Antimicrobial peptides: A natural alternative to chemical antibiotics andapotential for applied biotechnology

Electronic Journal of Biotechnology

Volumn 6, Issue 3, 2003, Pages 96-109

  Marshall, Sergio H ^a   Arenas, Gloria ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO   (Chile)

Author keywords

Applied biotechnology; Innate response; Natural antibiotics

Indexed keywords

4 HYDROXYCINNAMALDEHYDE; ANDROCTONIN; ANTIMICROBIAL CATIONIC PEPTIDE; BACTERIOCIN; BREVININ; BUFORIN; CATHELICIDIN; CECROPIN; DEFENSIN; DERMASEPTIN; DERMICIDIN; ENKELYTIN; HISTATIN; HISTONE H2B; LACTOFERRICIN C; MAGAININ DERIVATIVE; N ALANYL 5 S GLUTATHIONYL 3,4 DIHYDROXYPHENYLALANINE; NATURAL PRODUCT; NISIN; PARASIN; PEDIOCIN; PEPTIDE B; PROTEGRIN; PROTEIN MIAMP2C; SAKACIN; TACHYPLESIN; THANATIN; THIONINE; THROMBOCIDIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; BIOTECHNOLOGY; EUKARYOTE; PROKARYOTE; PROTEIN ANALYSIS; PROTEIN ISOLATION; PROTEIN PROCESSING; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; REVIEW;

ANIMALIA; EUKARYOTA; INVERTEBRATA; PROKARYOTA; VERTEBRATA;

EID: 3042781052     PISSN: 07173458     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (128)

1. ADEREM, A. and ULEVITCH, R. Toll-like receptors in the induction of the innate immune response. Nature, 2000,vol. 406, no. 6797, p. 782-787.
2. AKIRA, S.; TAKEDA, K. and KAICHO, T. Toll-like receptors: Critical proteins linking innate and acquired immunity. Nature Immunology, 2001, vol. 2, no. 8, p. 675-680.
3. AKIYAMA, N.; HIJIKATA, M.; KOBAYASHI, A.; YAMORI, T.; TSURUO, T. and NATORI, S. Anti-tumor effect of N-beta-alanyl-5-S-glutathionyl dihydroxyphenylalanine (5-S-GAD), a novel anti-bacterial substance from an insect. Anticancer Research, 2000, vol. 20, no. 1A, p. 357-362.
4. ANDERSEN, J.; OSBAKK, S.; VORLAND, L.; TRAAVIK, T. and GUTTEBERG, T. Lactoferrin and cyclic lactoferricin inhibit the entry of human cytomegalovirus into human fibroblasts. Antiviral Research, 2001, vol. 51, no. 2, p. 141-149.
5. ANDREU, D. and RIVAS, L. Animal antimicrobial peptides: an overview. Biopolymers, 1998, vol. 47, no. 6, p. 415-433.
6. BALS, R. Epithelial antimicrobial peptides in host defence against infection (Review). Respiratory Research, 2000, vol. 1, no. 3, p. 141-150.
7. BECHINGER, B.; ZASLOFF, M. and OPELLA, S.J. Structure and orientation of the antibiotic peptide magainin in membranes by solid-state nuclear magnetic resonance spectroscopy. Protein Sciences, 1993, vol. 2, no. 12, p. 2077-2084.
8. BOHLMANN, H. The role of thionins in the resistance of plants. In: DATTA, S.K., MUTHUKRISHNAN, S. eds. Pathogenesis-related proteins in plants, CRC Press, 1999, p. 207-234.
9. BOMAN, H. Gene-encoded peptide antibiotics and the concept of innate immunity: an update review. Scandinavian Journal Immunology, 1998, vol. 48, no. 1, p. 15-25.
10. BOMAN, H. Peptide antibiotics ant their role in innate immunity. Annual Review of Immunology, 1995, vol. 13, p. 61-92.
11. BROEKAERT, W.; CAMMUE, B.; DE BOLLE, M.; THEVISSEN, K.; DE SAMBLANX, G. and OSBORN, R. Antimicrobial peptides from plants. Critical Reviews in Plant Sciences, 1997, vol. 16, no. 3, p. 297-323.
12. BROEKAERT, W.; MARIEN, W.; TERRAS, F.; DE BOLLE, M.; PROOST, P.; VAN DAMME, J.; DILLEN, L.; CLAEYS, M.; REES, S. and VANDERLEYDEN, J. Antimicrobial peptides from Amaranthus caudatus seeds with sequence homology to the cysteine/glycine-rich domain of chitin-binding proteins. Biochemistry, 1992, vol. 31, no. 17, p. 4308-4314.
