-
1
-
-
72949093335
-
From pathogenesis to treatment of chronic lymphocytic leukaemia
-
Zenz T, Mertens D, Kuppers R, Dohner H, Stilgenbauer S. From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer 2010; 10: 37-50.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 37-50
-
-
Zenz, T.1
Mertens, D.2
Kuppers, R.3
Dohner, H.4
Stilgenbauer, S.5
-
2
-
-
40749132494
-
Chronic lymphocytic leukaemia
-
Dighiero G, Hamblin TJ. Chronic lymphocytic leukaemia. Lancet 2008; 371: 1017-29.
-
(2008)
Lancet
, vol.371
, pp. 1017-1029
-
-
Dighiero, G.1
Hamblin, T.J.2
-
3
-
-
34248354409
-
Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status
-
Mockridge CI, Potter KN, Wheatley I, Neville LA, Packham G, Stevenson FK. Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status. Blood 2007; 109: 4424-31.
-
(2007)
Blood
, vol.109
, pp. 4424-4431
-
-
Mockridge, C.I.1
Potter, K.N.2
Wheatley, I.3
Neville, L.A.4
Packham, G.5
Stevenson, F.K.6
-
4
-
-
0035803371
-
Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia
-
Rosenwald A, Alizadeh AA, Widhopf G, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 2001; 194: 1639-47.
-
(2001)
J Exp Med
, vol.194
, pp. 1639-1647
-
-
Rosenwald, A.1
Alizadeh, A.A.2
Widhopf, G.3
-
5
-
-
20044372326
-
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
-
Messmer BT, Messmer D, Allen SL, et al. In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest 2005; 115: 755-64.
-
(2005)
J Clin Invest
, vol.115
, pp. 755-764
-
-
Messmer, B.T.1
Messmer, D.2
Allen, S.L.3
-
6
-
-
78751549662
-
The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia
-
Herishanu Y, Perez-Galan P, Liu D, et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood 2011; 117: 563-74.
-
(2011)
Blood
, vol.117
, pp. 563-574
-
-
Herishanu, Y.1
Perez-Galan, P.2
Liu, D.3
-
7
-
-
0016740933
-
Clinical staging of chronic lymphocytic leukemia
-
Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS. Clinical staging of chronic lymphocytic leukemia. Blood 1975; 46: 219-34.
-
(1975)
Blood
, vol.46
, pp. 219-234
-
-
Rai, K.R.1
Sawitsky, A.2
Cronkite, E.P.3
Chanana, A.D.4
Levy, R.N.5
Pasternack, B.S.6
-
8
-
-
0019427092
-
A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis
-
Binet JL, Auquier A, Dighiero G, et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 1981; 48: 198-206.
-
(1981)
Cancer
, vol.48
, pp. 198-206
-
-
Binet, J.L.1
Auquier, A.2
Dighiero, G.3
-
9
-
-
0033567968
-
Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
-
Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999; 94: 1840-7.
-
(1999)
Blood
, vol.94
, pp. 1840-1847
-
-
Damle, R.N.1
Wasil, T.2
Fais, F.3
-
10
-
-
0033567907
-
Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
-
Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848-54.
-
(1999)
Blood
, vol.94
, pp. 1848-1854
-
-
Hamblin, T.J.1
Davis, Z.2
Gardiner, A.3
Oscier, D.G.4
Stevenson, F.K.5
-
11
-
-
14944352799
-
ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia
-
Chen L, Apgar J, Huynh L, et al. ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood 2005; 105: 2036-41.
-
(2005)
Blood
, vol.105
, pp. 2036-2041
-
-
Chen, L.1
Apgar, J.2
Huynh, L.3
-
12
-
-
0037114744
-
Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia
-
Chen L, Widhopf G, Huynh L, et al. Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood 2002; 100: 4609-14.
-
(2002)
Blood
, vol.100
, pp. 4609-4614
-
-
Chen, L.1
Widhopf, G.2
Huynh, L.3
-
13
-
-
20144385604
-
Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis
-
Contri A, Brunati AM, Trentin L, et al. Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis. J Clin Invest 2005; 115: 369-78.
-
(2005)
J Clin Invest
, vol.115
, pp. 369-378
-
-
Contri, A.1
Brunati, A.M.2
Trentin, L.3
-
14
-
-
70349284466
-
The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression
-
Baudot AD, Jeandel PY, Mouska X, et al. The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression. Oncogene 2009; 28: 3261-73.
-
(2009)
Oncogene
, vol.28
, pp. 3261-3273
-
-
Baudot, A.D.1
Jeandel, P.Y.2
Mouska, X.3
-
15
-
-
70349237504
-
B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: Specific targeting with a novel spleen tyrosine kinase inhibitor, R406
-
Quiroga MP, Balakrishnan K, Kurtova AV, et al. B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood 2009; 114: 1029-37.
-
(2009)
Blood
, vol.114
, pp. 1029-1037
-
-
Quiroga, M.P.1
Balakrishnan, K.2
Kurtova, A.V.3
-
16
-
-
77952886100
-
Spleen tyrosine kinase inhibition prevents chemokine-and integrin-mediated stromal protective effects in chronic lymphocytic leukemia
-
Buchner M, Baer C, Prinz G, et al. Spleen tyrosine kinase inhibition prevents chemokine-and integrin-mediated stromal protective effects in chronic lymphocytic leukemia. Blood; 115: 4497-506.
-
Blood
, vol.115
, pp. 4497-4506
-
-
Buchner, M.1
Baer, C.2
Prinz, G.3
-
17
-
-
0037111661
-
Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: Association with protein kinase Cdelta
-
Ringshausen I, Schneller F, Bogner C, et al. Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta. Blood 2002; 100: 3741-8.
-
(2002)
Blood
, vol.100
, pp. 3741-3748
-
-
Ringshausen, I.1
Schneller, F.2
Bogner, C.3
-
18
-
-
79959404661
-
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
-
Herman SE, Gordon AL, Hertlein E, et al. Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood 2011; 117: 6287-96.
-
(2011)
Blood
, vol.117
, pp. 6287-6296
-
-
Herman, S.E.1
Gordon, A.L.2
Hertlein, E.3
-
19
-
-
79955977369
-
The role of phosphatidylinositol 3-kinase-delta in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia
-
Herman SE, Lapalombella R, Gordon AL, et al. The role of phosphatidylinositol 3-kinase-delta in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia. Blood 2011; 117: 4323-7.
-
(2011)
Blood
, vol.117
, pp. 4323-4327
-
-
Herman, S.E.1
Lapalombella, R.2
Gordon, A.L.3
-
20
-
-
0034727833
-
Genomic aberrations and survival in chronic lymphocytic leukemia
-
Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910-6.
-
(2000)
N Engl J Med
, vol.343
, pp. 1910-1916
-
-
Dohner, H.1
Stilgenbauer, S.2
Benner, A.3
-
21
-
-
18744396337
-
Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
-
Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002; 99: 15524-9.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 15524-15529
-
-
Calin, G.A.1
Dumitru, C.D.2
Shimizu, M.3
-
22
-
-
36849045647
-
Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion
-
Austen B, Skowronska A, Baker C, et al. Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion. J Clin Oncol 2007; 25: 5448-57.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5448-5457
-
-
Austen, B.1
Skowronska, A.2
Baker, C.3
-
23
-
-
0033513587
-
Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia
-
Stankovic T, Weber P, Stewart G, et al. Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia. Lancet 1999; 353: 26-9.
-
(1999)
Lancet
, vol.353
, pp. 26-29
-
-
Stankovic, T.1
Weber, P.2
Stewart, G.3
-
24
-
-
84855370035
-
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia
-
Wang L, Lawrence MS, Wan Y, et al. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med 2011; 365: 2497-506.
-
(2011)
N Engl J Med
, vol.365
, pp. 2497-2506
-
-
Wang, L.1
Lawrence, M.S.2
Wan, Y.3
-
25
-
-
79551504914
-
TP53 mutation and survival in chronic lymphocytic leukemia
-
Zenz T, Eichhorst B, Busch R, et al. TP53 mutation and survival in chronic lymphocytic leukemia. J Clin Oncol 2010; 28: 4473-9.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4473-4479
-
-
Zenz, T.1
Eichhorst, B.2
Busch, R.3
-
26
-
-
70350511471
-
Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): Dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial
-
Zenz T, Habe S, Denzel T, et al. Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial. Blood 2009; 114: 2589-97.
-
(2009)
Blood
, vol.114
, pp. 2589-2597
-
-
Zenz, T.1
Habe, S.2
Denzel, T.3
-
27
-
-
0037103212
-
V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia
-
Krober A, Seiler T, Benner A, et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood 2002; 100: 1410-6.
-
(2002)
Blood
, vol.100
, pp. 1410-1416
-
-
Krober, A.1
Seiler, T.2
Benner, A.3
-
28
-
-
65549110908
-
Mir-34a as part of the resistance network in chronic lymphocytic leukemia
-
Zenz T, Mohr J, Eldering E, et al. miR-34a as part of the resistance network in chronic lymphocytic leukemia. Blood 2009; 113: 3801-8.
-
(2009)
Blood
, vol.113
, pp. 3801-3808
-
-
Zenz, T.1
Mohr, J.2
Eldering, E.3
-
29
-
-
20444416724
-
Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway
-
Deriano L, Guipaud O, Merle-Beral H, et al. Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway. Blood 2005; 105: 4776-83.
-
(2005)
Blood
, vol.105
, pp. 4776-4783
-
-
Deriano, L.1
Guipaud, O.2
Merle-Beral, H.3
-
30
-
-
52449095058
-
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia
-
Willmore E, Elliott SL, Mainou-Fowler T, et al. DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia. Clin Cancer Res 2008; 14: 3984-92.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3984-3992
-
-
Willmore, E.1
Elliott, S.L.2
Mainou-Fowler, T.3
-
31
-
-
52949139429
-
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
-
Di Bernardo MC, Crowther-Swanepoel D, Broderick P, et al. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Nat Genet 2008; 40: 1204-10.
-
(2008)
Nat Genet
, vol.40
, pp. 1204-1210
-
-
Di Bernardo, M.C.1
Crowther-Swanepoel, D.2
Broderick, P.3
-
32
-
-
75749138023
-
Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk
-
Crowther-Swanepoel D, Broderick P, Di Bernardo MC, et al. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. Nat Genet 2010; 42: 132-6.
-
(2010)
Nat Genet
, vol.42
, pp. 132-136
-
-
Crowther-Swanepoel, D.1
Broderick, P.2
Di Bernardo, M.C.3
-
33
-
-
33745952966
-
Variants in the ATM-BRCA2-CHEK2 axis predispose to chronic lymphocytic leukemia
-
Rudd MF, Sellick GS, Webb EL, Catovsky D, Houlston RS. Variants in the ATM-BRCA2-CHEK2 axis predispose to chronic lymphocytic leukemia. Blood 2006; 108: 638-44.
