Regulation of microtubule-associated proteins

International Review of Cytology

Volumn 210, Issue , 2001, Pages 163-226

  Cassimeris, L ^a   Spittle, C ^a  

^a LEHIGH UNIVERSITY   (United States)

Author keywords

Dynamic instability; MAPs; Microtubules; Oncoprotein 18 Stathmin; Phosphorylation; Tau; Tubulin

Indexed keywords

APC PROTEIN; BINDING PROTEIN; CELL CYCLE PROTEIN; CENTROMERE BINDING PROTEIN; CYTOPLASMIC LINKER PROTEIN; DOUBLECORTIN; KINESIN; LINK PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 2; MICROTUBULE ASSOCIATED PROTEIN 215; MICROTUBULE ASSOCIATED PROTEIN 230; MICROTUBULE ASSOCIATED PROTEIN 4; NUCLEAR MITOTIC APPARATUS PROTEIN; PROTEIN EB1; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN P53; PROTEIN P62; PROTEIN TPX2; REV PROTEIN; STABLE TUBULE ONLY POLYPEPTIDE; STATHMIN; TAU PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; BINDING COMPETITION; CELL CYCLE; CELLULAR DISTRIBUTION; CENTROMERE; DEPHOSPHORYLATION; DIMERIZATION; ECHINODERM; GENE EXPRESSION; MICROTUBULE; MICROTUBULE ASSEMBLY; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN STABILITY; REVIEW; STRESS; XENOPUS;

EID: 0034826896     PISSN: 00747696     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7696(01)10006-9     Document Type: Article