13. BROGDEN, K.; DE LUCCA, A.; BLAND, J. and ELLIOTT, S. Isolation of an ovine pulmonary surfactant-associated anionic peptide bactericidal for Pasteurella haemolytica. Proceeding National Academy of Sciences USA, 1996, vol. 93, no. 1, p. 412-416.
14. BŠCKHED, F.; SŠDERHŠLL, M.; EKMAN, P.; NORMARK, S. and RICHTER-DAHLFORS, A. Induction of innate immune responses by E. coli and purified LPS correlate to organ- and cell-specific expression of Toll-like receptors within the human urinary tract. Cellular Microbiology, vol. 5. In press, 2003.
15. BULET, P.; HETRU, C.; DIMARCQ, J. and HOFFMANN, D. Antimicrobial peptides in insects; structure and function. Developmental Comparative Immunology, 1999, vol. 23, no. 4-5, p. 329-344.
16. CHAKRABARTI, A.; GANAPATHI, T.R.; MUKHERJEE, P.K. and BAPAT, V.A. MSI-99, a magainin analogue, imparts enhanced disease resistance in transgenic tobacco and banana. Planta, 2003, vol. 216, no. 4, p. 587-596.
17. CHERNYSH, S.; KIM, S.I.; BECKEER, G.; PLESKACH, V.A.; FILATOVA, N.A.; ANIKIN, V.B.; PLATONOV, V.G. and BULET, P. Antiviral and antitumor peptides from insects. Proceedings of the National Academy of Science USA, 2002, vol. 99, no. 20, p. 12628-12632.
18. CHINCHAR, V.G.; WANG, J.; MURTI, G.; CAREY, C. and ROLLINS-SMITH, L. Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin. Virology, 2001, vol. 288, p. 351-357.
19. COLE, A.M.; DAROUICHE, R.O.; LEGARDA, D.; CONNELL, N. and DIAMON, G. Characterization of a fish antimicrobial peptide: gene expression subcellular localization and spectrum of activity. Antimicrobial Agents Chemotherapy, 2000, vol. 44, no. 8, p. 2039-2045.
20. COLE, A.M.; LIAO, H.I.; GANZ, T. and YANG, O.O. Antibacterial activity of peptides derived from envelope glycoproteins of HIV-1. FEBS Letters, 2003, vol. 535, no. 1-3, p. 195-199.
21. COM, E.; BOURGEON, F.; EVRARD, B.; GANZ, T.; COLLEU, D.; JEGOU, B. and PINEAU, C. Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans. Biology of Reproduction, 2003, vol. 68, p. 95-104.
22. CUDIC, M.; CONDIE, B.A.; WEINER, D.J.; LYSENKO, E.S.; XIANG, Z.Q.; INSUG, O.; BULET, P. and OTVOS, JR. L. Development of novel antibacterial peptides that kill resistant isolates. Peptides, vol. 24. In press, 2003.
23. CUDIC, M. and OTVOS, JR. Intracellular targets of antibacterial peptides. Current Drug Targets, 2002, vol. 3, p. 101-106.
24. DANGL, J.L. and JONES, J. D. Plant pathogens and integrated defense responses to infection. Nature, 2001, vol. 411, no. 6839, p. 826-833.
25. DECKER, H.; RYAN, M.; JAENICKE, E. and TERWILLIGER N. SDS-induced phenoloxidase activity of hemocyanins from Limulus polyphemus, Eurypelma californicum, and Cancer magister. Journal of Biological Chemistry, 2001, vol. 276, no. 2, p. 17796-17799.
26. DE LUCCA, A.J. Antifungal peptides: potential candidates for the treatment of fungal infections. Expert Opinion on Investigational Drugs,2000, vol. 9, no. 2, p. 273-299.
27. DESTOUMIEUX-GARZON, D.; SAULNIER, D.; GARNIER, J.; JOUFFREY, C.; BULET, P. and BACHERE, E. Crustacean immunity. Antifungal peptides are generated from the C terminus of shrimp hemocyanin in response to microbial challenge. Journal of Biological Chemistry, 2001, vol. 276, no. 45, p. 47070-47077.
28. DIMARCQ, J.L.; BULET, P.; HEBRU, CH. and HOFFMANN, J. Cysteine-rich antimicrobial peptides in invertebrates. Biopolymers, 1998, vol. 47, p. 465-477.
