-
1
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA. 1985 82 : 4245 9.
-
(1985)
Proc Natl Acad Sci USA.
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
2
-
-
0027184611
-
Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease
-
Miller DL, Papayannopoulos IA, Styles J, Bobin SA, Lin YY, Biemann K, Iqbal K. Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease. Arch Biochem Biophys. 1993 301 : 41 52.
-
(1993)
Arch Biochem Biophys.
, vol.301
, pp. 41-52
-
-
Miller, D.L.1
Papayannopoulos, I.A.2
Styles, J.3
Bobin, S.A.4
Lin, Y.Y.5
Biemann, K.6
Iqbal, K.7
-
3
-
-
0016243325
-
Protein changes in senile dementia
-
Iqbal K, Wisniewski HM, Shelanski ML, Brostoff S, Liwnicz BL, Terry RD. Protein changes in senile dementia. Brain Res. 1974 77 : 337 43.
-
(1974)
Brain Res.
, vol.77
, pp. 337-343
-
-
Iqbal, K.1
Wisniewski, H.M.2
Shelanski, M.L.3
Brostoff, S.4
Liwnicz, B.L.5
Terry, R.D.6
-
4
-
-
0023009658
-
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments
-
Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem. 1986 261 : 6084 9.
-
(1986)
J Biol Chem.
, vol.261
, pp. 6084-6089
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Quinlan, M.3
Tung, Y.C.4
Zaidi, M.S.5
Wisniewski, H.M.6
-
5
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA. 1986 83 : 4913 7.
-
(1986)
Proc Natl Acad Sci USA.
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
6
-
-
0022550260
-
Defective brain microtubule assembly in Alzheimer's disease
-
Iqbal K, Grundke-Iqbal I, Zaidi T, Merz PA, Wen GY, Shaikh SS, Wisniewski HM, Alafuzoff I, Winblad B. Defective brain microtubule assembly in Alzheimer's disease. Lancet. 1986 2 : 421 6.
-
(1986)
Lancet.
, vol.2
, pp. 421-426
-
-
Iqbal, K.1
Grundke-Iqbal, I.2
Zaidi, T.3
Merz, P.A.4
Wen, G.Y.5
Shaikh, S.S.6
Wisniewski, H.M.7
Alafuzoff, I.8
Winblad, B.9
-
7
-
-
0023905288
-
The primary structure and heterogeneity of tau protein from mouse brain
-
Lee G, Cowan N, Kirschner M. The primary structure and heterogeneity of tau protein from mouse brain. Science. 1988 239 : 285 8.
-
(1988)
Science.
, vol.239
, pp. 285-288
-
-
Lee, G.1
Cowan, N.2
Kirschner, M.3
-
8
-
-
0024507707
-
Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains
-
Himmler A, Drechsel D, Kirschner MW, Martin DW, Jr. Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains. Mol Cell Biol. 1989 9 : 1381 8.
-
(1989)
Mol Cell Biol.
, vol.9
, pp. 1381-1388
-
-
Himmler, A.1
Drechsel, D.2
Kirschner, M.W.3
Martin Jr., D.W.4
-
9
-
-
0024745894
-
Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
-
Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA. Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron. 1989 3 : 519 26.
-
(1989)
Neuron.
, vol.3
, pp. 519-526
-
-
Goedert, M.1
Spillantini, M.G.2
Jakes, R.3
Rutherford, D.4
Crowther, R.A.5
-
10
-
-
0023675999
-
A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau
-
Ishiguro K, Ihara Y, Uchida T, Imahori K. A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau. J Biochem. 1988 104 : 319 21.
-
(1988)
J Biochem.
, vol.104
, pp. 319-321
-
-
Ishiguro, K.1
Ihara, Y.2
Uchida, T.3
Imahori, K.4
-
11
-
-
0025856776
-
A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope
-
Ishiguro K, Omori A, Sato K, Tomizawa K, Imahori K, Uchida T. A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope. Neurosci Lett. 1991 128 : 195 8.
-
(1991)
Neurosci Lett.
, vol.128
, pp. 195-198
-
-
Ishiguro, K.1
Omori, A.2
Sato, K.3
Tomizawa, K.4
Imahori, K.5
Uchida, T.6
-
12
-
-
0027255817
-
Glycogen synthase kinase 3 beta is identical to tau protein kinase i generating several epitopes of paired helical filaments
-
Ishiguro K, Shiratsuchi A, Sato S, Omori A, Arioka M, Kobayashi S, Uchida T, Imahori K. Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments. FEBS Lett. 1993 325 : 167 72.
-
(1993)
FEBS Lett.
, vol.325
, pp. 167-172
-
-
Ishiguro, K.1
Shiratsuchi, A.2
Sato, S.3
Omori, A.4
Arioka, M.5
Kobayashi, S.6
Uchida, T.7
Imahori, K.8
-
13
-
-
0027370141
-
In vivo phosphorylation sites in fetal and adult rat tau
-
Watanabe A, Hasegawa M, Suzuki M, Takio K, Morishima-Kawashima M, Titani K, Arai T, Kosik KS, Ihara Y. In vivo phosphorylation sites in fetal and adult rat tau. J Biol Chem. 1993 268 : 25712 7.
-
(1993)
J Biol Chem.
, vol.268
, pp. 25712-25717
-
-
Watanabe, A.1
Hasegawa, M.2
Suzuki, M.3
Takio, K.4
Morishima-Kawashima, M.5
Titani, K.6
Arai, T.7
Kosik, K.S.8
Ihara, Y.9
-
14
-
-
0023140474
-
Ubiquitin is a component of paired helical filaments in Alzheimer's disease
-
Mori H, Kondo J, Ihara Y. Ubiquitin is a component of paired helical filaments in Alzheimer's disease. Science. 1987 235 : 1641 4.
-
(1987)
Science.
, vol.235
, pp. 1641-1644
-
-
Mori, H.1
Kondo, J.2
Ihara, Y.3
-
15
-
-
0027338266
-
Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
-
Biernat J, Gustke N, Drewes G, Mandelkow EM, Mandelkow E. Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding. Neuron. 1993 11 : 153 63.
-
(1993)
Neuron.
, vol.11
, pp. 153-163
-
-
Biernat, J.1
Gustke, N.2
Drewes, G.3
Mandelkow, E.M.4
Mandelkow, E.5
-
16
-
-
0028937631
-
Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262
-
Drewes G, Trinczek B, Illenberger S, Biernat J, Schmitt-Ulms G, Meyer HE, Mandelkow EM, Mandelkow E. Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262. J Biol Chem. 1995 270 : 7679 88.
-
(1995)
J Biol Chem.
, vol.270
, pp. 7679-7688
-
-
Drewes, G.1
Trinczek, B.2
Illenberger, S.3
Biernat, J.4
Schmitt-Ulms, G.5
Meyer, H.E.6
Mandelkow, E.M.7
Mandelkow, E.8
-
17
-
-
0027945346
-
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
-
Matsuo ES, Shin RW, Billingsley ML, Van deVoorde A, O'Connor M, Trojanowski JQ, Lee VM. Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron. 1994 13 : 989 1002.
-
(1994)
Neuron.
, vol.13
, pp. 989-1002
-
-
Matsuo, E.S.1
Shin, R.W.2
Billingsley, M.L.3
Van Devoorde, A.4
O'Connor, M.5
Trojanowski, J.Q.6
Lee, V.M.7
-
18
-
-
0028064431
-
Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A
-
Gong CX, Grundke-Iqbal I, Iqbal K. Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A. Neuroscience. 1994 61 : 765 72.
-
(1994)
Neuroscience.
, vol.61
, pp. 765-772
-
-
Gong, C.X.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
20
-
-
0022917474
-
Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease
-
Montejo de Garcini E, Serrano L, Avila J. Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease. Biochem Biophys Res Commun. 1986 141 : 790 6.
-
(1986)
Biochem Biophys Res Commun.
, vol.141
, pp. 790-796
-
-
Montejo De Garcini, E.1
Serrano, L.2
Avila, J.3
-
21
-
-
0031012497
-
Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration:sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau
-
Alonso AD, Grundke-Iqbal I, Barra HS, Iqbal K. Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration:sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc Natl Acad Sci USA. 1997 94 : 298 303.
-
(1997)
Proc Natl Acad Sci USA.
, vol.94
, pp. 298-303
-
-
Alonso, A.D.1
Grundke-Iqbal, I.2
Barra, H.S.3
Iqbal, K.4
-
22
-
-
0029999787
-
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
-
Alonso AD, Grundke-Iqbal I, Iqbal K. Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med. 1996 2 : 783 7.
-
(1996)
Nat Med.
, vol.2
, pp. 783-787
-
-
Alonso, A.D.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
23
-
-
0028227962
-
Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease
-
Alonso AD, Zaidi T, Grundke-Iqbal I, Iqbal K. Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc Natl Acad Sci USA. 1994 91 : 5562 6.
-
(1994)
Proc Natl Acad Sci USA.
, vol.91
, pp. 5562-5566
-
-
Alonso, A.D.1
Zaidi, T.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
24
-
-
0027374233
-
Detection of tau proteins in normal and Alzheimer's disease cere-brospinal fluid with a sensitive sandwich enzyme-linked immunosorbent assay
-
Vandermeeren M, Mercken M, Vanmechelen E, Six J, van de Voorde A, Martin JJ, Cras P. Detection of tau proteins in normal and Alzheimer's disease cere-brospinal fluid with a sensitive sandwich enzyme-linked immunosorbent assay. J Neurochem. 1993 61 : 1828 34.
-
(1993)
J Neurochem.
