308
-
-
Drewes, G.1
Ebneth, A.2
Preuss, U.3
Mandelkow, E.M.4
Mandelkow, E.5
-
54
-
-
0022896901
-
Tau protein function in living cells
-
Drubin DG, Kirschner MW. 1986. Tau protein function in living cells. J Cell Biol 103: 2739-2746.
-
(1986)
J Cell Biol
, vol.103
, pp. 2739-2746
-
-
Drubin, D.G.1
Kirschner, M.W.2
-
56
-
-
77953004116
-
The role of the lipid bilayer in tau aggregation
-
Elbaum-Garfinkle S, Ramlall T, Rhoades E. 2010. The role of the lipid bilayer in tau aggregation. Biophys J 98: 2722-2730.
-
(2010)
Biophys J
, vol.98
, pp. 2722-2730
-
-
Elbaum-Garfinkle, S.1
Ramlall, T.2
Rhoades, E.3
-
57
-
-
37549025063
-
BAG-1 associates with Hsc70. Tau complex and regulates the proteasomal degradation of Tau protein
-
Elliott E, Tsvetkov P, Ginzburg I. 2007. BAG-1 associates with Hsc70. Tau complex and regulates the proteasomal degradation of Tau protein. J Biol Chem 282: 37276-37284.
-
(2007)
J Biol Chem
, vol.282
, pp. 37276-37284
-
-
Elliott, E.1
Tsvetkov, P.2
Ginzburg, I.3
-
58
-
-
80053031684
-
Systematic identification of tubulin interacting fragments of the microtubule-associated protein TAU leads to a highly efficient promoter of microtubule assembly
-
Fauquant C, Redeker V, Landrieu I, Wieruzseski JM, Verdegem D, Laprevote O, Lippens G, Gigant B, Knossow M. 2011. Systematic identification of tubulin interacting fragments of the microtubule-associated protein TAU leads to a highly efficient promoter of microtubule assembly. J Biol Chem 286: 33358-33368.
-
(2011)
J Biol Chem
, vol.286
, pp. 33358-33368
-
-
Fauquant, C.1
Redeker, V.2
Landrieu, I.3
Wieruzseski, J.M.4
Verdegem, D.5
Laprevote, O.6
Lippens, G.7
Gigant, B.8
Knossow, M.9
-
59
-
-
0017646208
-
Microtubule assembly in vitro. Purification of assemblypromoting factors
-
Fellous A, Francon J, Lennon AM, Nunez J. 1977. Microtubule assembly in vitro. Purification of assemblypromoting factors. Eur J Biochem 78: 167-174.
-
(1977)
Eur J Biochem
, vol.78
, pp. 167-174
-
-
Fellous, A.1
Francon, J.2
Lennon, A.M.3
Nunez, J.4
-
60
-
-
0032516493
-
Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution
-
Friedhoff P, Schneider A, Mandelkow EM, Mandelkow E. 1998. Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution. Biochemistry 37: 10223-10230.
-
(1998)
Biochemistry
, vol.37
, pp. 10223-10230
-
-
Friedhoff, P.1
Schneider, A.2
Mandelkow, E.M.3
Mandelkow, E.4
-
61
-
-
67649273927
-
Propagation of tau misfolding from the outside to the inside of a cell
-
Frost B, Jacks RL, Diamond MI. 2009. Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem 284: 12845-12852.
-
(2009)
J Biol Chem
, vol.284
, pp. 12845-12852
-
-
Frost, B.1
Jacks, R.L.2
Diamond, M.I.3
-
62
-
-
33947286683
-
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
-
Fulga TA, Elson-Schwab I, Khurana V, Steinhilb ML, Spires TL, Hyman BT, Feany MB. 2007. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nat Cell Biol 9: 139-148.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 139-148
-
-
Fulga, T.A.1
Elson-Schwab, I.2
Khurana, V.3
Steinhilb, M.L.4
Spires, T.L.5
Hyman, B.T.6
Feany, M.B.7
-
63
-
-
0041689948
-
Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease
-
Gamblin TC, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet AL, Lu M, Fu Y, Garcia-Sierra F, LaPointe N, et al. 2003. Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci 100: 10032-10037.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 10032-10037
-
-
Gamblin, T.C.1
Chen, F.2
Zambrano, A.3
Abraha, A.4
Lagalwar, S.5
Guillozet, A.L.6
Lu, M.7
Fu, Y.8
Garcia-Sierra, F.9
LaPointe, N.10
-
64
-
-
0035140975
-
Going new places using an old MAP: Tau, microtubules and human neurodegenerative disease
-
Garcia ML, Cleveland DW. 2001. Going new places using an old MAP: Tau, microtubules and human neurodegenerative disease. Curr Opin Cell Biol 13: 41-48.
-
(2001)
Curr Opin Cell Biol
, vol.13
, pp. 41-48
-
-
Garcia, M.L.1
Cleveland, D.W.2
-
65
-
-
78449296170
-
Cleavage of Tau by calpain in Alzheimer's disease: The quest for the toxic 17 kD fragment
-
Garg S, Timm T, Mandelkow EM, Mandelkow E, Wang Y. 2011. Cleavage of Tau by calpain in Alzheimer's disease: The quest for the toxic 17 kD fragment. Neurobiol Aging 32: 1-14.
-
(2011)
Neurobiol Aging
, vol.32
, pp. 1-14
-
-
Garg, S.1
Timm, T.2
Mandelkow, E.M.3
Mandelkow, E.4
Wang, Y.5
-
66
-
-
0016344556
-
Turbidimetric studies of the in vitro assembly and disassembly of porcine neurotubules
-
Gaskin F, Cantor CR, Shelanski ML. 1974. Turbidimetric studies of the in vitro assembly and disassembly of porcine neurotubules. J Mol Biol 89: 737-755.
-
(1974)
J Mol Biol
, vol.89
, pp. 737-755
-
-
Gaskin, F.1
Cantor, C.R.2
Shelanski, M.L.3
-
67
-
-
79951873381
-
The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner
-
Gauthier-Kemper A, Weissmann C, Golovyashkina N, Sebo-Lemke Z, Drewes G, Gerke V, Heinisch JJ, Brandt R. 2011. The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner. J Cell Biol 192: 647-661.
-
(2011)
J Cell Biol
, vol.192
, pp. 647-661
-
-
Gauthier-Kemper, A.1
Weissmann, C.2
Golovyashkina, N.3
Sebo-Lemke, Z.4
Drewes, G.5
Gerke, V.6
Heinisch, J.J.7
Brandt, R.8
-
68
-
-
0034494233
-
Fibers of tau fragments, but not full length tau, exhibit a cross β-structure: Implications for the formation of paired helical filaments
-
Giannetti AM, Lindwall G, Chau MF, Radeke MJ, Feinstein SC, Kohlstaedt LA. 2000. Fibers of tau fragments, but not full length tau, exhibit a cross β-structure: Implications for the formation of paired helical filaments. Protein Sci 9: 2427-2435.
-
(2000)
Protein Sci
, vol.9
, pp. 2427-2435
-
-
Giannetti, A.M.1
Lindwall, G.2
Chau, M.F.3
Radeke, M.J.4
Feinstein, S.C.5
Kohlstaedt, L.A.6
-
69
-
-
0037466656
-
Initiation and synergistic fibrillization of tau and α-synuclein
-
Giasson BI, Forman MS, Higuchi M, Golbe LI, Graves CL, Kotzbauer PT, Trojanowski JQ, Lee VM. 2003. Initiation and synergistic fibrillization of tau and α-synuclein. Science 300: 636-640.
-
(2003)
Science
, vol.300
, pp. 636-640
-
-
Giasson, B.I.1
Forman, M.S.2
Higuchi, M.3
Golbe, L.I.4
Graves, C.L.5
Kotzbauer, P.T.6
Trojanowski, J.Q.7
Lee, V.M.8
-
70
-
-
0002792366
-
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: Identification as the microtubule-associated protein tau
-
Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A. 1988. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: Identification as the microtubule-associated protein tau. Proc Natl Acad Sci 85: 4051-4055.
-
(1988)
Proc Natl Acad Sci
, vol.85
, pp. 4051-4055
-
-
Goedert, M.1
Wischik, C.M.2
Crowther, R.A.3
Walker, J.E.4
Klug, A.5
-
71
-
-
0024387161
-
Cloning and sequencing of the cDNAencoding an isoform of microtubule-associated protein tau containing four tandem repeats: Differential expression of tau protein mRNAs in human brain
-
Goedert M, Spillantini MG, Potier MC, Ulrich J, Crowther RA. 1989. Cloning and sequencing of the cDNAencoding an isoform of microtubule-associated protein tau containing four tandem repeats: Differential expression of tau protein mRNAs in human brain. EMBO J 8: 393-399.
-
(1989)
EMBO J
, vol.8
, pp. 393-399
-
-
Goedert, M.1
Spillantini, M.G.2
Potier, M.C.3
Ulrich, J.4
Crowther, R.A.5
-
72
-
-
0026512915
-
Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system
-
Goedert M, Spillantini MG, Crowther RA. 1992. Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system. Proc Natl Acad Sci 89: 1983-1987.
-
(1992)
Proc Natl Acad Sci
, vol.89
, pp. 1983-1987
-
-
Goedert, M.1
Spillantini, M.G.2
Crowther, R.A.3
-
73
-
-
0027984739
-
Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: Identification of phosphorylation sites in tau protein
-
Goedert M, Jakes R, Crowther RA, Cohen P, Vanmechelen E, Vandermeeren M, Cras P. 1994. Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: Identification of phosphorylation sites in tau protein. Biochem J 301: 871-877.
-
(1994)
Biochem J
, vol.301
, pp. 871-877
-
-
Goedert, M.1
Jakes, R.2
Crowther, R.A.3
Cohen, P.4
Vanmechelen, E.5
Vandermeeren, M.6
Cras, P.7
-
74
-
-
0029907548
-
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
-
Goedert M, Jakes R, Spillantini MG, Hasegawa M, Smith MJ, Crowther RA. 1996. Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans. Nature 383: 550-553.
-
(1996)
Nature
, vol.383
, pp. 550-553
-
-
Goedert, M.1
Jakes, R.2
Spillantini, M.G.3
Hasegawa, M.4
Smith, M.J.5
Crowther, R.A.6
-
75
-
-
77954385676
-
The propagation of prion-like protein inclusions in neurodegenerative diseases
-
Goedert M, Clavaguera F, Tolnay M. 2010. The propagation of prion-like protein inclusions in neurodegenerative diseases. Trends Neurosci 33: 317-325.
-
(2010)
Trends Neurosci
, vol.33
, pp. 317-325
-
-
Goedert, M.1
Clavaguera, F.2
Tolnay, M.3
-
76
-
-
84864383087
-
Frontotemporal dementia: Implications for understanding Alzheimer disease
-
doi: 10.1101/cshperspect.a006254
-
Goedert M, Ghetti B, Grazia Spillantini M. 2011. Frontotemporal dementia: Implications for understanding Alzheimer disease. Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a006254.
-
(2011)
Cold Spring Harb Perspect Med
-
-
Goedert, M.1
Ghetti, B.2
Grazia Spillantini, M.3
-
77
-
-
0141753062
-
Proteasome inhibition stabilizes tau inclusions in oligodendroglial cells that occur after treatment with okadaic acid
-
Goldbaum O, Oppermann M, Handschuh M, Dabir D, Zhang B, Forman MS, Trojanowski JQ, Lee VM, Richter-Landsberg C. 2003. Proteasome inhibition stabilizes tau inclusions in oligodendroglial cells that occur after treatment with okadaic acid. J Neurosci 23: 8872-8880.
-
(2003)
J Neurosci
, vol.23
, pp. 8872-8880
-
-
Goldbaum, O.1
Oppermann, M.2
Handschuh, M.3
Dabir, D.4
Zhang, B.5
Forman, M.S.6
Trojanowski, J.Q.7
Lee, V.M.8
Richter-Landsberg, C.9
-
78
-
-
0028175215
-
Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau
-
Goode BL, Feinstein SC. 1994. Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau. JCell Biol 124: 769-782.
-
(1994)
JCell Biol
, vol.124
, pp. 769-782
-
-
Goode, B.L.1
Feinstein, S.C.2
-
79
-
-
68849123079
-
Accumulation of tau induced in neurites by microglial proinflammatory mediators
-
Gorlovoy P, Larionov S, Pham TT, Neumann H. 2009. Accumulation of tau induced in neurites by microglial proinflammatory mediators. FASEB J 23: 2502-2513.
-
(2009)
FASEB J
, vol.23
, pp. 2502-2513
-
-
Gorlovoy, P.1
Larionov, S.2
Pham, T.T.3
Neumann, H.4
-
80
-
-
0036956875
-
Studying gene function in eukaryotes by conditional gene inactivation
-
Gossen M, Bujard H. 2002. Studying gene function in eukaryotes by conditional gene inactivation. Annu Rev Genet 36: 153-173.
-
(2002)
Annu Rev Genet
, vol.36
, pp. 153-173
-
-
Gossen, M.1
Bujard, H.2
-
81
-
-
45749151056
-
Animal models of Alzheimer's disease and frontotemporal dementia
-
Gotz J, Ittner LM. 2008. Animal models of Alzheimer's disease and frontotemporal dementia. Nat Rev Neurosci 9: 532-544.
-
(2008)
Nat Rev Neurosci
, vol.9
, pp. 532-544
-
-
Gotz, J.1
Ittner, L.M.2
-
82
-
-
33847199377
-
Adecade of tau transgenic animal models and beyond
-
Gotz J, Deters N, Doldissen A, Bokhari L, Ke Y, Wiesner A, Schonrock N, Ittner LM. 2007. Adecade of tau transgenic animal models and beyond. Brain Pathol 17: 91-103.
-
(2007)
Brain Pathol
, vol.17
, pp. 91-103
-
-
Gotz, J.1
Deters, N.2
Doldissen, A.3
Bokhari, L.4
Ke, Y.5
Wiesner, A.6
Schonrock, N.7
Ittner, L.M.8
-
83
-
-
76549128091
-
Dissecting toxicity of tau and β-amyloid
-
Gotz J, Lim YA, Ke YD, Eckert A, Ittner LM. 2010. Dissecting toxicity of tau and β-amyloid. Neurodegener Dis 7: 10-12.
-
(2010)
Neurodegener Dis
, vol.7
, pp. 10-12
-
-
Gotz, J.1
Lim, Y.A.2
Ke, Y.D.3
Eckert, A.4
Ittner, L.M.5
-
84
-
-
0025292866
-
A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis
-
Greenberg SG, Davies P. 1990. A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis. Proc Natl Acad Sci 87: 5827-5831.
-
(1990)
Proc Natl Acad Sci
, vol.87
, pp. 5827-5831
-
-
Greenberg, S.G.1
Davies, P.2
-
85
-
-
0018129689
-
Evidence for actin filament-microtubule interaction mediated by microtubule-associated proteins
-
Griffith LM, Pollard TD. 1978. Evidence for actin filament-microtubule interaction mediated by microtubule-associated proteins. J Cell Biol 78: 958-965.
-
(1978)
J Cell Biol
, vol.78
, pp. 958-965
-
-
Griffith, L.M.1
Pollard, T.D.2
-
86
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI. 1986. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. ProcNatl Acad Sci 83: 4913-4917.
-
(1986)
ProcNatl Acad Sci
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
87
-
-
0029843684
-
Tau is widely expressed in rat tissues
-
Gu Y, Oyama F, Ihara Y. 1996. Tau is widely expressed in rat tissues. J Neurochem 67: 1235-1244.
-
(1996)
J Neurochem
, vol.67
, pp. 1235-1244
-
-
Gu, Y.1
Oyama, F.2
Ihara, Y.3
-
88
-
-
0028027088
-
Domains of tau protein and interactions with microtubules
-
Gustke N, Trinczek B, Biernat J, Mandelkow EM, Mandelkow E. 1994. Domains of tau protein and interactions with microtubules. Biochemistry 33: 9511-9522.
-
(1994)
Biochemistry
, vol.33
, pp. 9511-9522
-
-
Gustke, N.1
Trinczek, B.2
Biernat, J.3
Mandelkow, E.M.4
Mandelkow, E.5
-
89
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid β-peptide
-
Haass C, Selkoe DJ. 2007. Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid β-peptide. Nat Rev Mol Cell Biol 8: 101-112.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
90
-
-
77954239263
-
Biomarkers for Alzheimer's disease: Academic, industry and regulatory perspectives
-
Hampel H, Frank R, Broich K, Teipel SJ, Katz RG, Hardy J, Herholz K, Bokde AL, Jessen F, Hoessler YC, et al. 2010. Biomarkers for Alzheimer's disease: Academic, industry and regulatory perspectives. Nat Rev Drug Discov 9: 560-574.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 560-574
-
-
Hampel, H.1
Frank, R.2
Broich, K.3
Teipel, S.J.4
Katz, R.G.5
Hardy, J.6
Herholz, K.7
Bokde, A.L.8
Jessen, F.9
Hoessler, Y.C.10
-
91
-
-
0026487365
-
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase
-
Hanger DP, Hughes K, Woodgett JR, Brion JP, Anderton BH. 1992. Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase. Neurosci Lett 147: 58-62.
-
(1992)
Neurosci Lett
, vol.147
, pp. 58-62
-
-
Hanger, D.P.1
Hughes, K.2
Woodgett, J.R.3
Brion, J.P.4
Anderton, B.H.5
-
92
-
-
34548191034
-
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
-
Hanger DP, Byers HL, Wray S, Leung KY, Saxton MJ, Seereeram A, Reynolds CH, Ward MA, Anderton BH. 2007. Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. J Biol Chem 282: 23645-23654.
-
(2007)
J Biol Chem
, vol.282
, pp. 23645-23654
-
-
Hanger, D.P.1
Byers, H.L.2
Wray, S.3
Leung, K.Y.4
Saxton, M.J.5
Seereeram, A.6
Reynolds, C.H.7
Ward, M.A.8
Anderton, B.H.9
-
93
-
-
0036323447
-
MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction
-
Harada A, Teng J, Takei Y, Oguchi K, Hirokawa N. 2002. MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction. J Cell Biol 158: 541-549.
-
(2002)
J Cell Biol
, vol.158
, pp. 541-549
-
-
Harada, A.1
Teng, J.2
Takei, Y.3
Oguchi, K.4
Hirokawa, N.5
-
94
-
-
40849095902
-
The HapMap: Charting a course for genetic discovery in neurological diseases
-
Hardy J, Singleton A. 2008. The HapMap: Charting a course for genetic discovery in neurological diseases. ArchNeurol 65: 319-321.
-
(2008)
ArchNeurol
, vol.65
, pp. 319-321
-
-
Hardy, J.1
Singleton, A.2
-
95
-
-
33846203763
-
Hibernation model of tau phosphorylation in hamsters: Selective vulnerability of cholinergic basal forebrain neurons-Implications for Alzheimer's disease
-
Hartig W, Stieler J, Boerema AS, Wolf J, Schmidt U, Weissfuss J, Bullmann T, Strijkstra AM, Arendt T. 2007. Hibernation model of tau phosphorylation in hamsters: Selective vulnerability of cholinergic basal forebrain neurons-Implications for Alzheimer's disease. Eur J Neurosci 25: 69-80.
-
(2007)
Eur J Neurosci
, vol.25
, pp. 69-80
-
-
Hartig, W.1
Stieler, J.2
Boerema, A.S.3
Wolf, J.4
Schmidt, U.5
Weissfuss, J.6
Bullmann, T.7
Strijkstra, A.M.8
Arendt, T.9
-
96
-
-
0034682667
-
14-3-3z is an effector of tau protein phosphorylation
-
Hashiguchi M, Sobue K, Paudel HK. 2000. 14-3-3z is an effector of tau protein phosphorylation. J Biol Chem 275: 25247-25254.
-
(2000)
J Biol Chem
, vol.275
, pp. 25247-25254
-
-
Hashiguchi, M.1
Sobue, K.2
Paudel, H.K.3
-
98
-
-
0018149343
-
Radioimmunoassay for tubulin: A quantitative comparison of the tubulin content of different established tissue culture cells and tissues
-
Hiller G, Weber K. 1978. Radioimmunoassay for tubulin: A quantitative comparison of the tubulin content of different established tissue culture cells and tissues. Cell 14: 795-804.
-
(1978)
Cell
, vol.14
, pp. 795-804
-
-
Hiller, G.1
Weber, K.2
-
99
-
-
0024498630
-
Structure of the bovine tau gene: Alternatively spliced transcripts generate a protein family
-
Himmler A. 1989. Structure of the bovine tau gene: Alternatively spliced transcripts generate a protein family. Mol Cell Biol 9: 1389-1396.
-
(1989)
Mol Cell Biol
, vol.9
, pp. 1389-1396
-
-
Himmler, A.1
-
100
-
-
0024507707
-
Tau consists of a set of proteins with repeated Cterminal microtubule-binding domains and variable Nterminal domains
-
Himmler A, Drechsel D, Kirschner MW, Martin DW Jr. 1989. Tau consists of a set of proteins with repeated Cterminal microtubule-binding domains and variable Nterminal domains. Mol Cell Biol 9: 1381-1388.
-
(1989)
Mol Cell Biol
, vol.9
, pp. 1381-1388
-
-
Himmler, A.1
Drechsel, D.2
Kirschner, M.W.3
Martin Jr., D.W.4
-
101
-
-
0024094998
-
Tau proteins: The molecular structure and mode of binding on microtubules
-
Hirokawa N, Shiomura Y, Okabe S. 1988. Tau proteins: The molecular structure and mode of binding on microtubules. J Cell Biol 107: 1449-1459.
-
(1988)
J Cell Biol
, vol.107
, pp. 1449-1459
-
-
Hirokawa, N.1
Shiomura, Y.2
Okabe, S.3
-
102
-
-
0030028366
-
Selective stabilization of tau in axons and microtubuleassociated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons
-
Hirokawa N, Funakoshi T, Sato-Harada R, Kanai Y. 1996. Selective stabilization of tau in axons and microtubuleassociated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons. J Cell Biol 132: 667-679.
-
(1996)
J Cell Biol
, vol.132
, pp. 667-679
-
-
Hirokawa, N.1
Funakoshi, T.2
Sato-Harada, R.3
Kanai, Y.4
-
103
-
-
0032550175
-
Image reconstructions of microtubules decorated with monomeric and dimeric kinesins: Comparison with x-ray structure and implications for motility
-
Hoenger A, Sack S, Thormahlen M, Marx A, Muller J, Gross H, Mandelkow E. 1998. Image reconstructions of microtubules decorated with monomeric and dimeric kinesins: Comparison with x-ray structure and implications for motility. J Cell Biol 141: 419-430.
