Farm animal milk proteomics

Journal of Proteomics

Volumn 75, Issue 14, 2012, Pages 4259-4274

  Roncada, Paola ^a   Piras, Cristian ^b   Soggiu, Alessio ^c   Turk, Romana ^d   Urbani, Andrea ^e,f   Bonizzi, Luigi ^c  

^a Istituto Sperimentale Italiano Lazzaro Spallanzani   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF ZAGREB   (Croatia)

^e UNIVERSITY OF ROME TOR VERGATA   (Italy)

^f IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Dairy products; Farm animals; Milk; Proteomics; Quality; Safety

Indexed keywords

ALPHA CASEIN; BETA CASEIN; KAPPA CASEIN; LACTADHERIN; MILK PROTEIN; MUCIN; PROTEOME;

CHEESEMAKING; DAIRY INDUSTRY; DAIRY PRODUCT; ELECTROSPRAY MASS SPECTROMETRY; FARM ANIMAL; GLYCOSYLATION; MASS SPECTROMETRY; MASTITIS; NONHUMAN; PEPTIDOMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEOMICS; QUALITY CONTROL; REVIEW; SAFETY; TWO DIMENSIONAL ELECTROPHORESIS;

ANIMALS; ANIMALS, DOMESTIC; FOOD ANALYSIS; MILK; MILK PROTEINS; PROTEOME;

ANIMALIA;

EID: 84863819137     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2012.05.028     Document Type: Review

References (169)

1. D'Alessandro A., Scaloni A., Zolla L. Human milk proteins: an interactomics and updated functional overview. J Proteome Res 2010, 9:3339-3373.
2. Lönnerdal B. Bioactive proteins in human milk: mechanisms of action. J Pediatr 2010, 156:S26-S30.
3. O'Donnell R., Holland J., Deeth H., Alewood P. Milk proteomics. Int Dairy J 2004, 14:1013-1023.
4. Bianchi L., Puglia M., Landi C., Matteoni S., Perini D., Armini A., et al. Solubilization methods and reference 2-DE map of cow milk fat globules. J Proteomics 2009, 72:853-864.
5. D'Amato A., Bachi A., Fasoli E., Boschetti E., Peltre G., Sénéchal H., et al. In-depth exploration of cow's whey proteome via combinatorial peptide ligand libraries. J Proteome Res 2009, 8:3925-3936.
6. Reinhardt T.A., Lippolis J. Bovine milk fat globule membrane proteome. J Dairy Res 2006, 73:406.
7. Wu W., Wang X., Wu G., Kim S., Chen F., Wang J. Differential composition of proteomes in sow colostrum and milk from anterior and posterior mammary glands. J Anim Sci 2010, 88:2657-2664.
8. Anderson N., Powers M., Tollaksen S. Proteins of human milk. I. Identification of major components. Clin Chem 1982, 28:1045-1055.
9. Fox P., Kelly A. Developments in the chemistry and technology of milk proteins. Food Aust 2003, 55:231.
10. Gagnaire V., Jardin J., Jan G., Lortal S. Proteomics of milk and bacteria used in fermented dairy products: from qualitative to quantitative advances. J Dairy Sci 2009, 92:811-825.
11. Chianese L., Calabrese M.G., Ferranti P., Mauriello R., Garro G., De Simone C., et al. Proteomic characterization of donkey milk "caseome". J Chromatogr A 2010, 1217:4834-4840.
12. Jovanovic S., Barac M., Macej O., Vucic T., Lacnjevac C. SDS-PAGE analysis of soluble proteins in reconstituted milk exposed to different heat treatments. Sensors 2007, 7:371-383.
13. Hayes K., Nielsen S. Plasmin levels in fresh milk whey and commercial whey protein products. J Dairy Sci 2000, 83:387-394.
14. Tay E.P., Gam L.H. Proteomics of human and the domestic bovine and caprine milk. Asia-Pac J Mol Biol Biotechnol 2011, 19:45-53.
15. Pisanu S., Ghisaura S., Pagnozzi D., Biosa G., Tanca A., Roggio T., et al. The sheep milk fat globule membrane proteome. J Proteomics 2011, 74:350-358.
16. Roncada P., Gaviraghi A., Liberatori S., Canas B., Bini L., Greppi G.F. Identification of caseins in goat milk. Proteomics 2002, 2:723-726.
17. Claverol S., Burlet-Schiltz O., Gairin J.E., Monsarrat B. Characterization of protein variants and post-translational modifications: ESI-MSn analyses of intact proteins eluted from polyacrylamide gels. Mol Cell Proteomics 2003, 2:483-493.
18. Cunsolo V., Cairone E., Fontanini D., Criscione A., Muccilli V., Saletti R., et al. Sequence determination of αs1-casein isoforms from donkey by mass spectrometric methods. J Mass Spectrom 2009, 44:1742-1753.