, vol.61
, pp. 1828-1834
-
-
Vandermeeren, M.1
Mercken, M.2
Vanmechelen, E.3
Six, J.4
Van De Voorde, A.5
Martin, J.J.6
Cras, P.7
-
25
-
-
0033358671
-
Early-onset autosomal dominant Alzheimer disease: Prevalence, genetic heterogeneity, and mutation spectrum
-
Campion D, Dumanchin C, Hannequin D, Dubois B, Belliard S, Puel M, Thomas-Anterion C, Michon A, Martin C, Charbonnier F, Raux G, Camuzat A, Penet C, Mesnage V, Martinez M, Clerget-Darpoux F, Brice A, Frebourg T. Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum. Am J Hum Genet. 1999 65 : 664 70.
-
(1999)
Am J Hum Genet.
, vol.65
, pp. 664-670
-
-
Campion, D.1
Dumanchin, C.2
Hannequin, D.3
Dubois, B.4
Belliard, S.5
Puel, M.6
Thomas-Anterion, C.7
Michon, A.8
Martin, C.9
Charbonnier, F.10
Raux, G.11
Camuzat, A.12
Penet, C.13
Mesnage, V.14
Martinez, M.15
Clerget-Darpoux, F.16
Brice, A.17
Frebourg, T.18
-
26
-
-
14244253319
-
Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies
-
Iqbal K, Grundke-Iqbal I. Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies. Acta Neuropathol. 2005 109 : 25 31.
-
(2005)
Acta Neuropathol.
, vol.109
, pp. 25-31
-
-
Iqbal, K.1
Grundke-Iqbal, I.2
-
27
-
-
0022595501
-
Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques
-
Braak H, Braak E, Grundke-Iqbal I, Iqbal K. Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett. 1986 65 : 351 5.
-
(1986)
Neurosci Lett.
, vol.65
, pp. 351-355
-
-
Braak, H.1
Braak, E.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
28
-
-
0001521232
-
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains
-
Perry G, Friedman R, Shaw G, Chau V. Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains. Proc Natl Acad Sci USA. 1987 84 : 3033 6.
-
(1987)
Proc Natl Acad Sci USA.
, vol.84
, pp. 3033-3036
-
-
Perry, G.1
Friedman, R.2
Shaw, G.3
Chau, V.4
-
30
-
-
13444293174
-
Defining molecular targets to prevent Alzheimer disease
-
Selkoe DJ. Defining molecular targets to prevent Alzheimer disease. Arch Neurol. 2005 62 : 192 5.
-
(2005)
Arch Neurol.
, vol.62
, pp. 192-195
-
-
Selkoe, D.J.1
-
31
-
-
34548299424
-
Developing pharmacological therapies for Alzheimer disease
-
Iqbal K, Grundke-Iqbal I. Developing pharmacological therapies for Alzheimer disease. Cell Mol Life Sci. 2007 64 : 2234 44.
-
(2007)
Cell Mol Life Sci.
, vol.64
, pp. 2234-2244
-
-
Iqbal, K.1
Grundke-Iqbal, I.2
-
32
-
-
33749177143
-
A hundred years of Alzheimer's disease research
-
Hardy J. A hundred years of Alzheimer's disease research. Neuron. 2006 52 : 3 13.
-
(2006)
Neuron.
, vol.52
, pp. 3-13
-
-
Hardy, J.1
-
33
-
-
0023200370
-
Histopathological criteria for progressive dementia disorders: Clinical-pathological correlation and classification by multivariate data analysis
-
Alafuzoff I, Iqbal K, Friden H, Adolfsson R, Winblad B. Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis. Acta Neuropathol. 1987 74 : 209 25.
-
(1987)
Acta Neuropathol.
, vol.74
, pp. 209-225
-
-
Alafuzoff, I.1
Iqbal, K.2
Friden, H.3
Adolfsson, R.4
Winblad, B.5
-
34
-
-
0026740795
-
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
-
Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology. 1992 42 : 631 9.
-
(1992)
Neurology.
, vol.42
, pp. 631-639
-
-
Arriagada, P.V.1
Growdon, J.H.2
Hedley-Whyte, E.T.3
Hyman, B.T.4
-
35
-
-
0014851803
-
Observations on the brains of demented old people
-
Tomlinson BE, Blessed G, Roth M. Observations on the brains of demented old people. J Neurol Sci. 1970 11 : 205 42.
-
(1970)
J Neurol Sci.
, vol.11
, pp. 205-242
-
-
Tomlinson, B.E.1
Blessed, G.2
Roth, M.3
-
36
-
-
0023809230
-
Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques
-
Dickson DW, Farlo J, Davies P, Crystal H, Fuld P, Yen SH. Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques. Am J Pathol. 1988 132 : 86 101.
-
(1988)
Am J Pathol.
, vol.132
, pp. 86-101
-
-
Dickson, D.W.1
Farlo, J.2
Davies, P.3
Crystal, H.4
Fuld, P.5
Yen, S.H.6
-
37
-
-
0026512066
-
Identification of normal and pathological aging in prospectively studied nondemented elderly humans
-
Dickson DW, Crystal HA, Mattiace LA, Masur DM, Blau AD, Davies P, Yen SH, Aronson MK. Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiol Aging. 1992 13 : 179 89.
-
(1992)
Neurobiol Aging.
, vol.13
, pp. 179-189
-
-
Dickson, D.W.1
Crystal, H.A.2
Mattiace, L.A.3
Masur, D.M.4
Blau, A.D.5
Davies, P.6
Yen, S.H.7
Aronson, M.K.8
-
38
-
-
0023905906
-
Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques
-
Katzman R, Terry R, DeTeresa R, Brown T, Davies P, Fuld P, Renbing X, Peck A. Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol. 1988 23 : 138 44.
-
(1988)
Ann Neurol.
, vol.23
, pp. 138-144
-
-
Katzman, R.1
Terry, R.2
Deteresa, R.3
Brown, T.4
Davies, P.5
Fuld, P.6
Renbing, X.7
Peck, A.8
-
39
-
-
0032543684
-
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
-
Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, Hackett J, Adamson J, Lincoln S, Dickson D, Davies P, Petersen RC, Stevens M, de Graaff E, Wauters E, van Baren J, Hillebrand M, Joosse M, Kwon JM, Nowotny P, Che LK, Norton J, Morris JC, Reed LA, Trojanowski J, Basun H, Lannfelt L, Neystat M, Fahn S, Dark F, Tannenberg T, Dodd PR, Hayward N, Kwok JB, Schofield PR, Andreadis A, Snowden J, Craufurd D, Neary D, Owen F, Oostra BA, Hardy J, Goate A, van Swieten J, Mann D, Lynch T, Heutink P. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature. 1998 393 : 702 5.
-
(1998)
Nature.
, vol.393
, pp. 702-705
-
-
Hutton, M.1
Lendon, C.L.2
Rizzu, P.3
Baker, M.4
Froelich, S.5
Houlden, H.6
Pickering-Brown, S.7
Chakraverty, S.8
Isaacs, A.9
Grover, A.10
Hackett, J.11
Adamson, J.12
Lincoln, S.13
Dickson, D.14
Davies, P.15
Petersen, R.C.16
Stevens, M.17
De Graaff, E.18
Wauters, E.19
Van Baren, J.20
Hillebrand, M.21
Joosse, M.22
Kwon, J.M.23
Nowotny, P.24
Che, L.K.25
Norton, J.26
Morris, J.C.27
Reed, L.A.28
Trojanowski, J.29
Basun, H.30
Lannfelt, L.31
Neystat, M.32
Fahn, S.33
Dark, F.34
Tannenberg, T.35
Dodd, P.R.36
Hayward, N.37
Kwok, J.B.38
Schofield, P.R.39
Andreadis, A.40
Snowden, J.41
Craufurd, D.42
Neary, D.43
Owen, F.44
Oostra, B.A.45
Hardy, J.46
Goate, A.47
Van Swieten, J.48
Mann, D.49
Lynch, T.50
Heutink, P.51
more..
-
40
-
-
14444284106
-
Tau is a candidate gene for chromosome 17 frontotemporal dementia
-
Poorkaj P, Bird TD, Wijsman E, Nemens E, Garruto RM, Anderson L, Andreadis A, Wiederholt WC, Raskind M, Schellenberg GD. Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann Neurol. 1998 43 : 815 25.
-
(1998)
Ann Neurol.
, vol.43
, pp. 815-825
-
-
Poorkaj, P.1
Bird, T.D.2
Wijsman, E.3
Nemens, E.4
Garruto, R.M.5
Anderson, L.6
Andreadis, A.7
Wiederholt, W.C.8
Raskind, M.9
Schellenberg, G.D.10
-
41
-
-
0032560487
-
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
-
Spillantini MG, Murrell JR, Goedert M, Farlow MR, Klug A, Ghetti B. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc Natl Acad Sci USA. 1998 95 : 7737 41.
-
(1998)
Proc Natl Acad Sci USA.
, vol.95
, pp. 7737-7741
-
-
Spillantini, M.G.1
Murrell, J.R.2
Goedert, M.3
Farlow, M.R.4
Klug, A.5
Ghetti, B.6
-
42
-
-
4844219627
-
Promotion of hyperphosphorylation by frontotemporal dementia tau mutations
-
Alonso AD, Mederlyova A, Novak M, Grundke-Iqbal I, Iqbal K. Promotion of hyperphosphorylation by frontotemporal dementia tau mutations. J Biol Chem. 2004 279 : 34873 81.
-
(2004)
J Biol Chem.
, vol.279
, pp. 34873-34881
-
-
Alonso, A.D.1
Mederlyova, A.2
Novak, M.3
Grundke-Iqbal, I.4
Iqbal, K.5
-
43
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science. 1992 256 : 184 5.
-
(1992)
Science.
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
44
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002 297 : 353 6.
-
(2002)
Science.
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
45
-
-
0035943436
-
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
-
Gotz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science. 2001 293 : 1491 5.
-
(2001)
Science.