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257. Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2)
258. Organization of microtubles in dendrites and axons is determined by a short hydrophobic zipper in microtubule-associated proteins MAP2 and tau
259. Mitotic regulation of microtubule cross-linking activity of CENP-E kinetochore protein
260. Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein tau
261. Regulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: Evidence for MAP2 as a scaffolding protein
262. Subcellular localization of tau mRNA in differentiating neuronal cell culture: Implications for neuronal polarity
263. Common and distinct tubulin binding sites for microtubule-associated proteins
264. Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons
265. Two alternative promoters direct neuron-specific expression of the rat microtubule-associated protein 1B gene
266. Structural analysis of the proximal region of the microtubule-associated protein 1B promoter
267. Steric inhibition of cytoplasmic dynein and kinesin motility by MAP2
268. Functional analysis of the MAP2 repeat domain
269. Multiple forms of tubulin: Different gene products and covalent modifications
270. Human-specific nuclear protein that associates with the polar regions of the mitotic apparatus: Distribution in a human/hamster hybrid cell
271. Regulation of the expression and phosphorylation of microtubule-associated protein 1B during regeneration of adult dorsal root ganglion neurons
272. Differential regulation of microtubule-associated protein 1B (MAP1B) in rat CNS and PNS during development
273. Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments
274. The polarity and dynamics of microtubule assembly in the budding yeast Saccharomyces cerevisiae
275. Primary structure and microtubule-interacting domain of the SP-H antigen: A mitotic MAP located at the spindle pole and characterized as a homologous protein to NuMA
276. Identification of a minus end-specific microtubule-associated protein located at the mitotic poles in cultured mammalian cells
277. Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration
278. Microtubule dynamics and microtubule caps: A time-resolved cryo-electron microscopy study
279. A spatial gradient of tau protein phosphorylation in nascent axons
280. Mitotic centromere-associated kinesin is important for anaphase chromosome segregation
281. A muscle-specific variant of microtubule-associated protein 4 (MAP4) is required in myogenesis
282. Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B
283. The distribution and phosphorylation of the microtubule-associated protein MAP1B in growth cones
284. STOPs
285. Specific association of STOP protein with microtubules in vitro and with stable microtubules in mitotic spindles of cultured cells
286. Microtubule treadmills - Possible molecular machinery
287. Multiple signal transduction pathways induce phosphorylation of serines 16, 25 and 38 of oncoprotein 18 in T lymphocytes
288. Serine 25 on oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase
289. Serine 16 of oncoprotein 18 is a major cytosolic target for the Ca2+/calmodulin-dependent protein kinase-Gr
290. Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics
291. The phenotype of a "Cdc2 kinase target site-deficient" mutant of oncoprotein 18 reveals a role of this protein in cell cycle control
292. Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominately expressed in epithelial cells
293. Binding of E-MAP-115 to microtubules is regulated by cell cycle dependent phosphorylation
294. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein
295. ZYG-9, a Caenorhabditis elegans protein required for microtubule organization and function, is a component of meitotic and mitotic spindle poles
296. Stathmin gene family: Phylogenic conservation and developmental regulation in Xenopus
297. High and low molecular weight tau proteins are differentially expressed from a single gene
298. The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases
299. Teaching tumour suppressors new tricks
300. Katinin is responsible for the M-phase microtubule severing activity in Xenopus eggs
301. Identification of katanin, an ATPase that severs and disassembles stable microtubules
302. Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin
303. Regulation of microtubule-associated protein 1B (MAP1B) subunit composition
304. MAPIB is required for axon guidance and is involved in the development of the central and peripheral nervous system
305. Regulation of microtubule dynamics by extracellular signals: cAMP-dependent protein kinase switches off the activity of oncoprotein 18 in intact cells
306. Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18
307. Formation of spindle poles by dynein/dynactin-dependent transport of NuMA
308. A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly
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311. Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells
312. The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules
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325. Role of tubulin-associated proteins in microtubule nucleation and elongation
326. disl, which is required for sister chromatid separation, is a novel microtubule and spindle pole body-associating protein phosphorylated at the cdc2 target sites
327. Importin beta is a mitotic target of the small GTPase Ran in spindle assembly
328. EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue
329. Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin
330. Dissection of fission yeast microtubule associating protein p93Dis 1: Regions implicated in regulated localization and microtubule interaction
331. The adenomatous polyposis coli protein
332. The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration
333. Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2
334. Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm
335. Overexpression of full- or partial-length MAP4 stabilizes microtubules and alters cell growth
336. Microtubule-associated protein 4 (MAP4) regulates assembly, protomer-polymer partitioning and synthesis of tubulin in cultured cells
337. Tyrosine phosphorylation by the epidermal growth factor receptor kinase induces functional alterations in microtubule-associated protein 2
338. The microtubule binding domain of microtubule-associated protein MAP1B contains a repeated sequence motif unrelated to that of MAP2 and tau
339. High-resolution model of the microtubule