29. ERNST, R.K.; GUINA, T. and MILLER, S.I. How intracellular bacteria survive: surface modifications that promote resistance to host innate immune responses. Journal of Infectious Diseases, 1999, vol. 179, no. suppl. 2, p. S326-30.
30. EZEKOWITZ, Alan and HOFFMANN, Jules. Innate Immunity. Humana Press, 2003. 410 p. ISBN 1588290468.
31. FALES-WILLIAMS, A.J.; GALLUP, J.M.; RAMIREZ-ROMERO, R.; BROGDEN, K.A. and ACKERMAN, M.R. Increased anionic peptide distribution and intensity during progression and resolution of bacterial pneumonia. Clinical Diagnostic Laboratory Immunology, 2002, vol. 9, no. 1, p. 28-32.
32. FEARON, D.T. Innate immunity-beginning to fulfil its promise? Nature Immunology, 2000, vol. 2, p. 102-103.
33. FIMLAND, G.; EIJSINK, V.G. and NISSEN-MEYER, J. Comparative studies of immunity proteins of pediocin-like bacteriocins. Microbiology, 2002, vol. 148, p. 3661-3670.
34. FOGACA, A.C.; DA SILVA, P.I. JR.; MIRANDA, M.T.; BIANCHI, A.G.; MIRANDA, A.; RIBOLLA, P.E.M. and DAFFRE, S. Antimicrobial activity of a bovine hemoglobin fragment in the tick Boophilus microp. Journal of Biological Chemistry, 1999, vol. 274, no. 36, p. 25330-25334.
35. FROHM, M.; GUNNE, H.; BERGMAN, A.C.; AGERBERTH, B.; BERGMAN, T.; BOMAN, A.; LIDEN, S.; JORNVALL, H. and BOMAN, H.G. Biochemical and antibacterial analysis of human wound and blister fluid. European Journal of Biochemistry, 1996, vol. 237, no. 1, p. 86-92.
36. GANZ, T. The role of hepcidin in iron sequestration during infections and in the pathogenesis of anemia of chronic disease. Israeli Medical Association Journal, 2002, vol. 4, no. 11, p. 1043-1045.
37. GAO, A.G.; HAKIMI, S.M.; MITTANCK, CA.; WU, Y.; WOERNER, B.M.; STARK, D.M.; SHAH, D.M.; LIANG, J. and ROMMENS, C.M. Fungal pathogen protection in potato by expression of a plant defensin peptide. Nature Biotechnology, 2000, vol. 18, no. 12, p. 1307-1310.
38. GARCIA-OLMEDO, F.; MOLINA, A. and ALAMILO, J.M. Plant defense peptides. Biopolymers, 1998, vol. 47, p. 479-491.
39. GENNARO, R. and ZANETTI, M. Structural features and biological activities of the cathelicidin-derived antimicrobial peptides. Biopolymers, 2000, vol. 55, no. 1, p. 31-49.
40. HANCOCK, R.E.W. Cationic antimicrobial peptides: towards clinical applications. Expert Opinion on Investigational Drugs, 2000, vol. 9, p. 1723-1729.
41. HANCOCK, R.E.W. and CHAPPLE, D.S. Peptide antibiotics (Minireview). Antimicrobial Agents Chemotherapy, 1999, vol. 43, no. 6, p. 1317-1323.
42. HANCOCK, R.E.W. and LEHRER, R. Cationic peptides: a new source of antibiotics. Trends in Biotechnology, 1998, vol. 16, p. 82-88.
43. HAUGHT, C.; DAVIS, G.D.; SUBRAMANIAN, R.; JACKSON, K.W. and HARRISON, R.G. Recombinant production and purification of novel antimicrobial peptide in Escherichia coli. Biotechnology and Bioengineering, 1998, vol. 57, no. 1, p. 55-61.
44. HIEMSTRA, P.S.; EISENHAUER, P.B.; HARWIG, S.S.; VAN DER BARSELAAR, M.T.; VAN BURTH, R. and LEHRER, R.I. Antimicrobial proteins of murine macrophages. Infection and Immunity, 1993, vol. 61, no. 7, p. 3038-3046.
45. HIRSH, J. Bactericidal action of histone. The Journal of Experimental Medicine, 1958, vol. 108, p. 925-944.
46. HOFFMANN, J.A. and REICHHART, J.M. Drosophila innate immunity: an evolutionary perspective. Nature Immunology, 2002, vol. 3, no. 2, p. 121-126.
47. HOFFMANN, J.A.; KAFATOS F.C.; JANEWAY C.A. and EZEKOWITZ R.A. Phylogenetic perspectives in innate immunity. Science, 1999, vol. 284, no. 5418, p. 1313-1318.