, vol.293
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
46
-
-
0034426011
-
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
-
Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, Gwinn-Hardy K, Paul Murphy M, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, Dickson DW, Davies P, Hutton M. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet. 2000 25 : 402 5.
-
(2000)
Nat Genet.
, vol.25
, pp. 402-405
-
-
Lewis, J.1
McGowan, E.2
Rockwood, J.3
Melrose, H.4
Nacharaju, P.5
Van Slegtenhorst, M.6
Gwinn-Hardy, K.7
Paul Murphy, M.8
Baker, M.9
Yu, X.10
Duff, K.11
Hardy, J.12
Corral, A.13
Lin, W.L.14
Yen, S.H.15
Dickson, D.W.16
Davies, P.17
Hutton, M.18
-
47
-
-
0344845132
-
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
-
Oddo S, Caccamo A, Kitazawa M, Tseng BP, LaFerla FM. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging. 2003 24 : 1063 70.
-
(2003)
Neurobiol Aging.
, vol.24
, pp. 1063-1070
-
-
Oddo, S.1
Caccamo, A.2
Kitazawa, M.3
Tseng, B.P.4
Laferla, F.M.5
-
48
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
-
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003 39 : 409 21.
-
(2003)
Neuron.
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Metherate, R.7
Mattson, M.P.8
Akbari, Y.9
Laferla, F.M.10
-
49
-
-
0025296269
-
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
-
Levy E, Carman MD, Fernandez-Madrid IJ, Power MD, Lieberburg I, van Duinen SG, Bots GT, Luyendijk W, Frangione B. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science. 1990 248 : 1124 6.
-
(1990)
Science.
, vol.248
, pp. 1124-1126
-
-
Levy, E.1
Carman, M.D.2
Fernandez-Madrid, I.J.3
Power, M.D.4
Lieberburg, I.5
Van Duinen, S.G.6
Bots, G.T.7
Luyendijk, W.8
Frangione, B.9
-
50
-
-
3343005434
-
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: Effects of FAD mutations
-
Baki L, Shioi J, Wen P, Shao Z, Schwarzman A, Gama-Sosa M, Neve R, Robakis NK. PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J. 2004 23 : 2586 96.
-
(2004)
EMBO J.
, vol.23
, pp. 2586-2596
-
-
Baki, L.1
Shioi, J.2
Wen, P.3
Shao, Z.4
Schwarzman, A.5
Gama-Sosa, M.6
Neve, R.7
Robakis, N.K.8
-
51
-
-
34247334573
-
FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta
-
Shioi J, Georgakopoulos A, Mehta P, Kouchi Z, Litterst CM, Baki L, Robakis NK. FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta. J Neurochem. 2007 101 : 674 81.
-
(2007)
J Neurochem.
, vol.101
, pp. 674-681
-
-
Shioi, J.1
Georgakopoulos, A.2
Mehta, P.3
Kouchi, Z.4
Litterst, C.M.5
Baki, L.6
Robakis, N.K.7
-
52
-
-
0030783142
-
A conformation- and phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease
-
Jicha GA, Lane E, Vincent I, Otvos L, Jr., Hoffmann R, Davies P. A conformation- and phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease. J Neurochem. 1997 69 : 2087 95.
-
(1997)
J Neurochem.
, vol.69
, pp. 2087-2095
-
-
Jicha, G.A.1
Lane, E.2
Vincent, I.3
Otvos Jr., L.4
Hoffmann, R.5
Davies, P.6
-
53
-
-
0033558929
-
Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease
-
Jicha GA, Berenfeld B, Davies P. Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease. J Neurosci Res. 1999 55 : 713 23.
-
(1999)
J Neurosci Res.
, vol.55
, pp. 713-723
-
-
Jicha, G.A.1
Berenfeld, B.2
Davies, P.3
-
54
-
-
0033525221
-
Altered conformation of recombinant fron-totemporal dementia-17 mutant tau proteins
-
Jicha GA, Rockwood JM, Berenfeld B, Hutton M, Davies P. Altered conformation of recombinant fron-totemporal dementia-17 mutant tau proteins. Neurosci Lett. 1999 260 : 153 6.
-
(1999)
Neurosci Lett.
, vol.260
, pp. 153-156
-
-
Jicha, G.A.1
Rockwood, J.M.2
Berenfeld, B.3
Hutton, M.4
Davies, P.5
-
55
-
-
0026053022
-
Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51
-
Novak M, Jakes R, Edwards PC, Milstein C, Wischik CM. Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51. Proc Natl Acad Sci USA. 1991 88 : 5837 41.
-
(1991)
Proc Natl Acad Sci USA.
, vol.88
, pp. 5837-5841
-
-
Novak, M.1
Jakes, R.2
Edwards, P.C.3
Milstein, C.4
Wischik, C.M.5
-
56
-
-
0041689948
-
Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease
-
Gamblin TC, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet AL, Lu M, Fu Y, Garcia-Sierra F, LaPointe N, Miller R, Berry RW, Binder LI, Cryns VL. Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci USA. 2003 100 : 10032 7.
-
(2003)
Proc Natl Acad Sci USA.
, vol.100
, pp. 10032-10037
-
-
Gamblin, T.C.1
Chen, F.2
Zambrano, A.3
Abraha, A.4
Lagalwar, S.5
Guillozet, A.L.6
Lu, M.7
Fu, Y.8
Garcia-Sierra, F.9
Lapointe, N.10
Miller, R.11
Berry, R.W.12
Binder, L.I.13
Cryns, V.L.14
-
58
-
-
0027361281
-
Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease
-
Kopke E, Tung YC, Shaikh S, Alonso AC, Iqbal K, Grundke-Iqbal I. Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J Biol Chem. 1993 268 : 24374 84.
-
(1993)
J Biol Chem.
, vol.268
, pp. 24374-24384
-
-
Kopke, E.1
Tung, Y.C.2
Shaikh, S.3
Alonso, A.C.4
Iqbal, K.5
Grundke-Iqbal, I.6
-
59
-
-
0024312664
-
Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease
-
Iqbal K, Grundke-Iqbal I, Smith AJ, George L, Tung YC, Zaidi T. Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. Proc Natl Acad Sci USA. 1989 86 : 5646 50.
-
(1989)
Proc Natl Acad Sci USA.
, vol.86
, pp. 5646-5650
-
-
Iqbal, K.1
Grundke-Iqbal, I.2
Smith, A.J.3
George, L.4
Tung, Y.C.5
Zaidi, T.6
-
60
-
-
0025904444
-
A68: A major subunit of paired helical filaments and derivatized forms of normal Tau
-
Lee VM, Balin BJ, Otvos L Jr., Trojanowski JQ. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. Science. 1991 251 : 675 8.
-
(1991)
Science.
, vol.251
, pp. 675-678
-
-
Lee, V.M.1
Balin, B.J.2
Otvos Jr., L.3
Trojanowski, J.Q.4
-
62
-
-
0021338217
-
Phosphorylation affects the ability of tau protein to promote microtubule assembly
-
Lindwall G, Cole RD. Phosphorylation affects the ability of tau protein to promote microtubule assembly. J Biol Chem. 1984 259 : 5301 5.
-
(1984)
J Biol Chem.
, vol.259
, pp. 5301-5305
-
-
Lindwall, G.1
Cole, R.D.2
-
63
-
-
0028361538
-
Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation
-
Iqbal K, Zaidi T, Bancher C, Grundke-Iqbal I. Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation. FEBS. Lett. 1994 349 : 104 8.
-
(1994)
FEBS. Lett.
, vol.349
, pp. 104-108
-
-
Iqbal, K.1
Zaidi, T.2
Bancher, C.3
Grundke-Iqbal, I.4
-
64
-
-
0028852644
-
Guanosine triphosphate binding to betasubunit of tubulin in Alzheimer's disease brain: Role of microtubule-associated protein tau
-
Khatoon S, Grundke-Iqbal I, Iqbal K. Guanosine triphosphate binding to betasubunit of tubulin in Alzheimer's disease brain: role of microtubule-associated protein tau. J Neurochem. 1995 64 : 777 87.
-
(1995)
J Neurochem.
, vol.64
, pp. 777-787
-
-
Khatoon, S.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
65
-
-
0026694783
-
Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: A radioimmuno-slot-blot assay for nanograms of the protein
-
Khatoon S, Grundke-Iqbal I, Iqbal K. Brain levels of microtubule- associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein. J Neurochem. 1992 59 : 750 3.
-
(1992)
J Neurochem.
, vol.59
, pp. 750-753
-
-
Khatoon, S.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
66
-
-
0028095224
-
Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains
-
Khatoon S, Grundke-Iqbal I, Iqbal K. Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains. FEBS Lett. 1994 351 : 80 4.
-
(1994)
FEBS Lett.
, vol.351
, pp. 80-84
-
-
Khatoon, S.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
67
-
-
33745024475
-
Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity
-
Alonso AD, Li B, Grundke-Iqbal I, Iqbal K. Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. Proc Natl Acad Sci USA. 2006 23 : 8864 9.
-
(2006)
Proc Natl Acad Sci USA.
, vol.23
, pp. 8864-8869
-
-
Alonso, A.D.1
Li, B.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
68
-
-
34247574162
-
Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau
-
Li B, Chohan MO, Grundke-Iqbal I, Iqbal K. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau. Acta Neuropathol. 2007 113 : 501 11.
-
(2007)
Acta Neuropathol.
, vol.113
, pp. 501-511
-
-
Li, B.1
Chohan, M.O.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
69
-
-
0031911959
-
Subcellular distribution of protein phosphatases and abnormally phosphorylated tau in the temporal cortex from Alzheimer's disease and control brains
-
Pei JJ, Gong CX, Iqbal K, Grundke-Iqbal I, Wu QL, Wirblad B, Cowburn RF. Subcellular distribution of protein phosphatases and abnormally phosphorylated tau in the temporal cortex from Alzheimer's disease and control brains. J Neural Transm. 1998 105 : 69 83.