19. Holland J.W., Deeth H.C., Alewood P.F. Resolution and characterisation of multiple isoforms of bovine κ-casein by 2-DE following a reversible cysteine-tagging enrichment strategy. Proteomics 2006, 6:3087-3095.
20. Alonso-Fauste I., Andrés M., Iturralde M., Lampreave F., Gallart J., Álava M.A. Proteomic characterization by 2-DE in bovine serum and whey from healthy and mastitis affected farm animals. J Proteomics 2011, http://dx.doi.org/10.1016/j.jprot.2011.11.035.
21. Addis M.F., Pisanu S., Ghisaura S., Pagnozzi D., Marogna G., Tanca A., et al. Proteomics and pathway analyses of the milk fat globule in sheep naturally infected by Mycoplasma agalactiae provide indications of the in vivo response of the mammary epithelium to bacterial infection. Infect Immun 2011, 79:3833-3845.
22. Xia C., Zhang H., Wu L., Xu C., Zheng J., Yan Y., et al. Proteomic analysis of plasma from cows affected with milk fever using two-dimensional differential in-gel electrophoresis and mass spectrometry. Res Vet Sci 2011, http://dx.doi.org/10.1016/j.rvsc.2011.10.025.
23. Mollé D., Jardin J., Piot M., Pasco M., Léonil J., Gagnaire V. Comparison of electrospray and matrix-assisted laser desorption ionization on the same hybrid quadrupole time-of-flight tandem mass spectrometer: application to bidimensional liquid chromatography of proteins from bovine milk fraction. J Chromatogr A 2009, 1216:2424-2432.
24. Affolter M., Grass L., Vanrobaeys F., Casado B., Kussmann M. Qualitative and quantitative profiling of the bovine milk fat globule membrane proteome. J Proteomics 2010, 73:1079-1088.
25. Boehmer J.L., DeGrasse J.A., McFarland M.A., Tall E.A., Shefcheck K.J., Ward J.L., et al. The proteomic advantage: label-free quantification of proteins expressed in bovine milk during experimentally induced coliform mastitis. Vet Immunol Immunopathol 2010, 138:252-266.
26. Ham J.S., Han G.S., Jeong S.G., Seol K.H., Jang A.R., Oh M.H., et al. Determination of molecular weights of caprine milk proteins by matrix-assisted laser desorption/ionization mass spectrometry. J Dairy Sci 2012, 95:15-19.
27. Català-Clariana S., Benavente F., Giménez E., Barbosa J., Sanz-Nebot V. Identification of bioactive peptides in hypoallergenic infant milk formulas by capillary electrophoresis-mass spectrometry. Anal Chim Acta 2010, 683:119-125.
28. Somma A., Ferranti P., Addeo F., Mauriello R., Chianese L. Peptidomic approach based on combined capillary isoelectric focusing and mass spectrometry for the characterization of the plasmin primary products from bovine and water buffalo β-casein. J Chromatogr A 2008, 1192:294-300.
29. Lecoeur M., Gareil P., Varenne A. Separation and quantitation of milk whey proteins of close isoelectric points by on-line capillary isoelectric focusing-electrospray ionization mass spectrometry in glycerol-water media. J Chromatogr A 2010, 1217:7293-7301.
30. Mu{double acute}ller L., Bartak P., Bednář P., Fryšová I., Ševčík J., Lemr K. Capillary electrophoresis-mass spectrometry-a fast and reliable tool for the monitoring of milk adulteration. Electrophoresis 2008, 29:2088-2093.
31. Wilson N.L., Robinson L.J., Donnet A., Bovetto L., Packer N.H., Karlsson N.G. Glycoproteomics of milk: differences in sugar epitopes on human and bovine milk fat globule membranes. J Proteome Res 2008, 7:3687-3696.
32. Tao N., DePeters E., Freeman S., German J., Grimm R., Lebrilla C. Bovine milk glycome. J Dairy Sci 2008, 91:3768-3778.
33. Nwosu C.C., Aldredge D.L., Lee H., Lerno L.A., Zivkovic A.M., German J.B., et al. Comparison of the human and bovine milk N-glycome via high-performance microfluidic chip liquid chromatography and tandem mass spectrometry. J Proteome Res 2012, 10.1021/pr300008u.
34. Takimori S., Shimaoka H., Furukawa J.I., Yamashita T., Amano M., Fujitani N., et al. Alteration of the N-glycome of bovine milk glycoproteins during early lactation. FEBS J 2011, 10.1111/j.1742-4658.2011.08299.x.
35. Fadiel A., Anidi I., Eichenbaum K.D. Farm animal genomics and informatics: an update. Nucleic Acids Res 2005, 33:6308-6318.