-
(2006)
Blood
, vol.108
, pp. 638-644
-
-
Rudd, M.F.1
Sellick, G.S.2
Webb, E.L.3
Catovsky, D.4
Houlston, R.S.5
-
35
-
-
68549109746
-
DNA repair polymorphisms associated with cytogenetic subgroups in B-cell chronic lymphocytic leukemia
-
Ganster C, Neesen J, Zehetmayer S, et al. DNA repair polymorphisms associated with cytogenetic subgroups in B-cell chronic lymphocytic leukemia. Genes Chromosomes Cancer 2009; 48: 760-7.
-
(2009)
Genes Chromosomes Cancer
, vol.48
, pp. 760-767
-
-
Ganster, C.1
Neesen, J.2
Zehetmayer, S.3
-
36
-
-
77957361864
-
Targeting microRNAs in cancer: Rationale, strategies and challenges
-
Garzon R, Marcucci G, Croce CM. Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov 2010; 9: 775-89.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 775-789
-
-
Garzon, R.1
Marcucci, G.2
Croce, C.M.3
-
37
-
-
27244434788
-
A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
-
Calin GA, Ferracin M, Cimmino A, et al. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 2005; 353: 1793-801.
-
(2005)
N Engl J Med
, vol.353
, pp. 1793-1801
-
-
Calin, G.A.1
Ferracin, M.2
Cimmino, A.3
-
38
-
-
42449152333
-
MiR-15a and miR-16-1 cluster functions in human leukemia
-
Calin GA, Cimmino A, Fabbri M, et al. MiR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci USA 2008; 105: 5166-71.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 5166-5171
-
-
Calin, G.A.1
Cimmino, A.2
Fabbri, M.3
-
39
-
-
34250013672
-
Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice
-
Raveche ES, Salerno E, Scaglione BJ, et al. Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood 2007; 109: 5079-86.
-
(2007)
Blood
, vol.109
, pp. 5079-5086
-
-
Raveche, E.S.1
Salerno, E.2
Scaglione, B.J.3
-
40
-
-
73649116987
-
The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia
-
Klein U, Lia M, Crespo M, et al. The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell 2010; 17: 28-40.
-
(2010)
Cancer Cell
, vol.17
, pp. 28-40
-
-
Klein, U.1
Lia, M.2
Crespo, M.3
-
41
-
-
25444520537
-
MiR-15 and miR-16 induce apoptosis by targeting BCL2
-
Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 2005; 102: 13944-9.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 13944-13949
-
-
Cimmino, A.1
Calin, G.A.2
Fabbri, M.3
-
42
-
-
74249084440
-
MiR-15a and miR-16-1 in cancer: Discovery, function and future perspectives
-
Aqeilan RI, Calin GA, Croce CM. miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. Cell Death Differ 2010; 17: 215-20.
-
(2010)
Cell Death Differ
, vol.17
, pp. 215-220
-
-
Aqeilan, R.I.1
Calin, G.A.2
Croce, C.M.3
-
43
-
-
77956556260
-
MicroRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival
-
Rossi S, Shimizu M, Barbarotto E, et al. microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival. Blood 2010; 116: 945-52.
-
(2010)
Blood
, vol.116
, pp. 945-952
-
-
Rossi, S.1
Shimizu, M.2
Barbarotto, E.3
-
44
-
-
0037393911
-
Disparate expression of the PTEN gene: A novel finding in B-cell chronic lymphocytic leukaemia (B-CLL)
-
Leupin N, Cenni B, Novak U, et al. Disparate expression of the PTEN gene: a novel finding in B-cell chronic lymphocytic leukaemia (B-CLL). Br J Haematol 2003; 121: 97-100.
-
(2003)
Br J Haematol
, vol.121
, pp. 97-100
-
-
Leupin, N.1
Cenni, B.2
Novak, U.3
-
45
-
-
34249661649
-
Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia
-
Fulci V, Chiaretti S, Goldoni M, et al. Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia. Blood 2007; 109: 4944-51.
-
(2007)
Blood
, vol.109
, pp. 4944-4951
-
-
Fulci, V.1
Chiaretti, S.2
Goldoni, M.3
-
46
-
-
14844354250
-
Accumulation of miR-155 and BIC RNA in human B cell lymphomas
-
Eis PS, Tam W, Sun L, et al. Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci USA 2005; 102: 3627-32.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 3627-3632
-
-
Eis, P.S.1
Tam, W.2
Sun, L.3
-
47
-
-
34249945558
-
Regulation of primicroRNA BIC transcription and processing in Burkitt lymphoma
-
Kluiver J, van den Berg A, de Jong D, et al. Regulation of primicroRNA BIC transcription and processing in Burkitt lymphoma. Oncogene 2007; 26: 3769-76.
-
(2007)
Oncogene
, vol.26
, pp. 3769-3776
-
-
Kluiver, J.1
van den Berg, A.2
de Jong, D.3
-
48
-
-
0037402495
-
High expression of B-cell receptor inducible gene BIC in all subtypes of Hodgkin lymphoma
-
van den Berg A, Kroesen BJ, Kooistra K, et al. High expression of B-cell receptor inducible gene BIC in all subtypes of Hodgkin lymphoma. Genes Chromosomes Cancer 2003; 37: 20-8.
-
(2003)
Genes Chromosomes Cancer
, vol.37
, pp. 20-28
-
-
van den Berg, A.1
Kroesen, B.J.2
Kooistra, K.3
-
49
-
-
33646471662
-
Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice
-
Costinean S, Zanesi N, Pekarsky Y, et al. Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci USA 2006; 103: 7024-9.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 7024-7029
-
-
Costinean, S.1
Zanesi, N.2
Pekarsky, Y.3
-
50
-
-
33846190181
-
Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181
-
Pekarsky Y, Santanam U, Cimmino A, et al. Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res 2006; 66: 11590-3.
-
(2006)
Cancer Res
, vol.66
, pp. 11590-11593
-
-
Pekarsky, Y.1
Santanam, U.2
Cimmino, A.3
-
51
-
-
74049162482
-
Antileukemic activity of valproic acid in chronic lymphocytic leukemia B cells defined by microarray analysis
-
Stamatopoulos B, Meuleman N, De Bruyn C, et al. Antileukemic activity of valproic acid in chronic lymphocytic leukemia B cells defined by microarray analysis. Leukemia 2009; 23: 2281-9.
-
(2009)
Leukemia
, vol.23
, pp. 2281-2289
-
-
Stamatopoulos, B.1
Meuleman, N.2
de Bruyn, C.3
-
52
-
-
80052939685
-
MiR-181b is a biomarker of disease progression in chronic lymphocytic leukemia
-
Visone R, Veronese A, Rassenti LZ, et al. MiR-181b is a biomarker of disease progression in chronic lymphocytic leukemia. Blood 2011.
-
(2011)
Blood
-
-
Visone, R.1
Veronese, A.2
Rassenti, L.Z.3
-
53
-
-
62549148205
-
17p13/TP53 deletion in B-CLL patients is associated with microRNA-34a downregulation
-
Dijkstra MK, van Lom K, Tielemans D, et al. 17p13/TP53 deletion in B-CLL patients is associated with microRNA-34a downregulation. Leukemia 2009; 23: 625-7.
-
(2009)
Leukemia
, vol.23
, pp. 625-627
-
-
Dijkstra, M.K.1
van Lom, K.2
Tielemans, D.3
-
54
-
-
77953648407
-
MicroRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia
-
Asslaber D, Pinon JD, Seyfried I, et al. microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia. Blood 2010; 115: 4191-7.
-
(2010)
Blood
, vol.115
, pp. 4191-4197
-
-
Asslaber, D.1
Pinon, J.D.2
Seyfried, I.3
-
55
-
-
78650196925
-
MicroRNAs prevent the generation of autoreactive antibodies
-
Belver L, de Yebenes VG, Ramiro AR. MicroRNAs prevent the generation of autoreactive antibodies. Immunity 2010; 33: 713-22.
-
(2010)
Immunity
, vol.33
, pp. 713-722
-
-
Belver, L.1
de Yebenes, V.G.2
Ramiro, A.R.3
-
56
-
-
77956342464
-
MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers
-
Imam JS, Buddavarapu K, Lee-Chang JS, et al. MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers. Oncogene 2010; 29: 4971-9.
-
(2010)
Oncogene
, vol.29
, pp. 4971-4979
-
-
Imam, J.S.1
Buddavarapu, K.2
Lee-Chang, J.S.3
-
57
-
-
48749122914
-
Circulating microRNAs as stable blood-based markers for cancer detection
-
Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 2008; 105: 10513-8.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 10513-10518
-
-
Mitchell, P.S.1
Parkin, R.K.2
Kroh, E.M.3
-
58
-
-
79955582317
-
MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia
-
Moussay E, Wang K, Cho JH, et al. MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2011; 108: 6573-8.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 6573-6578
-
-
Moussay, E.1
Wang, K.2
Cho, J.H.3
-
59
-
-
0034667427
-
BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia
-
Pasqualucci L, Neri A, Baldini L, Dalla-Favera R, Migliazza A. BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia. Cancer Res 2000; 60: 5644-8.
-
(2000)
Cancer Res
, vol.60
, pp. 5644-5648
-
-
Pasqualucci, L.1
Neri, A.2
Baldini, L.3
Dalla-Favera, R.4
Migliazza, A.5
-
60
-
-
79960036578
-
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
-
Puente XS, Pinyol M, Quesada V, et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 2011; 475: 101-5.
-
(2011)
Nature
, vol.475
, pp. 101-105
-
-
Puente, X.S.1
Pinyol, M.2
Quesada, V.3
-
61
-
-
77958567414
-
NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL
-
Sportoletti P, Baldoni S, Cavalli L, et al. NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL. Br J Haematol 2010; 151: 404-6.
-
(2010)
Br J Haematol
, vol.151
, pp. 404-406
-
-
Sportoletti, P.1
Baldoni, S.2
-
62
-
-
79960353160
-
Analysis of the chronic lymphocytic leukemia coding genome: Role of NOTCH1 mutational activation
-
Fabbri G, Rasi S, Rossi D, et al. Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J Exp Med 2011; 208: 1389-401.
-
(2011)
J Exp Med
, vol.208
, pp. 1389-13401
-
-
Fabbri, G.1
Rasi, S.2
Rossi, D.3
-
63
-
-
79951698621
-
FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation
-
Babaei-Jadidi R, Li N, Saadeddin A, et al. FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. J Exp Med 2011; 208: 295-312.
-
(2011)
J Exp Med
, vol.208
, pp. 295-312
-
-
Babaei-Jadidi, R.1
Li, N.2
Saadeddin, A.3
-
64
-
-
34247566510
-
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
-
O'Neill LA, Bowie AG. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 2007; 7: 353-64.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 353-364
-
-
O'Neill, L.A.1
Bowie, A.G.2
-
65
-
-
0032189837
-
Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1
-
Ferrigno P, Posas F, Koepp D, Saito H, Silver PA. Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1. EMBO J 1998; 17: 5606-14.
-
(1998)
EMBO J
, vol.17
, pp. 5606-5614
-
-
Ferrigno, P.1
Posas, F.2
Koepp, D.3
Saito, H.4
Silver, P.A.5
-
66
-
-
25444513655
-
The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation
-
Kroll J, Shi X, Caprioli A, et al. The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation. Mol Cell Biol 2005; 25: 8531-40.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 8531-8540
-
-
Kroll, J.1
Shi, X.2
Caprioli, A.3
-
67
-
-
80052683181
-
IRF4 mutations in chronic lymphocytic leukemia
-
Havelange V, Pekarsky Y, Nakamura T, et al. IRF4 mutations in chronic lymphocytic leukemia. Blood 2011; 118: 2827-9.
-
(2011)
Blood
, vol.118
, pp. 2827-2829
-
-
Havelange, V.1
Pekarsky, Y.2
Nakamura, T.3
-
68
-
-
33747133955
-
Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation
-
Sciammas R, Shaffer AL, Schatz JH, Zhao H, Staudt LM, Singh H. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 2006; 25: 225-36.
-
(2006)
Immunity
, vol.25
, pp. 225-236
-
-
Sciammas, R.1
Shaffer, A.L.2
Schatz, J.H.3
Zhao, H.4
Staudt, L.M.5
Singh, H.6
-
69
-
-
77950524963
-
Aberrant splicing of the E-cadherin transcript is a novel mechanism of gene silencing in chronic lymphocytic leukemia cells
-
Sharma S, Lichtenstein A. Aberrant splicing of the E-cadherin transcript is a novel mechanism of gene silencing in chronic lymphocytic leukemia cells. Blood 2009; 114: 4179-85.
-
(2009)
Blood
, vol.114
, pp. 4179-4185
-
-
Sharma, S.1
Lichtenstein, A.2
-
70
-
-
77953955599
-
High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: Link with an activated microenvironment in CLL disease
-
Palacios F, Moreno P, Morande P, et al. High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease. Blood 2010; 115: 4488-96.
-
(2010)
Blood
, vol.115
, pp. 4488-4496
-
-
Palacios, F.1
Moreno, P.2
Morande, P.3
-
71
-
-
77649186881
-
Lipoprotein lipase is differentially expressed in prognostic subsets of chronic lymphocytic leukemia but displays invariably low catalytical activity
-
Mansouri M, Sevov M, Fahlgren E, et al. Lipoprotein lipase is differentially expressed in prognostic subsets of chronic lymphocytic leukemia but displays invariably low catalytical activity. Leuk Res 2010; 34: 301-6.
-
(2010)
Leuk Res
, vol.34
, pp. 301-306
-
-
Mansouri, M.1
Sevov, M.2
Fahlgren, E.3
-
72
-
-
68949184624
-
Gene expression profiling in chronic lymphocytic leukaemia
-
Codony C, Crespo M, Abrisqueta P, Montserrat E, Bosch F. Gene expression profiling in chronic lymphocytic leukaemia. Best Pract Res Clin Haematol 2009; 22: 211-22.
-
(2009)
Best Pract Res Clin Haematol
, vol.22
, pp. 211-222
-
-
Codony, C.1
Crespo, M.2
Abrisqueta, P.3
Montserrat, E.4
Bosch, F.5
-
73
-
-
70350452269
-
MiRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia
-
Pallasch CP, Patz M, Park YJ, et al. miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia. Blood 2009; 114: 3255-64.
-
(2009)
Blood
, vol.114
, pp. 3255-3264
-
-
Pallasch, C.P.1
Patz, M.2
Park, Y.J.3
-
74
-
-
73349139229
-
Identity of the elusive IgM Fc receptor (FcmuR) in humans
-
Kubagawa H, Oka S, Kubagawa Y, et al. Identity of the elusive IgM Fc receptor (FcmuR) in humans. J Exp Med 2009; 206: 2779-93.
-
(2009)
J Exp Med
, vol.206
, pp. 2779-2793
-
-
Kubagawa, H.1
Oka, S.2
Kubagawa, Y.3
-
75
-
-
77949890726
-
Identification of TOSO/FAIM3 as an Fc receptor for IgM
-
Shima H, Takatsu H, Fukuda S, et al. Identification of TOSO/FAIM3 as an Fc receptor for IgM. Int Immunol 2010; 22: 149-56.
-
(2010)
Int Immunol
, vol.22
, pp. 149-156
-
-
Shima, H.1
Takatsu, H.2
Fukuda, S.3
-
76
-
-
80054751083
-
TOSO, the Fcμ Receptor, Is Highly Expressed on Chronic Lymphocytic Leukemia B Cells, Internalizes upon IgM Binding, Shuttles to the Lysosome, and Is Downregulated in Response to TLR Activation
-
Vire B, David A, Wiestner A. TOSO, the Fcμ Receptor, Is Highly Expressed on Chronic Lymphocytic Leukemia B Cells, Internalizes upon IgM Binding, Shuttles to the Lysosome, and Is Downregulated in Response to TLR Activation. J Immunol 2011.
-
(2011)
J Immunol
-
-
Vire, B.1
David, A.2
Wiestner, A.3
-
77
-
-
84869215211
-
Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients
-
Hancer VS, Diz-Kucukkaya R, Aktan M. Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients. Med Oncol 2011.
-
(2011)
Med Oncol
-
-
Hancer, V.S.1
Diz-Kucukkaya, R.2
Aktan, M.3
-
78
-
-
0242468050
-
Regulating antigen-receptor gene assembly
-
Schlissel MS. Regulating antigen-receptor gene assembly. Nat Rev Immunol 2003; 3: 890-9.
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 890-899
-
-
Schlissel, M.S.1
-
79
-
-
47249099558
-
B lymphocytes: How they develop and function
-
LeBien TW, Tedder TF. B lymphocytes: how they develop and function. Blood 2008; 112: 1570-80.
-
(2008)
Blood
, vol.112
, pp. 1570-1580
-
-
Lebien, T.W.1
Tedder, T.F.2
-
80
-
-
0041689676
-
Predominant autoantibody production by early human B cell precursors
-
Wardemann H, Yurasov S, Schaefer A, Young JW, Meffre E, Nussenzweig MC. Predominant autoantibody production by early human B cell precursors. Science 2003; 301: 1374-7.
-
(2003)
Science
, vol.301
, pp. 1374-1377
-
-
Wardemann, H.1
Yurasov, S.2
Schaefer, A.3
Young, J.W.4
Meffre, E.5
Nussenzweig, M.C.6
-
81
-
-
37849035658
-
Sites and stages of autoreactive B cell activation and regulation
-
Shlomchik MJ. Sites and stages of autoreactive B cell activation and regulation. Immunity 2008; 28: 18-28.
-
(2008)
Immunity
, vol.28
, pp. 18-28
-
-
Shlomchik, M.J.1
-
82
-
-
0034264851
-
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
-
Revy P, Muto T, Levy Y, et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 2000; 102: 565-75.
-
(2000)
Cell
, vol.102
, pp. 565-575
-
-
Revy, P.1
Muto, T.2
Levy, Y.3
-
83
-
-
0034268780
-
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
-
Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000; 102: 553-63.
-
(2000)
Cell
, vol.102
, pp. 553-563
-
-
Muramatsu, M.1
Kinoshita, K.2
Fagarasan, S.3
Yamada, S.4
Shinkai, Y.5
Honjo, T.6
-
85
-
-
0035013708
-
Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens
-
Martin F, Oliver AM, Kearney JF. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity 2001; 14: 617-29.
-
(2001)
Immunity
, vol.14
, pp. 617-629
-
-
Martin, F.1
Oliver, A.M.2
Kearney, J.F.3
-
86
-
-
22544470027
-
B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae
-
Haas KM, Poe JC, Steeber DA, Tedder TF. B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. Immunity 2005; 23: 7-18.
-
(2005)
Immunity
, vol.23
, pp. 7-18
-
-
Haas, K.M.1
Poe, J.C.2
Steeber, D.A.3
Tedder, T.F.4
-
87
-
-
0035803464
-
Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells
-
Klein U, Tu Y, Stolovitzky GA, et al. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med 2001; 194: 1625-38.
-
(2001)
J Exp Med
, vol.194
, pp. 1625-1638
-
-
Klein, U.1
Tu, Y.2
Stolovitzky, G.A.3
-
88
-
-
4344704897
-
Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia
-
Messmer BT, Albesiano E, Efremov DG, et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med 2004; 200: 519-25.
-
(2004)
J Exp Med
, vol.200
, pp. 519-525
-
-
Messmer, B.T.1
Albesiano, E.2
Efremov, D.G.3
-
89
-
-
33846108722
-
Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations
-
Stamatopoulos K, Belessi C, Moreno C, et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations. Blood 2007; 109: 259-70.
-
(2007)
Blood
, vol.109
, pp. 259-270
-
-
Stamatopoulos, K.1
Belessi, C.2
Moreno, C.3
-
90
-
-
38949203770
-
Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: Implications for the role of antigen selection in leukemogenesis
-
Murray F, Darzentas N, Hadzidimitriou A, et al. Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood 2008; 111: 1524-33.
-
(2008)
Blood
, vol.111
, pp. 1524-1533
-
-
Murray, F.1
Darzentas, N.2
Hadzidimitriou, A.3
-
91
-
-
79951498701
-
Cellular origin(s) of chronic lymphocytic leukemia: Cautionary notes and additional considerations and possibilities
-
Chiorazzi N, Ferrarini M. Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood 2011; 117: 1781-91.
-
(2011)
Blood
, vol.117
, pp. 1781-1791
-
-
Chiorazzi, N.1
Ferrarini, M.2
-
92
-
-
33845513520
-
ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia
-
Ghia P, Stamatopoulos K, Belessi C, et al. ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia. Leukemia 2007; 21: 1-3.
-
(2007)
Leukemia
, vol.21
, pp. 1-3
-
-
Ghia, P.1
Stamatopoulos, K.2
Belessi, C.3
-
93
-
-
79958131059
-
Immunoglobulin sequence analysis and prognostication in CLL: Guidelines from the ERIC review board for reliable interpretation of problematic cases
-
Langerak AW, Davi F, Ghia P, et al. Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases. Leukemia 2011; 25: 979-84.
-
(2011)
Leukemia
, vol.25
, pp. 979-984
-
-
Langerak, A.W.1
Davi, F.2
Ghia, P.3
-
94
-
-
38349048239
-
Determination of IGHV gene mutational status in chronic lymphocytic leukemia: Bioinformatics advances meet clinical needs
-
Davi F, Rosenquist R, Ghia P, Belessi C, Stamatopoulos K. Determination of IGHV gene mutational status in chronic lymphocytic leukemia: bioinformatics advances meet clinical needs. Leukemia 2008; 22: 212-4.
-
(2008)
Leukemia
, vol.22
, pp. 212-214
-
-
Davi, F.1
Rosenquist, R.2
Ghia, P.3
Belessi, C.4
Stamatopoulos, K.5
-
95
-
-
22144480303
-
The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia
-
Oppezzo P, Vasconcelos Y, Settegrana C, et al. The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia. Blood 2005; 106: 650-7.
-
(2005)
Blood
, vol.106
, pp. 650-657
-
-
Oppezzo, P.1
Vasconcelos, Y.2
Settegrana, C.3
-
96
-
-
21744437314
-
High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia
-
Heintel D, Kienle D, Shehata M, et al. High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia. Leukemia 2005; 19: 1216-23.
-
(2005)
Leukemia
, vol.19
, pp. 1216-1223
-
-
Heintel, D.1
Kienle, D.2
Shehata, M.3
-
97
-
-
32544451164
-
The predictive value of lipoprotein lipase for survival in chronic lymphocytic leukemia
-
van't Veer MB, Brooijmans AM, Langerak AW, et al. The predictive value of lipoprotein lipase for survival in chronic lymphocytic leukemia. Haematologica 2006; 91: 56-63.
-
(2006)
Haematologica
, vol.91
, pp. 56-63
-
-
van't Veer, M.B.1
Brooijmans, A.M.2
Langerak, A.W.3
-
98
-
-
73949158411
-
High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia
-
Herling M, Patel KA, Weit N, et al. High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia. Blood 2009; 114: 4675-86.
-
(2009)
Blood
, vol.114
, pp. 4675-4686
-
-
Herling, M.1
Patel, K.A.2
Weit, N.3
-
99
-
-
0037085801
-
Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia
-
Tobin G, Thunberg U, Johnson A, et al. Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood 2002; 99: 2262-4.
-
(2002)
Blood
, vol.99
, pp. 2262-2264
-
-
Tobin, G.1
Thunberg, U.2
Johnson, A.3
-
100
-
-
0042744704
-
High frequency of p53 dysfunction and low level of VH mutation in chronic lymphocytic leukemia patients using the VH3-21 gene segment
-
Lin K, Manocha S, Harris RJ, Matrai Z, Sherrington PD, Pettitt AR. High frequency of p53 dysfunction and low level of VH mutation in chronic lymphocytic leukemia patients using the VH3-21 gene segment. Blood 2003; 102: 1145-6.
-
(2003)
Blood
, vol.102
, pp. 1145-1146
-
-
Lin, K.1
Manocha, S.2
Harris, R.J.3
Matrai, Z.4
Sherrington, P.D.5
Pettitt, A.R.6
-
101
-
-
33645507226
-
Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status
-
Thorselius M, Krober A, Murray F, et al. Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status. Blood 2006; 107: 2889-94.
-
(2006)
Blood
, vol.107
, pp. 2889-2894
-
-
Thorselius, M.1
Krober, A.2
Murray, F.3
-
102
-
-
0030639650
-
Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features
-
Johnson TA, Rassenti LZ, Kipps TJ. Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J Immunol 1997; 158: 235-46.
-
(1997)
J Immunol
, vol.158
, pp. 235-246
-
-
Johnson, T.A.1
Rassenti, L.Z.2
Kipps, T.J.3
-
103
-
-
0000634555
-
Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia
-
Kipps TJ, Tomhave E, Pratt LF, Duffy S, Chen PP, Carson DA. Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 1989; 86: 5913-7.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 5913-5917
-
-
Kipps, T.J.1
Tomhave, E.2
Pratt, L.F.3
Duffy, S.4
Chen, P.P.5
Carson, D.A.6
-
104
-
-
0028355650
-
The pathogenesis of chronic lymphocytic leukemia: Analysis of the antibody repertoire
-
Schroeder HW, Jr., Dighiero G. The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire. Immunol Today 1994; 15: 288-94.
-
(1994)
Immunol Today
, vol.15
, pp. 288-294
-
-
Schroeder Jr., H.W.1
Dighiero, G.2
-
105
-
-
84863511926
-
Stereotyped B cell receptors in chronic lymphocytic leukemia
-
P. Ghia Rr, F. Davi, ed., Wolters Kluwer Health Italy: Milan
-
Stamatopoulos K. Stereotyped B cell receptors in chronic lymphocytic leukemia. In: P. Ghia Rr, F. Davi, ed., Immunoglobulin gene analysis in chronic lymphocytic leukemia. Wolters Kluwer Health Italy: Milan 2009; pp. 95-112.
-
(2009)
Immunoglobulin Gene Analysis In Chronic Lymphocytic Leukemia
, pp. 95-112
-
-
Stamatopoulos, K.1
-
106
-
-
0032532668
-
Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
-
Fais F, Ghiotto F, Hashimoto S, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998; 102: 1515-25.
-
(1998)
J Clin Invest
, vol.102
, pp. 1515-1525
-
-
Fais, F.1
Ghiotto, F.2
Hashimoto, S.3
-
107
-
-
0035164178
-
Normal B cells express 51p1-encoded Ig heavy chains that are distinct from those expressed by chronic lymphocytic leukemia B cells
-
Widhopf GF, 2nd, Kipps TJ. Normal B cells express 51p1-encoded Ig heavy chains that are distinct from those expressed by chronic lymphocytic leukemia B cells. J Immunol 2001; 166: 95-102.
-
(2001)
J Immunol
, vol.166
, pp. 95-102
-
-
Widhopf II, G.F.1
Kipps, T.J.2
-
108
-
-
0038281374
-
Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire
-
Potter KN, Orchard J, Critchley E, Mockridge CI, Jose A, Stevenson FK. Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire. Blood 2003; 101: 3082-4.
-
(2003)
Blood
, vol.101
, pp. 3082-3084
-
-
Potter, K.N.1
Orchard, J.2
Critchley, E.3
Mockridge, C.I.4
Jose, A.5
Stevenson, F.K.6
-
109
-
-
10744230550
-
Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: Implicating recognition of a common antigen epitope
-
Tobin G, Thunberg U, Johnson A, et al. Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope. Blood 2003; 101: 4952-7.
-
(2003)
Blood
, vol.101
, pp. 4952-4957
-
-
Tobin, G.1
Thunberg, U.2
Johnson, A.3
-
110
-
-
4944244255
-
Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins
-
Widhopf GF, 2nd, Rassenti LZ, Toy TL, Gribben JG, Wierda WG, Kipps TJ. Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood 2004; 104: 2499-504.
-
(2004)
Blood
, vol.104
, pp. 2499-2504
-
-
Widhopf II, G.F.1
Rassenti, L.Z.2
Toy, T.L.3
Gribben, J.G.4
Wierda, W.G.5
Kipps, T.J.6
-
111
-
-
11144356992
-
Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia
-
Ghiotto F, Fais F, Valetto A, et al. Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia. J Clin Invest 2004; 113: 1008-16.
-
(2004)
J Clin Invest
, vol.113
, pp. 1008-1016
-
-
Ghiotto, F.1
Fais, F.2
Valetto, A.3
-
112
-
-
7244232709
-
Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia
-
Tobin G, Thunberg U, Karlsson K, et al. Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood 2004; 104: 2879-85.
-
(2004)
Blood
, vol.104
, pp. 2879-2885
-
-
Tobin, G.1
Thunberg, U.2
Karlsson, K.3
-
113
-
-
74249107417
-
A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: Molecular and computational evidence
-
Darzentas N, Hadzidimitriou A, Murray F, et al. A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence. Leukemia 2010; 24: 125-32.
-
(2010)
Leukemia
, vol.24
, pp. 125-132
-
-
Darzentas, N.1
Hadzidimitriou, A.2
Murray, F.3
-
114
-
-
33746238516
-
IGHV gene insertions and deletions in chronic lymphocytic leukemia: CLLbiased deletions in a subset of cases with stereotyped receptors
-
Belessi CJ, Davi FB, Stamatopoulos KE, et al. IGHV gene insertions and deletions in chronic lymphocytic leukemia: CLLbiased deletions in a subset of cases with stereotyped receptors. Eur J Immunol 2006; 36: 1963-74.
-
(2006)
Eur J Immunol
, vol.36
, pp. 1963-1974
-
-
Belessi, C.J.1
Davi, F.B.2
Stamatopoulos, K.E.3
-
115
-
-
13544275555
-
Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: The lesson of the IGHV3-21 gene
-
Ghia P, Stamatopoulos K, Belessi C, et al. Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Blood 2005; 105: 1678-85.
-
(2005)
Blood
, vol.105
, pp. 1678-1685
-
-
Ghia, P.1
Stamatopoulos, K.2
Belessi, C.3
-
116
-
-
27144549307
-
Differential effects on CLL cell survival exerted by different microenvironmental elements
-
Ghia P, Circosta P, Scielzo C, et al. Differential effects on CLL cell survival exerted by different microenvironmental elements. Curr Top Microbiol Immunol 2005; 294: 135-45.
-
(2005)
Curr Top Microbiol Immunol
, vol.294
, pp. 135-145
-
-
Ghia, P.1
Circosta, P.2
Scielzo, C.3
-
117
-
-
73349090583
-
Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: Implications for ongoing interactions with antigen
-
Sutton LA, Kostareli E, Hadzidimitriou A, et al. Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen. Blood 2009; 114: 4460-8.
-
(2009)
Blood
, vol.114
, pp. 4460-4468
-
-
Sutton, L.A.1
Kostareli, E.2
Hadzidimitriou, A.3
-
118
-
-
55349111133
-
Peritoneal B-cell subsets in the genus Mus: Their role in innate immunity
-
Thiriot A, Freitas AA, Rueff-Juy D. Peritoneal B-cell subsets in the genus Mus: their role in innate immunity. Crit Rev Immunol 2008; 28: 341-61.
-
(2008)
Crit Rev Immunol
, vol.28
, pp. 341-361
-
-
Thiriot, A.1
Freitas, A.A.2
Rueff-Juy, D.3
-
119
-
-
78650600361
-
The double life of a B-1 cell: Self-reactivity selects for protective effector functions
-
Baumgarth N. The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat Rev Immunol 2011; 11: 34-46.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 34-46
-
-
Baumgarth, N.1
-
120
-
-
33747761954
-
B-1 B cell development
-
Hardy RR. B-1 B cell development. J Immunol 2006; 177: 2749-54.
-
(2006)
J Immunol
, vol.177
, pp. 2749-2754
-
-
Hardy, R.R.1
-
121
-
-
0036217975
-
Origins and functions of B-1 cells with notes on the role of CD5
-
Berland R, Wortis HH. Origins and functions of B-1 cells with notes on the role of CD5. Annu Rev Immunol 2002; 20: 253-300.