-
(1998)
J Cell Biol
, vol.141
, pp. 419-430
-
-
Hoenger, A.1
Sack, S.2
Thormahlen, M.3
Marx, A.4
Muller, J.5
Gross, H.6
Mandelkow, E.7
-
104
-
-
0032484089
-
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17
-
Hong M, Zhukareva V, Vogelsberg-Ragaglia V, Wszolek Z, Reed L, Miller BI, Geschwind DH, Bird TD, McKeel D, Goate A, et al. 1998. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science 282: 1914-1917.
-
(1998)
Science
, vol.282
, pp. 1914-1917
-
-
Hong, M.1
Zhukareva, V.2
Vogelsberg-Ragaglia, V.3
Wszolek, Z.4
Reed, L.5
Miller, B.I.6
Geschwind, D.H.7
Bird, T.D.8
McKeel, D.9
Goate, A.10
-
105
-
-
70449753435
-
Control of neuronal polarity and plasticity-A renaissance for microtubules?
-
Hoogenraad CC, Bradke F. 2009. Control of neuronal polarity and plasticity-A renaissance for microtubules?. Trends Cell Biol 19: 669-676.
-
(2009)
Trends Cell Biol
, vol.19
, pp. 669-676
-
-
Hoogenraad, C.C.1
Bradke, F.2
-
106
-
-
4544248870
-
Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease
-
Horowitz PM, Patterson KR, Guillozet-Bongaarts AL, Reynolds MR, Carroll CA, Weintraub ST, Bennett DA, Cryns VL, Berry RW, Binder LI. 2004. Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. J Neurosci 24: 7895-7902.
-
(2004)
J Neurosci
, vol.24
, pp. 7895-7902
-
-
Horowitz, P.M.1
Patterson, K.R.2
Guillozet-Bongaarts, A.L.3
Reynolds, M.R.4
Carroll, C.A.5
Weintraub, S.T.6
Bennett, D.A.7
Cryns, V.L.8
Berry, R.W.9
Binder, L.I.10
-
107
-
-
0032543684
-
0-splice-site mutations in tau with the inherited dementia FTDP-17
-
0-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393: 702-705.
-
(1998)
Nature
, vol.393
, pp. 702-705
-
-
Hutton, M.1
Lendon, C.L.2
Rizzu, P.3
Baker, M.4
Froelich, S.5
Houlden, H.6
Pickering-Brown, S.7
Chakraverty, S.8
Isaacs, A.9
Grover, A.10
-
108
-
-
17044461433
-
The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: Implications for Alzheimer's disease
-
Illenberger S, Zheng-Fischhofer Q, Preuss U, Stamer K, Baumann K, Trinczek B, Biernat J, Godemann R, Mandelkow EM, Mandelkow E. 1998. The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: Implications for Alzheimer's disease. Mol Biol Cell 9: 1495-1512.
-
(1998)
Mol Biol Cell
, vol.9
, pp. 1495-1512
-
-
Illenberger, S.1
Zheng-Fischhofer, Q.2
Preuss, U.3
Stamer, K.4
Baumann, K.5
Trinczek, B.6
Biernat, J.7
Godemann, R.8
Mandelkow, E.M.9
Mandelkow, E.10
-
109
-
-
41149156856
-
Alzheimer neurofibrillary degeneration: Significance, etiopathogenesis, therapeutics and prevention
-
Iqbal K, Grundke-Iqbal I. 2008. Alzheimer neurofibrillary degeneration: Significance, etiopathogenesis, therapeutics and prevention. J Cell Mol Med 12: 38-55.
-
(2008)
J Cell Mol Med
, vol.12
, pp. 38-55
-
-
Iqbal, K.1
Grundke-Iqbal, I.2
-
110
-
-
49149105134
-
Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly
-
Iqbal K, Alonso Adel C, Grundke-Iqbal I. 2008. Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly. J Alzheimers Dis 14: 365-370.
-
(2008)
J Alzheimers Dis
, vol.14
, pp. 365-370
-
-
Iqbal, K.1
Alonso Adel, C.2
Grundke-Iqbal, I.3
-
111
-
-
67349142329
-
Mechanisms of tau-induced neurodegeneration
-
Iqbal K, Liu F, Gong CX, Alonso Adel C, Grundke-Iqbal I. 2009. Mechanisms of tau-induced neurodegeneration. Acta Neuropathol 118: 53-69.
-
(2009)
Acta Neuropathol
, vol.118
, pp. 53-69
-
-
Iqbal, K.1
Liu, F.2
Gong, C.X.3
Alonso Adel, C.4
Grundke-Iqbal, I.5
-
112
-
-
0035882526
-
Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments
-
Ishihara T, Higuchi M, Zhang B, Yoshiyama Y, Hong M, Trojanowski JQ, Lee VM. 2001. Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments. J Neurosci 21: 6026-6035.
-
(2001)
J Neurosci
, vol.21
, pp. 6026-6035
-
-
Ishihara, T.1
Higuchi, M.2
Zhang, B.3
Yoshiyama, Y.4
Hong, M.5
Trojanowski, J.Q.6
Lee, V.M.7
-
113
-
-
68949105821
-
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease
-
Ittner LM, Ke YD, Gotz J. 2009. Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. J Biol Chem 284: 20909-20916.
-
(2009)
J Biol Chem
, vol.284
, pp. 20909-20916
-
-
Ittner, L.M.1
Ke, Y.D.2
Gotz, J.3
-
114
-
-
77955322042
-
Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models
-
Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wolfing H, Chieng BC, Christie MJ, Napier IA, et al. 2010. Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models. Cell 142: 387-397.
-
(2010)
Cell
, vol.142
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
Bi, M.4
Gladbach, A.5
van Eersel, J.6
Wolfing, H.7
Chieng, B.C.8
Christie, M.J.9
Napier, I.A.10
-
115
-
-
33144463940
-
Global hairpin folding of tau in solution
-
Jeganathan S, von Bergen M, Brutlach H, Steinhoff HJ, Mandelkow E. 2006. Global hairpin folding of tau in solution. Biochemistry 45: 2283-2293.
-
(2006)
Biochemistry
, vol.45
, pp. 2283-2293
-
-
Jeganathan, S.1
von Bergen, M.2
Brutlach, H.3
Steinhoff, H.J.4
Mandelkow, E.5
-
116
-
-
0033520474
-
α-Synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356
-
Jensen PH, Hager H, Nielsen MS, Hojrup P, Gliemann J, Jakes R. 1999. α-Synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356. J Biol Chem 274: 25481-25489.
-
(1999)
J Biol Chem
, vol.274
, pp. 25481-25489
-
-
Jensen, P.H.1
Hager, H.2
Nielsen, M.S.3
Hojrup, P.4
Gliemann, J.5
Jakes, R.6
-
117
-
-
74949110831
-
The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules
-
Jinwal UK, Koren J, Borysov SI, Schmid AB, Abisambra JF, Blair LJ, Johnson AG, Jones JR, Shults CL, O'Leary JC, et al. 2010. The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. J Neurosci 30: 591-599.
-
(2010)
J Neurosci
, vol.30
, pp. 591-599
-
-
Jinwal, U.K.1
Koren, J.2
Borysov, S.I.3
Schmid, A.B.4
Abisambra, J.F.5
Blair, L.J.6
Johnson, A.G.7
Jones, J.R.8
Shults, C.L.9
O'Leary, J.C.10
-
118
-
-
79955759163
-
The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics
-
Jinwal UK, Trotter JH, Abisambra JF, Koren J, Lawson LY, Vestal GD, O'Leary JC, Johnson AG, Jin Y, Jones JR, et al. 2011. The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics. J Biol Chem 286: 16976-16983.
-
(2011)
J Biol Chem
, vol.286
, pp. 16976-16983
-
-
Jinwal, U.K.1
Trotter, J.H.2
Abisambra, J.F.3
Koren, J.4
Lawson, L.Y.5
Vestal, G.D.6
O'Leary, J.C.7
Johnson, A.G.8
Jin, Y.9
Jones, J.R.10
-
119
-
-
0030590911
-
RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments
-
Kampers T, Friedhoff P, Biernat J, Mandelkow EM, Mandelkow E. 1996. RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments. FEBS Lett 399: 344-349.
-
(1996)
FEBS Lett
, vol.399
, pp. 344-349
-
-
Kampers, T.1
Friedhoff, P.2
Biernat, J.3
Mandelkow, E.M.4
Mandelkow, E.5
-
120
-
-
79960032374
-
Pathogenic forms of Tau inhibit kinesindependent axonal transport through a mechanism involving activation of axonal phosphotransferases
-
Kanaan NM, Morfini GA, Lapointe NE, Pigino GF, Patterson KR, Song Y, Andreadis A, Fu Y, Brady ST, Binder LI. 2011. Pathogenic forms of Tau inhibit kinesindependent axonal transport through a mechanism involving activation of axonal phosphotransferases. J Neurosci 31: 9858-9868.
-
(2011)
J Neurosci
, vol.31
, pp. 9858-9868
-
-
Kanaan, N.M.1
Morfini, G.A.2
Lapointe, N.E.3
Pigino, G.F.4
Patterson, K.R.5
Song, Y.6
Andreadis, A.7
Fu, Y.8
Brady, S.T.9
Binder, L.I.10
-
121
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Muller-Hill B. 1987. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325: 733-736.
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
122
-
-
33748174617
-
A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration
-
Karsten SL, Sang TK, Gehman LT, Chatterjee S, Liu J, Lawless GM, Sengupta S, Berry RW, Pomakian J, Oh HS, et al. 2006. A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. Neuron 51: 549-560.
-
(2006)
Neuron
, vol.51
, pp. 549-560
-
-
Karsten, S.L.1
Sang, T.K.2
Gehman, L.T.3
Chatterjee, S.4
Liu, J.5
Lawless, G.M.6
Sengupta, S.7
Berry, R.W.8
Pomakian, J.9
Oh, H.S.10
-
123
-
-
37049011456
-
Inhibition of tau aggregation in cell models of tauopathy
-
Khlistunova I, Pickhardt M, Biernat J, Wang Y, Mandelkow EM, Mandelkow E. 2007. Inhibition of tau aggregation in cell models of tauopathy. Curr Alzheimer Res 4: 544-546.
-
(2007)
Curr Alzheimer Res
, vol.4
, pp. 544-546
-
-
Khlistunova, I.1
Pickhardt, M.2
Biernat, J.3
Wang, Y.4
Mandelkow, E.M.5
Mandelkow, E.6
-
124
-
-
37049048544
-
Paired helical filaments in electron microscopy of Alzheimer's disease
-
Kidd M. 1963. Paired helical filaments in electron microscopy of Alzheimer's disease. Nature 197: 192-193.
-
(1963)
Nature
, vol.197
, pp. 192-193
-
-
Kidd, M.1
-
125
-
-
0034695259
-
15 A resolution model of the monomeric kinesin motor, KIF1A
-
Kikkawa M, Okada Y, Hirokawa N. 2000. 15 A resolution model of the monomeric kinesin motor, KIF1A. Cell 100: 241-252.
-
(2000)
Cell
, vol.100
, pp. 241-252
-
-
Kikkawa, M.1
Okada, Y.2
Hirokawa, N.3
-
126
-
-
0036469248
-
Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinasewith the cytoskeletal protein tau
-
Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J. 2002. Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinasewith the cytoskeletal protein tau. J Neurosci 22: 698-707.
-
(2002)
J Neurosci
, vol.22
, pp. 698-707
-
-
Klein, C.1
Kramer, E.M.2
Cardine, A.M.3
Schraven, B.4
Brandt, R.5
Trotter, J.6
-
127
-
-
34548620157
-
Swimming against the tide: Mobility of the microtubule-associated protein tau in neurons
-
Konzack S, Thies E, Marx A, Mandelkow EM, Mandelkow E. 2007. Swimming against the tide: Mobility of the microtubule-associated protein tau in neurons. J Neurosci 27: 9916-9927.