340. Structure of the αβ tubulin dimer by electron crystallography
341. Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran
342. Rapid turnover of microtubule-associated protein MAP2 in the axon revealed by microinjection of biotinylated MAP2 into cultured neurons
343. Analysis of MAP 4 function in living cells using green fluorescent protein (GFP) chimeras
344. cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics
345. MAP4 is the in vivo substrate for CDC2 kinase in HeLa cells: Identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4
346. Phosphorylation-dependent localization of microtubule-associated protein MAP2c to the actin cytoskeleton
347. The stathmin family
348. Microtubule dynamics in vitro are regulated by the tubulin isotype composition
349. Rapid treadmilling of brain microtubules free of microtubule-associated proteins in vitro and its suppression by tau
350. Embryonic MAP2 lacks the cross-linking sidearm sequences and dendritic targeting signal of adult MAP2
351. MAP4: A microtubule-associated protein specific for a subset of tissue microtubules
352. Microtubule assembly in clarified Xenopus egg extracts
353. GABAc receptors are localized with the microtubule-associated protein 1B in mammalian cone photoreceptors
354. Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments
355. Microtubule associated protein MAP1A is an actin-binding and crosslinking protein
356. Modulation of microtubule shape in vitro by high molecular weight microtubule associated proteins MAP1A, MAP1B and MAP2
357. Purified native microtubule associated protein MAP1A: Kinetics of microtubule assembly and MAP1A/tubulin stoichiometry
358. Dephosphorylated but not phosphorylated microtubule associated protein MAP1B binds to microfilaments
359. Changes in mRNA abundance of microtubule-associated proteins in the rat brain following electroconvulsive shock
360. Regulating cell proliferation: As easy as APC
361. Wnt signaling in oncogenesis and embryogenesis - A look outside the nucleus
362. CLIP-170 highlights growing microtubule ends in vivo
363. CLIP-170 links endocytic vesicles to microtubules
364. Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons
365. The adenomatous polyposis coli (APC) tumor suppressor
366. Dynamics of beta-catenin interactions with APC protein regulate epithelial tubulogenesis
367. Tau is a candidate gene for chromosome 17 frontotemporal dementia
368. The "jaws" model of taumicrotubule interaction examined in CHO cells
369. Redistribution of the nuclear mitotic apparatus protein (NuMA) during mitosis and nuclear assembly
370. Brain microtubule-associated proteins modulate microtubule dynamic instability in vitro. Real-time observations using video microscopy
371. Cellular samurai: Katanin and the severing of microtubules
372. Postsynaptic mechanisms for bidirectional control of MAP2 phosphorylation by glutamate receptors
373. Differential expression of distinct microtubule-associated proteins during brain development
374. Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10
375. CLIP-170
376. Binding of pp 170 to microtubules is regulated by phosphorylation
377. Microtubule treadmilling in vivo
378. Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly
379. Association of the APC gene product with β-catenin
380. The APC protein and Ecadherin form similar but independent complexes with alpha-catenin, β-catenin, and plakoglobin
381. Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B-19K protein
382. Identification of a tau promoter region mediating tissue-specific-regulated expression in PC12 cells
383. Direct observation of microtubule dynamics in living cells
384. Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function
385. Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit
386. Phosphorylation regulates the assembly of NuMA in a mammalian mitotic extract
387. Microtubule-associated protein 1B: Molecular structure, localization, and phosphorylation-dependent expression in developing neurons
388. The Saccharomyces cerevisiae kinesinrelated motor kar3p acts at preanaphase spindle poles to limit the number and length of cytoplasmic microtubules
389. Tubulin dynamics in cultured mammalian cells
390. CENP-E function at kinetochores is essential for chromosome alignment
391. Regulation of the microtubule binding protein, doublecortin
392. Bim1 encodes a microtubule-binding protein in yeast
393. Mutations at phosphorylation sites of Xenopus microtubule-associated protein 4 affect its microtubule-binding ability and chromosome movement during mitosis
394. MAP1A and MAP1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS
395. Normal development of mice lacking metablastin (P 19), a phosphoprotein implicated in cell cycle regulation
396. New features of microtubule dynamic instability behavior observed in vivo
397. Phosphorylation of microtubule-associated proteins regulates their interaction with actin filaments
398. Making sense of the multiple MAP-2 transcripts and their role in the neuron
399. A novel microtubule-associated protein-2 expressed in oligodendrocytes in multiple sclerosis lesions
400. Antisense MAP-2 oligonucleotides induce changes in microtubule assembly and neuritic elongation in pre-existing neurites of rat cortical neurons
401. The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins
402. Relief of p53-mediated transcriptional repression by the adenovirus E1B 19 kDa protein or the cellular bcl-2 protein
403. Regulation of a major microtubule-associated protein by MPF and MAP kinase
404. Mutations at phosphorylation sites of Xenopus microtubule-associated protein 4 affect its microtubule-binding ability and chromosome movement during mitosis
405. The structure of microtubule ends during the elongation and shortening phases of dynamic instability examined by negative-stain electron microscopy
406. A new class of microtubule-associated proteins in plants
407. The kinesin Kip3p of Saccaromyces cerevisiae depolymerizes microtubules in vitro
408. Wild-type but not mutant APC associates with the microtubule cytoskeleton
409. Stathmin: A relay phosphoprotein for multiple signal transduction?
410. Identification with cellular microtubules of one of the co-assembling microtubule-associated proteins
411. A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle
412. Regulation of the phosphorylation state and microtubule-binding activity of tau by protein phosphatase 2A
413. Phosphorylation of NuMA occurs during nuclear envelope breakdown and not mitotic spindle assembly
414. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
415. The Interaction of TOGp with microtubules and tubulin
416. Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: Attenuation with riluzole pretreatment
417. Op18/stathmin caps a kinked protofilament-like tubulin tetramer
418. APC binds to the novel protein EB1
419. EMAP, an echinoderm microtubule-associated protein found in microtubule-ribosome complexes
420. Temperature and pH govern the self-assembly of microtubules from unfertilized sea-urchin egg extracts
421. Conservation of the WD-repeat, microtubule-binding protein, EMAP, in sea urchins, humans, and the nematode C. elegans
422. The difference in the binding of phosphatidylinositol distinguishes MAP2 from MAP2C and Tau
423. Microtubule-associated protein 2 levels decrease in hippocampus following traumatic brain injury
424. Delayed development of nervous system in mice homozygous for disrupted microtubule-associated protein 1B (MAP1B) gene
425. Defects in axonal elongation and neuronal migration in mice with disrupted tau and maplb genes
426. Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B, MAP2 or tau
427. Nuclear proteins of the bovine esophageal epithelium. II. The NuMA gene gives rise to multiple mRNAs and gene products reactive with monoclonal antibody W1
428. Nuclear mitotic apparatus protein (NuMA): Spindle association, nuclear targeting, and differential subcellular localization of various NuMA isoforms
429. Patient mutations in doublecortin define a repeated tubulin-binding domain
430. Extensive cAMP-dependent and cAMP-independent phosphorylation of microtubule-associated protein 2
431. EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability
432. Yeast Bim1p promotes G1-specific dynamics of microtubules
433. Novel features of the light chain of microtubule-associated protein MAP1B: Microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain
434. Microtubule-binding property of microtubule-associated protein 2 differs from that of microtubule-associated protein 4 and tau
435. A new model for microtubuleassociated protein (MAP)-induced microtubule assembly
436. Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis
437. Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts
438. Centrophilin: A novel mitotic spindle protein involved in microtubule nucleation
439. Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules
440. Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34
441. Numerous phosphates of microtubule associated protein 2 in living rat brain
442. Mapmodulin: A possible modulator of the interaction of microtubule-associated proteins with microtubules
443. Accumulation of microtubule-associated protein 1A (MAP1A) in differentiating P19 embryonal carcinoma cells
444. Characterization of the microtubulebinding domain of microtubule-associated protein 1A and its effects on microtubule dynamics
445. Severing of stable microtubules by a mitotically activated protein in Xenopus egg extracts
446. Structure and phosphorylation of microtubule-associated protein 2 (MAP2)
447. Differences in the regulation of microtubule dynamics by microtubule-associated proteins MAP1B and MAP2
448. XMAP from Xenopus eggs promote rapid plus end assembly of microtubules and rapid microtubule polymer turnover
449. Phosphorylation by CDK1 regulates XMAP215 function in vitro
450. Colocalization of cytoplasmic dynein with dynactin and CLIP-170 at microtubule distal ends
451. Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis
452. XKCM1: A Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly
453. Dynamic instability of individual, MAP-free microtubules analyzed by video light microscopy: Rate constants and transition frequencies
454. Stu2p: A microtubule-binding protein that is an essential component of the yeast spindle pole body
455. Removal of MAP4 from microtubules in vivo produces no discernable phenotype at the cellular level
456. In vivo phosphorylation sites in fetal and adult rat tau
457. Actomyosin-based retrograde flow of microtubules in the lamella of migrating epithelial cells influences microtubule dynamic instability and turnover and is associated with microtubule breakage and treadmilling
458. HIV-1 Rev depolymerizes microtubules to form stable bilayered rings
459. A protein factor essential for microtubule assembly
460. A model for microtubule-associated protein 4 structure
461. Expanding the role of HsEg5 within the mitotic and post-mitotic phases of the cell cycle
462. Plant microtubules meet their MAPs and mimics
463. Role of importin-{beta} in coupling ran to dowstream targets in microtubule assembly
464. Stimulation of microtubule aster formation and spindle assembly by the small GTPase ran
465. Localization of the kinesinlike protein Xk1p2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein
466. TPX2, a novel Xenopus MAP involved in spindle pole organization
467. Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium
468. Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis
469. Polyglycylation of tubulin is essential and affects cell motility and division in Tetrahymena thermophila
470. Sequence-specific and phosphorylation-dependent proline isomerization: A potential mitotic regulatory mechanism
471. Specific binding of acidic phospholipids to microtubule-associated protein MAP1B regulates its interaction with tubulin
472. NuMA: An unusually long coiled-coil related protein in the mammalian nucleus
473. A 62-kDa mitotic apparatus protein required for mitotic progression is sequestered to the interphase nucleus by associating with the chromosomes during anaphase
474. Spindle dynamics and cell cycle regulation of dynein in the budding yeast, Saccharomyces cerevisiae
475. CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase
476. CENP-E is a putative kinetochore motor that accumulates just before mitosis
477. Microinjection of intact MAP4 and fragments induces changes of the cytoskeleton in PtK2 cells
478. CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila
479. Identification of two distinct microtubule binding domains on recombinant rat MAP 1B
480. Active MAP kinase in mitosis: Localization at kinetochores and association with the motor protein CENP-E
481. Localization of NuMA protein isoforms in the nuclear matrix of mammalian cells
482. Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts
483. Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein
484. The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells