Proteomic characterization by 2-DE in bovine serum and whey from healthy and mastitis affected farm animals

Journal of Proteomics

Volumn 75, Issue 10, 2012, Pages 3015-3030

  Alonso Fauste, Idoia ^a   Andrés, Marta ^a   Iturralde, María ^a   Lampreave, Fermín ^a   Gallart, Javier ^b   Álava, María A ^a  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b Asociación Interprofesional Lechera de Aragón Zaragoza   (Spain)

Author keywords

2D electrophoresis; Acute phase proteins; Mastitis; Sera; Whey

Indexed keywords

BOVINE SERUM ALBUMIN; CASEIN; IMMUNOGLOBULIN; ISOPROTEIN; LACTOFERRIN; MILK PROTEIN; PEROXIREDOXIN 5;

ARTICLE; BIOLOGICAL ACTIVITY; BLOOD SAMPLING; CATTLE DISEASE; CONTROLLED STUDY; DOWN REGULATION; FARM ANIMAL; MAMMARY GLAND; MASTITIS; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEOMICS; TWO DIMENSIONAL ELECTROPHORESIS; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANIMALS, DOMESTIC; BLOOD CHEMICAL ANALYSIS; CATTLE; CLUSTER ANALYSIS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; HEALTH; MASS SPECTROMETRY; MASTITIS, BOVINE; MILK; MILK PROTEINS; MODELS, BIOLOGICAL; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

ANIMALIA; BOVINAE;

EID: 84861341390     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2011.11.035     Document Type: Article

References (95)