-
(2007)
J Neurosci
, vol.27
, pp. 9916-9927
-
-
Konzack, S.1
Thies, E.2
Marx, A.3
Mandelkow, E.M.4
Mandelkow, E.5
-
128
-
-
0027361281
-
Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease
-
Kopke E, Tung YC, Shaikh S, Alonso AC, Iqbal K, Grundke-Iqbal I. 1993. Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J Biol Chem 268: 24374-24384.
-
(1993)
J Biol Chem
, vol.268
, pp. 24374-24384
-
-
Kopke, E.1
Tung, Y.C.2
Shaikh, S.3
Alonso, A.C.4
Iqbal, K.5
Grundke-Iqbal, I.6
-
129
-
-
0009364134
-
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease
-
Kosik KS, Joachim CL, Selkoe DJ. 1986. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci 83: 4044-4048.
-
(1986)
Proc Natl Acad Sci
, vol.83
, pp. 4044-4048
-
-
Kosik, K.S.1
Joachim, C.L.2
Selkoe, D.J.3
-
130
-
-
0024109687
-
Epitopes that span the tau molecule are shared with paired helical filaments
-
Kosik KS, Orecchio LD, Binder L, Trojanowski JQ, Lee VM, Lee G. 1988. Epitopes that span the tau molecule are shared with paired helical filaments. Neuron 1: 817-825.
-
(1988)
Neuron
, vol.1
, pp. 817-825
-
-
Kosik, K.S.1
Orecchio, L.D.2
Binder, L.3
Trojanowski, J.Q.4
Lee, V.M.5
Lee, G.6
-
131
-
-
0024641959
-
Developmentally regulated expression of specific tau sequences
-
Kosik KS, Orecchio LD, Bakalis S, Neve RL. 1989. Developmentally regulated expression of specific tau sequences. Neuron 2: 1389-1397.
-
(1989)
Neuron
, vol.2
, pp. 1389-1397
-
-
Kosik, K.S.1
Orecchio, L.D.2
Bakalis, S.3
Neve, R.L.4
-
132
-
-
34548389257
-
SUT-1 enables tauinduced neurotoxicity in C. elegans
-
Kraemer BC, Schellenberg GD. 2007. SUT-1 enables tauinduced neurotoxicity in C. elegans. Hum Mol Genet 16: 1959-1971.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 1959-1971
-
-
Kraemer, B.C.1
Schellenberg, G.D.2
-
133
-
-
0028065142
-
Analysis of microtubule-associated protein tau glycation in paired helical filaments
-
Ledesma MD, Bonay P, Colaco C, Avila J. 1994. Analysis of microtubule-associated protein tau glycation in paired helical filaments. J Biol Chem 269: 21614-21619.
-
(1994)
J Biol Chem
, vol.269
, pp. 21614-21619
-
-
Ledesma, M.D.1
Bonay, P.2
Colaco, C.3
Avila, J.4
-
134
-
-
0021357249
-
Calmodulin binds to both microtubule-associated protein 2 and tau proteins
-
Lee YC, Wolff J. 1984. Calmodulin binds to both microtubule-associated protein 2 and tau proteins. J Biol Chem 259: 1226-1230.
-
(1984)
J Biol Chem
, vol.259
, pp. 1226-1230
-
-
Lee, Y.C.1
Wolff, J.2
-
135
-
-
0023905288
-
The primary structure and heterogeneity of tau protein from mouse brain
-
Lee G, Cowan N, Kirschner M. 1988. The primary structure and heterogeneity of tau protein from mouse brain. Science 239: 285-288.
-
(1988)
Science
, vol.239
, pp. 285-288
-
-
Lee, G.1
Cowan, N.2
Kirschner, M.3
-
136
-
-
0344505849
-
Tau interacts with src-family non-receptor tyrosine kinases
-
Lee G, Newman ST, Gard DL, Band H, Panchamoorthy G. 1998. Tau interacts with src-family non-receptor tyrosine kinases. J Cell Sci 111: 3167-3177.
-
(1998)
J Cell Sci
, vol.111
, pp. 3167-3177
-
-
Lee, G.1
Newman, S.T.2
Gard, D.L.3
Band, H.4
Panchamoorthy, G.5
-
138
-
-
84863867694
-
Developing therapeutic approaches to Tau, selected kinases, and related neuronal protein targets
-
doi: 10.1101/cshperspect.a006437
-
Lee V, Brunden KR, Hutton M, Trojanowski JQ. 2011. Developing therapeutic approaches to Tau, selected kinases, and related neuronal protein targets. Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a006437.
-
(2011)
Cold Spring Harb Perspect Med
-
-
Lee, V.1
Brunden, K.R.2
Hutton, M.3
Trojanowski, J.Q.4
-
139
-
-
0034426011
-
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
-
Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, Gwinn-Hardy K, Paul Murphy M, Baker M, Yu X, et al. 2000. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet 25: 402-405.
-
(2000)
Nat Genet
, vol.25
, pp. 402-405
-
-
Lewis, J.1
McGowan, E.2
Rockwood, J.3
Melrose, H.4
Nacharaju, P.5
van Slegtenhorst, M.6
Gwinn-Hardy, K.7
Paul Murphy, M.8
Baker, M.9
Yu, X.10
-
140
-
-
33646008860
-
Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting
-
Li X, Lu F, Wang JZ, Gong CX. 2006. Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting. Eur J Neurosci 23: 2078-2086.
-
(2006)
Eur J Neurosci
, vol.23
, pp. 2078-2086
-
-
Li, X.1
Lu, F.2
Wang, J.Z.3
Gong, C.X.4
-
141
-
-
0026647916
-
Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau
-
Lichtenberg-Kraag B, Mandelkow EM, Biernat J, Steiner B, Schroter C, Gustke N, Meyer HE, Mandelkow E. 1992. Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau. Proc Natl Acad Sci 89: 5384-5388.
-
(1992)
Proc Natl Acad Sci
, vol.89
, pp. 5384-5388
-
-
Lichtenberg-Kraag, B.1
Mandelkow, E.M.2
Biernat, J.3
Steiner, B.4
Schroter, C.5
Gustke, N.6
Meyer, H.E.7
Mandelkow, E.8
-
142
-
-
0043069764
-
Role of the prolyl isomerase Pin1 in protecting against agedependent neurodegeneration
-
Liou YC, Sun A, Ryo A, Zhou XZ, Yu ZX, Huang HK, Uchida T, Bronson R, Bing G, Li X, et al. 2003. Role of the prolyl isomerase Pin1 in protecting against agedependent neurodegeneration. Nature 424: 556-561.
-
(2003)
Nature
, vol.424
, pp. 556-561
-
-
Liou, Y.C.1
Sun, A.2
Ryo, A.3
Zhou, X.Z.4
Yu, Z.X.5
Huang, H.K.6
Uchida, T.7
Bronson, R.8
Bing, G.9
Li, X.10
-
143
-
-
0345672750
-
Common and distinct tubulin binding sites for microtubule-associated proteins
-
Littauer UZ, Giveon D, Thierauf M, Ginzburg I, Ponstingl H. 1986. Common and distinct tubulin binding sites for microtubule-associated proteins. Proc Natl Acad Sci 83: 7162-7166.
-
(1986)
Proc Natl Acad Sci
, vol.83
, pp. 7162-7166
-
-
Littauer, U.Z.1
Giveon, D.2
Thierauf, M.3
Ginzburg, I.4
Ponstingl, H.5
-
145
-
-
0028853922
-
Functional implications for the microtubule-associated protein tau: Localization in oligodendrocytes
-
LoPresti P, Szuchet S, Papasozomenos SC, Zinkowski RP, Binder LI. 1995. Functional implications for the microtubule-associated protein tau: Localization in oligodendrocytes. Proc Natl Acad Sci 92: 10369-10373.
-
(1995)
Proc Natl Acad Sci
, vol.92
, pp. 10369-10373
-
-
LoPresti, P.1
Szuchet, S.2
Papasozomenos, S.C.3
Zinkowski, R.P.4
Binder, L.I.5
-
146
-
-
0033600242
-
The prolyl isomerase Pin1 restores the function of Alzheimerassociated phosphorylated tau protein
-
Lu PJ, Wulf G, Zhou XZ, Davies P, Lu KP. 1999. The prolyl isomerase Pin1 restores the function of Alzheimerassociated phosphorylated tau protein. Nature 399: 784-788.
-
(1999)
Nature
, vol.399
, pp. 784-788
-
-
Lu, P.J.1
Wulf, G.2
Zhou, X.Z.3
Davies, P.4
Lu, K.P.5
-
147
-
-
35649028013
-
Interaction of tau protein with the dynactin complex
-
Magnani E, Fan J, Gasparini L, Golding M, Williams M, Schiavo G, Goedert M, Amos LA, Spillantini MG. 2007. Interaction of tau protein with the dynactin complex. EMBO J 26: 4546-4554.
-
(2007)
EMBO J
, vol.26
, pp. 4546-4554
-
-
Magnani, E.1
Fan, J.2
Gasparini, L.3
Golding, M.4
Williams, M.5
Schiavo, G.6
Goedert, M.7
Amos, L.A.8
Spillantini, M.G.9
-
149
-
-
0026619584
-
Glycogen synthase kinase-3 and the Alzheimer-like state of microtubuleassociated protein tau
-
Mandelkow EM, Drewes G, Biernat J, Gustke N, Van Lint J, Vandenheede JR, Mandelkow E. 1992. Glycogen synthase kinase-3 and the Alzheimer-like state of microtubuleassociated protein tau. FEBS Lett 314: 315-321.
-
(1992)
FEBS Lett
, vol.314
, pp. 315-321
-
-
Mandelkow, E.M.1
Drewes, G.2
Biernat, J.3
Gustke, N.4
van Lint, J.5
Vandenheede, J.R.6
Mandelkow, E.7
-
150
-
-
5444273804
-
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons
-
Mandelkow EM, Thies E, Trinczek B, Biernat J, Mandelkow E. 2004. MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons. J Cell Biol 167: 99-110.
-
(2004)
J Cell Biol
, vol.167
, pp. 99-110
-
-
Mandelkow, E.M.1
Thies, E.2
Trinczek, B.3
Biernat, J.4
Mandelkow, E.5
-
151
-
-
3142699791
-
Template-assisted filament growth by parallel stacking of tau
-
Margittai M, Langen R. 2004. Template-assisted filament growth by parallel stacking of tau. Proc Natl Acad Sci 101: 10278-10283.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 10278-10283
-
-
Margittai, M.1
Langen, R.2
-
152
-
-
33846002029
-
Side chain-dependent stacking modulates tau filament structure
-
Margittai M, Langen R. 2006. Side chain-dependent stacking modulates tau filament structure. J Biol Chem 281: 37820-37827.
-
(2006)
J Biol Chem
, vol.281
, pp. 37820-37827
-
-
Margittai, M.1
Langen, R.2
-
153
-
-
0027945346
-
Biopsyderived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
-
Matsuo ES, Shin RW, Billingsley ML, Van deVoorde A, O'Connor M, Trojanowski JQ, Lee VM. 1994. Biopsyderived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron 13: 989-1002.
-
(1994)
Neuron
, vol.13
, pp. 989-1002
-
-
Matsuo, E.S.1
Shin, R.W.2
Billingsley, M.L.3
van de Voorde, A.4
O'Connor, M.5
Trojanowski, J.Q.6
Lee, V.M.7
-
154
-
-
3943092621
-
Pathways towards and away from Alzheimer's disease
-
Mattson MP. 2004. Pathways towards and away from Alzheimer's disease. Nature 430: 631-639.
-
(2004)
Nature
, vol.430
, pp. 631-639
-
-
Mattson, M.P.1
-
155
-
-
0029588380
-
Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: Evidence for dynamic interactions of tau with microtubules in vivo
-
Mercken M, Fischer I, Kosik KS, Nixon RA. 1995. Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: Evidence for dynamic interactions of tau with microtubules in vivo. J Neurosci 15: 8259-8267.
-
(1995)
J Neurosci
, vol.15
, pp. 8259-8267
-
-
Mercken, M.1
Fischer, I.2
Kosik, K.S.3
Nixon, R.A.4
-
156
-
-
77957001697
-
Acetylation of tau inhibits its degradation and contributes to tauopathy
-
Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, SeeleyWW, Huang EJ, Shen Y, Masliah E, Mukherjee C, et al. 2010. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 67: 953-966.
-
(2010)
Neuron
, vol.67
, pp. 953-966
-
-
Min, S.W.1
Cho, S.H.2
Zhou, Y.3
Schroeder, S.4
Haroutunian, V.5
Seeley, W.W.6
Huang, E.J.7
Shen, Y.8
Masliah, E.9
Mukherjee, C.10
-
157
-
-
38549129613
-
The potential for β-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy
-
Mocanu MM, Nissen A, Eckermann K, Khlistunova I, Biernat J, Drexler D, Petrova O, Schonig K, Bujard H, Mandelkow E, et al. 2008. The potential for β-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. J Neurosci 28: 737-748.
-
(2008)
J Neurosci
, vol.28
, pp. 737-748
-
-
Mocanu, M.M.1
Nissen, A.2
Eckermann, K.3
Khlistunova, I.4
Biernat, J.5
Drexler, D.6
Petrova, O.7
Schonig, K.8
Bujard, H.9
Mandelkow, E.10
-
158
-
-
2942657327
-
Mechanism of microtubule stabilization by doublecortin
-
Moores CA, Perderiset M, Francis F, Chelly J, Houdusse A, Milligan RA. 2004. Mechanism of microtubule stabilization by doublecortin. Mol Cell 14: 833-839.
-
(2004)
Mol Cell
, vol.14
, pp. 833-839
-
-
Moores, C.A.1
Perderiset, M.2
Francis, F.3
Chelly, J.4
Houdusse, A.5
Milligan, R.A.6
-
159
-
-
0347949620
-
Characterization by atomic force microscopy of Alzheimer paired helical filaments under physiological conditions
-
Moreno-Herrero F, Perez M, Baro AM, Avila J. 2004. Characterization by atomic force microscopy of Alzheimer paired helical filaments under physiological conditions. Biophys J 86: 517-525.
-
(2004)
Biophys J
, vol.86
, pp. 517-525
-
-
Moreno-Herrero, F.1
Perez, M.2
Baro, A.M.3
Avila, J.4
-
160
-
-
0027193036
-
Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments
-
Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Titani K, Ihara Y. 1993. Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments. Neuron 10: 1151-1160.
-
(1993)
Neuron
, vol.10
, pp. 1151-1160
-
-
Morishima-Kawashima, M.1
Hasegawa, M.2
Takio, K.3
Suzuki, M.4
Titani, K.5
Ihara, Y.6
-
161
-
-
0029943566
-
The pool of map kinase associated with microtubules is small but constitutively active
-
Morishima-Kawashima M, Kosik KS. 1996. The pool of map kinase associated with microtubules is small but constitutively active. Mol Biol Cell 7: 893-905.
-
(1996)
Mol Biol Cell
, vol.7
, pp. 893-905
-
-
Morishima-Kawashima, M.1
Kosik, K.S.2
-
162
-
-
70350455151
-
Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway
-
Morita T, Sobue K. 2009. Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway. J Biol Chem 284: 27734-27745.
-
(2009)
J Biol Chem
, vol.284
, pp. 27734-27745
-
-
Morita, T.1
Sobue, K.2
-
165
-
-
21644446496
-
Sites of tau important for aggregation populate {β}-structure and bind to microtubules and polyanions
-
Mukrasch MD, Biernat J, von Bergen M, Griesinger C, Mandelkow E, Zweckstetter M. 2005. Sites of tau important for aggregation populate {β}-structure and bind to microtubules and polyanions. J Biol Chem 280: 24978-24986.
-
(2005)
J Biol Chem
, vol.280
, pp. 24978-24986
-
-
Mukrasch, M.D.1
Biernat, J.2
von Bergen, M.3
Griesinger, C.4
Mandelkow, E.5
Zweckstetter, M.6
-
166
-
-
61349120815
-
Structural polymorphism of 441-residue tau at single residue resolution
-
Mukrasch MD, Bibow S, Korukottu J, Jeganathan S, Biernat J, Griesinger C, Mandelkow E, Zweckstetter M. 2009. Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol 7: e34.
-
(2009)
PLoS Biol
, vol.7
-
-
Mukrasch, M.D.1
Bibow, S.2
Korukottu, J.3
Jeganathan, S.4
Biernat, J.5
Griesinger, C.6
Mandelkow, E.7
Zweckstetter, M.8
-
167
-
-
33847178181
-
The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts
-
Myers AJ, Pittman AM, Zhao AS, Rohrer K, Kaleem M, Marlowe L, Lees A, Leung D, McKeith IG, Perry RH, et al. 2007. The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts. Neurobiol Dis 25: 561-570.
-
(2007)
Neurobiol Dis
, vol.25
, pp. 561-570
-
-
Myers, A.J.1
Pittman, A.M.2
Zhao, A.S.3
Rohrer, K.4
Kaleem, M.5
Marlowe, L.6
Lees, A.7
Leung, D.8
McKeith, I.G.9
Perry, R.H.10
-
168
-
-
52949123661
-
Domain conformation of tau protein studied by solution small-angle X-ray scattering
-
Mylonas E, Hascher A, Bernado P, Blackledge M, Mandelkow E, Svergun DI. 2008. Domain conformation of tau protein studied by solution small-angle X-ray scattering. Biochemistry 47: 10345-10353.
-
(2008)
Biochemistry
, vol.47
, pp. 10345-10353
-
-
Mylonas, E.1
Hascher, A.2
Bernado, P.3
Blackledge, M.4
Mandelkow, E.5
Svergun, D.I.6
-
169
-
-
0141656303
-
Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head
-
Nakata T, Hirokawa N. 2003. Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head. J Cell Biol 162: 1045-1055.
-
(2003)
J Cell Biol
, vol.162
, pp. 1045-1055
-
-
Nakata, T.1
Hirokawa, N.2
-
170
-
-
0022827447
-
Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2
-
Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA. 1986. Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. Brain Res 387: 271-280.
-
(1986)
Brain Res
, vol.387
, pp. 271-280
-
-
Neve, R.L.1
Harris, P.2
Kosik, K.S.3
Kurnit, D.M.4
Donlon, T.A.5
-
172
-
-
0025006964
-
Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins
-
Obar RA, Collins CA, Hammarback JA, Shpetner HS, Vallee RB. 1990. Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins. Nature 347: 256-261.
-
(1990)
Nature
, vol.347
, pp. 256-261
-
-
Obar, R.A.1
Collins, C.A.2
Hammarback, J.A.3
Shpetner, H.S.4
Vallee, R.B.5
-
173
-
-
4043167747
-
Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
-
Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM. 2004. Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 43: 321-332.
-
(2004)
Neuron
, vol.43
, pp. 321-332
-
-
Oddo, S.1
Billings, L.2
Kesslak, J.P.3
Cribbs, D.H.4
LaFerla, F.M.5
-
174
-
-
0025161635
-
Calmodulin binds to a tubulin binding site of the microtubule-associated protein tau
-
Padilla R, Maccioni RB, Avila J. 1990. Calmodulin binds to a tubulin binding site of the microtubule-associated protein tau. Mol Cell Biochem 97: 35-41.
-
(1990)
Mol Cell Biochem
, vol.97
, pp. 35-41
-
-
Padilla, R.1
Maccioni, R.B.2
Avila, J.3
-
175
-
-
0042924434
-
Differential regulation of microtubule dynamics by three-and four-repeat tau: Implications for the onset of neurodegenerative disease
-
Panda D, Samuel JC, Massie M, Feinstein SC, Wilson L. 2003. Differential regulation of microtubule dynamics by three-and four-repeat tau: Implications for the onset of neurodegenerative disease. Proc Natl Acad Sci 100: 9548-9553.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 9548-9553
-
-
Panda, D.1
Samuel, J.C.2
Massie, M.3
Feinstein, S.C.4
Wilson, L.5
-
176
-
-
0023505501
-
Phosphorylation determines two distinct species of Tau in the central nervous system
-
Papasozomenos SC, Binder LI. 1987. Phosphorylation determines two distinct species of Tau in the central nervous system. Cell Motil Cytoskeleton 8: 210-226.
-
(1987)
Cell Motil Cytoskeleton
, vol.8
, pp. 210-226
-
-
Papasozomenos, S.C.1
Binder, L.I.2
-
177
-
-
20044370830
-
The generation of a 17 kDa neurotoxic fragment: An alternative mechanism by which tau mediates β-amyloid-induced neurodegeneration
-
Park SY, Ferreira A. 2005. The generation of a 17 kDa neurotoxic fragment: An alternative mechanism by which tau mediates β-amyloid-induced neurodegeneration. J Neurosci 25: 5365-5375.
-
(2005)
J Neurosci
, vol.25
, pp. 5365-5375
-
-
Park, S.Y.1
Ferreira, A.2
-
178
-
-
0029796168
-
Polymerization of tau into filaments in the presence of heparin: The minimal sequence required for tau-tau interaction
-
Perez M, Valpuesta JM, Medina M, Montejo de Garcini E, Avila J. 1996. Polymerization of tau into filaments in the presence of heparin: The minimal sequence required for tau-tau interaction. J Neurochem 67: 1183-1190.
-
(1996)
J Neurochem
, vol.67
, pp. 1183-1190
-
-
Perez, M.1
Valpuesta, J.M.2
Medina, M.3
Montejo de Garcini, E.4
Avila, J.5
-
179
-
-
20944442870
-
2 annihilation
-
2 annihilation. Phys Rev Lett 35: 1489.
-
(1975)
Phys Rev Lett
, vol.35
, pp. 1489
-
-
Perl, M.L.1
Abrams, G.S.2
Boyarski, A.M.3
Breidenbach, M.4
Briggs, D.D.5
Bulos, F.6
Chinowsky, W.7
Dakin, J.T.8
Feldman, G.J.9
Friedberg, C.E.10
-
180
-
-
11144356089
-
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
-
Petrucelli L, DicksonD, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, et al. 2004. CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Hum Mol Genet 13: 703-714.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 703-714
-
-
Petrucelli, L.1
Dickson, D.2
Kehoe, K.3
Taylor, J.4
Snyder, H.5
Grover, A.6
de Lucia, M.7
McGowan, E.8
Lewis, J.9
Prihar, G.10
-
181
-
-
13544251748
-
Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
-
Pickhardt M, Gazova Z, von Bergen M, Khlistunova I, Wang Y, Hascher A, Mandelkow EM, Biernat J, Mandelkow E. 2005. Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. J Biol Chem 280: 3628-3635.
-
(2005)
J Biol Chem
, vol.280
, pp. 3628-3635
-
-
Pickhardt, M.1
Gazova, Z.2
von Bergen, M.3
Khlistunova, I.4
Wang, Y.5
Hascher, A.6
Mandelkow, E.M.7
Biernat, J.8
Mandelkow, E.9
-
182
-
-
33947536100
-
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia
-
Planel E, Richter KE, Nolan CE, Finley JE, Liu L, Wen Y, Krishnamurthy P, Herman M, Wang L, Schachter JB, et al. 2007a. Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. J Neurosci 27: 3090-3097.
-
(2007)
J Neurosci
, vol.27
, pp. 3090-3097
-
-
Planel, E.1
Richter, K.E.2
Nolan, C.E.3
Finley, J.E.4
Liu, L.5
Wen, Y.6
Krishnamurthy, P.7
Herman, M.8
Wang, L.9
Schachter, J.B.10
-
183
-
-
37249040432
-
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms
-
Planel E, Tatebayashi Y, Miyasaka T, Liu L, Wang L, Herman M, Yu WH, Luchsinger JA, Wadzinski B, Duff KE, et al. 2007b. Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J Neurosci 27: 13635-13648.
-
(2007)
J Neurosci
, vol.27
, pp. 13635-13648
-
-
Planel, E.1
Tatebayashi, Y.2
Miyasaka, T.3
Liu, L.4
Wang, L.5
Herman, M.6
Yu, W.H.7
Luchsinger, J.A.8
Wadzinski, B.9
Duff, K.E.10
-
184
-
-
0030635801
-
Paired helical filaments are twisted ribbons composed of two parallel and aligned components: Image reconstruction and modeling of filament structure using atomic force microscopy
-
Pollanen MS, Markiewicz P, Goh MC. 1997. Paired helical filaments are twisted ribbons composed of two parallel and aligned components: Image reconstruction and modeling of filament structure using atomic force microscopy. J Neuropathol Exp Neurol 56: 79-85.
-
(1997)
J Neuropathol Exp Neurol
, vol.56
, pp. 79-85
-
-
Pollanen, M.S.1
Markiewicz, P.2
Goh, M.C.3
-
185
-
-
14444284106
-
Tau is a candidate gene for chromosome 17 frontotemporal dementia
-
Poorkaj P, Bird TD, Wijsman E, Nemens E, Garruto RM, Anderson L, Andreadis A, Wiederholt WC, Raskind M, Schellenberg GD. 1998. Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann Neurol 43: 815-825.
-
(1998)
Ann Neurol
, vol.43
, pp. 815-825
-
-
Poorkaj, P.1
Bird, T.D.2
Wijsman, E.3
Nemens, E.4
Garruto, R.M.5
Anderson, L.6
Andreadis, A.7
Wiederholt, W.C.8
Raskind, M.9
Schellenberg, G.D.10
-
186
-
-
34250854596
-
Nitration in neurodegeneration: Deciphering the "Hows" "nYs"
-
Reynolds MR, Berry RW, Binder LI. 2007. Nitration in neurodegeneration: Deciphering the "Hows" "nYs". Biochemistry 46: 7325-7336.
-
(2007)
Biochemistry
, vol.46
, pp. 7325-7336
-
-
Reynolds, M.R.1
Berry, R.W.2
Binder, L.I.3
-
187
-
-
49649119504
-
Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cg1, Grb2, and Src family kinases
-
Reynolds CH, Garwood CJ, Wray S, Price C, Kellie S, Perera T, Zvelebil M, Yang A, Sheppard PW, Varndell IM, et al. 2008. Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cg1, Grb2, and Src family kinases. J Biol Chem 283: 18177-18186.
-
(2008)
J Biol Chem
, vol.283
, pp. 18177-18186
-
-
Reynolds, C.H.1
Garwood, C.J.2
Wray, S.3
Price, C.4
Kellie, S.5
Perera, T.6
Zvelebil, M.7
Yang, A.8
Sheppard, P.W.9
Varndell, I.M.10
-
188
-
-
3242749074
-
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology
-
Rissman RA, PoonWW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. 2004. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest 114: 121-130.
-
(2004)
J Clin Invest
, vol.114
, pp. 121-130
-
-
Rissman, R.A.1
Poon, W.W.2
Blurton-Jones, M.3
Oddo, S.4
Torp, R.5
Vitek, M.P.6
LaFerla, F.M.7
Rohn, T.T.8
Cotman, C.W.9
-
189
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model
-
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L. 2007. Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model. Science 316: 750-754.
-
(2007)
Science
, vol.316
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
Gerstein, H.7
Yu, G.Q.8
Mucke, L.9
-
190
-
-
1842432582
-
MAP2c, but not tau, binds and bundles F-actin via its microtubule binding domain
-
Roger B, Al-Bassam J, Dehmelt L, Milligan RA, Halpain S. 2004. MAP2c, but not tau, binds and bundles F-actin via its microtubule binding domain. Curr Biol 14: 363-371.
-
(2004)
Curr Biol
, vol.14
, pp. 363-371
-
-
Roger, B.1
Al-Bassam, J.2
Dehmelt, L.3
Milligan, R.A.4
Halpain, S.5
-
191
-
-
0031405880
-
X-ray structure of motor and neck domains from rat brain kinesin
-
Sack S, Muller J, Marx A, Thormahlen M, Mandelkow EM, Brady ST, Mandelkow E. 1997. X-ray structure of motor and neck domains from rat brain kinesin. Biochemistry 36: 16155-16165.
-
(1997)
Biochemistry
, vol.36
, pp. 16155-16165
-
-
Sack, S.1
Muller, J.2
Marx, A.3
Thormahlen, M.4
Mandelkow, E.M.5
Brady, S.T.6
Mandelkow, E.7
-
192
-
-
78649767505
-
Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease
-
Salminen A, Ojala J, Kaarniranta K, Hiltunen M, Soininen H. 2011. Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. Prog Neurobiol 93: 99-110.
-
(2011)
Prog Neurobiol
, vol.93
, pp. 99-110
-
-
Salminen, A.1
Ojala, J.2
Kaarniranta, K.3
Hiltunen, M.4
Soininen, H.5
-
194
-
-
22344438508
-
Tau suppression in a neurodegenerative mouse model improves memory function
-
Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, et al. 2005. Tau suppression in a neurodegenerative mouse model improves memory function. Science 309: 476-481.
-
(2005)
Science
, vol.309
, pp. 476-481
-
-
Santacruz, K.1
Lewis, J.2
Spires, T.3
Paulson, J.4
Kotilinek, L.5
Ingelsson, M.6
Guimaraes, A.7
DeTure, M.8
Ramsden, M.9
McGowan, E.10
-
195
-
-
2442590898
-
Surface-decoration of microtubules by human tau
-
Santarella RA, Skiniotis G, Goldie KN, Tittmann P, Gross H, Mandelkow EM, Mandelkow E, Hoenger A. 2004. Surface-decoration of microtubules by human tau. J Mol Biol 339: 539-553.
-
(2004)
J Mol Biol
, vol.339
, pp. 539-553
-
-
Santarella, R.A.1
Skiniotis, G.2
Goldie, K.N.3
Tittmann, P.4
Gross, H.5
Mandelkow, E.M.6
Mandelkow, E.7
Hoenger, A.8
-
196
-
-
57049139853
-
Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone
-
Sarkar M, Kuret J, Lee G. 2008. Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone. J Neurosci Res 86: 2763-2773.
-
(2008)
J Neurosci Res
, vol.86
, pp. 2763-2773
-
-
Sarkar, M.1
Kuret, J.2
Lee, G.3
-
197
-
-
34249290108
-
Atomic structures of amyloid cross-β spines reveal varied steric zippers
-
Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, et al. 2007. Atomic structures of amyloid cross-β spines reveal varied steric zippers. Nature 447: 453-457.
-
(2007)
Nature
, vol.447
, pp. 453-457
-
-
Sawaya, M.R.1
Sambashivan, S.2
Nelson, R.3
Ivanova, M.I.4
Sievers, S.A.5
Apostol, M.I.6
Thompson, M.J.7
Balbirnie, M.8
Wiltzius, J.J.9
McFarlane, H.T.10
-
198
-
-
34249008806
-
Tau protein binding forms a 1 nm thick layer along protofilaments without affecting the radial elasticity of microtubules
-
Schaap IA, Hoffmann B, Carrasco C, Merkel R, Schmidt CF. 2007. Tau protein binding forms a 1 nm thick layer along protofilaments without affecting the radial elasticity of microtubules. J Struct Biol 158: 282-292.
-
(2007)
J Struct Biol
, vol.158
, pp. 282-292
-
-
Schaap, I.A.1
Hoffmann, B.2
Carrasco, C.3
Merkel, R.4
Schmidt, C.F.5
-
199
-
-
46749113005
-
Tau-based treatment strategies in neurodegenerative diseases
-
Schneider A, Mandelkow E. 2008. Tau-based treatment strategies in neurodegenerative diseases. Neurotherapeutics 5: 443-457.
-
(2008)
Neurotherapeutics
, vol.5
, pp. 443-457
-
-
Schneider, A.1
Mandelkow, E.2
-
200
-
-
0033596946
-
Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments
-
Schneider A, Biernat J, von Bergen M, Mandelkow E, Mandelkow EM. 1999. Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments. Biochemistry 38: 3549-3558.
-
(1999)
Biochemistry
, vol.38
, pp. 3549-3558
-
-
Schneider, A.1
Biernat, J.2
von Bergen, M.3
Mandelkow, E.4
Mandelkow, E.M.5
-
201
-
-
0028170411
-
Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for β-structure
-
SchweersO, Schonbrunn-Hanebeck E, Marx A, Mandelkow E. 1994. Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for β-structure. J Biol Chem 269: 24290-24297.
-
(1994)
J Biol Chem
, vol.269
, pp. 24290-24297
-
-
Schweers, O.1
Schonbrunn-Hanebeck, E.2
Marx, A.3
Mandelkow, E.4
-
202
-
-
0029114196
-
Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments
-
SchweersO, Mandelkow EM, Biernat J, Mandelkow E. 1995. Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments. Proc Natl Acad Sci 92: 8463-8467.
-
(1995)
Proc Natl Acad Sci
, vol.92
, pp. 8463-8467
-
-
Schweers, O.1
Mandelkow, E.M.2
Biernat, J.3
Mandelkow, E.4
-
203
-
-
35348936103
-
Beyond amyloid: The next generation of Alzheimer's disease therapeutics
-
Seabrook GR, Ray WJ, Shearman M, Hutton M. 2007. Beyond amyloid: The next generation of Alzheimer's disease therapeutics. Mol Interv 7: 261-270.
-
(2007)
Mol Interv
, vol.7
, pp. 261-270
-
-
Seabrook, G.R.1
Ray, W.J.2
Shearman, M.3
Hutton, M.4
-
204
-
-
0037119947
-
Single-molecule investigation of the interference between kinesin, tau and MAP2c
-
Seitz A, Kojima H, Oiwa K, Mandelkow EM, Song YH, Mandelkow E. 2002. Single-molecule investigation of the interference between kinesin, tau and MAP2c. EMBO J 21: 4896-4905.
-
(2002)
EMBO J
, vol.21
, pp. 4896-4905
-
-
Seitz, A.1
Kojima, H.2
Oiwa, K.3
Mandelkow, E.M.4
Song, Y.H.5
Mandelkow, E.6
-
205
-
-
43449128899
-
Biochemistry of Tau in Alzheimer's disease and related neurological disorders
-
Sergeant N, Bretteville A, Hamdane M, Caillet-Boudin ML, Grognet P, Bombois S, Blum D, Delacourte A, Pasquier F, Vanmechelen E, et al. 2008. Biochemistry of Tau in Alzheimer's disease and related neurological disorders. Expert Rev Proteomics 5: 207-224.
-
(2008)
Expert Rev Proteomics
, vol.5
, pp. 207-224
-
-
Sergeant, N.1
Bretteville, A.2
Hamdane, M.3
Caillet-Boudin, M.L.4
Grognet, P.5
Bombois, S.6
Blum, D.7
Delacourte, A.8
Pasquier, F.9
Vanmechelen, E.10
-
206
-
-
0028978701
-
Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau
-
Seubert P, Mawal-Dewan M, Barbour R, Jakes R, Goedert M, Johnson GV, Litersky JM, Schenk D, Lieberburg I, Trojanowski JQ, et al. 1995. Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau. J Biol Chem 270: 18917-18922.
-
(1995)
J Biol Chem
, vol.270
, pp. 18917-18922
-
-
Seubert, P.1
Mawal-Dewan, M.2
Barbour, R.3
Jakes, R.4
Goedert, M.5
Johnson, G.V.6
Litersky, J.M.7
Schenk, D.8
Lieberburg, I.9
Trojanowski, J.Q.10
-
207
-
-
33947314641
-
Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptordependent signaling pathway
-
Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. 2007. Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptordependent signaling pathway. J Neurosci 27: 2866-2875.
-
(2007)
J Neurosci
, vol.27
, pp. 2866-2875
-
-
Shankar, G.M.1
Bloodgood, B.L.2
Townsend, M.3
Walsh, D.M.4
Selkoe, D.J.5
Sabatini, B.L.6
-
208
-
-
2342444942
-
Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival
-
Shimura H, Miura-Shimura Y, Kosik KS. 2004a. Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival. J Biol Chem 279: 17957-17962.
-
(2004)
J Biol Chem
, vol.279
, pp. 17957-17962
-
-
Shimura, H.1
Miura-Shimura, Y.2
Kosik, K.S.3
-
209
-
-
1042266624
-
CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival
-
Shimura H, Schwartz D, Gygi SP, Kosik KS. 2004b. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. J Biol Chem 279: 4869-4876.
-
(2004)
J Biol Chem
, vol.279
, pp. 4869-4876
-
-
Shimura, H.1
Schwartz, D.2
Gygi, S.P.3
Kosik, K.S.4
-
210
-
-
79960065022
-
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
-
Sievers SA, Karanicolas J, ChangHW, Zhao A, Jiang L, Zirafi O, Stevens JT, Munch J, Baker D, Eisenberg D. 2011. Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature 475: 96-100.
-
(2011)
Nature
, vol.475
, pp. 96-100
-
-
Sievers, S.A.1
Karanicolas, J.2
Chang, H.W.3
Zhao, A.4
Jiang, L.5
Zirafi, O.6
Stevens, J.T.7
Munch, J.8
Baker, D.9
Eisenberg, D.10
-
211
-
-
26944496813
-
Regions of tau implicated in the paired helical fragment core as defined by NMR
-
Sillen A, Leroy A, Wieruszeski JM, Loyens A, Beauvillain JC, Buee L, Landrieu I, Lippens G. 2005. Regions of tau implicated in the paired helical fragment core as defined by NMR. Chembiochem 6: 1849-1856.
-
(2005)
Chembiochem
, vol.6
, pp. 1849-1856
-
-
Sillen, A.1
Leroy, A.2
Wieruszeski, J.M.3
Loyens, A.4
Beauvillain, J.C.5
Buee, L.6
Landrieu, I.7
Lippens, G.8
-
212
-
-
33947383699
-
NMRinvestigation of the interaction between the neuronal protein tau and the microtubules
-
Sillen A, Barbier P, Landrieu I, Lefebvre S, Wieruszeski JM, Leroy A, Peyrot V, Lippens G. 2007. NMRinvestigation of the interaction between the neuronal protein tau and the microtubules. Biochemistry 46: 3055-3064.
-
(2007)
Biochemistry
, vol.46
, pp. 3055-3064
-
-
Sillen, A.1
Barbier, P.2
Landrieu, I.3
Lefebvre, S.4
Wieruszeski, J.M.5
Leroy, A.6
Peyrot, V.7
Lippens, G.8
-
213
-
-
69249212121
-
Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3z
-
Sluchanko NN, Seit-Nebi AS, Gusev NB. 2009. Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3z. FEBS Lett 583: 2739-2742.
-
(2009)
FEBS Lett
, vol.583
, pp. 2739-2742
-
-
Sluchanko, N.N.1
Seit-Nebi, A.S.2
Gusev, N.B.3
-
214
-
-
1242307774
-
The peptidyl prolyl cis/trans-isomerase Pin1 recognizes the phospho-Thr212-Pro213 site on Tau
-
Smet C, Sambo AV, Wieruszeski JM, Leroy A, Landrieu I, Buee L, Lippens G. 2004. The peptidyl prolyl cis/trans-isomerase Pin1 recognizes the phospho-Thr212-Pro213 site on Tau. Biochemistry 43: 2032-2040.
-
(2004)
Biochemistry
, vol.43
, pp. 2032-2040
-
-
Smet, C.1
Sambo, A.V.2
Wieruszeski, J.M.3
Leroy, A.4
Landrieu, I.5
Buee, L.6
Lippens, G.7
-
215
-
-
0033520355
-
Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies
-
Sontag E, Nunbhakdi-Craig V, Lee G, Brandt R, Kamibayashi C, Kuret J, White CL 3rd, Mumby MC, Bloom GS. 1999. Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies. J Biol Chem 274: 25490-25498.
-
(1999)
J Biol Chem
, vol.274
, pp. 25490-25498
-
-
Sontag, E.1
Nunbhakdi-Craig, V.2
Lee, G.3
Brandt, R.4
Kamibayashi, C.5
Kuret, J.6
White III, C.L.7
Mumby, M.C.8
Bloom, G.S.9
-
216
-
-
0032560487
-
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
-
Spillantini MG, Murrell JR, Goedert M, Farlow MR, Klug A, Ghetti B. 1998. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. ProcNatl Acad Sci 95: 7737-7741.
-
(1998)
ProcNatl Acad Sci
, vol.95
, pp. 7737-7741
-
-
Spillantini, M.G.1
Murrell, J.R.2
Goedert, M.3
Farlow, M.R.4
Klug, A.5
Ghetti, B.6
-
217
-
-
61649085621
-
Tau pathophysiology in neurodegeneration: A tangled issue
-
Spires-Jones TL, Stoothoff WH, de Calignon A, Jones PB, Hyman BT. 2009. Tau pathophysiology in neurodegeneration: A tangled issue. Trends Neurosci 32: 150-159.
-
(2009)
Trends Neurosci
, vol.32
, pp. 150-159
-
-
Spires-Jones, T.L.1
Stoothoff, W.H.2
de Calignon, A.3
Jones, P.B.4
Hyman, B.T.5
-
218
-
-
0037128935
-
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
-
Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM. 2002. Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol 156: 1051-1063.
-
(2002)
J Cell Biol
, vol.156
, pp. 1051-1063
-
-
Stamer, K.1
Vogel, R.2
Thies, E.3
Mandelkow, E.4
Mandelkow, E.M.5
-
219
-
-
0025013270
-
Phosphorylation of microtubule-associated protein tau: Identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles
-
Steiner B, Mandelkow EM, Biernat J, Gustke N, Meyer HE, Schmidt B, Mieskes G, Soling HD, Drechsel D, Kirschner MW, et al. 1990. Phosphorylation of microtubule-associated protein tau: Identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles. EMBO J 9: 3539-3544.
-
(1990)
EMBO J
, vol.9
, pp. 3539-3544
-
-
Steiner, B.1
Mandelkow, E.M.2
Biernat, J.3
Gustke, N.4
Meyer, H.E.5
Schmidt, B.6
Mieskes, G.7
Soling, H.D.8
Drechsel, D.9
Kirschner, M.W.10
-
220
-
-
10944227282
-
Tau phosphorylation: Physiological and pathological consequences
-
Stoothoff WH, Johnson GV. 2005. Tau phosphorylation: Physiological and pathological consequences. Biochim Biophys Acta 1739: 280-297.
-
(2005)
Biochim Biophys Acta
, vol.1739
, pp. 280-297
-
-
Stoothoff, W.H.1
Johnson, G.V.2
-
221
-
-
0028035306
-
Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: Implications for Alzheimer disease
-
Strittmatter WJ, Saunders AM, Goedert M, Weisgraber KH, Dong LM, Jakes R, Huang DY, Pericak-Vance M, Schmechel D, Roses AD. 1994. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: Implications for Alzheimer disease. Proc Natl Acad Sci 91: 11183-11186.
-
(1994)
Proc Natl Acad Sci
, vol.91
, pp. 11183-11186
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Goedert, M.3
Weisgraber, K.H.4
Dong, L.M.5
Jakes, R.6
Huang, D.Y.7
Pericak-Vance, M.8
Schmechel, D.9
Roses, A.D.10
-
222
-
-
79953003312
-
Nuclear tau, a key player in neuronal DNA protection
-
Sultan A, Nesslany F, Violet M, Begard S, Loyens A, Talahari S, Mansuroglu Z, Marzin D, Sergeant N, Humez S, et al. 2011. Nuclear tau, a key player in neuronal DNA protection. J Biol Chem 286: 4566-4575.
-
(2011)
J Biol Chem
, vol.286
, pp. 4566-4575
-
-
Sultan, A.1
Nesslany, F.2
Violet, M.3
Begard, S.4
Loyens, A.5
Talahari, S.6
Mansuroglu, Z.7
Marzin, D.8
Sergeant, N.9
Humez, S.10
-
223
-
-
0037023679
-
Glycogen synthase kinase-3β is complexed with tau protein in brain microtubules
-
Sun W, Qureshi HY, Cafferty PW, Sobue K, Agarwal-Mawal A, Neufield KD, Paudel HK. 2002. Glycogen synthase kinase-3β is complexed with tau protein in brain microtubules. J Biol Chem 277: 11933-11940.
-
(2002)
J Biol Chem
, vol.277
, pp. 11933-11940
-
-
Sun, W.1
Qureshi, H.Y.2
Cafferty, P.W.3
Sobue, K.4
Agarwal-Mawal, A.5
Neufield, K.D.6
Paudel, H.K.7
-
224
-
-
79951818085
-
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant
-
Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, et al. 2011. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. J Neurosci 31: 2511-2525.
-
(2011)
J Neurosci
, vol.31
, pp. 2511-2525
-
-
Sydow, A.1
van der Jeugd, A.2
Zheng, F.3
Ahmed, T.4
Balschun, D.5
Petrova, O.6
Drexler, D.7
Zhou, L.8
Rune, G.9
Mandelkow, E.10
-
225
-
-
13144265717
-
Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau
-
Takashima A, Murayama M, Murayama O, Kohno T, Honda T, Yasutake K, Nihonmatsu N, Mercken M, Yamaguchi H, Sugihara S, et al. 1998. Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau. Proc Natl Acad Sci 95: 9637-9641.
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 9637-9641
-
-
Takashima, A.1
Murayama, M.2
Murayama, O.3
Kohno, T.4
Honda, T.5
Yasutake, K.6
Nihonmatsu, N.7
Mercken, M.8
Yamaguchi, H.9
Sugihara, S.10
-
226
-
-
19544362550
-
Upregulation of inhibitors of protein phosphatase-2A in Alzheimer's disease
-
Tanimukai H, Grundke-Iqbal I, Iqbal K. 2005. Upregulation of inhibitors of protein phosphatase-2A in Alzheimer's disease. Am J Pathol 166: 1761-1771.
-
(2005)
Am J Pathol
, vol.166
, pp. 1761-1771
-
-
Tanimukai, H.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
227
-
-
0036047004
-
Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease
-
Terwel D, Dewachter I, Van Leuven F. 2002. Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease. Neuromolecular Med 2: 151-165.
-
(2002)
Neuromolecular Med
, vol.2
, pp. 151-165
-
-
Terwel, D.1
Dewachter, I.2
van Leuven, F.3
-
228
-
-
33947307791
-
Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1
-
Thies E, MandelkowEM. 2007. Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1. J Neurosci 27: 2896-2907.
-
(2007)
J Neurosci
, vol.27
, pp. 2896-2907
-
-
Thies, E.1
Mandelkow, E.M.2
-
229
-
-
67849111948
-
Binding of Hsp90 to tau promotes a conformational change and aggregation of tau protein
-
Tortosa E, Santa-Maria I, Moreno F, Lim F, Perez M, Avila J. 2009. Binding of Hsp90 to tau promotes a conformational change and aggregation of tau protein. JAlzheimers Dis 17: 319-325.
-
(2009)
JAlzheimers Dis
, vol.17
, pp. 319-325
-
-
Tortosa, E.1
Santa-Maria, I.2
Moreno, F.3
Lim, F.4
Perez, M.5
Avila, J.6
-
230
-
-
0027446346
-
Dynamics of microtubules bundled by microtubule associated protein 2C (MAP2C)
-
Umeyama T, Okabe S, Kanai Y, Hirokawa N. 1993. Dynamics of microtubules bundled by microtubule associated protein 2C (MAP2C). J Cell Biol 120: 451-465.
-
(1993)
J Cell Biol
, vol.120
, pp. 451-465
-
-
Umeyama, T.1
Okabe, S.2
Kanai, Y.3
Hirokawa, N.4
-
231
-
-
27844470590
-
Molecular motors implicated in the axonal transport of tau and α-synuclein
-
Utton MA, Noble WJ, Hill JE, Anderton BH, Hanger DP. 2005. Molecular motors implicated in the axonal transport of tau and α-synuclein. J Cell Sci 118: 4645-4654.
-
(2005)
J Cell Sci
, vol.118
, pp. 4645-4654
-
-
Utton, M.A.1
Noble, W.J.2
Hill, J.E.3
Anderton, B.H.4
Hanger, D.P.5
-
232
-
-
79958815089
-
Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments
-
doi: 10.1016/j.neurobiolaging.2009.1012.1001
-
Veeranna, Yang DS, Lee JH, Vinod KY, Stavrides P, Amin ND, Pant HC, Nixon RA. 2009. Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments. Neurobiol Aging 2010 doi: 10.1016/j.neurobiolaging.2009.1012.1001.
-
(2009)
Neurobiol Aging 2010
-
-
Veeranna, Y.D.S.1
Lee, J.H.2
Vinod, K.Y.3
Stavrides, P.4
Amin, N.D.5
Pant, H.C.6
Nixon, R.A.7
-
233
-
-
0034625060
-
Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif (306)VQIVYK(311) forming β structure
-
von Bergen M, Friedhoff P, Biernat J, Heberle J, Mandelkow EM, Mandelkow E. 2000. Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif (306)VQIVYK(311) forming β structure. Proc Natl Acad Sci 97: 5129-5134.
-
(2000)
Proc Natl Acad Sci
, vol.97
, pp. 5129-5134
-
-
von Bergen, M.1
Friedhoff, P.2
Biernat, J.3
Heberle, J.4
Mandelkow, E.M.5
Mandelkow, E.6
-
234
-
-
0035930625
-
Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local β-structure
-
von Bergen M, Barghorn S, Li L, Marx A, Biernat J, MandelkowEM, MandelkowE. 2001. Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local β-structure. J Biol Chem 276: 48165-48174.
-
(2001)
J Biol Chem
, vol.276
, pp. 48165-48174
-
-
von Bergen, M.1
Barghorn, S.2
Li, L.3
Marx, A.4
Biernat, J.5
Mandelkow, E.M.6
Mandelkow, E.7
-
235
-
-
70349987102
-
Tau fragmentation, aggregation and clearance: The dual role of lysosomal processing
-
Wang Y, Martinez-Vicente M, KrugerU, Kaushik S, Wong E, Mandelkow EM, Cuervo AM, Mandelkow E. 2009. Tau fragmentation, aggregation and clearance: The dual role of lysosomal processing. Hum Mol Genet 18: 4153-4170.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 4153-4170
-
-
Wang, Y.1
Martinez-Vicente, M.2
Kruger, U.3
Kaushik, S.4
Wong, E.5
Mandelkow, E.M.6
Cuervo, A.M.7
Mandelkow, E.8
-
236
-
-
4544300178
-
Molecular aging of tau: Disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo
-
Watanabe A, Hong WK, Dohmae N, Takio K, Morishima-Kawashima M, Ihara Y. 2004. Molecular aging of tau: Disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo. J Neurochem 90: 1302-1311.
-
(2004)
J Neurochem
, vol.90
, pp. 1302-1311
-
-
Watanabe, A.1
Hong, W.K.2
Dohmae, N.3
Takio, K.4
Morishima-Kawashima, M.5
Ihara, Y.6
-
237
-
-
77956242962
-
Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability
-
Wegmann S, Jung YJ, Chinnathambi S, Mandelkow EM, Mandelkow E, Muller DJ. 2010. Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability. J Biol Chem 285: 27302-27313.
-
(2010)
J Biol Chem
, vol.285
, pp. 27302-27313
-
-
Wegmann, S.1
Jung, Y.J.2
Chinnathambi, S.3
Mandelkow, E.M.4
Mandelkow, E.5
Muller, D.J.6
-
239
-
-
0015520152
-
Microtubule formation in vitro in solutions containing low calcium concentrations
-
Weisenberg RC. 1972. Microtubule formation in vitro in solutions containing low calcium concentrations. Science 177: 1104-1105.
-
(1972)
Science
, vol.177
, pp. 1104-1105
-
-
Weisenberg, R.C.1
-
240
-
-
18744364420
-
Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd
-
Wendt TG, Volkmann N, Skiniotis G, Goldie KN, Muller J, Mandelkow E, Hoenger A. 2002. Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd. EMBO J 21: 5969-5978.
-
(2002)
EMBO J
, vol.21
, pp. 5969-5978
-
-
Wendt, T.G.1
Volkmann, N.2
Skiniotis, G.3
Goldie, K.N.4
Muller, J.5
Mandelkow, E.6
Hoenger, A.7
-
241
-
-
70350435136
-
Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubuleassociated protein during the assembly of alzheimer-like neuritic cytoskeletal striations
-
Whiteman IT, Gervasio OL, Cullen KM, Guillemin GJ, Jeong EV, Witting PK, Antao ST, Minamide LS, Bamburg JR, Goldsbury C. 2009. Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubuleassociated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. J Neurosci 29: 12994-13005.
-
(2009)
J Neurosci
, vol.29
, pp. 12994-13005
-
-
Whiteman, I.T.1
Gervasio, O.L.2
Cullen, K.M.3
Guillemin, G.J.4
Jeong, E.V.5
Witting, P.K.6
Antao, S.T.7
Minamide, L.S.8
Bamburg, J.R.9
Goldsbury, C.10
-
242
-
-
0026755755
-
Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro
-
Wille H, Drewes G, Biernat J, Mandelkow EM, Mandelkow E. 1992. Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro. J Cell Biol 118: 573-584.
-
(1992)
J Cell Biol
, vol.118
, pp. 573-584
-
-
Wille, H.1
Drewes, G.2
Biernat, J.3
Mandelkow, E.M.4
Mandelkow, E.5
-
243
-
-
43249114144
-
Membrane-bound β-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism
-
Williamson R, Usardi A, Hanger DP, Anderton BH. 2008. Membrane-bound β-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism. FASEB J 22: 1552-1559.
-
(2008)
FASEB J
, vol.22
, pp. 1552-1559
-
-
Williamson, R.1
Usardi, A.2
Hanger, D.P.3
Anderton, B.H.4
-
244
-
-
0028826633
-
Polymerization of microtubule-associated protein tau under near-physiological conditions
-
Wilson DM, Binder LI. 1995. Polymerization of microtubule-associated protein tau under near-physiological conditions. J Biol Chem 270: 24306-24314.
-
(1995)
J Biol Chem
, vol.270
, pp. 24306-24314
-
-
Wilson, D.M.1
Binder, L.I.2
-
245
-
-
0030923223
-
Free fatty acids stimulate the polymerization of tau and amyloid β peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease
-
Wilson DM, Binder LI. 1997. Free fatty acids stimulate the polymerization of tau and amyloid β peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease. Am J Pathol 150: 2181-2195.
-
(1997)
Am J Pathol
, vol.150
, pp. 2181-2195
-
-
Wilson, D.M.1
Binder, L.I.2
-
246
-
-
11244309692
-
New microtubule/tubulintargeted anticancer drugs and novel chemotherapeutic strategies
-
Wilson L, Jordan MA. 2004. New microtubule/tubulintargeted anticancer drugs and novel chemotherapeutic strategies. J Chemother 16: 83-85.
-
(2004)
J Chemother
, vol.16
, pp. 83-85
-
-
Wilson, L.1
Jordan, M.A.2
-
247
-
-
0024044195
-
Structural characterization of the core of the paired helical filament of Alzheimer disease
-
Wischik CM, Novak M, Edwards PC, Klug A, Tichelaar W, Crowther RA. 1988. Structural characterization of the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci 85: 4884-4888.
-
(1988)
Proc Natl Acad Sci
, vol.85
, pp. 4884-4888
-
-
Wischik, C.M.1
Novak, M.2
Edwards, P.C.3
Klug, A.4
Tichelaar, W.5
Crowther, R.A.6
-
248
-
-
65249116483
-
Tau mutations in neurodegenerative diseases
-
Wolfe MS. 2009. Tau mutations in neurodegenerative diseases. J Biol Chem 284: 6021-6025.
-
(2009)
J Biol Chem
, vol.284
, pp. 6021-6025
-
-
Wolfe, M.S.1
-
250
-
-
1842685948
-
Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)
-
Wood JG, Mirra SS, Pollock NJ, Binder LI. 1986. Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau). Proc Natl Acad Sci 83: 4040-4043.
-
(1986)
Proc Natl Acad Sci
, vol.83
, pp. 4040-4043
-
-
Wood, J.G.1
Mirra, S.S.2
Pollock, N.J.3
Binder, L.I.4
-
251
-
-
80052940324
-
In vivo microdialysis reveals age-dependent decrease of brain interstitial tau levels in P301S human tau transgenic mice
-
Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes B, Binder LI, Mandelkow EM, Diamond MI, Lee V.M. Y, Holtzman DM. 2011. In vivo microdialysis reveals age-dependent decrease of brain interstitial tau levels in P301S human tau transgenic mice. J Neurosci 31: 13110-13117.
-
(2011)
J Neurosci
, vol.31
, pp. 13110-13117
-
-
Yamada, K.1
Cirrito, J.R.2
Stewart, F.R.3
Jiang, H.4
Finn, M.B.5
Holmes, B.6
Binder, L.I.7
Mandelkow, E.M.8
Diamond, M.I.9
Lee, V.M.Y.10
Holtzman, D.M.11
-
252
-
-
77956587739
-
Aβ oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines
-
Zempel H, Thies E, Mandelkow E, Mandelkow EM. 2010. Aβ oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J Neurosci 30: 11938-11950.
-
(2010)
J Neurosci
, vol.30
, pp. 11938-11950
-
-
Zempel, H.1
Thies, E.2
Mandelkow, E.3
Mandelkow, E.M.4
|