-
(2002)
Annu Rev Immunol
, vol.20
, pp. 253-300
-
-
Berland, R.1
Wortis, H.H.2
-
122
-
-
0033515101
-
Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system
-
Baumgarth N, Herman OC, Jager GC, Brown L, Herzenberg LA. Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system. Proc Natl Acad Sci USA 1999; 96: 2250-5.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 2250-2255
-
-
Baumgarth, N.1
Herman, O.C.2
Jager, G.C.3
Brown, L.4
Herzenberg, L.A.5
-
123
-
-
59649112173
-
Dual role for B-1a cells in immunity to influenza virus infection
-
Choi YS, Baumgarth N. Dual role for B-1a cells in immunity to influenza virus infection. J Exp Med 2008; 205: 3053-64.
-
(2008)
J Exp Med
, vol.205
, pp. 3053-3064
-
-
Choi, Y.S.1
Baumgarth, N.2
-
124
-
-
0028354220
-
Development of B-1 cells: Segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression
-
Arnold LW, Pennell CA, McCray SK, Clarke SH. Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression. J Exp Med 1994; 179: 1585-95.
-
(1994)
J Exp Med
, vol.179
, pp. 1585-1595
-
-
Arnold, L.W.1
Pennell, C.A.2
McCray, S.K.3
Clarke, S.H.4
-
125
-
-
0942268731
-
Selection during development of VH11+ B cells: A model for natural autoantibody-producing CD5+ B cells
-
Hardy RR, Wei CJ, Hayakawa K. Selection during development of VH11+ B cells: a model for natural autoantibody-producing CD5+ B cells. Immunol Rev 2004; 197: 60-74.
-
(2004)
Immunol Rev
, vol.197
, pp. 60-74
-
-
Hardy, R.R.1
Wei, C.J.2
Hayakawa, K.3
-
126
-
-
0033516689
-
Positive selection of natural autoreactive B cells
-
Hayakawa K, Asano M, Shinton SA, et al. Positive selection of natural autoreactive B cells. Science 1999; 285: 113-6.
-
(1999)
Science
, vol.285
, pp. 113-116
-
-
Hayakawa, K.1
Asano, M.2
Shinton, S.A.3
-
127
-
-
78651509914
-
Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70
-
Griffin DO, Holodick NE, Rothstein TL. Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70. J Exp Med 2011; 208: 67-80.
-
(2011)
J Exp Med
, vol.208
, pp. 67-80
-
-
Griffin, D.O.1
Holodick, N.E.2
Rothstein, T.L.3
-
128
-
-
20444454585
-
Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity
-
Herve M, Xu K, Ng YS, et al. Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J Clin Invest 2005; 115: 1636-43.
-
(2005)
J Clin Invest
, vol.115
, pp. 1636-1643
-
-
Herve, M.1
Xu, K.2
Ng, Y.S.3
-
129
-
-
55749091407
-
Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA
-
Chu CC, Catera R, Hatzi K, et al. Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. Blood 2008; 112: 5122-9.
-
(2008)
Blood
, vol.112
, pp. 5122-5129
-
-
Chu, C.C.1
Catera, R.2
Hatzi, K.3
-
130
-
-
33744495071
-
HCV-NS3 and IgG-Fc crossreactive IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferations
-
De Re V, Sansonno D, Simula MP, et al. HCV-NS3 and IgG-Fc crossreactive IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferations. Leukemia 2006; 20: 1145-54.
-
(2006)
Leukemia
, vol.20
, pp. 1145-1154
-
-
de Re, V.1
Sansonno, D.2
Simula, M.P.3
-
131
-
-
0036785583
-
Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen
-
Potter KN, Hobby P, Klijn S, Stevenson FK, Sutton BJ. Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen. J Immunol 2002; 169: 3777-82.
-
(2002)
J Immunol
, vol.169
, pp. 3777-3782
-
-
Potter, K.N.1
Hobby, P.2
Klijn, S.3
Stevenson, F.K.4
Sutton, B.J.5
-
132
-
-
1642355937
-
Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45/B220 on the surface of human B lymphocytes
-
Cappione AJ, Pugh-Bernard AE, Anolik JH, Sanz I. Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45/B220 on the surface of human B lymphocytes. J Immunol 2004; 172: 4298-307.
-
(2004)
J Immunol
, vol.172
, pp. 4298-4307
-
-
Cappione, A.J.1
Pugh-Bernard, A.E.2
Anolik, J.H.3
Sanz, I.4
-
133
-
-
67349164793
-
Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors
-
Kostareli E, Hadzidimitriou A, Stavroyianni N, et al. Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors. Leukemia 2009; 23: 919-24.
-
(2009)
Leukemia
, vol.23
, pp. 919-924
-
-
Kostareli, E.1
Hadzidimitriou, A.2
Stavroyianni, N.3
-
134
-
-
55749114077
-
Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation
-
Catera R, Silverman GJ, Hatzi K, et al. Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation. Mol Med 2008; 14: 665-74.
-
(2008)
Mol Med
, vol.14
, pp. 665-674
-
-
Catera, R.1
Silverman, G.J.2
Hatzi, K.3
-
135
-
-
43549093570
-
A new perspective: Molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies
-
Lanemo Myhrinder A, Hellqvist E, Sidorova E, et al. A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood 2008; 111: 3838-48.
-
(2008)
Blood
, vol.111
, pp. 3838-3848
-
-
Lanemo Myhrinder, A.1
Hellqvist, E.2
Sidorova, E.3
-
136
-
-
77957125242
-
Oligomeric organization of the B-cell antigen receptor on resting cells
-
Yang J, Reth M. Oligomeric organization of the B-cell antigen receptor on resting cells. Nature 2010; 467: 465-9.
-
(2010)
Nature
, vol.467
, pp. 465-469
-
-
Yang, J.1
Reth, M.2
-
137
-
-
0028793187
-
Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases
-
Johnson SA, Pleiman CM, Pao L, Schneringer J, Hippen K, Cambier JC. Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases. J Immunol 1995; 155: 4596-603.
-
(1995)
J Immunol
, vol.155
, pp. 4596-4603
-
-
Johnson, S.A.1
Pleiman, C.M.2
Pao, L.3
Schneringer, J.4
Hippen, K.5
Cambier, J.C.6
-
138
-
-
0036866477
-
Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop
-
Rolli V, Gallwitz M, Wossning T, et al. Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop. Mol Cell 2002; 10: 1057-69.
-
(2002)
Mol Cell
, vol.10
, pp. 1057-1069
-
-
Rolli, V.1
Gallwitz, M.2
Wossning, T.3
-
139
-
-
0033561627
-
Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase
-
Buhl AM, Cambier JC. Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase. J Immunol 1999; 162: 4438-46.
-
(1999)
J Immunol
, vol.162
, pp. 4438-4446
-
-
Buhl, A.M.1
Cambier, J.C.2
-
140
-
-
0033697728
-
CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification
-
Fujimoto M, Fujimoto Y, Poe JC, et al. CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity 2000; 13: 47-57.
-
(2000)
Immunity
, vol.13
, pp. 47-57
-
-
Fujimoto, M.1
Fujimoto, Y.2
Poe, J.C.3
-
141
-
-
0032076954
-
CD19 as a membraneanchored adaptor protein of B lymphocytes: Costimulation of lipid and protein kinases by recruitment of Vav
-
O'Rourke LM, Tooze R, Turner M, et al. CD19 as a membraneanchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav. Immunity 1998; 8: 635-45.
-
(1998)
Immunity
, vol.8
, pp. 635-645
-
-
O'Rourke, L.M.1
Tooze, R.2
Turner, M.3
-
142
-
-
0037148505
-
Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation
-
Inabe K, Ishiai M, Scharenberg AM, Freshney N, Downward J, Kurosaki T. Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. J Exp Med 2002; 195: 189-200.
-
(2002)
J Exp Med
, vol.195
, pp. 189-200
-
-
Inabe, K.1
Ishiai, M.2
Scharenberg, A.M.3
Freshney, N.4
Downward, J.5
Kurosaki, T.6
-
143
-
-
0034507903
-
BCAP: The tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
-
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T. BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 2000; 13: 817-27.
-
(2000)
Immunity
, vol.13
, pp. 817-827
-
-
Okada, T.1
Maeda, A.2
Iwamatsu, A.3
Gotoh, K.4
Kurosaki, T.5
-
144
-
-
0027441332
-
The gene involved in Xlinked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases
-
Vetrie D, Vorechovsky I, Sideras P, et al. The gene involved in Xlinked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature 1993; 361: 226-33.
-
(1993)
Nature
, vol.361
, pp. 226-233
-
-
Vetrie, D.1
Vorechovsky, I.2
Sideras, P.3
-
145
-
-
0027399081
-
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
-
Tsukada S, Saffran DC, Rawlings DJ, et al. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell 1993; 72: 279-90.
-
(1993)
Cell
, vol.72
, pp. 279-290
-
-
Tsukada, S.1
Saffran, D.C.2
Rawlings, D.J.3
-
146
-
-
0028033527
-
B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia
-
de Weers M, Brouns GS, Hinshelwood S, et al. B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia. J Biol Chem 1994; 269: 23857-60.
-
(1994)
J Biol Chem
, vol.269
, pp. 23857-23860
-
-
de Weers, M.1
Brouns, G.S.2
Hinshelwood, S.3
-
147
-
-
0035844208
-
Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk
-
Saito K, Scharenberg AM, Kinet JP. Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk. J Biol Chem 2001; 276: 16201-6.
-
(2001)
J Biol Chem
, vol.276
, pp. 16201-16206
-
-
Saito, K.1
Scharenberg, A.M.2
Kinet, J.P.3
-
148
-
-
0030038840
-
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases
-
Rawlings DJ, Scharenberg AM, Park H, et al. Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science 1996; 271: 822-5.
-
(1996)
Science
, vol.271
, pp. 822-825
-
-
Rawlings, D.J.1
Scharenberg, A.M.2
Park, H.3
-
149
-
-
0030916169
-
Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function
-
Kurosaki T, Kurosaki M. Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function. J Biol Chem 1997; 272: 15595-8.
-
(1997)
J Biol Chem
, vol.272
, pp. 15595-15598
-
-
Kurosaki, T.1
Kurosaki, M.2
-
150
-
-
0030152357
-
Regulation of Btk function by a major autophosphorylation site within the SH3 domain
-
Park H, Wahl MI, Afar DE, et al. Regulation of Btk function by a major autophosphorylation site within the SH3 domain. Immunity 1996; 4: 515-25.
-
(1996)
Immunity
, vol.4
, pp. 515-525
-
-
Park, H.1
Wahl, M.I.2
Afar, D.E.3
-
151
-
-
0345447618
-
Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity
-
Middendorp S, Dingjan GM, Maas A, Dahlenborg K, Hendriks RW. Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity. J Immunol 2003; 171: 5988-96.