36. Cunsolo V., Muccilli V., Saletti R., Foti S. Applications of mass spectrometry techniques in the investigation of milk proteome. Eur J Mass Spectrom (Chichester, Eng) 2011, 17(4):305-320.
37. Ginger M.R., Grigor M.R. Comparative aspects of milk caseins. Comp Biochem Physiol B Biochem Mol Biol 1999, 124:133-145.
38. Nora K., Denis S. Shift in the isoelectric-point of milk proteins as a consequence of adaptive divergence between the milks of mammalian species. Biol Direct Jul. 29 2011, 6:40.
39. Casado B., Affolter M., Kussmann M. OMICS-rooted studies of milk proteins, oligosaccharides and lipids. J Proteomics 2009, 73:196-208.
40. Minkiewicz P., Dziuba J., Iwaniak A., Dziuba M., Darewicz M. Biopep database and other programs for processing bioactive peptide sequences. J AOAC Int 2008, 91:965-980.
41. D'Alessandro A., Zolla L., Scaloni A. The bovine milk proteome: cherishing, nourishing and fostering molecular complexity. An interactomics and functional overview. Mol Biosyst 2011, 7:579-597.
42. Barabási A.L., Oltvai Z.N. Network biology: understanding the cell's functional organization. Nat Rev Genet 2004, 5:101-113.
43. Lemay D.G., Lynn D.J., Martin W.F., Neville M.C., Casey T.M., Rincon G., et al. The bovine lactation genome: insights into the evolution of mammalian milk. Genome Biol 2009, 10:R43.
44. Ibeagha-Awemu E.M., Ibeagha A.E., Messier S., Zhao X. Proteomics, genomics and pathway analyses of E. coli and S. aureus infected milk whey reveal molecular pathways and networks involved in mastitis. J Proteome Res Sep. 3 2010, 9(9):4604-4619.
45. Lönnerdal B. Nutritional and physiologic significance of human milk proteins. Am J Clin Nutr 2003, 77:1537S-1543S.
46. Malacarne M., Martuzzi F., Summer A., Mariani P. Protein and fat composition of mare's milk: some nutritional remarks with reference to human and cow's milk. Int Dairy J 2002, 12:869-877.
47. Guo H., Pang K., Zhang X., Zhao L., Chen S., Dong M., et al. Composition, physiochemical properties, nitrogen fraction distribution, and amino acid profile of donkey milk. J Dairy Sci 2007, 90:1635-1643.
48. Frederiksen P., Andersen K., Hammershøj M., Poulsen H., Sørensen J., Bakman M., et al. Composition and effect of blending of noncoagulating, poorly coagulating, and well-coagulating bovine milk from individual Danish Holstein cows. J Dairy Sci 2011, 94:4787-4799.
49. Bramanti E., Sortino C., Onor M., Beni F., Raspi G. Separation and determination of denatured αs1-, αs2-, β- and κ-caseins by hydrophobic interaction chromatography in cows', ewes' and goats' milk, milk mixtures and cheeses. J Chromatogr A 2003, 994:59-74.
50. Miranda G., Mahé M.F., Leroux C., Martin P. Proteomic tools to characterize the protein fraction of Equidae milk. Proteomics 2004, 4:2496-2509.
51. D'auria E., Agostoni C., Giovannini M., Riva E., Zetterström R., Fortin R., et al. Proteomic evaluation of milk from different mammalian species as a substitute for breast milk. Acta Paediatr 2005, 94:1708-1713.
52. Holland J.W., Deeth H.C., Alewood P.F. Proteomic analysis of κ-casein micro-heterogeneity. Proteomics 2004, 4:743-752.
53. Holland J.W., Deeth H.C., Alewood P.F. Analysis of O-glycosylation site occupancy in bovine κ-casein glycoforms separated by two-dimensional gel electrophoresis. Proteomics 2005, 5:990-1002.
54. Brophy B., Smolenski G., Wheeler T., Wells D., L'Huillier P., Laible G. Cloned transgenic cattle produce milk with higher levels of bold beta-casein and kappa-casein. Nat Biotechnol 2003, 21:157-162.
55. Waterhouse A.M., Procter J.B., Martin D.M.A., Clamp M., Barton G.J. Jalview Version 2-a multiple sequence alignment editor and analysis workbench. Bioinformatics 2009, 25:1189-1191.
56. Ciavardelli D., Sacchetta P., Federici G., Di Ilio C., Urbani A. Protein phosphorylation stoichiometry by simultaneous ICP-QMS determination of phosphorus and sulfur oxide ions: a multivariate optimization of plasma operating conditions. Talanta 2010, 80:1513-1525.