48. HONG, R.W.; SHCHEPETOV, M.; WEISER, J.N.; AXELSEN, P.H. Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A. Antimicrobial Agents and Chemotherapy, 2003, vol. 47, no. 1, p. 1-6.
49. HUBERT, F.; NEL, T. and ROCH, P. A member of the arthropod defensin family from edible mediterranean mussels (Mytilus galloprovincialis). European Journal of Biochemistry, 1996, vol. 240, no. 1, p. 302-306.
50. HULTMARK, D.; STEINER, H.; RASMUSON, T. and BOMAN, H.G. Insect immunity. Purification and properties of three inducible bactericidal proteins from hemolymph of immunized pupae of Hyalophora cecropia. European Journal of Biochemistry, 1980, vol. 106, no. 1, p. 7-16.
51. IWANAGA, S.; MUTA, T.; SHIGENAGA, T.; MIURA, Y.; SEKI, N.; SAITO, T. and KAWABATA, S. Role of hemocyte-derived granular components in invertebrate defense. Annals of the New York Academy of Sciences, 1994, vol. 712, p. 102-116.
52. JACK, R.W.; TAGG, J.R. and RAY, B. Bacteriocins of gram-positive bacteria. Microbiology Review, 1995, vol. 59, no. 2, p. 171-200.
53. JAMES C.; ROVERSI, P. and TAWFIK, D.S. Antibody multispecificity mediated by conformational diversity. Science, 2003, vol. 299, no. 5611, p. 1362-1367.
54. JONES, E.M.; SMART, A.; BLOOMBERG, G.; BURGESS, L. and MILLER, M.R. Lactoferricin, a new antimicrobial peptide. The Journal of Applied Bacteriology, 1994, vol. 77, no. 2, p. 208-214.
55. KOLTER, R. and MORENO F. Genetics of ribosomally synthesized peptide antibiotics. Annual Review of Microbiology, 1992, vol. 46, p. 141-163.
56. KRAGOL, G.; LOVAS, S.; VARADI, G.; CONDIE B.A.; HOFFMANN R. and OTVOS L. Jr. The antibacterial pyrrhocoricin inhibits the ATPase action of DnaK and prevents chaperone-assisted protein folding. Biochemistry, 2001, vol. 40, no. 10, p. 3016-3026.
57. KRIJGSVELD, J.; ZAAT, S.A.J.; MEELDIJK, J.; VAN VEELEN, P.A.; FANG, G.; POOLMAN, B.; BRANDT, E.; EHLERT, J.E.; KUIJPERS, A.J.; ENGBERS, G.H.M.; FEIJEN, J.; and DANKERT, J. Thrombocidins, microbicidal proteins from human blood platelets are C-terminal deletion products of CXC chemokines. Journal of Biological Chemistry, 2000, vol. 275, no. 27, p. 20374-20381.
58. LAI, R.; LIU, H.; HUI LEE, W. and ZHANG, Y. An anionic antimicrobial peptide from toad Bombina maxima. Biochemical and Biophysical Research Communications, 2002, vol. 295, no. 4, p. 796-799.
59. LAMBERTY, M.; ZACHARY, D.; LANOT, R.; BORDEREAU, C.; ROBERT, A.; HOFFMANN, J.A. and BULET, P. Insect immunity. constitutive expression of a cysteine-rich antifungal and a linear antibacterial peptide in termite insect. Journal of Biological Chemistry, 2001, vol. 276, no. 6, p. 4085-4092.
60. LAUTH, X.; SHIKE, H.; BURNS, J.C.; WESTERMAN, M.E.; OSTLAND, V.E.; CARLBERG, J.M.; VAN OLST, J.C.; NIZET, V.; TAYLOR, S.W.; SHIMIZU, C.H. and BULET, P. Discovery and characterization of two isoforms of moronecidins, a novel antimicrobial peptide from hybrid striped bass. Journal of Biological Chemistry, 2002, vol. 277, no. 7, p. 5030-5039.
61. LEEM, J.Y.; JEONG, I.L.; PARK, K.T. and PARK, H.Y. Isolation of p-hydroxycinnamaldehyde as an antibacterial substance from the saw fly, Acantholyda parki S. FEBS Letters, 1999, vol. 442, no. 1, p. 53-56.
62. LEEM, J.Y. Purification and characterization of N-alanyl-5-S- gluthathionyl-3,4-dihydroxyphenylalanine, a novel antibacterial substance of Sarcophaga peregrina (Flesh fly). Journal of Biological Chemistry, 1996, vol. 271, no. 23, p. 13573-13577.