-
(2003)
J Immunol
, vol.171
, pp. 5988-5996
-
-
Middendorp, S.1
Dingjan, G.M.2
Maas, A.3
Dahlenborg, K.4
Hendriks, R.W.5
-
152
-
-
0032541388
-
SLP-65: A new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation
-
Wienands J, Schweikert J, Wollscheid B, Jumaa H, Nielsen PJ, Reth M. SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation. J Exp Med 1998; 188: 791-5.
-
(1998)
J Exp Med
, vol.188
, pp. 791-795
-
-
Wienands, J.1
Schweikert, J.2
Wollscheid, B.3
Jumaa, H.4
Nielsen, P.J.5
Reth, M.6
-
153
-
-
0033229798
-
Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65
-
Jumaa H, Wollscheid B, Mitterer M, Wienands J, Reth M, Nielsen PJ. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity 1999; 11: 547-54.
-
(1999)
Immunity
, vol.11
, pp. 547-554
-
-
Jumaa, H.1
Wollscheid, B.2
Mitterer, M.3
Wienands, J.4
Reth, M.5
Nielsen, P.J.6
-
154
-
-
0033521085
-
Requirement for B cell linker protein (BLNK) in B cell development
-
Pappu R, Cheng AM, Li B, et al. Requirement for B cell linker protein (BLNK) in B cell development. Science 1999; 286: 1949-54.
-
(1999)
Science
, vol.286
, pp. 1949-1954
-
-
Pappu, R.1
Cheng, A.M.2
Li, B.3
-
155
-
-
0033521148
-
An essential role for BLNK in human B cell development
-
Minegishi Y, Rohrer J, Coustan-Smith E, et al. An essential role for BLNK in human B cell development. Science 1999; 286: 1954-7.
-
(1999)
Science
, vol.286
, pp. 1954-1957
-
-
Minegishi, Y.1
Rohrer, J.2
Coustan-Smith, E.3
-
156
-
-
0032127159
-
BLNK: A central linker protein in B cell activation
-
Fu C, Turck CW, Kurosaki T, Chan AC. BLNK: a central linker protein in B cell activation. Immunity 1998; 9: 93-103.
-
(1998)
Immunity
, vol.9
, pp. 93-103
-
-
Fu, C.1
Turck, C.W.2
Kurosaki, T.3
Chan, A.C.4
-
157
-
-
0037011114
-
BLNK: Molecular scaffolding through 'cis'-mediated organization of signaling proteins
-
Chiu CW, Dalton M, Ishiai M, Kurosaki T, Chan AC. BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins. EMBO J 2002; 21: 6461-72.
-
(2002)
EMBO J
, vol.21
, pp. 6461-6472
-
-
Chiu, C.W.1
Dalton, M.2
Ishiai, M.3
Kurosaki, T.4
Chan, A.C.5
-
158
-
-
0033214220
-
Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling
-
Hashimoto S, Iwamatsu A, Ishiai M, et al. Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling. Blood 1999; 94: 2357-64.
-
(1999)
Blood
, vol.94
, pp. 2357-2364
-
-
Hashimoto, S.1
Iwamatsu, A.2
Ishiai, M.3
-
159
-
-
0033056366
-
BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells
-
Ishiai M, Kurosaki M, Pappu R, et al. BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells. Immunity 1999; 10: 117-25.
-
(1999)
Immunity
, vol.10
, pp. 117-125
-
-
Ishiai, M.1
Kurosaki, M.2
Pappu, R.3
-
160
-
-
42249090333
-
Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen
-
Weber M, Treanor B, Depoil D, et al. Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen. J Exp Med 2008; 205: 853-68.
-
(2008)
J Exp Med
, vol.205
, pp. 853-868
-
-
Weber, M.1
Treanor, B.2
Depoil, D.3
-
161
-
-
0032748581
-
Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt
-
Craxton A, Jiang A, Kurosaki T, Clark EA. Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt. J Biol Chem 1999; 274: 30644-50.
-
(1999)
J Biol Chem
, vol.274
, pp. 30644-30650
-
-
Craxton, A.1
Jiang, A.2
Kurosaki, T.3
Clark, E.A.4
-
162
-
-
0036333737
-
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
-
Scheid MP, Marignani PA, Woodgett JR. Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol Cell Biol 2002; 22: 6247-60.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 6247-6260
-
-
Scheid, M.P.1
Marignani, P.A.2
Woodgett, J.R.3
-
163
-
-
2342667375
-
Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling
-
Fruman DA. Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling. Curr Opin Immunol 2004; 16: 314-20.
-
(2004)
Curr Opin Immunol
, vol.16
, pp. 314-320
-
-
Fruman, D.A.1
-
164
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999; 96: 857-68.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
-
165
-
-
0038362751
-
Akt activation promotes degradation of tuberin and FOXO3a via the proteasome
-
Plas DR, Thompson CB. Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. J Biol Chem 2003; 278: 12361-6.
-
(2003)
J Biol Chem
, vol.278
, pp. 12361-12366
-
-
Plas, D.R.1
Thompson, C.B.2
-
166
-
-
0030890234
-
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
-
Beals CR, Sheridan CM, Turck CW, Gardner P, Crabtree GR. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 1997; 275: 1930-4.
-
(1997)
Science
, vol.275
, pp. 1930-1934
-
-
Beals, C.R.1
Sheridan, C.M.2
Turck, C.W.3
Gardner, P.4
Crabtree, G.R.5
-
168
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91: 231-41.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
-
169
-
-
33846964621
-
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
-
Willis SN, Fletcher JI, Kaufmann T, et al. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 2007; 315: 856-9.
-
(2007)
Science
, vol.315
, pp. 856-859
-
-
Willis, S.N.1
Fletcher, J.I.2
Kaufmann, T.3
-
170
-
-
33644855216
-
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
-
Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell 2006; 21: 749-60.
-
(2006)
Mol Cell
, vol.21
, pp. 749-760
-
-
Maurer, U.1
Charvet, C.2
Wagman, A.S.3
Dejardin, E.4
Green, D.R.5
-
171
-
-
0031007450
-
Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor
-
Sugawara H, Kurosaki M, Takata M, Kurosaki T. Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor. EMBO J 1997; 16: 3078-88.
-
(1997)
EMBO J
, vol.16
, pp. 3078-3088
-
-
Sugawara, H.1
Kurosaki, M.2
Takata, M.3
Kurosaki, T.4
-
172
-
-
45449093954
-
Calcium signaling in lymphocytes
-
Oh-hora M, Rao A. Calcium signaling in lymphocytes. Curr Opin Immunol 2008; 20: 250-8.
-
(2008)
Curr Opin Immunol
, vol.20
, pp. 250-258
-
-
Oh-Hora, M.1
Rao, A.2
-
173
-
-
37549011707
-
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells
-
Shinohara H, Maeda S, Watarai H, Kurosaki T. IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells. J Exp Med 2007; 204: 3285-93.
-
(2007)
J Exp Med
, vol.204
, pp. 3285-3293
-
-
Shinohara, H.1
Maeda, S.2
Watarai, H.3
Kurosaki, T.4
-
174
-
-
77955288093
-
Roles of the NF-kappaB pathway in lymphocyte development and function
-
Gerondakis S, Siebenlist U. Roles of the NF-kappaB pathway in lymphocyte development and function. Cold Spring Harb Perspect Biol 2010; 2: a000182.
-
(2010)
Cold Spring Harb Perspect Biol
, vol.2
-
-
Gerondakis, S.1
Siebenlist, U.2
-
175
-
-
0032487507
-
Involvement of guanosine triphosphatases and phospholipase C-gamma2 in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor
-
Hashimoto A, Okada H, Jiang A, et al. Involvement of guanosine triphosphatases and phospholipase C-gamma2 in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor. J Exp Med 1998; 188: 1287-95.
-
(1998)
J Exp Med
, vol.188
, pp. 1287-1295
-
-
Hashimoto, A.1
Okada, H.2
Jiang, A.3
-
176
-
-
0030888186
-
Differential activation of transcription factors induced by Ca2+ response amplitude and duration
-
Dolmetsch RE, Lewis RS, Goodnow CC, Healy JI. Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature 1997; 386: 855-8.
-
(1997)
Nature
, vol.386
, pp. 855-858
-
-
Dolmetsch, R.E.1
Lewis, R.S.2
Goodnow, C.C.3
Healy, J.I.4
-
177
-
-
0141483523
-
Transcriptional regulation by calcium, calcineurin, and NFAT
-
Hogan PG, Chen L, Nardone J, Rao A. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 2003; 17: 2205-32.
-
(2003)
Genes Dev
, vol.17
, pp. 2205-2232
-
-
Hogan, P.G.1
Chen, L.2
Nardone, J.3
Rao, A.4
-
178
-
-
36148978171
-
Signaling pathways activated by antigen-receptor engagement in chronic lymphocytic leukemia B-cells
-
Efremov DG, Gobessi S, Longo PG. Signaling pathways activated by antigen-receptor engagement in chronic lymphocytic leukemia B-cells. Autoimmun Rev 2007; 7: 102-8.
-
(2007)
Autoimmun Rev
, vol.7
, pp. 102-108
-
-
Efremov, D.G.1
Gobessi, S.2
Longo, P.G.3
-
179
-
-
78649792807
-
The role of the B-cell receptor in the pathogenesis of chronic lymphocytic leukaemia
-
Packham G, Stevenson F. The role of the B-cell receptor in the pathogenesis of chronic lymphocytic leukaemia. Semin Cancer Biol 2010; 20: 391-9.
-
(2010)
Semin Cancer Biol
, vol.20
, pp. 391-399
-
-
Packham, G.1
Stevenson, F.2
-
180
-
-
0025253488
-
Altered signal transduction secondary to surface IgM cross-linking on B-chronic lymphocytic leukemia cells. Differential activation of the phosphatidylinositol-specific phospholipase C
-
Hivroz C, Geny B, Brouet JC, Grillot-Courvalin C. Altered signal transduction secondary to surface IgM cross-linking on B-chronic lymphocytic leukemia cells. Differential activation of the phosphatidylinositol-specific phospholipase C. J Immunol 1990; 144: 2351-8.
-
(1990)
J Immunol
, vol.144
, pp. 2351-2358
-
-
Hivroz, C.1
Geny, B.2
Brouet, J.C.3
Grillot-Courvalin, C.4
-
181
-
-
0027318287
-
Defective calcium response in B-chronic lymphocytic leukemia cells. Alteration of early protein tyrosine phosphorylation and of the mechanism responsible for cell calcium influx
-
Michel F, Merle-Beral H, Legac E, Michel A, Debre P, Bismuth G. Defective calcium response in B-chronic lymphocytic leukemia cells. Alteration of early protein tyrosine phosphorylation and of the mechanism responsible for cell calcium influx. J Immunol 1993; 150: 3624-33.