57. Matéos A., Miclo L., Mollé D., Dary A., Girardet J.M., Gaillard J.L. Equine [alpha] S1-casein: Characterization of alternative splicing isoforms and determination of phosphorylation levels. J Dairy Sci 2009, 92:3604-3615.
58. Matéos A., Girardet J.M., Mollé D., Corbier C., Gaillard J.L., Miclo L. Identification of phosphorylation sites of equine β-casein isoforms. Rapid Commun Mass Spectrom 2010, 24:1533-1542.
59. Cunsolo V., Cairone E., Saletti R., Muccilli V., Foti S. Sequence and phosphorylation level determination of two donkey β-caseins by mass spectrometry. Rapid Commun Mass Spectrom 2009, 23:1907-1916.
60. Ferranti P., Scaloni A., Caira S., Chianese L., Malorni A., Addeo F. The primary structure of water buffalo α s1-and β-casein: identification of phosphorylation sites and characterization of a novel β-casein variant. J Protein Chem 1998, 17:835-844.
61. Fox P.F. Advanced dairy chemistry: proteins 2003, Elsevier.
62. Amigo L., Recio I., Ramos M. Genetic polymorphism of ovine milk proteins: its influence on technological properties of milk-a review. Int Dairy J 2000, 10:135-149.
63. Clark S., Sherbon J. Genetic variants of alphas1-CN in goat milk: breed distribution and associations with milk composition and coagulation properties. Small Rumin Res 2000, 38:135-143.
64. Greppi G., Roncada P., Fortin R. Protein components of goat's milk. Dairy goats feeding and nutrition 2008, 2:71-94.
65. Atkinson S.A., Lönnerdal B. Protein and non-protein nitrogen in human milk 1989, CRC Press.
66. Ochirkhuyag B., Chobert J.M., Dalgalarrondo M., Haertlé T. Characterization of mare caseins. Identification of-and-caseins. Lait 2000, 80:223-235.
67. Egito A., Miclo L., Lopez C., Adam A., Girardet J.M., Gaillard J.L. Separation and characterization of mares' milk αs1-, β-, κ-caseins, γ-casein-like, and proteose peptone component 5-like peptides. J Dairy Sci 2002, 85:697-706.
68. Ono T., Creamer L. Structure of goat casein micelles. N Z J Dairy Sci Technol 1986, 21:57-64.
69. Ono T., Kohno H., Odagiri S., Takagi T. Subunit components of casein micelles from bovine, ovine, caprine and equine milks. J Dairy Res 1989, 56:61-68.
70. Patel R., Mistry V. Physicochemical and structural properties of ultrafiltered buffalo milk and milk powder1. J Dairy Sci 1997, 80:812-817.
71. Attia H., Kherouatou N., Nasri M., Khorchani T. Characterization of the dromedary milk casein micelle and study of its changes during acidification. Lait 2000, 80:503-515.
72. Welsch U., Schumacher U., Buchheim W., Schinko I., Jenness P., Patton S. Histochemical and biochemical observations on milk-fat-globule membranes from several mammalian species. Acta Histochem Suppl 1990, 40:59.
73. Buchheim W., Lund S., Scholtissek J. Vergleichende Untersuchungen zur Struktur und Grösse von Caseinmicellen in der Milch verschiedener Species. Kieler Milchw Forsch 1989, 41:253-265.
74. Chianese L., Calabrese M.G., Ferranti P., Mauriello R., Garro G., De Simone C., et al. Proteomic characterization of donkey milk "caseome". J Chromatogr A 2010, 1217:4834-4840.
75. Heid H.W., Keenan T.W. Intracellular origin and secretion of milk fat globules. Eur J Cell Biol 2005, 84:245-258.
76. Mather I.H., Keenan T.W. Origin and secretion of milk lipids. J Mammary Gland Biol Neoplasia 1998, 3:259-273.
77. Fortunato D., Giuffrida M.G., Cavaletto M., Garoffo L.P., Dellavalle G., Napolitano L., et al. Structural proteome of human colostral fat globule membrane proteins. Proteomics 2003, 3:897-905.
78. Mather I.H. A review and proposed nomenclature for major proteins of the milk-fat globule membrane. J Dairy Sci 2000, 83:203-247.
79. Gu S., Chen J., Dobos K.M., Bradbury E.M., Belisle J.T., Chen X. Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol Cell Proteomics 2003, 2:1284-1296.
80. Peirce M.J., Wait R., Begum S., Saklatvala J., Cope A.P. Expression profiling of lymphocyte plasma membrane proteins. Mol Cell Proteomics 2004, 3:56-65.
81. Murgiano L., Timperio A.M., Zolla L., Bongiorni S., Valentini A., Pariset L. Comparison of milk fat globule membrane (MFGM) proteins of Chianina and Holstein cattle breed milk samples through proteomics methods. Nutrients 2009, 1:302-315.
