Molecular aging of tau: Disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo

Journal of Neurochemistry

Volumn 90, Issue 6, 2004, Pages 1302-1311

  Watanabe, Atsushi ^b,c   Hong, Won Kyoung ^a   Dohmae, Naoshi ^b   Takio, Koji ^b,d   Morishima Kawashima, Maho ^a   Ihara, Yasuo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^d RIKEN HARIMA INSTITUTE   (Japan)

Author keywords

Non disulfide aggregation; Non enzymatic cleavage; Paired helical filaments; Smear; Succinimide intermediate; Tau

Indexed keywords

DIMER; DISULFIDE; RECOMBINANT PROTEIN; SUCCINIMIDE; TAU PROTEIN;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; BRAIN; CONTROLLED STUDY; DEAMINATION; DEGRADATION; ELECTRON MICROSCOPY; HUMAN; HUMAN TISSUE; IMMUNOCHEMISTRY; ISOMERIZATION; MASS SPECTROMETRY; OLIGOMERIZATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; WESTERN BLOTTING;

AGING; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISULFIDES; ENZYMES; HUMANS; MASS SPECTROMETRY; MICROSCOPY, ELECTRON; NEUROFIBRILLARY TANGLES; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; TAU PROTEINS; TEMPERATURE; TIME FACTORS;

EID: 4544300178     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02611.x     Document Type: Article

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