1. Dinarello C.A. Cytokines as endogenous pyrogens. J Infect Dis 1999, 179(Suppl. 2):S294-S304.
2. Gabay C., Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999, 340:448-454.
3. Kushner I. The phenomenon of the acute phase response. Ann N Y Acad Sci 1982, 389:39-48.
4. Schreiber G., Howlett G., Nagashima M., Millership A., Martin H., Urban J., et al. The acute phase response of plasma protein synthesis during experimental inflammation. J Biol Chem 1982, 257:10271-10277.
5. Sevaljevic L.M., Zunic G.D. Acute-phase protein synthesis in rats is influenced by alterations in plasma and muscle free amino acid pools related to lower plasma volume following trauma. J Nutr 1996, 126:3136-3142.
6. Thomas T., Schreiber G. Acute-phase response of plasma protein synthesis during experimental inflammation in neonatal rats. Inflammation 1985, 9:1-7.
7. Ceron J.J., Eckersall P.D., Martynez-Subiela S. Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet Clin Pathol 2005, 34:85-99.
8. Gruys E., Toussaint M.J., Upragarin N., Van E.A., Adewuyi A.A., Candiani D., et al. Acute phase reactants, challenge in the near future of animal production and veterinary medicine. J Zhejiang Univ Sci B 2005, 6:941-947.
9. Murata H., Shimada N., Yoshioka M. Current research on acute phase proteins in veterinary diagnosis: an overview. Vet J 2004, 168:28-40.
10. Petersen H.H., Nielsen J.P., Heegaard P.M. Application of acute phase protein measurements in veterinary clinical chemistry. Vet Res 2004, 35:163-187.
11. Conner J.G., Eckersall P.D., Wiseman A., Aitchison T.C., Douglas T.A. Bovine acute phase response following turpentine injection. Res Vet Sci 1988, 44:82-88.
12. Conner J.G., Eckersall P.D., Wiseman A., Bain R.K., Douglas T.A. Acute phase response in calves following infection with Pasteurella haemolytica, Ostertagia ostertagi and endotoxin administration. Res Vet Sci 1989, 47:203-207.
13. Eckersall P.D., Young F.J., Nolan A.M., Knight C.H., McComb C., Waterston M.M., et al. Acute phase proteins in bovine milk in an experimental model of Staphylococcus aureus subclinical mastitis. J Dairy Sci 2006, 89:1488-1501.
14. Ganheim C., Alenius S., Persson Waller K. Acute phase proteins as indicators of calf herd health. Vet J 2007, 173:645-651.
15. Glass E.J., Craigmile S.C., Springbett A., Preston P.M., Kirvar E., Wilkie G.M., et al. The protozoan parasite, Theileria annulata, induces a distinct acute phase protein response in cattle that is associated with pathology. Int J Parasitol 2003, 33:1409-1418.
16. Hirvonen J., Pyorala S., Jousimies-Somer H. Acute phase response in heifers with experimentally induced mastitis. J Dairy Res 1996, 63:351-360.
17. Pineiro M., Andres M., Iturralde M., Carmona S., Hirvonen J., Pyorala S., et al. ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4) is a new acute-phase protein isolated from cattle during experimental infection. Infect Immun 2004, 72:3777-3782.
18. Dayer E., Dayer J.M., Roux-Lombard P. Primer: the practical use of biological markers of rheumatic and systemic inflammatory diseases. Nat Clin Pract Rheumatol 2007, 3:512-520.
19. Kent J. Acute phase proteins: their use in veterinary diagnosis. Br Vet J 1992, 148:279-282.
20. Toussaint M.J.M., van Ederen A.M., Gruys E. Implication of clinical pathology in assessment of animal health and in animal production and meat inspection. Comp Haematol Int 1995, 5:149-157.
21. Hillerton J.E., Berry E.A. Treating mastitis in the cow-a tradition or an archaism. J Appl Microbiol 2005, 98:1250-1255.
22. Hirvonen J., Pyorala S., Heinasuo A., Jousimies-Somer H. Penicillin G and penicillin G-tinidazole treatment of experimentally induced summer mastitis-effect on elimination rates of bacteria and outcome of the disease. Vet Microbiol 1994, 42:307-315.
23. Pyorala S. Indicators of inflammation in the diagnosis of mastitis. Vet Res 2003, 34:565-578.
24. Zhao X., Lacasse P. Mammary tissue damage during bovine mastitis: causes and control. J Anim Sci 2008, 86:57-65.
25. Seegers H., Fourichon C., Beaudeau F. Production effects related to mastitis and mastitis economics in dairy cattle herds. Vet Res 2003, 34:475-491.
26. Eckersall P.D., Young F.J., McComb C., Hogarth C.J., Safi S., Weber A., et al. Acute phase proteins in serum and milk from dairy cows with clinical mastitis. Vet Rec 2001, 148:35-41.
27. Ceciliani F., Pocacqua V., Provasi E., Comunian C., Bertolini A., Bronzo V., et al. Identification of the bovine alpha1-acid glycoprotein in colostrum and milk. Vet Res 2005, 36:735-746.