82. Cebo C., Caillat H., Bouvier F., Martin P. Major proteins of the goat milk fat globule membrane. J Dairy Sci 2010, 93:868-876.
83. Spertino S., Cipriani V., De Angelis C., Giuffrida M.G., Marsano F., Cavaletto M. Proteome profile and biological activity of caprine, bovine and human milk fat globules. Mol Biosyst 2012, 8(4):967-974.
84. Senda A., Fukuda K., Ishii T., Urashima T. Changes in the bovine whey proteome during the early lactation period. Anim Sci J 2011, 82(5):698-706.
85. Cunsolo V., Saletti R., Muccilli V., Foti S. Characterization of the protein profile of donkey's milk whey fraction. J Mass Spectrom 2007, 42:1162-1174.
86. Criscione A., Cunsolo V., Bordonaro S., Guastella A.M., Saletti R., Zuccaro A., et al. Donkeys' milk protein fraction investigated by electrophoretic methods and mass spectrometric analysis. Int Dairy J 2009, 19:190-197.
87. Buffoni J.N., Bonizzi I., Paciullo A., Ramunno L., Feligini M. Characterization of the major whey proteins from milk of Mediterranean water buffalo (Bubalus bubalis). Food Chem 2011, 127:1515-1520.
88. Fox P., Kelly A. Indigenous enzymes in milk: overview and historical aspects-Part 1. Int Dairy J 2006, 16:500-516.
89. Lorenz H., Jäger C., Willems H., Baljer G. PCR detection of Coxiella burnetii from different clinical specimens, especially bovine milk, on the basis of DNA preparation with a silica matrix. Appl Environ Microbiol 1998, 64:4234-4237.
90. Millar D., Ford J., Sanderson J., Withey S., Tizard M., Doran T., et al. IS900 PCR to detect Mycobacterium paratuberculosis in retail supplies of whole pasteurized cows' milk in England and Wales. Appl Environ Microbiol 1996, 62:3446-3452.
91. Muramatsu Y., Yanase T., Okabayashi T., Ueno H., Morita C. Detection of Coxiella burnetii in cow's milk by PCR-enzyme-linked immunosorbent assay combined with a novel sample preparation method. Appl Environ Microbiol 1997, 63:2142-2146.
92. Kim C.H., Khan M., Morin D., Hurley W., Tripathy D., Kehrli M., et al. Optimization of the PCR for detection of Staphylococcus aureus nuc gene in bovine milk. J Dairy Sci 2001, 84:74-83.
93. Cai H.Y., Bell-Rogers P., Parker L., Prescott J.F. Development of a real-time PCR for detection of Mycoplasma bovis in bovine milk and lung samples. J Vet Diagn Invest 2005, 17:537.
94. Salgado M., Kruze J., Collins M.T. Diagnosis of paratuberculosis by fecal culture and ELISA on milk and serum samples in two types of Chilean dairy goat herds. J Vet Diagn Invest 2007, 19:99.
95. Cho D., Sung N., Collins M.T. Identification of proteins of potential diagnostic value for bovine paratuberculosis. Proteomics 2006, 6:5785-5794.
96. Matsushita T., Dinsmore R.P., Eberhart R.J., Jones G.M., McDonald J.S., Sears P.M., et al. Performance studies of an enzyme-linked immunosorbent assay for detecting Staphylococcus aureus antibody in bovine milk. J Vet Diagn Invest 1990, 2:163.
97. Eckersall P., Young F., McComb C., Hogarth C., Safi S., Fitzpatrick J., et al. Acute phase proteins in serum and milk from dairy cows with clinical mastitis. Vet Rec 2001, 148:35-41.
98. Grönlund U., Hultén C., Eckersall P.D., Hogarth C., Waller K.P. Haptoglobin and serum amyloid A in milk and serum during acute and chronic experimentally induced Staphylococcus aureus mastitis. J Dairy Res 2003, 70:379-386.
99. Zeng R., Bequette B., Vinyard B., Bannerman D. Determination of milk and blood concentrations of lipopolysaccharide-binding protein in cows with naturally acquired subclinical and clinical mastitis. J Dairy Sci 2009, 92:980-989.
100. Tabrizi A.D., Batavani R., Rezaei S.A., Ahmadi M. Fibrinogen and ceruloplasmin in plasma and milk from dairy cows with subclinical and clinical mastitis. Pak J Biol Sci 2008, 11:571.
101. De Mol R., Ouweltjes W. Detection model for mastitis in cows milked in an automatic milking system. Prev Vet Med 2001, 49:71-82.
102. Kamphuis C., Sherlock R., Jago J., Mein G., Hogeveen H. Automatic detection of clinical mastitis is improved by in-line monitoring of somatic cell count. J Dairy Sci 2008, 91:4560-4570.