63. LEHRER, R.I. and GANZ, T. Defensin of vertebrate animals. Current Opinion in Immunology, 2002, vol. 14, no. 1, p. 96-102.
64. LEMAITRE, C.; ORANGE, N.; SAGLIO, P.; SAINT, N.; GAGNON, J. and MOLLE, G. Characterization and ion channel activities of novel antibacterial proteins from the skin mucosa of carp (Cyprinus carpio). European Journal of Biochemistry, 1996, vol. 240, no. 1, p. 143-149.
65. LI,S.S.; GULLBO, J.; LINDHOLM, P.; LARSSON, R.; THUNBERG, E.; SAMUELSSON, G.; BOHLIN, L. and CLAESON, P. Ligatoxin B, a new cytotoxic protein with a novel helix-turn-helix DNA-binding domain from the mistletoe Phoradendron liga. Biochemistry Journal, 2002, vol. 366, no. 2, 405-413.
66. LIU, L.; ROBERTS, A.A. and GANZ, T. By IL-1 Signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. Journal of Immunology, 2003, vol. 170, no. 1, p. 575-580.
67. LIU, Y.; LUO, J.; XU, C.; REN, F.; PENG, C.; WU, G. and ZHAO, J. Purification, characterization, and molecular cloning of the gene of a seed-specific antimicrobial protein from pokeweed. Plant Physiology, 2000, vol. 122, no. 4, p. 1015-1024.
68. LÜDERS, T.; BIRKEMO, G.A.; FIMLAND, G.; NISSEN-MEYER, J. and NES, I.F. Strong synergy between a eukaryotic antimicrobial peptide and bacteriocins from lactic acid bacteria. Applied and Environmental Microbiology, 2003, vol. 69, no. 3, p. 1797-1799.
69. MAINOUS III, Arch and POMEROY, Claire. Management of Antimicrobials in Infectious Diseases. Humana Press, 2001. 349 p. ISBN 0-89603-821-1.
70. MANDARD, N.; BULET, P.; CAILLE, A.; DAFFRE, S. and VOVELLE, F. The solution structure of gomesin an antimicrobial cysteine-rich peptide from spider. European Journal of Biochemistry, 2002, vol. 269, no. 4, p. 1190-1198.
71. MANDARD, N.; SY, D.; MAUFRAIS, C.; BONMATIN J.M.; BULET, P.; HETRU, C. and VOVELLE, F. Androctonin, a novel antimicrobial peptide from scorpion Androctonus australis: solution structure and molecular dynamics simulations in the presence of a lipid monolayer. Journal of Biomolecular Structure and. Dynamics, 1999, vol. 17, no. 2, p. 367-380.
72. MARCUS, J.P.; GOULTER, K.C.; GREEN, J.L.; HARRISON, S.J. and MANNERS, J.M. Purification, characterisation and cDNA cloning of an antimicrobial peptide from Macadamia integrifolia. European Journal of Biochemistry, 1997, vol. 244, no. 3, p. 743-749.
73. MARTEMYANOV, K.A.; SHIROKOV, V.A.; KURNASOV, O.V.; GUDKOV, A.T. and SPIRIN, A.S. Cell-free production of biologically active polypeptides: Application to the synthesis of antibacterial peptide cecropin. Protein Expression and Purification, 2001, vol. 21, no. 3, p. 456-461.
74. MATSUZAKI, K. Why and how peptide-lipid interaction utilized for self defense? Magainins and tachyplesins as archetypes. Biochimica et Biophysca Acta, 1999, vol. 1462, no. 1-2, p. 1-10.
75. MITTA, G.; VANDENBULCKE, F.; HUBERT, F. and ROCH, P. Mussel defensins are synthesised and processed in granulocytes then released into the plasma after bacterial challenge. Journal of Cell Sciences, 1999, vol. 112, no. 23, p. 4233-4242.
76. MORASSUTTI, C.; DE AMICIS, F.; SKERLAVAJ, B.; ZANETTI, M. and MARCHETTI, S. Production of recombinant antimicrobial peptide in transgenic plants using a modified VMA intein expression system. FEBS Letters, 2002, vol. 519, no. 1-3, p. 141-146.
77. MUÑOZ, M.; VANDENBULCKE, F.; GUEGUEN, Y. and BACHÈRE, E. Expression of penaeidin antimicrobial peptides in early larval stages of the shrimp Penaeus vannamei. Developmental and Comparative Immunology, 2003, vol. 27, no. 4, p. 283-289.