28. Anderson L., Anderson N.G. High resolution two-dimensional electrophoresis of human plasma proteins. Proc Natl Acad Sci U S A 1977, 74.
29. Pieper R., Gatlin C.L., Makusky A.J., Russo P.S., Schatz C.R., Miller S.S., et al. The human serum proteome: display of nearly 3700 chromatographically separated protein spots on two-dimensional electrophoresis gels and identification of 325 distinct proteins. Proteomics 2003, 3.
30. Gianazza E., Eberini I., Villa P., Fratelli M., Pinna C., Wait R., et al. Monitoring the effects of drug treatment in rat models of disease by serum protein analysis. J Chromatogr 2002, B771:107-130.
31. Wait R., Miller I., Eberini I., Cairoli F., Veronesi C., Battocchio M., et al. Strategies for proteomics with incompletely characterized genomes: the proteome of Bos taurus serum. Electrophoresis 2002, 23:3418-3427.
32. Miller I., Friedlein A., Tsangaris G., Maris A., Fountoulakis M., Gemeiner M. The serum proteome of Equus caballus. Proteomics 2004, 4:3227-3234.
33. Miller I., Gemeiner M. Two-dimensional electrophoresis of cat sera: protein identification by cross reacting antibodies against human serum proteins. Electrophoresis 1992, 13:450-453.
34. Wait R., Chiesa G., Parolini C., Miller I., Begum S., Brambilla D., et al. Reference maps of mouse serum acute-phase proteins: changes with LPS-induced inflammation and apolipoprotein A-I and A-II transgenes. Proteomics 2005, 5.
35. Miller I., Wait R., Sipos W., Gemeiner M. A proteomic reference map for pig serum proteins as a prerequisite for diagnostic applications. Res Vet Sci 2009, 86:362-367.
36. Hyvonen P., Suojala L., Orro T., Haaranen J., Simola O., Rontved C., et al. Transgenic cows that produce recombinant human lactoferrin in milk are not protected from experimental Escherichia coli intramammary infection. Infect Immun 2006, 74:6206-6212.
37. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
38. Ramagli L., Rodriguez L. Quantitation of microgram amount of protein in two-dimensional polyacrylamide-gel electrophoresis sample buffer. Electrophoresis 1985, 6:559-563.
39. Shevchenko A., Wilm M., Vorm O., Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem 1996, 68:850-858.
40. Suckau D., Resemann A., Schuerenberg M., Hufnagel P., Franzen J., Holle A. A novel MALDI LIFT-TOF/TOF mass spectrometer for proteomics. Anal Bioanal Chem 2003, 376:952-965.
41. Perkins D.N., Pappin D.J., Creasy D.M., Cottrell J.S. Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis 1999, 20:3551-3567.
42. Lampreave F., Gonzalez-Ramon N., Martinez-Ayensa S., Hernandez M.A., Lorenzo H.K., Garcia-Gil A., et al. Characterization of the acute phase serum protein response in pigs. Electrophoresis 1994, 15:672-676.
43. Carpintero R., Pineiro M., Andres M., Iturralde M., Alava M.A., Heegaard P.M., et al. The concentration of apolipoprotein A-I decreases during experimentally induced acute-phase processes in pigs. Infect Immun 2005, 73:3184-3187.
44. Gonzalez-Ramon N., Hoebe K., Alava M.A., Van Leengoed L., Pineiro M., Carmona S., et al. Pig MAP/ITIH4 and haptoglobin are interleukin-6-dependent acute-phase plasma proteins in porcine primary cultured hepatocytes. Eur J Biochem 2000, 267:1878-1885.
45. Lampreave F., Alava M.A., Pineiro A. Concanavalin A crossed affinoimmunoelectrophoretic analysis of the major pig serum proteins during fetal development. Electrophoresis 1993, 14:214-219.
46. Lampreave F., Alava M., Pineiro A. Lectin affinity immunoelectrophoresis of serum glycoproteins. J Chromatogr A 1995, 698:107-122.
47. Wong D.W., Camirand W.M., Pavlath A.E. Structures and functionalities of milk proteins. Crit Rev Food Sci Nutr 1996, 36:807-844.
48. Bannerman D.D., Chockalingam A., Paape M.J., Hope J.C. The bovine innate immune response during experimentally-induced Pseudomonas aeruginosa mastitis. Vet Immunol Immunopathol 2005, 107:201-215.
49. Kauf A.C., Rosenbusch R.F., Paape M.J., Bannerman D.D. Innate immune response to intramammary Mycoplasma bovis infection. J Dairy Sci 2007, 90:3336-3348.
50. Symons D.B., Wright L.J. Changes in bovine mammary gland permeability after intramammary exotoxin infusion. J Comp Pathol 1974, 84:9-17.
51. Murakami K., Lagarde M., Yuki Y. Identification of minor proteins of human colostrum and mature milk by two-dimensional electrophoresis. Electrophoresis 1998, 19:2521-2527.