103. Chagunda M., Friggens N., Rasmussen M.D., Larsen T. A model for detection of individual cow mastitis based on an indicator measured in milk. J Dairy Sci 2006, 89:2980-2998.
104. Friggens N., Chagunda M., Bjerring M., Ridder C., Hojsgaard S., Larsen T. Estimating degree of mastitis from time-series measurements in milk: a test of a model based on lactate dehydrogenase measurements. J Dairy Sci 2007, 90:5415-5427.
105. Hogarth C.J., Fitzpatrick J.L., Nolan A.M., Young F.J., Pitt A., Eckersall P.D. Differential protein composition of bovine whey: a comparison of whey from healthy animals and from those with clinical mastitis. Proteomics 2004, 4:2094-2100.
106. Danielsen M., Codrea M.C., Ingvartsen K.L., Friggens N.C., Bendixen E., Røntved C.M. Quantitative milk proteomics-host responses to lipopolysaccharide-mediated inflammation of bovine mammary gland. Proteomics 2010, 10:2240-2249.
107. Smolenski G., Haines S., Fiona Y.S.K., Bond J., Farr V., Davis S.R., et al. Characterisation of host defence proteins in milk using a proteomic approach. J Proteome Res 2007, 6:207-215.
108. Baeker R., Haebel S., Schlatterer K., Schlatterer B. Lipocalin-type prostaglandin D synthase in milk: a new biomarker for bovine mastitis. Prostaglandins Other Lipid Mediat 2002, 67:75-88.
109. Barrio M.B., Rainard P., Poutrel B. Milk complement and the opsonophagocytosis and killing of Staphylococcus aureus mastitis isolates by bovine neutrophils. Microb Pathog 2003, 34:1-9.
110. Pakkanen R., Aalto J. Growth factors and antimicrobial factors of bovine colostrum. Int Dairy J 1997, 7:285-297.
111. Chianese L., Caira S., Ferranti P., Laezza P., Malorni A., Mucchetti G., et al. The oligopeptides of sweet and acid cheese whey. Lait 1997, 77:699-715.
112. Korhonen H., Pihlanto A. Bioactive peptides: production and functionality. Int Dairy J 2006, 16:945-960.
113. Kilara A., Panyam D. Peptides from milk proteins and their properties. Crit Rev Food Sci Nutr 2003, 43:607-633.
114. Fitzgerald R.J., Murray B.A. Bioactive peptides and lactic fermentations. Int J Dairy Technol 2006, 59:118-125.
115. Gobbetti M., Stepaniak L., De Angelis M., Corsetti A., Di Cagno R. Latent bioactive peptides in milk proteins: proteolytic activation and significance in dairy processing. Crit Rev Food Sci Nutr 2002, 42:223-239.
116. Singh T., Fox P., Hojrup P., Healy A. A scheme for the fractionation of cheese nitrogen and identification of principal peptides. Int Dairy J 1994, 4:111-122.
117. Addeo F., Chianese L., Sacchi R., Musso S.S., Ferranti P., Malorni A. Characterization of the oligopeptides of Parmigiano-Reggiano cheese soluble in 120g trichloroacetic acid/l. J Dairy Res 1994, 61:365-374.
118. Addeo F., Chianese L., Salzano A., Sacchi R., Cappuccio U., Ferranti P., et al. Characterization of the 12% trichloroacetic acid-insoluble oligopeptides of Parmigiano-Reggiano cheese. J Dairy Res 1992, 59:401-411.
119. Ferranti P., Itolli E., Barone F., Malorni A., Garro G., Laezza P., et al. Combined high resolution chromatographic techniques (FPLC and HPLC) and mass spectrometry-based identification of peptides and proteins in Grana Padano cheese. Lait 1997, 77:683-697.
120. Panchaud A., Affolter M., Kussmann M. Mass spectrometry for nutritional peptidomics: how to analyze food bioactives and their health effects. J Proteomics 2011, http://dx.doi.org/10.1016/j.jprot.2011.12.022.
121. Iwaniak A., Dziuba J. BIOPEP-PBIL tool for the analysis of the structure of biologically active motifs derived from food proteins. Food Technol Biotechnol 2011, 49:118-127.
122. Nagpal R., Behare P., Rana R., Kumar A., Kumar M., Arora S., et al. Bioactive peptides derived from milk proteins and their health beneficial potentials: an update. Food Funct 2011, 2:18-27.
123. Antila P., Paakkari I., Järvinen A., Mattila M., Laukkanen M., Pihlanto-Leppälä A., et al. Opioid peptides derived from in-vitro proteolysis of bovine whey proteins. Int Dairy J 1991, 1:215-229.
124. Bellamy W., Takase M., Wakabayashi H., Kawase K., Tomita M. Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin. J Appl Microbiol 1992, 73:472-479.