78. MUÑOZ, M.; VANDENBULCKE, F.; SAULNIER, D.; and BACHÈRE, E. Expression and distribution of penaeidin antimicrobial peptides are regulated by haemocyte reactions in microbial challenged shrimp. European Journal of Biochemistry, 2002, vol. 269, no. 45, p. 2678-2689.
79. NAKAJIMA Y.; VAN DER GOES VAN NATERS-YASUI, A.; TAYLOR, D. and YAMAKAWA M. Two isoforms of a member of the arthropod defensin family from the soft tick, Ornithodoros moubata (Acari: Argasidae). Insect Biochemistry and Molecular Biology, 2001, vol. 31, no. 8, p. 747-751.
80. NATHAN, C. Catalytic antibody bridges innate and adaptive immunity. Science, 2002, vol. 298, no. 5601, p. 2143-2144.
81. NOVAK, R.; HENRIQUES, B.; CHARPENTIER, E.; NORMARK, S. and TUOMANEN, E. Emergence of vancomycin tolerance in Streptococcus pneumoniae. Nature, 1999, vol. 399, no. 6736, p. 590-591.
82. OSCÁRIZ, J.C. and PISABARRO, A.G. Classification and mode of action of membrane-active bacteriocins produced by gram-positive bacteria. International Microbiology, 2001, vol. 4, no. 1, p. 13-19.
83. OSUKY, M.; ZHOU, G.; OSUSKA, L.; HANCOCK, R.E.W.; KAY, W.W. and MISRA, S. Transgenic plants expressing cationic peptide chimeras exibit broad-spectrum resistance to phytopathogens. Nature Biotechnology, 2000, vol. 18, no. 11, p. 1162-1166.
84. OTVOS, L. Jr. Antibacterial peptides isolated from insects. Journal of Peptide Sciences, 2000, vol. 6, no. 10, p. 497-511.
85. PARK, C.J.; PARK, C.B.; HONG S.S.; LEE, H.S.; LEE, S.Y. and KIM, S.C. Characterization and cDNA cloning of two glycine-and histidin-rich antimicrobial peptides from the roots of shepherd's purse, Capsella bursa-pastor. Plant Molecular Biology, 2000, vol. 44, no. 2, p. 187-197.
86. PARK, I.Y. Parasin I, an antimicrobial peptide derived from histone H2A in the catfish, Parasilurus asotus. FEBS Letters, 1998, vol. 437, no.3, p. 258-262.
87. PARK, C.B.; KIM, H.S. and KIM, S.C. Mechanism of action of the antimicrobial peptide buforin II: buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions. Biochemical Biophysical Research Communication, 1998, vol. 244, no. 1, p. 253-257.
88. PARK, C.B.; KIM MS. and KIM S.C. A novel antimicrobial peptide from Bufo bufo gargarizans. Biochemical Biophysical Research Communications, 1996, vol. 218, no. 1, p. 408-413.
89. PATRZYKAT, A.; ZHANG, L.; MENDOZA, V.; IWAMA, G.K. and HANCOCK, R.E.W. Synergy of histone-derived peptides of coho salmon with lysozyme and flounder pleurodicin. Antimicrobial Agents Chemotherapy, 2001, vol. 45, no. 5, p. 1337-1342.
90. PESCHEL, A. How do bacteria resist human antimicrobial peptides? Trends in Microbiology, 2002, vol. 10, no. 4, p. 179-196.
91. POLLOCK, J.J.; DENPITIYA, L.; MACKAY, B.J. and IACONO, V.J. Fungistatic and fungicidal activity of human parotid salivary histidine-rich polypeptides on Candida albicans. Infection and Immunity, 1984, vol. 40, no. 3, p. 702-707.
92. PONTI, D.; MANGONI, M.L.; MIGNOGNA, G.; SIMMACO M. and BARRA D. An amphibian antimicrobial peptide variant expressed in Nicotiana tabacum confers resistance to phytopathogens. Biochemical Journal, 2003, vol. 15, no. 370, p. 121-127.
93. PUTSEP, K.; BRANDEN, C.I.; BOMAN, H.G. and NORMARK, S. Antibacterial peptide from Helicobacter pylori. Nature, 1999, vol. 398, no. 6729, p. 671-672.
94. RODER, B.L.; WANDALL, D.A.; FRIMODT-MOLLER, N.; ESPERSEN, F.; SKINHOJ, P. and ROSDAHL, V.T. Clinical features of Staphylococcus aureus endocarditis: a 10-year experience in Denmark. Archives Internal Medicine, 1999, vol. 159, no. 5, p. 462-469.