52. Baeker R., Haebel S., Schlatterer K., Schlatterer B. Lipocalin-type prostaglandin D synthase in milk: a new biomarker for bovine mastitis. Prostaglandins Other Lipid Mediat 2002, 67:75-88.
53. Boehmer J.L., Bannerman D.D., Shefcheck K., Ward J.L. Proteomic analysis of differentially expressed proteins in bovine milk during experimentally induced Escherichia coli mastitis. J Dairy Sci 2008, 91:4206-4218.
54. Hogarth C.J., Fitzpatrick J.L., Nolan A.M., Young F.J., Pitt A., Eckersall P.D. Differential protein composition of bovine whey: a comparison of whey from healthy animals and from those with clinical mastitis. Proteomics 2004, 4:2094-2100.
55. Smolenski G., Haines S., Kwan F.Y., Bond J., Farr V., Davis S.R., et al. Characterisation of host defence proteins in milk using a proteomic approach. J Proteome Res 2007, 6:207-215.
56. Yamada M., Murakami K., Wallingford J.C., Yuki Y. Identification of low-abundance proteins of bovine colostral and mature milk using two-dimensional electrophoresis followed by microsequencing and mass spectrometry. Electrophoresis 2002, 23:1153-1160.
57. Molloy M.P., Herbert B.R., Yan J.X., Williams K.L., Gooley A.A. Identification of wallaby milk whey proteins separated by two-dimensional electrophoresis, using amino acid analysis and sequence tagging. Electrophoresis 1997, 18:1073-1078.
58. Gianazza E., Arnaud P. A general method for fractionation of plasma proteins. Dye-ligand affinity chromatography on immobilized Cibacron blue F3-GA. Biochem J 1982, 201:129-136.
59. Gonzalez-Ramon N., Alava M.A., Sarsa J.A., Pineiro M., Escartin A., Garcia-Gil A., et al. The major acute phase serum protein in pigs is homologous to human plasma kallikrein sensitive PK-120. FEBS Lett 1995, 371:227-230.
60. Duan X., Yarmush D., Berthiaume F., Jayaraman A., Yarmush M.L. Immunodepletion of albumin for two-dimensional gel detection of new mouse acute-phase protein and other plasma proteins. Proteomics 2005, 5:3991-4000.
61. Gong Y., Li X., Yang B., Ying W., Li D., Zhang Y., et al. Different immunoaffinity fractionation strategies to characterize the human plasma proteome. J Proteome Res 2006, 5:1379-1387.
62. Steel L.F., Trotter M.G., Nakajima P.B., Mattu T.S., Gonye G., Block T. Efficient and specific removal of albumin from human serum samples. Mol Cell Proteomics 2003, 2:262-270.
63. Jinbo T., Sakamoto T., Yamamoto S. Serum alpha2-macroglobulin and cytokine measurements in an acute inflammation model in rats. Lab Anim 2002, 36:153-157.
64. Strnad M., Radojicic C., Marinkovic D., Magic Z. Variability of haptoglobin and alpha 2-macroglobulin in Albino Oxford and Dark Augustin inbred strains of rats before and after trauma. Vojnosanit Pregl 2000, 57:381-386.
65. Isaac L., Florido M.P., Fecchio D., Singer L.M. Murine alpha-2-macroglobulin increase during inflammatory responses and tumor growth. Inflamm Res 1999, 48:446-452.
66. Kristiansson M.H., Bhat V.B., Babu I.R., Wishnok J.S., Tannenbaum S.R. Comparative time-dependent analysis of potential inflammation biomarkers in lymphoma-bearing SJL mice. J Proteome Res 2007, 6:1735-1744.
67. Banks R.E., Evans S.W., Alexander D., Van Leuven F., Whicher J.T., McMahon M.J. Alpha 2 macroglobulin state in acute pancreatitis. Raised values of alpha 2 macroglobulin-protease complexes in severe and mild attacks. Gut 1991, 32:430-434.
68. Bohe M., Genell S., Ohlsson K. Protease inhibitors in plasma and faecal extracts from patients with active inflammatory bowel disease. Scand J Gastroenterol 1986, 21:598-604.
69. Chodorowska G., Wojnowska D., Juszkiewicz-Borowiec M. C-reactive protein and alpha2-macroglobulin plasma activity in medium-severe and severe psoriasis. J Eur Acad Dermatol Venereol 2004, 18:180-183.
70. Makis A.C., Hatzimichael E.C., Mavridis A., Bourantas K.L. Alpha-2-macroglobulin and interleukin-6 levels in steady-state sickle cell disease patients. Acta Haematol 2000, 104:164-168.
71. Soury E., Olivier E., Daveau M., Hiron M., Claeyssens S., Risler J.L., et al. The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human. Biochem Biophys Res Commun 1998, 243:522-530.
72. Bhanumathy C.D., Tang Y., Monga S.P., Katuri V., Cox J.A., Mishra B., et al. Itih-4, a serine protease inhibitor regulated in interleukin-6-dependent liver formation: role in liver development and regeneration. Dev Dyn 2002, 223:59-69.
73. Cai T., Yu P., Monga S.P., Mishra B., Mishra L. Identification of mouse itih-4 encoding a glycoprotein with two EF-hand motifs from early embryonic liver. Biochim Biophys Acta 1998, 1398:32-37.