-
(1993)
J Immunol
, vol.150
, pp. 3624-3633
-
-
Michel, F.1
Merle-Beral, H.2
Legac, E.3
Michel, A.4
Debre, P.5
Bismuth, G.6
-
182
-
-
0029144435
-
Antigen receptor nonresponsiveness in chronic lymphocytic leukemia B cells
-
Lankester AC, van Schijndel GM, van der Schoot CE, van Oers MH, van Noesel CJ, van Lier RA. Antigen receptor nonresponsiveness in chronic lymphocytic leukemia B cells. Blood 1995; 86: 1090-7.
-
(1995)
Blood
, vol.86
, pp. 1090-1097
-
-
Lankester, A.C.1
van Schijndel, G.M.2
van der Schoot, C.E.3
van Oers, M.H.4
van Noesel, C.J.5
van Lier, R.A.6
-
183
-
-
0029836635
-
CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis
-
Zupo S, Isnardi L, Megna M, et al. CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis. Blood 1996; 88: 1365-74.
-
(1996)
Blood
, vol.88
, pp. 1365-1374
-
-
Zupo, S.1
Isnardi, L.2
Megna, M.3
-
184
-
-
0034651926
-
Apoptosis or plasma cell differentiation of CD38-positive B-chronic lymphocytic leukemia cells induced by cross-linking of surface IgM or IgD
-
Zupo S, Massara R, Dono M, et al. Apoptosis or plasma cell differentiation of CD38-positive B-chronic lymphocytic leukemia cells induced by cross-linking of surface IgM or IgD. Blood 2000; 95: 1199-206.
-
(2000)
Blood
, vol.95
, pp. 1199-1206
-
-
Zupo, S.1
Massara, R.2
Dono, M.3
-
185
-
-
0035892106
-
Survival of leukemic B cells promoted by engagement of the antigen receptor
-
Bernal A, Pastore RD, Asgary Z, et al. Survival of leukemic B cells promoted by engagement of the antigen receptor. Blood 2001; 98: 3050-7.
-
(2001)
Blood
, vol.98
, pp. 3050-3057
-
-
Bernal, A.1
Pastore, R.D.2
Asgary, Z.3
-
186
-
-
23844466900
-
B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia
-
Allsup DJ, Kamiguti AS, Lin K, et al. B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia. Cancer Res 2005; 65: 7328-37.
-
(2005)
Cancer Res
, vol.65
, pp. 7328-7337
-
-
Allsup, D.J.1
Kamiguti, A.S.2
Lin, K.3
-
187
-
-
14844366139
-
B cell response to surface IgM cross-linking identifies different prognostic groups of B-chronic lymphocytic leukemia patients
-
Nedellec S, Renaudineau Y, Bordron A, et al. B cell response to surface IgM cross-linking identifies different prognostic groups of B-chronic lymphocytic leukemia patients. J Immunol 2005; 174: 3749-56.
-
(2005)
J Immunol
, vol.174
, pp. 3749-3756
-
-
Nedellec, S.1
Renaudineau, Y.2
Bordron, A.3
-
188
-
-
47249152803
-
Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: A molecular signature of anergy
-
Muzio M, Apollonio B, Scielzo C, et al. Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy. Blood 2008; 112: 188-95.
-
(2008)
Blood
, vol.112
, pp. 188-195
-
-
Muzio, M.1
Apollonio, B.2
Scielzo, C.3
-
189
-
-
0037306842
-
Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia
-
Lanham S, Hamblin T, Oscier D, Ibbotson R, Stevenson F, Packham G. Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia. Blood 2003; 101: 1087-93.
-
(2003)
Blood
, vol.101
, pp. 1087-1093
-
-
Lanham, S.1
Hamblin, T.2
Oscier, D.3
Ibbotson, R.4
Stevenson, F.5
Packham, G.6
-
190
-
-
33746924345
-
Survival response to B-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression
-
Deglesne PA, Chevallier N, Letestu R, et al. Survival response to B-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression. Cancer Res 2006; 66: 7158-66.
-
(2006)
Cancer Res
, vol.66
, pp. 7158-7166
-
-
Deglesne, P.A.1
Chevallier, N.2
Letestu, R.3
-
191
-
-
50949128066
-
BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells
-
Guarini A, Chiaretti S, Tavolaro S, et al. BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells. Blood 2008; 112: 782-92.
-
(2008)
Blood
, vol.112
, pp. 782-792
-
-
Guarini, A.1
Chiaretti, S.2
Tavolaro, S.3
-
192
-
-
20444389401
-
Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells
-
Petlickovski A, Laurenti L, Li X, et al. Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells. Blood 2005; 105: 4820-7.
-
(2005)
Blood
, vol.105
, pp. 4820-4827
-
-
Petlickovski, A.1
Laurenti, L.2
Li, X.3
-
193
-
-
77953647130
-
Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo
-
Krysov S, Potter KN, Mockridge CI et al. Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo. Blood 2010; 115: 4198-205.
-
(2010)
Blood
, vol.115
, pp. 4198-4205
-
-
Krysov, S.1
Potter, K.N.2
Mockridge, C.I.3
-
194
-
-
70350685770
-
Adaptive regulation at the cell surface by N-glycosylation
-
Dennis JW, Lau KS, Demetriou M, Nabi IR. Adaptive regulation at the cell surface by N-glycosylation. Traffic 2009; 10: 1569-78.
-
(2009)
Traffic
, vol.10
, pp. 1569-1578
-
-
Dennis, J.W.1
Lau, K.S.2
Demetriou, M.3
Nabi, I.R.4
-
195
-
-
0033120422
-
An alternatively spliced form of CD79b gene may account for altered B-cell receptor expression in B-chronic lymphocytic leukemia
-
Alfarano A, Indraccolo S, Circosta P, et al. An alternatively spliced form of CD79b gene may account for altered B-cell receptor expression in B-chronic lymphocytic leukemia. Blood 1999; 93: 2327-35.
-
(1999)
Blood
, vol.93
, pp. 2327-2335
-
-
Alfarano, A.1
Indraccolo, S.2
Circosta, P.3
-
196
-
-
0036839315
-
The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis
-
Cragg MS, Chan HT, Fox MD, et al. The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis. Blood 2002; 100: 3068-76.
-
(2002)
Blood
, vol.100
, pp. 3068-3076
-
-
Cragg, M.S.1
Chan, H.T.2
Fox, M.D.3
-
197
-
-
27244433608
-
Heterogeneous intracellular expression of B-cell receptor components in B-cell chronic lymphocytic leukaemia (B-CLL) cells and effects of CD79b gene transfer on surface immunoglobulin levels in a BCLL-derived cell line
-
Minuzzo S, Indraccolo S, Tosello V, et al. Heterogeneous intracellular expression of B-cell receptor components in B-cell chronic lymphocytic leukaemia (B-CLL) cells and effects of CD79b gene transfer on surface immunoglobulin levels in a BCLL-derived cell line. Br J Haematol 2005; 130: 878-89.
-
(2005)
Br J Haematol
, vol.130
, pp. 878-889
-
-
Minuzzo, S.1
Indraccolo, S.2
Tosello, V.3
-
198
-
-
79955846227
-
IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells
-
Coscia M, Pantaleoni F, Riganti C, et al. IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells. Leukemia 2011; 25: 828-37.
-
(2011)
Leukemia
, vol.25
, pp. 828-837
-
-
Coscia, M.1
Pantaleoni, F.2
Riganti, C.3
-
199
-
-
51649130092
-
The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes
-
Veldurthy A, Patz M, Hagist S, et al. The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes. Blood 2008; 112: 1443-52.
-
(2008)
Blood
, vol.112
, pp. 1443-1452
-
-
Veldurthy, A.1
Patz, M.2
Hagist, S.3
-
200
-
-
55949135223
-
Dasatinib sensitizes primary chronic lymphocytic leukaemia lymphocytes to chlorambucil and fludarabine in vitro
-
Amrein L, Hernandez TA, Ferrario C, et al. Dasatinib sensitizes primary chronic lymphocytic leukaemia lymphocytes to chlorambucil and fludarabine in vitro. Br J Haematol 2008; 143: 698-706.
-
(2008)
Br J Haematol
, vol.143
, pp. 698-706
-
-
Amrein, L.1
Hernandez, T.A.2
Ferrario, C.3
-
201
-
-
0033179893
-
Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop
-
Fujimoto M, Bradney AP, Poe JC, Steeber DA, Tedder TF. Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop. Immunity 1999; 11: 191-200.
-
(1999)
Immunity
, vol.11
, pp. 191-200
-
-
Fujimoto, M.1
Bradney, A.P.2
Poe, J.C.3
Steeber, D.A.4
Tedder, T.F.5
-
202
-
-
0032473487
-
Inhibition of the B cell by CD22: A requirement for Lyn
-
Smith KG, Tarlinton DM, Doody GM, Hibbs ML, Fearon DT. Inhibition of the B cell by CD22: a requirement for Lyn. J Exp Med 1998; 187: 807-11.
-
(1998)
J Exp Med
, vol.187
, pp. 807-811
-
-
Smith, K.G.1
Tarlinton, D.M.2
Doody, G.M.3
Hibbs, M.L.4
Fearon, D.T.5
-
203
-
-
0032550365
-
A double-edged kinase Lyn: A positive and negative regulator for antigen receptor-mediated signals
-
Nishizumi H, Horikawa K, Mlinaric-Rascan I, Yamamoto T. A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals. J Exp Med 1998; 187: 1343-8.
-
(1998)
J Exp Med
, vol.187
, pp. 1343-1348
-
-
Nishizumi, H.1
Horikawa, K.2
Mlinaric-Rascan, I.3
Yamamoto, T.4
-
204
-
-
67650458526
-
Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia
-
Buchner M, Fuchs S, Prinz G, et al. Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia. Cancer Res 2009; 69: 5424-32.
-
(2009)
Cancer Res
, vol.69
, pp. 5424-5432
-
-
Buchner, M.1
Fuchs, S.2
Prinz, G.3
-
205
-
-
64849113027
-
Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells
-
Gobessi S, Laurenti L, Longo PG, et al. Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells. Leukemia 2009; 23: 686-97.
-
(2009)
Leukemia
, vol.23
, pp. 686-697
-
-
Gobessi, S.1
Laurenti, L.2
Longo, P.G.3
-
206
-
-
78649759107
-
The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu-TCL1 transgenic mouse model of CLL by blocking antigendependent B-cell receptor signaling
-
Suljagic M, Longo PG, Bennardo S, et al. The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu-TCL1 transgenic mouse model of CLL by blocking antigendependent B-cell receptor signaling. Blood 2010; 116: 4894-905.
-
(2010)
Blood
, vol.116
, pp. 4894-4905
-
-
Suljagic, M.1
Longo, P.G.2
Bennardo, S.3
-
207
-
-
77951002653
-
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
-
Friedberg JW, Sharman J, Sweetenham J, et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood 2010; 115: 2578-85.