95. RECIO, I.; SLANGEN, C.J. and VISSER, S. Method for the production of antibacterial peptides from biological fluids at an ionic membrane. Application to the isolation of nisin and caprine lactoferricin. Internal Report, 2003, Department of Product Technology, NIZO food research, P.O. Box 20, 6710 BA eds., The Netherlands.
96. RUISSEN, A.L.A.; GROENINCK, J.; HELMERHORST, E.J.; WALGREEN-WETERINGS, E.; VAN'T HOF, W.; VEERMAN, E.C.I. and NIEUW AMERONGEN, A.V. Effects of Histatin 5 and derived peptides on Candida albicans. Biochemical Journal, 2001, vol. 356, no. 2, p. 361-368.
97. SAITOH, H.; KIBA, A.; NISHIHARA, M.; YAMAMURA, S.; SUZUKI, K. and TERAUCHI, R. Production of antimicrobial defensin in Nicotiana benthamiana with a potato virus X vector. Molecular Plant and Microbe Interactions, 2001, vol. 2, no. 1, p. 111-115.
98. SALZET, M. Vertebrate innate immunity resembles a mosaic of invertebrate immune responses. Trends in Immunology, 2001, vol. 22, no. 6, p. 285-288.
99. SALZET, M. and TASIEMSKI, A. Involvement of pro-enkephalin-derived peptides in immunity. Developmental and Comparative Immunology, 2001, vol. 25, no. 3, p. 177-185.
100. SCHIBLI, D.J.; EPAND, R.F.; VOGEL, A.J. and EPAND, R.M. Tryptophan-rich antimicrobial peptides: comparative properties and membrane interactions. Biochemistry and Cellular Biology, 2002, vol. 80, no. 5, p. 667-677.
101. SCHILLINGER, U.; GEISEN, R. and HOLZAPFEL, W.H. Potential of antagonistic microorganisms and bacteriocins for the biological preservation of food. Trends in Food Sciences and Technology, 1996, vol. 7, no. 5, p. 158-164.
102. SCHITTEK, B.; HIPFEL, R.; SAUER, B.; BAUER, J.; KALBACHER, H.; STEVANOVIC, S.; SCHIRLE, M.; SCHROEDER, K.; BLIN, N.; MEIER, F.; RASSNER, G. and GARBE, C. Dermcidin: a novel human antibiotic peptide secreted by sweat glands. Nature Immunology, 2001, vol. 2, no. 12, p. 1133-1137.
103. SEGURA, A.; MORENO, M.; MOLINA, A. and GARCÍA-OLMEDO, F. Novel defensin subfamily from spinach (Spinacia oleracea). FEBS Letters, 1998, vol. 435, no. 13, p. 159-162.
104. SELITRENNIKOFF, C.P. Antifungal proteins. Applied and Environmental Microbiology, 2001, vol. 67, no.7, p. 2883-2894.
105. SILVA, Jr.P.I.; DAFFRE, S. and BULET, P. Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. Journal of Biological Chemistry, 2000, vol. 275, no. 43, p. 33464-33470.
106. SIMMACO, M.; MIGNOGNA, G. and BARRA, D. Antimicrobial peptide from amphibian skin: What do they tell us? Biopolymers, 1998, vol. 47, no. 6, p. 435-450.
107. SIMON, L.; FREMAUX, C.; CENATIEMPO, Y. and BERJEAUD, J.M. Sakacin G, a new type of antilisterial bacteriocin. Applied and Environmental Microbiology, 2002, vol. 68, no. 12, p. 6416-6420.
108. SINGH, P.K.; PARSEK, M.R.; GREENBERG, E.P. and WELSH, M.J. A component of innate immunity prevents bacterial biofilm development. Nature, 2002, vol. 417, no. 6888, p. 552-555.
109. TAILOR, R.H.; ACLAND, D.P.; ATTENBOROUGH, S.; CAMMUE, B.P.; EVANS, I.J.; OSBORN, R.W.; RAY, J.A.; REES, S.B. and BROEKAERT, W.F. A novel family of small cysteine-rich antimicrobial peptides from seed of Impatiens balsamina is derived from a single precursor protein. Journal of Biological Chemistry, 1997, vol. 272, no. 39, p. 24480-24487.
110. TANAKA, K. P-I3 - kinase p85 is a target molecule of proline-rich antimicrobial peptide to suppress proliferation of ras - transformed cells. Japanese Journal of Cancer Research, 2001, vol. 92, no. 9, p. 959-967.