125. FitzGerald R.J., Meisel H. Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme. Br J Nutr 2000, 84:33-37.
126. Pihlanto-Leppälä A. Bioactive peptides derived from bovine whey proteins: opioid and ace-inhibitory peptides. Trends Food Sci Technol 2000, 11:347-356.
127. Gill H.S., Doull F., Rutherfurd K., Cross M. Immunoregulatory peptides in bovine milk. Br J Nutr 2000, 84:111-117.
128. Park Y.W. Overview of bioactive components in milk and dairy products 2009, Wiley Online Library.
129. Hansen M., Sandström B., Jensen M., Sørensen S.S. Casein phosphopeptides improve zinc and calcium absorption from rice-based but not from whole-grain infant cereal. J Pediatr Gastroenterol Nutr 1997, 24:56.
130. Meisel H. Multifunctional peptides encrypted in milk proteins. Biofactors 2004, 21:55-61.
131. Patten G.S., Head R.J., Abeywardena M.Y. Effects of casoxin 4 on morphine inhibition of small animal intestinal contractility and gut transit in the mouse. Clin Exp Gastroenterol 2011, 4:23.
132. Phelan M., Kerins D. The potential role of milk-derived peptides in cardiovascular disease. Food Funct 2011, 2:153-167.
133. Nagpal R., Behare P., Rana R., Kumar A., Kumar M., Arora S., et al. Bioactive peptides derived from milk proteins and their health beneficial potentials: an update. Food Funct 2011, 2:18-27.
134. Marshall S.H., Arenas G. Antimicrobial peptides: a natural alternative to chemical antibiotics and a potential for applied biotechnology. Electron J Biotechnol 2003, 6:271-284.
135. Chiba H., Tani F., Yoshikawa M. Opioid antagonist peptides derived from b-casein. J Dairy Res 1989, 56:363-366.
136. Nakamura Y., Yamamoto N., Sakai K., Okubo A., Yamazaki S., Takano T. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci 1995, 78:777-783.
137. Jäkälä P., Vapaatalo H. Antihypertensive peptides from milk proteins. Pharmaceuticals 2010, 3:251-272.
138. Muro Urista C., Álvarez Fernández R., Riera Rodriguez F., Arana Cuenca A., Téllez Jurado A. Review: production and functionality of active peptides from milk. Food Sci Technol Int 2011, 17:293-317.
139. Jauhiainen T., Pilvi T., Cheng Z.J., Kautiainen H., Vapaatalo H., Korpela R., et al. Milk products containing bioactive tripeptides have an antihypertensive effect in double transgenic rats (dTGR) harbouring human renin and human angiotensinogen genes. J Nutr Metab 2009, 2010.
140. Kayser H., Meisel H. Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins. FEBS Lett 1996, 383:18-20.
141. Adamczyk E. Application of polymerase chain reaction for detection of goats' milk adulteration by milk of cow. J Dairy Res 2001, 68:333-336.
142. Maudet C., Taberlet P. Detection of cows' milk in goats' cheeses inferred from mitochondrial DNA polymorphism. J Dairy Res 2001, 68:229-235.
143. Lopez-Calleja I., Gonzalez I., Fajardo V., Rodriguez M., Hernandez P., Garcia T., et al. Rapid detection of cows' milk in sheeps' and goats' milk by a species-specific polymerase chain reaction technique. J Dairy Sci 2004, 87:2839-2845.
144. D'Ambrosio C., Arena S., Salzano A.M., Renzone G., Ledda L., Scaloni A. A proteomic characterization of water buffalo milk fractions describing PTM of major species and the identification of minor components involved in nutrient delivery and defense against pathogens. Proteomics 2008, 8:3657-3666.
145. Cuollo M., Caira S., Fierro O., Pinto G., Picariello G., Addeo F. Toward milk speciation through the monitoring of casein proteotypic peptides. Rapid Commun Mass Spectrom 2010, 24:1687-1696.
146. Arena S., Renzone G., Novi G., Paffetti A., Bernardini G., Santucci A., et al. Modern proteomic methodologies for the characterization of lactosylation protein targets in milk. Proteomics 2010, 10:3414-3434.
147. Arena S., Renzone G., Novi G., Scaloni A. Redox proteomics of fat globules unveils broad protein lactosylation and compositional changes in milk samples subjected to various technological procedures. J Proteomics 2011, 74:2453-2475.
148. Pinto G., Caira S., Cuollo M., Fierro O., Nicolai M.A., Chianese L., et al. Lactosylated casein phosphopeptides as specific indicators of heated milks. Anal Bioanal Chem 2012, 402:1961-1972.
149. Holland J.W., Gupta R., Deeth H.C., Alewood P.F. Proteomic analysis of temperature-dependent changes in stored UHT milk. J Agric Food Chem 2011, 59:1837-1846.