-
(1998)
J Neural Transm.
, vol.105
, pp. 69-83
-
-
Pei, J.J.1
Gong, C.X.2
Iqbal, K.3
Grundke-Iqbal, I.4
Wu, Q.L.5
Wirblad, B.6
Cowburn, R.F.7
-
70
-
-
0028902487
-
Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B
-
Wang JZ, Gong CX, Zaidi T, Grundke-Iqbal I, Iqbal K. Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B. J. Biol. Chem. 1995 270 : 4854 60.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 4854-4860
-
-
Wang, J.Z.1
Gong, C.X.2
Zaidi, T.3
Grundke-Iqbal, I.4
Iqbal, K.5
-
71
-
-
0029995590
-
Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1
-
Wang JZ, Grundke-Iqbal I, Iqbal K. Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1. Brain Res. Mol. Brain Res. 1996 38 : 200 8.
-
(1996)
Brain Res. Mol. Brain Res.
, vol.38
, pp. 200-208
-
-
Wang, J.Z.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
72
-
-
27444437758
-
Disease-related modifications in tau affect the interaction between Fyn and Tau
-
Bhaskar K, Yen SH, Lee G. Disease-related modifications in tau affect the interaction between Fyn and Tau. J Biol Chem. 2005 280 : 35119 25.
-
(2005)
J Biol Chem.
, vol.280
, pp. 35119-35125
-
-
Bhaskar, K.1
Yen, S.H.2
Lee, G.3
-
73
-
-
0028899714
-
Proline-directed and non-proline-directed phosphorylation of PHF-tau
-
Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Titani K, Ihara Y. Proline-directed and non-proline-directed phosphorylation of PHF-tau. J Biol Chem. 1995 270 : 823 9.
-
(1995)
J Biol Chem.
, vol.270
, pp. 823-829
-
-
Morishima-Kawashima, M.1
Hasegawa, M.2
Takio, K.3
Suzuki, M.4
Yoshida, H.5
Titani, K.6
Ihara, Y.7
-
74
-
-
0031741247
-
New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry
-
Hanger DP, Betts JC, Loviny TL, Blackstock WP, Anderton BH. New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry. J Neurochem. 1998 71 : 2465 76.
-
(1998)
J Neurochem.
, vol.71
, pp. 2465-2476
-
-
Hanger, D.P.1
Betts, J.C.2
Loviny, T.L.3
Blackstock, W.P.4
Anderton, B.H.5
-
75
-
-
0028220180
-
Comparison of the phosphorylation of microtubule-associated protein tau by non-proline dependent protein kinases
-
Singh TJ, Grundke-Iqbal I, McDonald B, Iqbal K. Comparison of the phosphorylation of microtubule-associated protein tau by non-proline dependent protein kinases. Mol Cell Biochem. 1994 131 : 181 9.
-
(1994)
Mol Cell Biochem.
, vol.131
, pp. 181-189
-
-
Singh, T.J.1
Grundke-Iqbal, I.2
McDonald, B.3
Iqbal, K.4
-
76
-
-
0033302735
-
Tau protein in normal and Alzheimer's disease brain: An update
-
Johnson GV, Hartigan JA. Tau protein in normal and Alzheimer's disease brain: an update. J Alzheimers Dis. 1999 1 : 329 51.
-
(1999)
J Alzheimers Dis.
, vol.1
, pp. 329-351
-
-
Johnson, G.V.1
Hartigan, J.A.2
-
77
-
-
19944375450
-
Tau pathology in Alzheimer disease and other tauopathies
-
Iqbal K, Alonso Adel C, Chen S, Chohan MO, El-Akkad E, Gong CX, Khatoon S, Li B, Liu F, Rahman A, Tanimukai H, Grundke-Iqbal I. Tau pathology in Alzheimer disease and other tauopathies. Biochim Biophys Acta. 2005 1739 : 198 210.
-
(2005)
Biochim Biophys Acta.
, vol.1739
, pp. 198-210
-
-
Iqbal, K.1
Alonso Adel, C.2
Chen, S.3
Chohan, M.O.4
El-Akkad, E.5
Gong, C.X.6
Khatoon, S.7
Li, B.8
Liu, F.9
Rahman, A.10
Tanimukai, H.11
Grundke-Iqbal, I.12
-
78
-
-
0042679509
-
Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease
-
Pei JJ, Gong CX, An WL, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K. Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease. Am J Pathol. 2003 163 : 845 58.
-
(2003)
Am J Pathol.
, vol.163
, pp. 845-858
-
-
Pei, J.J.1
Gong, C.X.2
An, W.L.3
Winblad, B.4
Cowburn, R.F.5
Grundke-Iqbal, I.6
Iqbal, K.7
-
79
-
-
0032566623
-
Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase
-
Wang JZ, Wu Q, Smith A, Grundke-Iqbal I, Iqbal K. Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase. FEBS Lett. 1998 436 : 28 34.
-
(1998)
FEBS Lett.
, vol.436
, pp. 28-34
-
-
Wang, J.Z.1
Wu, Q.2
Smith, A.3
Grundke-Iqbal, I.4
Iqbal, K.5
-
80
-
-
0035223461
-
Sites of phosphorylation in tau and factors affecting their regulation
-
Anderton BH, Betts J, Blackstock WP, Brion JP, Chapman S, Connell J, Dayanandan R, Gallo JM, Gibb G, Hanger DP, Hutton M, Kardalinou E, Leroy K, Lovestone S, Mack T, Reynolds CH, Van Slegtenhorst M. Sites of phosphorylation in tau and factors affecting their regulation. Biochem Soc Symp. 2001 : 73 80.
-
(2001)
Biochem Soc Symp.
, pp. 73-80
-
-
Anderton, B.H.1
Betts, J.2
Blackstock, W.P.3
Brion, J.P.4
Chapman, S.5
Connell, J.6
Dayanandan, R.7
Gallo, J.M.8
Gibb, G.9
Hanger, D.P.10
Hutton, M.11
Kardalinou, E.12
Leroy, K.13
Lovestone, S.14
MacK, T.15
Reynolds, C.H.16
Van Slegtenhorst, M.17
-
81
-
-
0025286104
-
Molecular cloning and expression of glycogen synthase kinase-3/factor A
-
Woodgett JR. Molecular cloning and expression of glycogen synthase kinase-3/factor A. Embo J. 1990 9 : 2431 8.
-
(1990)
Embo J.
, vol.9
, pp. 2431-2438
-
-
Woodgett, J.R.1
-
82
-
-
0027425599
-
Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system
-
Tsai LH, Takahashi T, Caviness VS, Jr., Harlow E. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development. 1993 119 : 1029 40.
-
(1993)
Development.
, vol.119
, pp. 1029-1040
-
-
Tsai, L.H.1
Takahashi, T.2
Caviness Jr., V.S.3
Harlow, E.4
-
83
-
-
0028122011
-
A brain-specific activator of cyclin-dependent kinase 5
-
Lew J, Huang QQ, Qi Z, Winkfein RJ, Aebersold R, Hunt T, Wang JH. A brain-specific activator of cyclin-dependent kinase 5. Nature. 1994 371 : 423 6.
-
(1994)
Nature.
, vol.371
, pp. 423-426
-
-
Lew, J.1
Huang, Q.Q.2
Qi, Z.3
Winkfein, R.J.4
Aebersold, R.5
Hunt, T.6
Wang, J.H.7
-
84
-
-
0032578024
-
Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration
-
Pei JJ, Grundke-Iqbal I, Iqbal K, Bogdanovic N, Winblad B, Cowburn RF. Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration. Brain Res. 1998 797 : 267 77.
-
(1998)
Brain Res.
, vol.797
, pp. 267-277
-
-
Pei, J.J.1
Grundke-Iqbal, I.2
Iqbal, K.3
Bogdanovic, N.4
Winblad, B.5
Cowburn, R.F.6
-
85
-
-
0032850599
-
Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes
-
Pei JJ, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF. Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes. J Neuropathol Exp Neurol. 1999 58 : 1010 9.
-
(1999)
J Neuropathol Exp Neurol.
, vol.58
, pp. 1010-1019
-
-
Pei, J.J.1
Braak, E.2
Braak, H.3
Grundke-Iqbal, I.4
Iqbal, K.5
Winblad, B.6
Cowburn, R.F.7
-
86
-
-
0029994754
-
Phosphorylation of tau by glycogen synthase kinase-3 beta in intact mammalian cells: The effects on the organization and stability of microtubules
-
Lovestone S, Hartley CL, Pearce J, Anderton BH. Phosphorylation of tau by glycogen synthase kinase-3 beta in intact mammalian cells: the effects on the organization and stability of microtubules. Neuroscience. 1996 73 : 1145 57.
-
(1996)
Neuroscience.
, vol.73
, pp. 1145-1157
-
-
Lovestone, S.1
Hartley, C.L.2
Pearce, J.3
Anderton, B.H.4
-
87
-
-
0030449964
-
Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
-
Stambolic V, Ruel L, Woodgett JR. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol. 1996 6 : 1664 8.
-
(1996)
Curr Biol.
, vol.6
, pp. 1664-1668
-
-
Stambolic, V.1
Ruel, L.2
Woodgett, J.R.3
-
88
-
-
0029998294
-
Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation
-
Wagner U, Utton M, Gallo JM, Miller CC. Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation. J Cell Sci. 1996 109 : 1537 43.
-
(1996)
J Cell Sci.
, vol.109
, pp. 1537-1543
-
-
Wagner, U.1
Utton, M.2
Gallo, J.M.3
Miller, C.C.4
-
89
-
-
0030868557
-
Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3
-
Hong M, Chen DC, Klein PS, Lee VM. Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3. J Biol Chem. 1997 272 : 25326 32.
-
(1997)
J Biol Chem.
, vol.272
, pp. 25326-25332
-
-
Hong, M.1
Chen, D.C.2
Klein, P.S.3
Lee, V.M.4
-
90
-
-
0034731461
-
Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice
-
Spittaels K, Van den Haute C, Van Dorpe J, Geerts H, Mercken M, Bruynseels K, Lasrado R, Vandezande K, Laenen I, Boon T, Van Lint J, Vandenheede J, Moechars D, Loos R, Van Leuven F. Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. J Biol Chem. 2000 275 : 41340 9.
-
(2000)
J Biol Chem.
, vol.275
, pp. 41340-41349
-
-
Spittaels, K.1
Van Den Haute, C.2
Van Dorpe, J.3
Geerts, H.4
Mercken, M.5
Bruynseels, K.6
Lasrado, R.7
Vandezande, K.8
Laenen, I.9
Boon, T.10
Van Lint, J.11
Vandenheede, J.12
Moechars, D.13
Loos, R.14
Van Leuven, F.15
-
91
-
-
0035863188
-
Decreased nuclear betacatenin, tau hyperphosphorylation and neurodegen-eration in GSK-3beta conditional transgenic mice
-
Lucas JJ, Hernandez F, Gomez-Ramos P, Moran MA, Hen R, Avila J. Decreased nuclear betacatenin, tau hyperphosphorylation and neurodegen-eration in GSK-3beta conditional transgenic mice. EMBO J. 2001 20 : 27 39.
-
(2001)
EMBO J.
, vol.20
, pp. 27-39
-
-
Lucas, J.J.1
Hernandez, F.2
Gomez-Ramos, P.3
Moran, M.A.4
Hen, R.5
Avila, J.6
-
92
-
-
0242720372
-
Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model
-
Perez M, Hernandez F, Lim F, Diaz-Nido J, Avila J. Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model. J Alzheimers Dis. 2003 5 : 301 8.
-
(2003)
J Alzheimers Dis.
, vol.5
, pp. 301-308
-
-
Perez, M.1
Hernandez, F.2
Lim, F.3
Diaz-Nido, J.4
Avila, J.5
-
93
-
-
2342425038
-
Role of tau phosphorylation by glycogen synthase kinase-3beta in the regulation of organelle transport
-
Tatebayashi Y, Haque N, Tung YC, Iqbal K, Grundke-Iqbal I. Role of tau phosphorylation by glycogen synthase kinase-3beta in the regulation of organelle transport. J Cell Sci. 2004 117 : 1653 63.
-
(2004)
J Cell Sci.
, vol.117
, pp. 1653-1663
-
-
Tatebayashi, Y.1
Haque, N.2
Tung, Y.C.3
Iqbal, K.4
Grundke-Iqbal, I.5
-
94
-
-
0034595834
-
Calpain-dependent prote-olytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25
-
Kusakawa G, Saito T, Onuki R, Ishiguro K, Kishimoto T, Hisanaga S. Calpain-dependent prote-olytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25. J Biol Chem. 2000 275 : 17166 72.
-
(2000)
J Biol Chem.
, vol.275
, pp. 17166-17172
-
-
Kusakawa, G.1
Saito, T.2
Onuki, R.3
Ishiguro, K.4
Kishimoto, T.5
Hisanaga, S.6
-
95
-
-
0037040934
-
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
-
Patzke H, Tsai LH. Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. J Biol Chem. 2002 277 : 8054 60.
-
(2002)
J Biol Chem.
, vol.277
, pp. 8054-8060
-
-
Patzke, H.1
Tsai, L.H.2
-
96
-
-
0345405447
-
Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
-
Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron. 2003 40 : 471 83.
-
(2003)
Neuron.
, vol.40
, pp. 471-483
-
-
Cruz, J.C.1
Tseng, H.C.2
Goldman, J.A.3
Shih, H.4
Tsai, L.H.5
-
97
-
-
0038689162
-
Cdk5 is a key factor in tau aggregation and tangle formation in vivo
-
Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J, Wang L, Kondo T, Davies P, Burns M, Veeranna, Nixon R, Dickson D, Matsuoka Y, Ahlijanian M, Lau LF, Duff K. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron. 2003 38 : 555 65.
-
(2003)
Neuron.
, vol.38
, pp. 555-565
-
-
Noble, W.1
Olm, V.2
Takata, K.3
Casey, E.4
Mary, O.5
Meyerson, J.6
Gaynor, K.7
Lafrancois, J.8
Wang, L.9
Kondo, T.10
Davies, P.11
Burns, M.12
Veeranna13
Nixon, R.14
Dickson, D.15
Matsuoka, Y.16
Ahlijanian, M.17
Lau, L.F.18
Duff, K.19
-
98
-
-
0026549985
-
Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state
-
Drewes G, Lichtenberg-Kraag B, Doring F, Mandelkow EM, Biernat J, Goris J, Doree M, Mandelkow E. Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state. EMBO J. 1992 11 : 2131 8.
-
(1992)
EMBO J.
, vol.11
, pp. 2131-2138
-
-
Drewes, G.1
Lichtenberg-Kraag, B.2
Doring, F.3
Mandelkow, E.M.4
Biernat, J.5
Goris, J.6
Doree, M.7
Mandelkow, E.8
-
99
-
-
0026694067
-
Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease
-
Ledesma MD, Correas I, Avila J, Diaz-Nido J. Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease. FEBS Lett. 1992 308 : 218 24.
-
(1992)
FEBS Lett.
, vol.308
, pp. 218-224
-
-
Ledesma, M.D.1
Correas, I.2
Avila, J.3
Diaz-Nido, J.4
-
100
-
-
0027181221
-
Brain protein kinase PK40erk converts TAU into a PHF-like form as found in Alzheimer's disease
-
Roder HM, Eden PA, Ingram VM. Brain protein kinase PK40erk converts TAU into a PHF-like form as found in Alzheimer's disease. Biochem Biophys Res Commun. 1993 193 : 639 47.
-
(1993)
Biochem Biophys Res Commun.
, vol.193
, pp. 639-647
-
-
Roder, H.M.1
Eden, P.A.2
Ingram, V.M.3
-
101
-
-
0035087703
-
Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration
-
Pei JJ, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF. Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration. J Alzheimers Dis. 2001 3 : 41 8.
-
(2001)
J Alzheimers Dis.
, vol.3
, pp. 41-48
-
-
Pei, J.J.1
Braak, E.2
Braak, H.3
Grundke-Iqbal, I.4
Iqbal, K.5
Winblad, B.6
Cowburn, R.F.7
-
102
-
-
0041343303
-
Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
-
An WL, Cowburn RF, Li L, Braak H, Alafuzoff I, Iqbal K, Iqbal IG, Winblad B, Pei JJ. Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. Am J Pathol. 2003 163 : 591 607.
-
(2003)
Am J Pathol.
, vol.163
, pp. 591-607
-
-
An, W.L.1
Cowburn, R.F.2
Li, L.3
Braak, H.4
Alafuzoff, I.5
Iqbal, K.6
Iqbal, I.G.7
Winblad, B.8
Pei, J.J.9
-
103
-
-
0042679510
-
Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice
-
Kins S, Kurosinski P, Nitsch RM, Gotz J. Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice. Am J Pathol. 2003 163 : 833 43.
-
(2003)
Am J Pathol.
, vol.163
, pp. 833-843
-
-
Kins, S.1
Kurosinski, P.2
Nitsch, R.M.3
Gotz, J.4
-
104
-
-
0025013270
-
Phosphorylation of microtubule-associated protein tau: Identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles
-
Steiner B, Mandelkow EM, Biernat J, Gustke N, Meyer HE, Schmidt B, Mieskes G, Soling HD, Drechsel D, Kirschner MW, et al. Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles. EMBO J. 1990 9 : 3539 44.
-
(1990)
EMBO J.
, vol.9
, pp. 3539-3544
-
-
Steiner, B.1
Mandelkow, E.M.2
Biernat, J.3
Gustke, N.4
Meyer, H.E.5
Schmidt, B.6
Mieskes, G.7
Soling, H.D.8
Drechsel, D.9
Kirschner, M.W.10
-
105
-
-
0029888525
-
Calcium/calmodulin-dependent protein kinase II phosphorylates tau at Ser-262 but only partially inhibits its binding to microtubules
-
Singh TJ, Wang JZ, Novak M, Kontzekova E, Grundke-Iqbal I, Iqbal K. Calcium/calmodulin-dependent protein kinase II phosphorylates tau at Ser-262 but only partially inhibits its binding to microtubules. FEBS Lett. 1996 387 : 145 8.
-
(1996)
FEBS Lett.
, vol.387
, pp. 145-148
-
-
Singh, T.J.1
Wang, J.Z.2
Novak, M.3
Kontzekova, E.4
Grundke-Iqbal, I.5
Iqbal, K.6
-
106
-
-
0031727983
-
Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK
-
Sironi JJ, Yen SH, Gondal JA, Wu Q, Grundke-Iqbal I, Iqbal K. Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK. FEBS Lett. 1998 436 : 471 5.
-
(1998)
FEBS Lett.
, vol.436
, pp. 471-475
-
-
Sironi, J.J.1
Yen, S.H.2
Gondal, J.A.3
Wu, Q.4
Grundke-Iqbal, I.5
Iqbal, K.6
-
107
-
-
0035830740
-
Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at ser 262/356
-
Bennecib M, Gong CX, Grundke-Iqbal I, Iqbal K. Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356. FEBS Lett. 2001 490 : 15 22.
-
(2001)
FEBS Lett.
, vol.490
, pp. 15-22
-
-
Bennecib, M.1
Gong, C.X.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
108
-
-
0027508998
-
Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly
-
Scott CW, Spreen RC, Herman JL, Chow FP, Davison MD, Young J, Caputo CB. Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly. J Biol Chem. 1993 268 : 1166 73.
-
(1993)
J Biol Chem.
, vol.268
, pp. 1166-1173
-
-
Scott, C.W.1
Spreen, R.C.2
Herman, J.L.3
Chow, F.P.4
Davison, M.D.5
Young, J.6
Caputo, C.B.7
-
109
-
-
0030969575
-
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption
-
Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell. 1997 89 : 297 308.
-
(1997)
Cell.
, vol.89
, pp. 297-308
-
-
Drewes, G.1
Ebneth, A.2
Preuss, U.3
Mandelkow, E.M.4
Mandelkow, E.5
-
110
-
-
0037414833
-
Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding
-
Cho JH, Johnson GV. Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding. J Biol Chem. 2003 278 : 187 93.
-
(2003)
J Biol Chem.
, vol.278
, pp. 187-193
-
-
Cho, J.H.1
Johnson, G.V.2
-
111
-
-
0028871109
-
Phosphorylation of tau protein by casein kinase-1 converts it to an abnormal Alzheimer-like state
-
Singh TJ, Grundke-Iqbal I, Iqbal K. Phosphorylation of tau protein by casein kinase-1 converts it to an abnormal Alzheimer-like state. J Neurochem. 1995 64 : 1420 3.
-
(1995)
J Neurochem.
, vol.64
, pp. 1420-1423
-
-
Singh, T.J.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
112
-
-
0031052339
-
Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5
-
Sengupta A, Wu Q, Grundke-Iqbal I, Iqbal K, Singh TJ. Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5. Mol. Cell. Biochem. 1997 167 : 99 105.
-
(1997)
Mol. Cell. Biochem.
, vol.167
, pp. 99-105
-
-
Sengupta, A.1
Wu, Q.2
Grundke-Iqbal, I.3
Iqbal, K.4
Singh, T.J.5
-
113
-
-
9644257211
-
Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain
-
Liu SJ, Zhang JY, Li HL, Fang ZY, Wang Q, Deng HM, Gong CX, Grundke-Iqbal I, Iqbal K, Wang JZ. Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. J. Biol. Chem. 2004 279 : 50078 88.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 50078-50088
-
-
Liu, S.J.1
Zhang, J.Y.2
Li, H.L.3
Fang, Z.Y.4
Wang, Q.5
Deng, H.M.6
Gong, C.X.7
Grundke-Iqbal, I.8
Iqbal, K.9
Wang, J.Z.10
-
114
-
-
0029113874
-
Phosphatase activity toward abnormally phosphorylated tau:decrease in Alzheimer disease brain
-
Gong CX, Shaikh S, Wang JZ, Zaidi T, Grundke-Iqbal I, Iqbal K. Phosphatase activity toward abnormally phosphorylated tau:decrease in Alzheimer disease brain. J Neurochem. 1995 65 : 732 8.
-
(1995)
J Neurochem.
, vol.65
, pp. 732-738
-
-
Gong, C.X.1
Shaikh, S.2
Wang, J.Z.3
Zaidi, T.4
Grundke-Iqbal, I.5
Iqbal, K.6
-
115
-
-
0034088846
-
Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease
-
Gong CX, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. J Biol Chem. 2000 275 : 5535 44.
-
(2000)
J Biol Chem.
, vol.275
, pp. 5535-5544
-
-
Gong, C.X.1
Lidsky, T.2
Wegiel, J.3
Zuck, L.4
Grundke-Iqbal, I.5
Iqbal, K.6
-
116
-
-
27644478606
-
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
-
Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neurosci. 2005 22 : 1942 50.
-
(2005)
Eur J Neurosci.
, vol.22
, pp. 1942-1950
-
-
Liu, F.1
Grundke-Iqbal, I.2
Iqbal, K.3
Gong, C.X.4
-
117
-
-
2442465965
-
Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration
-
Li L, Sengupta A, Haque N, Grundke-Iqbal I, Iqbal K. Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration. FEBS Lett. 2004 566 : 261 9.
-
(2004)
FEBS Lett.
, vol.566
, pp. 261-269
-
-
Li, L.1
Sengupta, A.2
Haque, N.3
Grundke-Iqbal, I.4
Iqbal, K.5
-
118
-
-
0032540459
-
The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: The role of protein phosphatases
-
Tanaka T, Zhong J, Iqbal K, Trenkner E, Grundke-Iqbal I. The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases. FEBS. Lett. 1998 426 : 248 54.
-
(1998)
FEBS. Lett.
, vol.426
, pp. 248-254
-
-
Tanaka, T.1
Zhong, J.2
Iqbal, K.3
Trenkner, E.4
Grundke-Iqbal, I.5
-
119
-
-
0342948840
-
Multiple forms of phosphatase from human brain: Isolation and partial characterization of affi-gel blue binding phosphatases
-
Cheng LY, Wang JZ, Gong CX, Pei JJ, Zaidi T, Grundke-Iqbal I, Iqbal K. Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue binding phosphatases. Neurochem Res. 2000 25 : 107 20.
-
(2000)
Neurochem Res.
, vol.25
, pp. 107-120
-
-
Cheng, L.Y.1
Wang, J.Z.2
Gong, C.X.3
Pei, J.J.4
Zaidi, T.5
Grundke-Iqbal, I.6
Iqbal, K.7
-
120
-
-
0034928877
-
Multiple forms of phosphatase from human brain: Isolation and partial characterization of affigel blue nonbinding phosphatase activities
-
Cheng LY, Wang JZ, Gong CX, Pei JJ, Zaidi T, Grundke-Iqbal I, Iqbal K. Multiple forms of phosphatase from human brain: isolation and partial characterization of affigel blue nonbinding phosphatase activities. Neurochem Res. 2001 26 : 425 38.
-
(2001)
Neurochem Res.
, vol.26
, pp. 425-438
-
-
Cheng, L.Y.1
Wang, J.Z.2
Gong, C.X.3
Pei, J.J.4
Zaidi, T.5
Grundke-Iqbal, I.6
Iqbal, K.7
-
121
-
-
0032159462
-
Physiologic importance of protein phosphatase inhibitors
-
Oliver CJ, Shenolikar S. Physiologic importance of protein phosphatase inhibitors. Front Biosci. 1998 3 : D961 72.
-
(1998)
Front Biosci.
, vol.3
-
-
Oliver, C.J.1
Shenolikar, S.2
-
122
-
-
0024397415
-
The structure and regulation of protein phosphatases
-
Cohen P. The structure and regulation of protein phosphatases. Annu Rev Biochem. 1989 58 : 453 508.
-
(1989)
Annu Rev Biochem.
, vol.58
, pp. 453-508
-
-
Cohen, P.1
-
123
-
-
0023737187
-
Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle
-
Cohen P, Alemany S, Hemmings BA, Resink TJ, Stralfors P, Tung HY. Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle. Methods Enzymol. 1988 159 : 390 408.
-
(1988)
Methods Enzymol.
, vol.159
, pp. 390-408
-
-
Cohen, P.1
Alemany, S.2
Hemmings, B.A.3
Resink, T.J.4
Stralfors, P.5
Tung, H.Y.6
-
124
-
-
0025994387
-
Protein phosphorylation and neuronal function
-
Walaas SI, Greengard P. Protein phosphorylation and neuronal function. Pharmacol Rev. 1991 43 : 299 349.
-
(1991)
Pharmacol Rev.
, vol.43
, pp. 299-349
-
-
Walaas, S.I.1
Greengard, P.2
-
125
-
-
0033010457
-
Role of calcineurin and protein phosphatase-2A in the regulation of DARPP-32 dephosphorylation in neostriatal neurons
-
Nishi A, Snyder GL, Nairn AC, Greengard P. Role of calcineurin and protein phosphatase-2A in the regulation of DARPP-32 dephosphorylation in neostriatal neurons. J Neurochem. 1999 72 : 2015 21.
-
(1999)
J Neurochem.
, vol.72
, pp. 2015-2021
-
-
Nishi, A.1
Snyder, G.L.2
Nairn, A.C.3
Greengard, P.4
-
126
-
-
0028931302
-
Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney
-
Li M, Guo H, Damuni Z. Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney. Biochemistry. 1995 34 : 1988 96.
-
(1995)
Biochemistry.
, vol.34
, pp. 1988-1996
-
-
Li, M.1
Guo, H.2
Damuni, Z.3
-
127
-
-
0029665228
-
Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A
-
Li M, Makkinje A, Damuni Z. Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A. Biochemistry. 1996 35 : 6998 7002.
-
(1996)
Biochemistry.
, vol.35
, pp. 6998-7002
-
-
Li, M.1
Makkinje, A.2
Damuni, Z.3
-
128
-
-
0029889342
-
The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A
-
Li M, Makkinje A, Damuni Z. The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. J Biol Chem. 1996 271 : 11059 62.
-
(1996)
J Biol Chem.
, vol.271
, pp. 11059-11062
-
-
Li, M.1
Makkinje, A.2
Damuni, Z.3
-
129
-
-
11844273281
-
Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau
-
Tsujio I, Zaidi T, Xu J, Kotula L, Grundke-Iqbal I, Iqbal K. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. FEBS Lett. 2005 579 : 363 72.
-
(2005)
FEBS Lett.
, vol.579
, pp. 363-372
-
-
Tsujio, I.1
Zaidi, T.2
Xu, J.3
Kotula, L.4
Grundke-Iqbal, I.5
Iqbal, K.6
-
130
-
-
0030813618
-
Biochemical characterization of mapmodulin, a protein that binds microtubule-associated proteins
-
Ulitzur N, Rancano C, Pfeffer SR. Biochemical characterization of mapmodulin, a protein that binds microtubule-associated proteins. J Biol Chem. 1997 272 : 30577 82.
-
(1997)
J Biol Chem.
, vol.272
, pp. 30577-30582
-
-
Ulitzur, N.1
Rancano, C.2
Pfeffer, S.R.3
-
131
-
-
0026693436
-
Can, a putative onco-gene associated with myeloid leukemogenesis, may be activated by fusion of its 3′half to different genes: Characterization of the set gene
-
von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G. Can, a putative onco-gene associated with myeloid leukemogenesis, may be activated by fusion of its 3′half to different genes: characterization of the set gene. Mol Cell Biol. 1992 12 : 3346 55.
-
(1992)
Mol Cell Biol.
, vol.12
, pp. 3346-3355
-
-
Von Lindern, M.1
Van Baal, S.2
Wiegant, J.3
Raap, A.4
Hagemeijer, A.5
Grosveld, G.6
-
132
-
-
19544362550
-
Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease
-
Tanimukai H, Grundke-Iqbal I, Iqbal K. Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease. Am J Pathol. 2005 166 : 1761 71.
-
(2005)
Am J Pathol.
, vol.166
, pp. 1761-1771
-
-
Tanimukai, H.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
133
-
-
41149176740
-
PP2A affect tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A
-
PP2A affect tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. Alzheimer's & Dementia. 2006 2 : S471.
-
(2006)
Alzheimer's & Dementia.
, vol.2
-
-
Chen, S.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
134
-
-
0035811050
-
Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments
-
Alonso AD, Zaidi T, Novak M, Grundke-Iqbal I, Iqbal K. Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments. Proc Natl Acad Sci USA. 2001 98 : 6923 8.
-
(2001)
Proc Natl Acad Sci USA.
, vol.98
, pp. 6923-6928
-
-
Alonso, A.D.1
Zaidi, T.2
Novak, M.3
Grundke-Iqbal, I.4
Iqbal, K.5
-
135
-
-
33846212717
-
Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration
-
Wang JZ, Grundke-Iqbal I, Iqbal K. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. Eur J Neurosci. 2007 25 : 59 68.
-
(2007)
Eur J Neurosci.
, vol.25
, pp. 59-68
-
-
Wang, J.Z.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
136
-
-
0029815467
-
Glycosylation of microtubule-associated protein tau: An abnormal posttranslational modification in Alzheimer's disease
-
Wang JZ, Grundke-Iqbal I, Iqbal K. Glycosylation of microtubule- associated protein tau: an abnormal posttranslational modification in Alzheimer's disease. Nat Med. 1996 2 : 871 5.
-
(1996)
Nat Med.
, vol.2
, pp. 871-875
-
-
Wang, J.Z.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
137
-
-
0037070224
-
Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease
-
Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Merkle RK, Gong CX. Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease. FEBS Lett. 2002 512 : 101 6.
-
(2002)
FEBS Lett.
, vol.512
, pp. 101-106
-
-
Liu, F.1
Zaidi, T.2
Iqbal, K.3
Grundke-Iqbal, I.4
Merkle, R.K.5
Gong, C.X.6
-
138
-
-
0037163879
-
Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta
-
Liu F, Iqbal K, Grundke-Iqbal I, Gong CX. Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta. FEBS Lett. 2002 530 : 209 14.
-
(2002)
FEBS Lett.
, vol.530
, pp. 209-214
-
-
Liu, F.1
Iqbal, K.2
Grundke-Iqbal, I.3
Gong, C.X.4
-
139
-
-
0037049240
-
Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5
-
Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Gong CX. Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5. Neuroscience. 2002 115 : 829 37.
-
(2002)
Neuroscience.
, vol.115
, pp. 829-837
-
-
Liu, F.1
Zaidi, T.2
Iqbal, K.3
Grundke-Iqbal, I.4
Gong, C.X.5
-
140
-
-
10544236116
-
The microtubule-associated protein tau is extensively modified with O-linked N-acetylglu-cosamine
-
Arnold CS, Johnson GV, Cole RN, Dong DL, Lee M, Hart GW. The microtubule-associated protein tau is extensively modified with O-linked N-acetylglu-cosamine. J Biol Chem. 1996 271 : 28741 4.
-
(1996)
J Biol Chem.
, vol.271
, pp. 28741-28744
-
-
Arnold, C.S.1
Johnson, G.V.2
Cole, R.N.3
Dong, D.L.4
Lee, M.5
Hart, G.W.6
-
141
-
-
0029657990
-
O-GlcNAcylation of key nuclear and cytoskeletal proteins: Reciprocity with O-phosphorylation and putative roles in protein multimerization
-
Hart GW, Kreppel LK, Comer FI, Arnold CS, Snow DM, Ye Z, Cheng X, DellaManna D, Caine DS, Earles BJ, Akimoto Y, Cole RN, Hayes BK. O-GlcNAcylation of key nuclear and cytoskeletal proteins: reciprocity with O-phosphorylation and putative roles in protein multimerization. Glycobiology. 1996 6 : 711 6.
-
(1996)
Glycobiology.
, vol.6
, pp. 711-716
-
-
Hart, G.W.1
Kreppel, L.K.2
Comer, F.I.3
Arnold, C.S.4
Snow, D.M.5
Ye, Z.6
Cheng, X.7
Dellamanna, D.8
Caine, D.S.9
Earles, B.J.10
Akimoto, Y.11
Cole, R.N.12
Hayes, B.K.13
-
142
-
-
0030943923
-
Dynamic O-linked glycosylation of nuclear and cytoskeletal proteins
-
Hart GW. Dynamic O-linked glycosylation of nuclear and cytoskeletal proteins. Annu Rev Biochem. 1997 66 : 315 35.
-
(1997)
Annu Rev Biochem.
, vol.66
, pp. 315-335
-
-
Hart, G.W.1
-
143
-
-
3242739968
-
O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease
-
Liu F, Iqbal K, Grundke-Iqbal I, Hart GW, Gong CX. O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci USA. 2004 101 : 10804 9.
-
(2004)
Proc Natl Acad Sci USA.
, vol.101
, pp. 10804-10809
-
-
Liu, F.1
Iqbal, K.2
Grundke-Iqbal, I.3
Hart, G.W.4
Gong, C.X.5
-
144
-
-
0021271971
-
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
-
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984 34 : 939 44.
-
(1984)
Neurology.
, vol.34
, pp. 939-944
-
-
McKhann, G.1
Drachman, D.2
Folstein, M.3
Katzman, R.4
Price, D.5
Stadlan, E.M.6
-
145
-
-
0342749141
-
Pathological heterogeneity of Alzheimer type dementia
-
ed. Iqbal, K., Winblad, B., Nishimura, T., Takeda, M., Wisniewski, H.M. Vol. Chichester, UK: John Wiley & Sons Ltd.
-
Mizutani T, Sakata M, Snook ME, et al. Pathological heterogeneity of Alzheimer type dementia. Alzheimer Disease: Biology, Diagnosis and Therapeutics, ed. Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM. Vol. 33. 1997, Chichester, UK : John Wiley & Sons Ltd. 247 55.
-
(1997)
Alzheimer Disease: Biology, Diagnosis and Therapeutics
, vol.33
, pp. 247-255
-
-
Mizutani, T.1
Sakata, M.2
Snook, M.E.3
-
146
-
-
22044433461
-
Measuring atrophy in Alzheimer diseaseL a serial MRI study over 6 and 12 months
-
Schott JM, Price SL, Frost C, Whitwell JL, Rossor MN, Fox NC. Measuring atrophy in Alzheimer diseaseL a serial MRI study over 6 and 12 months. Neurology. 2005 65 : 119 24.
-
(2005)
Neurology.
, vol.65
, pp. 119-124
-
-
Schott, J.M.1
Price, S.L.2
Frost, C.3
Whitwell, J.L.4
Rossor, M.N.5
Fox, N.C.6
-
147
-
-
5644227314
-
Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease
-
Karas GB, Scheltens P, Rombouts SA, Visser PJ, van Schijndel RA, Fox NC, Barkhof F. Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease. Neuroimage. 2004 23 : 708 16.
-
(2004)
Neuroimage.
, vol.23
, pp. 708-716
-
-
Karas, G.B.1
Scheltens, P.2
Rombouts, S.A.3
Visser, P.J.4
Van Schijndel, R.A.5
Fox, N.C.6
Barkhof, F.7
-
148
-
-
33645871592
-
In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid using the novel gamma-secretase inhibitor N-[cis-4-[(4-chlorophenyl) sulfonyl]-4-(2,5-difluorophenyl) cyclohexyl]-1,1, 1-trifluoromethanesulfonamide (MRK-560) in the rat
-
Best JD, Jay MT, Otu F, Churcher I, Reilly M, Morentin-Gutierrez P, Pattison C, Harrison T, Shearman MS, Atack JR. In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid using the novel gamma-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5- difluorophenyl) cyclohexyl]-1,1, 1-trifluoromethanesulfonamide (MRK-560) in the rat. J Pharmacol Exp Ther. 2006 317 : 786 90.
-
(2006)
J Pharmacol Exp Ther.
, vol.317
, pp. 786-790
-
-
Best, J.D.1
Jay, M.T.2
Otu, F.3
Churcher, I.4
Reilly, M.5
Morentin-Gutierrez, P.6
Pattison, C.7
Harrison, T.8
Shearman, M.S.9
Atack, J.R.10
-
149
-
-
33645310409
-
Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT:a novel non-transgenic model for Abeta production inhibitors
-
El Mouedden M, Vandermeeren M, Meert T, Mercken M. Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT:a novel non-transgenic model for Abeta production inhibitors. Curr Pharm Des. 2006 12 : 671 6.
-
(2006)
Curr Pharm Des.
, vol.12
, pp. 671-676
-
-
El Mouedden, M.1
Vandermeeren, M.2
Meert, T.3
Mercken, M.4
-
150
-
-
33644832047
-
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans
-
Fagan AM, Mintun MA, Mach RH, Lee SY, Dence CS, Shah AR, LaRossa GN,
-
(2006)
Ann Neurol.
, vol.59
, pp. 512-519
-
-
Fagan, A.M.1
Mintun, M.A.2
MacH, R.H.3
Lee, S.Y.4
Dence, C.S.5
Shah, A.R.6
Larossa, G.N.7
Spinner, M.L.8
Klunk, W.E.9
Mathis, C.A.10
Dekosky, S.T.11
Morris, J.C.12
Holtzman, D.M.13
-
151
-
-
0346124139
-
Cerebrospinal fluid tau and betaamyloid: How well do these biomarkers reflect autopsy-confirmed dementia diagnoses?
-
Clark CM, Xie S, Chittams J, Ewbank D, Peskind E, Galasko D, Morris JC, McKeel DW, Jr., Farlow M, Weitlauf SL, Quinn J, Kaye J, Knopman D, Arai H, Doody RS, DeCarli C, Leight S, Lee VM, Trojanowski JQ. Cerebrospinal fluid tau and betaamyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses? Arch Neurol. 2003 60 : 1696 702.
-
(2003)
Arch Neurol.
, vol.60
, pp. 1696-1702
-
-
Clark, C.M.1
Xie, S.2
Chittams, J.3
Ewbank, D.4
Peskind, E.5
Galasko, D.6
Morris, J.C.7
McKeel Jr., D.W.8
Farlow, M.9
Weitlauf, S.L.10
Quinn, J.11
Kaye, J.12
Knopman, D.13
Arai, H.14
Doody, R.S.15
Decarli, C.16
Leight, S.17
Lee, V.M.18
Trojanowski, J.Q.19
-
152
-
-
33750589818
-
CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
-
Buerger K, Ewers M, Pirttila T, Zinkowski R, Alafuzoff I, Teipel SJ, DeBernardis J, Kerkman D, McCulloch C, Soininen H, Hampel H. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain. 2006 129 : 3035 41.
-
(2006)
Brain.
, vol.129
, pp. 3035-3041
-
-
Buerger, K.1
Ewers, M.2
Pirttila, T.3
Zinkowski, R.4
Alafuzoff, I.5
Teipel, S.J.6
Debernardis, J.7
Kerkman, D.8
McCulloch, C.9
Soininen, H.10
Hampel, H.11
-
153
-
-
0032955871
-
Quantification of axonal damage in traumatic brain injury: Affinity purification and characterization of cerebrospinal fluid tau proteins
-
Zemlan FP, Rosenberg WS, Luebbe PA, Campbell TA, Dean GE, Weiner NE, Cohen JA, Rudick RA, Woo D. Quantification of axonal damage in traumatic brain injury: affinity purification and characterization of cerebrospinal fluid tau proteins. J Neurochem. 1999 72 : 741 50.
-
(1999)
J Neurochem.
, vol.72
, pp. 741-750
-
-
Zemlan, F.P.1
Rosenberg, W.S.2
Luebbe, P.A.3
Campbell, T.A.4
Dean, G.E.5
Weiner, N.E.6
Cohen, J.A.7
Rudick, R.A.8
Woo, D.9
-
154
-
-
27644583266
-
Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers
-
Iqbal K, Flory M, Khatoon S, Soininen H, Pirttila T, Lehtovirta M, Alafuzoff I, Blennow K, Andreasen N, Vanmechelen E, Grundke-Iqbal I. Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers. Ann Neurol. 2005 58 : 748 57.
-
(2005)
Ann Neurol.
, vol.58
, pp. 748-757
-
-
Iqbal, K.1
Flory, M.2
Khatoon, S.3
Soininen, H.4
Pirttila, T.5
Lehtovirta, M.6
Alafuzoff, I.7
Blennow, K.8
Andreasen, N.9
Vanmechelen, E.10
Grundke-Iqbal, I.11
-
155
-
-
0032033832
-
Consensus report of the Working Group on: "molecular and Biochemical Markers of Alzheimer's Disease". the Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group
-
Anonymous.
-
Anonymous. Consensus report of the Working Group on: "Molecular and Biochemical Markers of Alzheimer's Disease". The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group. Neurobiol Aging. 1998 19 : 109 16.
-
(1998)
Neurobiol Aging.
, vol.19
, pp. 109-116
-
-
-
156
-
-
33745370049
-
Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine
-
Chohan MO, Khatoon S, Iqbal IG, Iqbal K. Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine. FEBS Lett. 2006 580 : 3973 9.
-
(2006)
FEBS Lett.
, vol.580
, pp. 3973-3979
-
-
Chohan, M.O.1
Khatoon, S.2
Iqbal, I.G.3
Iqbal, K.4
-
157
-
-
34548063499
-
Reduction of hyperphosphorylated tau during memantine treatment of Alzheimer's disease
-
Gunnarsson M, Kilander L, Sudelof J, Basun H, Lannfelt L. Reduction of hyperphosphorylated tau during memantine treatment of Alzheimer's disease. Alzheimer's & Dementia. 2006 2 : 63 4.
-
(2006)
Alzheimer's & Dementia.
, vol.2
, pp. 63-64
-
-
Gunnarsson, M.1
Kilander, L.2
Sudelof, J.3
Basun, H.4
Lannfelt, L.5
-
158
-
-
0032983786
-
Memantine in severe dementia: Results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine)
-
Winblad B, Poritis N. Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine). Int J Geriatr Psychiatry. 1999 14 : 135 46.
-
(1999)
Int J Geriatr Psychiatry.
, vol.14
, pp. 135-146
-
-
Winblad, B.1
Poritis, N.2
-
159
-
-
0037417238
-
Memantine in moderate-to-severe Alzheimer's disease
-
Reisberg B, Doody R, Stoffler A, Schmitt F, Ferris S, Mobius HJ. Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med. 2003 348 : 1333 41.
-
(2003)
N Engl J Med.
, vol.348
, pp. 1333-1341
-
-
Reisberg, B.1
Doody, R.2
Stoffler, A.3
Schmitt, F.4
Ferris, S.5
Mobius, H.J.6
-
160
-
-
27844553889
-
Truncation and activation of calcineurin A by calpain i in Alzheimer disease brain
-
Liu F, Grundke-Iqbal I, Iqbal K, Oda Y, Tomizawa K, Gong CX. Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain. J Biol Chem. 2005 280 : 37755 62.
-
(2005)
J Biol Chem.
, vol.280
, pp. 37755-37762
-
-
Liu, F.1
Grundke-Iqbal, I.2
Iqbal, K.3
Oda, Y.4
Tomizawa, K.5
Gong, C.X.6
-
161
-
-
33847369469
-
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
-
Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS, Jr., Hutton M, Burrows F, Petrucelli L. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J Clin Invest. 2007 117 : 648 58.
-
(2007)
J Clin Invest.
, vol.117
, pp. 648-658
-
-
Dickey, C.A.1
Kamal, A.2
Lundgren, K.3
Klosak, N.4
Bailey, R.M.5
Dunmore, J.6
Ash, P.7
Shoraka, S.8
Zlatkovic, J.9
Eckman, C.B.10
Patterson, C.11
Dickson, D.W.12
Nahman Jr., N.S.13
Hutton, M.14
Burrows, F.15
Petrucelli, L.16
-
162
-
-
19944429064
-
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
-
Zhang B, Maiti A, Shively S, Lakhani F, McDonald-Jones G, Bruce J, Lee EB, Xie SX, Joyce S, Li C, Toleikis PM, Lee VM, Trojanowski JQ. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proc Natl Acad Sci USA. 2005 102 : 227 31.
-
(2005)
Proc Natl Acad Sci USA.
, vol.102
, pp. 227-231
-
-
Zhang, B.1
Maiti, A.2
Shively, S.3
Lakhani, F.4
McDonald-Jones, G.5
Bruce, J.6
Lee, E.B.7
Xie, S.X.8
Joyce, S.9
Li, C.10
Toleikis, P.M.11
Lee, V.M.12
Trojanowski, J.Q.13
-
163
-
-
34548146119
-
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
-
Asuni AA, Boutajangout A, Quartermain D, Sigurdsson EM. Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J Neurosci. 2007 27 : 9115 29.
-
(2007)
J Neurosci.
, vol.27
, pp. 9115-9129
-
-
Asuni, A.A.1
Boutajangout, A.2
Quartermain, D.3
Sigurdsson, E.M.4
-
164
-
-
13244295499
-
{beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents
-
Michaelis ML, Ansar S, Chen Y, Reiff ER, Seyb KI, Himes RH, Audus KL, Georg GI. {beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents. J Pharmacol Exp Ther. 2005 312 : 659 68.
-
(2005)
J Pharmacol Exp Ther.
, vol.312
, pp. 659-668
-
-
Michaelis, M.L.1
Ansar, S.2
Chen, Y.3
Reiff, E.R.4
Seyb, K.I.5
Himes, R.H.6
Audus, K.L.7
Georg, G.I.8
-
165
-
-
0030805991
-
Frequency of stages of Alzheimer-related lesions in different age categories
-
Braak H, Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging. 1997 18 : 351 7.
-
(1997)
Neurobiol Aging.
, vol.18
, pp. 351-357
-
-
Braak, H.1
Braak, E.2
-
166
-
-
33645776373
-
On the discovery of the genetic association of Apolipoprotein e genotypes and common late-onset Alzheimer disease
-
Roses AD. On the discovery of the genetic association of Apolipoprotein E genotypes and common late-onset Alzheimer disease. J Alzheimers Dis. 2006 9 : 361 6.
-
(2006)
J Alzheimers Dis.
, vol.9
, pp. 361-366
-
-
Roses, A.D.1
|