111. TANG, Y.Q.; YUANG, J.; OSAPAY, G.D.; OSAPAY, K.; TRAN, D.; MILLER, C.J.; OUELLETTE, A.J. and SELSTED, M.E. A cyclic antimicrobial peptide produces in primate leukocytes by the ligation of two truncated alpha-defensins. Science, 1999, vol. 286, no. 5439, p. 498-502.
112. THEVISSEN, K.; CAMMUE, B.; LEMAIRE, K.; WINDERICKX, J.; DICKSON, R.C.; LESTER, R.L.; FERKET, K.K.; VAN EVEN, F.; PARRET, A.H. and BROEKAERT, W. A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii). Proceedings of the National Academy of Science USA, 2000, vol. 97, no. 8, p. 9531-9536.
113. THEVISSEN, K.; TERRAS, F.R.G. and BROEKAERT, W.F. Permeabilization of fungal membranes by plant defensins inhibits fungal. Applied and Environmental Microbiology, 1999, vol. 65, no. 12, p. 5451-5458.
114. TOSSI, A. and SANDRI, L. Molecular diversity in gene-encoded, cationic antimicrobials polypeptides. Current Pharmaceutical Design, 2002, vol. 8, no. 9, p. 743-761.
115. TSAI, H. and BOBEK, L.A. Human salivary histatins: promising anti-fungal therapeutic agents. Critical Reviews in Oral Biology and Medicine, 1998, vol. 9, no. 4, p. 480-497.
116. TZOU, P.; REICHART, J.M. and LEMAITRE, B. Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants. Proceedings of the National Academy of Science USA, 2002, vol. 99, no. 4, p. 2152-2157.
117. UTENG, M.; HAUGE, H.H.; BRONDZ, I.; NISSEN-MEYER, J. and FIMLAND, G. Rapid two-step procedure for large-scale purification of Pediocin-like bacteriocins and other cationic antimicrobial peptides from complex culture medium. Applied and Environmental Microbiology, 2002, vol. 68, no. 2, p. 952-956.
118. VAN DER BIESEN, E.A. Quest for antimicrobial genes to engineer disease-resistant crops. Trends in Plant Sciences, 2001, vol. 6, no. 3, p. 89-91.
119. VIZIOLI, J. and SALZET, M. Antimicrobial peptides: new weapons to control parasitic infections? Trends in Parasitology, 2003, vol. 19, In press.
120. VIZIOLI, J., and SALZET, M. Antimicrobial peptides from animals: focus on invertebrates. Trends in Pharmacological Sciences, 2002, vol. 23, no. 11, p. 494-496.
121. VIZIOLI, J.; BULET, P.; HOFFMANN, J.A.; KAFATOS, F.C.; MÜLLER H.M. and DIMOPOULOS, G. Gambicin: a novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae. Proceedings of the National Academy of Science USA, 2001, vol. 98, no. 22, p. 12630-12635.
122. WANG, Y.; GRIFFITHS W.J.; CURSTEDT, T. and JOHANSSON, J. Porcine pulmonary surfactant preparations contain the antibacterial peptide prophenin and a C-terminal 18-residue fragment thereof. FEBS Letters, 1999, vol. 460, no. 2, p. 257-262.
123. WELLING, M.M.; PAULUSMA-ANNEMA, A.; BALTER, H.S.; PAUWELS, E.K. and NIBBERING, P.H. Tenehtium-99m labeled antimicrobial peptide discriminate between bacterial infection and sterile inflammations. European Journal of Nuclear Medicine, 2000, vol. 27, no. 3, p. 292-301.
124. YAMAUCHI, K. Biologically functional proteins of milk and peptides derived from milk proteins. Bulletin IDF, 1992, vol. 272, no. 1, p. 51-58.
125. ZASLOFF, M. Antimicrobial peptides of multicellular organisms. Nature, 2002, vol. 415, no. 6870, p. 389-395.
126. ZASLOFF, M. Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation characterization of two active forms, and partial cDNA sequence of a precursor. Proceeding of the National Academy of Sciences USA, 1987, vol. 84, no. 9, p. 5449-5453.
127. ZHENG, X.L. and ZHENG, A.L. Genomic organization and regulation of three cecropin genes in Anopheles gambiae. Insect Molecular Biology, 2002, vol. 11, no. 6, p. 517-525.
128. ZHOU, Q.J.; SHAO, J.Z. and XIANG, L.X. Progress in fish antibacterial peptide research. Progress in Biochemistry and Biophysics, 2002, vol. 29, no. 5, p. 682-685.