150. Champomier-Verges M.C., Maguin E., Mistou M.Y., Anglade P., Chich J.F. Lactic acid bacteria and proteomics: current knowledge and perspectives. J Chromatogr B Analyt Technol Biomed Life Sci 2002, 771:329-342.
151. Manso M., Leonil J., Jan G., Gagnaire V. Application of proteomics to the characterisation of milk and dairy products. Int Dairy J 2005, 15:845-855.
152. Gagnaire V., Piot M., Camier B., Vissers J.P.C., Jan G., Leonil J. Survey of bacterial proteins released in cheese: a proteomic approach. Int J Food Microbiol 2004, 94:185-201.
153. Fox P.F., McSweeney P.L.H. Proteolysis in cheese during ripening. Food Rev Int 1996, 12:457-509.
154. Belitz H.D., Kaiser K.P. Monitoring cheddar cheese ripening by chemical indices of proteolysis. 3. Identification of several high-molecular mass peptides. Z Lebensm Unters Forsch 1993, 197:118-122.
155. Addeo F., Garro G., Intorcia N., Pellegrino L., Resmini P., Chianese L. Gel electrophoresis and immunoblotting for the detection of casein proteolysis in cheese. J Dairy Res 1995, 62:297-309.
156. Ferranti P., Barone F., Chianese L., Addeo F., Scaloni A., Pellegrino L., et al. Phosphopeptides from Grana Padano cheese: nature, origin and changes during ripening. J Dairy Res 1997, 64:601-615.
157. Sforza S., Ferroni L., Galaverna G., Dossena A., Marchelli R. Extraction, semi-quantification, and fast on-line identification of oligopeptides in Grana Padano cheese by HPLC-MS. J Agric Food Chem 2003, 51:2130-2135.
158. Gaiaschi A., Beretta B., Poiesi C., Conti A., Giuffrida M.G., Galli C.L., et al. Proteolysis of alphas-casein as a marker of Grana Padano cheese ripening. J Dairy Sci 2000, 83:2733-2739.
159. Gaiaschi A., Beretta B., Poiesi C., Conti A., Giuffrida M.G., Galli C.L., et al. Proteolysis of beta-casein as a marker of Grana Padano cheese ripening. J Dairy Sci 2001, 84:60-65.
160. Sforza S., Galaverna G., Dossena A., Marchelli R., Neviani E., Pinelli C. Study of the oligopeptide fraction in Grana Padano and Parmigiano-Reggiano cheeses by liquid chromatography electrospray ionization mass spectrometry. Eur J Mass Spectrom (Chichester, Eng) 2004, 10:421-427.
161. Lund M., Ardo Y. Purification and identification of water-soluble phosphopeptides from cheese using Fe(III) affinity chromatography and mass spectrometry. J Agric Food Chem 2004, 52:6616-6622.
162. Gagnaire V., Piot M., Camier B., Vissers J.P., Jan G., Leonil J. Survey of bacterial proteins released in cheese: a proteomic approach. Int J Food Microbiol 2004, 94:185-201.
163. Pessione A., Lamberti C., Pessione E. Proteomics as a tool for studying energy metabolism in lactic acid bacteria. Mol Biosyst 2010, 6:1419-1430.
164. Champomier-Verges M.C., Maguin E., Mistou M.Y., Anglade P., Chich J.F. Lactic acid bacteria and proteomics: current knowledge and perspectives. J Chromatogr B Analyt Technol Biomed Life Sci 2002, 771:329-342.
165. Herve-Jimenez L., Guillouard I., Guedon E., Gautier C., Boudebbouze S., Hols P., et al. Physiology of Streptococcus thermophilus during the late stage of milk fermentation with special regard to sulfur amino-acid metabolism. Proteomics 2008, 8:4273-4286.
166. Streit F., Delettre J., Corrieu G., Beal C. Acid adaptation of Lactobacillus delbrueckii subsp. bulgaricus induces physiological responses at membrane and cytosolic levels that improves cryotolerance. J Appl Microbiol 2008, 105:1071-1080.
167. Guarino C., Fuselli F., La Mantia A., Longo L., Faberi A., Marianella R.M. Peptidomic approach, based on liquid chromatography/electrospray ionization tandem mass spectrometry, for detecting sheep's milk in goat's and cow's cheeses. Rapid Commun Mass Spectrom 2010, 24:705-713.
168. Saz J.M., Marina M.L. High performance liquid chromatography and capillary electrophoresis in the analysis of soybean proteins and peptides in foodstuffs. J Sep Sci 2007, 30:431-451.
169. Meyer B., Al-Diab D., Vollmer G., Pischetsrieder M. Mapping the glycoxidation product Nε-carboxymethyllysine in the milk proteome. Proteomics 2011, 11:420-428.