Paired Helical Filaments Are Twisted Ribbons Composed of Two Parallel and Aligned Components: Image Reconstruction and Modeling of Filament Structure Using Atomic Force Microscopy

Journal of Neuropathology and Experimental Neurology

Volumn 56, Issue 1, 1997, Pages 79-85

  Pollanen, Michael S ^a,b   Markiewicz, Peter ^b   Goh, M Cynthia ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Alzheimer's disease; Atomic force microscopy; Image analysis; Image processing; Neurofibrillary tangles; Paired helical filaments

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; ATOMIC FORCE MICROSCOPY; AUDIOVISUAL EQUIPMENT; CHEMISTRY; HUMAN; IMAGE PROCESSING; LIMBIC SYSTEM; NEUROFIBRILLARY TANGLE; PATHOLOGY; ULTRASTRUCTURE;

ALZHEIMER DISEASE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LIMBIC SYSTEM; MICROSCOPY, ATOMIC FORCE; MODELS, STRUCTURAL; NEUROFIBRILLARY TANGLES;

EID: 0030635801     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199701000-00008     Document Type: Article

References (26)

1. Kidd M. Paired helical filaments in electron microscopy of Alzheimer's disease. Nature 1963;197:192-93
2. Kidd M. Alzheimer's disease - an electron microscopical study. Brain 1964;87:307-20
3. Wolstenholme GEW, O'Connor M, eds. Alzheimer's disease and related conditions. Ciba Foundation Symposium. J & A Churchill: London, 1970
4. Wisniewski HM, Narang HK, Terry RD. Neurofibrillary tangles of paired helical filaments. J Neurol Sci 1976;27:173-81
5. Ksiezak-Reding H, Wall JS. Mass and physical dimensions of two distinct populations of paired helical filaments. Neuro Bio Aging 1994;15:11-19
6. Miyakawa T, Katsuragi S, Araki K, Hashimura T, Kimura T, Kuramoto R. Ultrastructure of neurofibriliary tangles in Alzheimer's disease. Virchows Archiv B Cell Pathol 1989;57:267-73
7. Wen GY, Wisniewski HM. High resolution analysis of paired helical filaments in Alzheimer's disease. J Electron Microsc Tech 1987;5:347-55
8. Wisniewski H, Terry RD, Hirano A. Neurofibrillary pathology. J Neuropathol Exp Neurol 1970;29:163-76
9. Wisniewski HM, Merz PA, Iqbak K. Ultrastructure of paired helical filaments of Alzheimer's neurofibriliary tangle. J Neuropathol Exp Neurol 1984;43:643-56
10. Wisniewski HM, Wen GY. Substructures of paired helical filaments from Alzheimer's disease neurofibriliary tangles. Acta Neuropathol (Berl) 1985;66:173-76
11. Crowther RA, Wischik CM. Image reconstruction of the Alzheimer paired helical filament. EMBO J 1985;4:3661-65
12. Crowther RA. Straight and paired helical filaments in Alzheimer's disease have a common structural unit. Proc Natl Acad Sci USA 1991;88:2288-92
13. Crowther RA, Olesen OF, Smith MJ, Goedert M. Assembly of Alzheimer-like filaments from full-length tau protein. FEBS Lett 1994;337:135-38
14. Wischik CM, Novak M, Edwards PC, Klug A, Tichelaar W, Crowther RA. Structural characterization of the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci USA 1988;85:4884-88
15. Kirschner DA, Abraham C, Selkoe D. X-ray diffraction and from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-β conformation. Proc Natl Acad Sci USA 1986;83:503-7
16. Ohtsubo K, Izumiyama N, Shimada H, Tachikawa T, Nakamura H. Three-dimensional structure of Alzheimer's neurofibrillary tangles of the aged human brain revealed by the quick-freeze, deep-etch replica method. Acta Neuropathol 1990;79:480-85
17. Appelt DM, Balin BJ. Analysis of paired helical filaments (PHF) found in alzheimer's disease using freeze-drying/rotary shadowing. J Struct Biol 1993;111:85-95
18. Ruben GC, Iqbal K, Grandke-Iqbal I, Johnson JE. The organization of the microtubule associated protein tau in Alzheimer paired helical filaments. Brain Res 1993;602:1-13
19. Ruben GC, Iqbal K, Wisniewski HM, Johnson JE, Grundke-Iqbal I. Alzheimer neurofibrillary tangles contain 2.1 nm filaments structurally identical to the microtubule-associated protein tau: A high resolution transmission electron microscope study of tangles and senile plaque core amyloid. Brain Res 1992;590:164-79
20. Pollanen MS, Markiewicz P, Bergeron C, Goh MC. Twisted-ribbon structure of Alzheimer paired helical filaments revealed by atomic force microscopy. Am J Pathol 1994;144:869-73
21. Greenberg SC, Davies P. A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis. Proc Natl Acad Sci USA 1990;87:5827-31
22. Iqbal K, Zaidi T, Thompson CH, Merz PA, Wisniewski HM. Alzheimer paired helical filaments: Bulk isolation, solubility, and protein composition. Acta Neuropathologica 1984;62:167-77
23. Markiewicz P, Goh MC. Atomic force microscopy probe visualization and improvement of images using a simple decovolution procedure. Langmuir 1994;10:5-7
24. Ikonomovic MD, Armstrong DM, Yen SH, Obecemea C, Vidic B. Atomic force microscopy of paired helical filaments isolated from the autopsied brains of patients with Alzheimer's disease and immunolabelled against microtubule associated protein tau. Am J Pathol 1995;147:516-28
25. Pollanen MS, Markiewicz P, Goh MC, Bergeron C. Alzheimer paired helical filaments: A comparison with the twisted ribbon model. Acta Neuropathologica 1995;90:194-97
26. Ruben GC, Novak M, Edwards PC, Iqbal K. Alzheimer paired helical filaments, untreated and pronase digested, studied by vertical platinum-carbon replication and high resolution transmission electron microscopy. Brain Research 1995;675:1-12