74. Choi-Miura N.H., Takahashi K., Yoda M., Saito K., Hori M., Ozaki H., et al. The novel acute phase protein, IHRP, inhibits actin polymerization and phagocytosis of polymorphonuclear cells. Inflamm Res 2000, 49:305-310.
75. Carpintero R., Alonso C., Pineiro M., Iturralde M., Andres M., Le Potier M.F., et al. Pig major acute-phase protein and apolipoprotein A-I responses correlate with the clinical course of experimentally induced African Swine Fever and Aujeszky's disease. Vet Res 2007, 38:741-753.
76. Daveau M., Jean L., Soury E., Olivier E., Masson S., Lyoumi S., et al. Hepatic and extra-hepatic transcription of inter-alpha-inhibitor family genes under normal or acute inflammatory conditions in rat. Arch Biochem Biophys 1998, 350:315-323.
77. Pineiro M., Alava M.A., Gonzalez-Ramon N., Osada J., Lasierra P., Larrad L., et al. ITIH4 serum concentration increases during acute-phase processes in human patients and is up-regulated by interleukin-6 in hepatocarcinoma HepG2 cells. Biochem Biophys Res Commun 1999, 263:224-229.
78. Bourry A., Poutrel B. Bovine mastitis caused by Listeria monocytogenes: kinetics of antibody responses in serum and milk after experimental infection. J Dairy Sci 1996, 79:2189-2195.
79. Ingenbleek Y., Young V. Transthyretin (prealbumin) in health and disease: nutritional implications. Annu Rev Nutr 1994, 14:495-533.
80. Cabana V.G., Lukens J.R., Rice K.S., Hawkins T.J., Getz G.S. HDL content and composition in acute phase response in three species: triglyceride enrichment of HDL a factor in its decrease. J Lipid Res 1996, 37:2662-2674.
81. Oikawa S., Katoh N. Decreases in serum apolipoprotein B-100 and A-I concentrations in cows with milk fever and downer cows. Can J Vet Res 2002, 66:31-34.
82. Oikawa S., Katoh N., Itoh H., Miyamoto T., Konno M., Kajita T. Decreased serum apolipoprotein A-I concentrations in cows infected with Salmonella typhimurium. Can J Vet Res 1997, 61:182-186.
83. Steel D.M., Whitehead A.S. The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. Immunol Today 1994, 15:81-88.
84. Hiss S., Mielenz M., Bruckmaier R.M., Sauerwein H. Haptoglobin concentrations in blood and milk after endotoxin challenge and quantification of mammary Hp mRNA expression. J Dairy Sci 2004, 87:3778-3784.
85. Tabrizi A.D., Batavani R.A., Rezaei S.A., Ahmadi M. Fibrinogen and ceruloplasmin in plasma and milk from dairy cows with subclinical and clinical mastitis. Pak J Biol Sci 2008, 11:571-576.
86. Gruys E., Toussaint M.J., Niewold T.A., Koopmans S.J. Acute phase reaction and acute phase proteins. J Zhejiang Univ Sci B 2005, 6:1045-1056.
87. Tolosano E., Altruda F. Hemopexin: structure, function, and regulation. DNA Cell Biol 2002, 21:297-306.
88. Kutila T., Suojala L., Lehtolainen T., Saloniemi H., Kaartinen L., Tahti M., et al. The efficacy of bovine lactoferrin in the treatment of cows with experimentally induced Escherichia coli mastitis. J Vet Pharmacol Ther 2004, 27:197-202.
89. Hagiwara S., Kawai K., Anri A., Nagahata H. Lactoferrin concentrations in milk from normal and subclinical mastitic cows. J Vet Med Sci 2003, 65:319-323.
90. Fetherston C.M., Lai C.T., Hartmann P.E. Relationships between symptoms and changes in breast physiology during lactation mastitis. Breastfeed Med 2006, 1:136-145.
91. Janota-Bassalik L., Zajac M., Pietraszek A., Piotrowska E. Bacteriostatic activity in cow's milk from udders infected with Streptococcus agalactiae and Staphylococcus aureus. Acta Microbiol Pol 1977, 26:413-419.
92. Sakai S., Nonobe E., Satow T., Imakawa K., Nagaoka K. Production of hydrogen peroxide by a small molecular mass compound in milk from Holstein cows with high and low milk somatic cell count. J Dairy Res 2008, 75:335-339.
93. Iturralde M., Monleon I., Aguilo J.I., Martinez-Lorenzo M.J., Lampreave F., Pineiro A., et al. Altered cellular protein expression pattern correlates with delayed doxorubicin-induced apoptosis in highly proliferative Jurkat cell sublines. Curr Trends Immunol 2004, 6:111-125.
94. Lampreave F., Alava M., Piñeiro M. Developments in lectin affinity immunoelectrophoresis of serum glycoproteins. Trends Anal Chem 1996, 15:122-129.
95. Monleon I., Iturralde M., Martinez-Lorenzo M.J., Monteagudo L., Lasierra P., Larrad L., et al. Lack of Fas/CD95 surface expression in highly proliferative leukemic cell lines correlates with loss of CtBP/BARS and redirection of the protein toward giant lysosomal structures. Cell Growth Differ 2002, 13:315-324.