-
(2010)
Blood
, vol.115
, pp. 2578-2585
-
-
Friedberg, J.W.1
Sharman, J.2
Sweetenham, J.3
-
208
-
-
77957333252
-
An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis
-
Weinblatt ME, Kavanaugh A, Genovese MC, Musser TK, Grossbard EB, Magilavy DB. An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis. N Engl J Med 2010; 363: 1303-12.
-
(2010)
N Engl J Med
, vol.363
, pp. 1303-1312
-
-
Weinblatt, M.E.1
Kavanaugh, A.2
Genovese, M.C.3
Musser, T.K.4
Grossbard, E.B.5
Magilavy, D.B.6
-
209
-
-
0031788487
-
The Syk family of protein tyrosine kinases in T-cell activation and development
-
Chu DH, Morita CT, Weiss A. The Syk family of protein tyrosine kinases in T-cell activation and development. Immunol Rev 1998; 165: 167-80.
-
(1998)
Immunol Rev
, vol.165
, pp. 167-180
-
-
Chu, D.H.1
Morita, C.T.2
Weiss, A.3
-
210
-
-
33644953267
-
B lymphocytes in humans express ZAP-70 when activated in vivo
-
Cutrona G, Colombo M, Matis S, et al. B lymphocytes in humans express ZAP-70 when activated in vivo. Eur J Immunol 2006; 36: 558-69.
-
(2006)
Eur J Immunol
, vol.36
, pp. 558-569
-
-
Cutrona, G.1
Colombo, M.2
Matis, S.3
-
211
-
-
33646472451
-
ZAP-70 is expressed by normal and malignant human B-cell subsets of different maturational stage
-
Scielzo C, Camporeale A, Geuna M, et al. ZAP-70 is expressed by normal and malignant human B-cell subsets of different maturational stage. Leukemia 2006; 20: 689-95.
-
(2006)
Leukemia
, vol.20
, pp. 689-695
-
-
Scielzo, C.1
Camporeale, A.2
Geuna, M.3
-
212
-
-
0037396717
-
Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion
-
Schweighoffer E, Vanes L, Mathiot A, Nakamura T, Tybulewicz VL. Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion. Immunity 2003; 18: 523-33.
-
(2003)
Immunity
, vol.18
, pp. 523-533
-
-
Schweighoffer, E.1
Vanes, L.2
Mathiot, A.3
Nakamura, T.4
Tybulewicz, V.L.5
-
213
-
-
0041429608
-
LAT links the pre-BCR to calcium signaling
-
Su YW, Jumaa H. LAT links the pre-BCR to calcium signaling. Immunity 2003; 19: 295-305.
-
(2003)
Immunity
, vol.19
, pp. 295-305
-
-
Su, Y.W.1
Jumaa, H.2
-
214
-
-
8144221736
-
An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion
-
Wen R, Chen Y, Schuman J, Fu et al. An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. EMBO J 2004; 23: 4007-17.
-
(2004)
EMBO J
, vol.23
, pp. 4007-4017
-
-
Wen, R.1
Chen, Y.2
Schuman, J.F.3
-
215
-
-
0034606219
-
Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk
-
Ellmeier W, Jung S, Sunshine MJ, et al. Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk. J Exp Med 2000; 192: 1611-24.
-
(2000)
J Exp Med
, vol.192
, pp. 1611-1624
-
-
Ellmeier, W.1
Jung, S.2
Sunshine, M.J.3
-
216
-
-
74249108856
-
Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia
-
Sanchez-Aguilera A, Rattmann I, Drew DZ, et al. Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia. Leukemia 2010; 24: 97-104.
-
(2010)
Leukemia
, vol.24
, pp. 97-104
-
-
Sanchez-Aguilera, A.1
Rattmann, I.2
Drew, D.Z.3
-
217
-
-
58849137589
-
TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells
-
Bekeredjian-Ding I, Doster A, Schiller M, et al. TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells. J Immunol 2008; 181: 8267-77.
-
(2008)
J Immunol
, vol.181
, pp. 8267-8277
-
-
Bekeredjian-Ding, I.1
Doster, A.2
Schiller, M.3
-
218
-
-
4143105617
-
ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia
-
Rassenti LZ, Huynh L, Toy TL, et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004; 351: 893-901.
-
(2004)
N Engl J Med
, vol.351
, pp. 893-901
-
-
Rassenti, L.Z.1
Huynh, L.2
Toy, T.L.3
-
219
-
-
33847412872
-
ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells
-
Gobessi S, Laurenti L, Longo PG, Sica S, Leone G, Efremov DG. ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells. Blood 2007; 109: 2032-9.
-
(2007)
Blood
, vol.109
, pp. 2032-2039
-
-
Gobessi, S.1
Laurenti, L.2
Longo, P.G.3
Sica, S.4
Leone, G.5
Efremov, D.G.6
-
220
-
-
41949140313
-
ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia
-
Chen L, Huynh L, Apgar J, et al. ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia. Blood 2008; 111: 2685-92.
-
(2008)
Blood
, vol.111
, pp. 2685-2692
-
-
Chen, L.1
Huynh, L.2
Apgar, J.3
-
221
-
-
79955725823
-
Aberrantly activated anti-apoptotic signalling mechanisms in chronic lymphocytic leukaemia cells: Clues to the identification of novel therapeutic targets
-
Wickremasinghe RG, Prentice AG, Steele AJ. Aberrantly activated anti-apoptotic signalling mechanisms in chronic lymphocytic leukaemia cells: clues to the identification of novel therapeutic targets. Br J Haematol 2011; 153: 545-56.
-
(2011)
Br J Haematol
, vol.153
, pp. 545-556
-
-
Wickremasinghe, R.G.1
Prentice, A.G.2
Steele, A.J.3
-
222
-
-
77958497298
-
Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity
-
Uckun FM, Qazi S. Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity. Expert Opin Ther Pat 2010; 20: 1457-70.
-
(2010)
Expert Opin Ther Pat
, vol.20
, pp. 1457-1470
-
-
Uckun, F.M.1
Qazi, S.2
-
223
-
-
38049084406
-
Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
-
Pan Z, Scheerens H, Li SJ, et al. Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. ChemMedChem 2007; 2: 58-61.
-
(2007)
ChemMedChem
, vol.2
, pp. 58-61
-
-
Pan, Z.1
Scheerens, H.2
Li, S.J.3
-
224
-
-
84863508104
-
Bruton's tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
-
Ponader S, Chen SS, Buggy JJ, et al. Bruton's tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood 2011.
-
(2011)
Blood
-
-
Ponader, S.1
Chen, S.S.2
Buggy, J.J.3
-
225
-
-
84858636448
-
The clinically active BTK inhibitor PCI-32765 targets B-cell receptor-and chemokinecontrolled adhesion and migration in chronic lymphocytic leukemia
-
Rooij MF, Kuil A, Geest CR, et al. The clinically active BTK inhibitor PCI-32765 targets B-cell receptor-and chemokinecontrolled adhesion and migration in chronic lymphocytic leukemia. Blood 2012.
-
(2012)
Blood
-
-
Rooij, M.F.1
Kuil, A.2
Geest, C.R.3
-
226
-
-
67651037334
-
A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen
-
Ter Brugge PJ, Ta VB, de Bruijn MJ, et al. A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen. Blood 2009; 114: 119-27.
-
(2009)
Blood
, vol.114
, pp. 119-127
-
-
Brugge, T.P.J.1
Ta, V.B.2
de Bruijn, M.J.3
-
227
-
-
77955625479
-
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
-
Honigberg LA, Smith AM, Sirisawad M, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci USA 2010; 107: 13075-80.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 13075-13080
-
-
Honigberg, L.A.1
Smith, A.M.2
Sirisawad, M.3
-
228
-
-
84856461639
-
Trial watch: BTK inhibitor shows positive results in B cell malignancies
-
Harrison C. Trial watch: BTK inhibitor shows positive results in B cell malignancies. Nat Rev Drug Discov 2012; 11: 96-7.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 96-97
-
-
Harrison, C.1
-
229
-
-
78650433517
-
Specific Btk inhibition suppresses B cell-and myeloid cell-mediated arthritis
-
Di Paolo JA, Huang T, Balazs M, et al. Specific Btk inhibition suppresses B cell-and myeloid cell-mediated arthritis. Nat Chem Biol 2011; 7: 41-50.
-
(2011)
Nat Chem Biol
, vol.7
, pp. 41-50
-
-
Di Paolo, J.A.1
Huang, T.2
Balazs, M.3
-
230
-
-
78650463027
-
Drug discovery: New Btk inhibitor holds promise
-
Hendriks RW. Drug discovery: New Btk inhibitor holds promise. Nat Chem Biol 2011; 7: 4-5.
-
(2011)
Nat Chem Biol
, vol.7
, pp. 4-5
-
-
Hendriks, R.W.1
-
231
-
-
79960257240
-
Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in man
-
Hendriks RW, Bredius RG, Pike-Overzet K, Staal FJ. Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in man. Expert Opin Ther Targets 2011; 15: 1003-21.
-
(2011)
Expert Opin Ther Targets
, vol.15
, pp. 1003-1021
-
-
Hendriks, R.W.1
Bredius, R.G.2
Pike-Overzet, K.3
Staal, F.J.4
-
232
-
-
70350453607
-
Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38
-
Graeff R, Liu Q, Kriksunov IA, et al. Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38. J Biol Chem 2009; 284: 27629-36.
-
(2009)
J Biol Chem
, vol.284
, pp. 27629-27636
-
-
Graeff, R.1
Liu, Q.2
Kriksunov, I.A.3
-
233
-
-
0031930758
-
Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member
-
Deaglio S, Morra M, Mallone R, et al. Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member. J Immunol 1998; 160: 395-402.
-
(1998)
J Immunol
, vol.160
, pp. 395-402
-
-
Deaglio, S.1
Morra, M.2
Mallone, R.3
-
234
-
-
34249986412
-
CD38/CD19: A lipid raftdependent signaling complex in human B cells
-
Deaglio S, Vaisitti T, Billington R, et al. CD38/CD19: a lipid raftdependent signaling complex in human B cells. Blood 2007; 109: 5390-8.
-
(2007)
Blood
, vol.109
, pp. 5390-5398
-
-
Deaglio, S.1
Vaisitti, T.2
Billington, R.3
-
235
-
-
0031183025
-
CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol 3-kinase
-
Kitanaka A, Ito C, Coustan-Smith E, Campana D. CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol 3-kinase. J Immunol 1997; 159: 184-92.
-
(1997)
J Immunol
, vol.159
, pp. 184-192
-
-
Kitanaka, A.1
Ito, C.2
Coustan-Smith, E.3
Campana, D.4
-
236
-
-
37049023065
-
CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential
-
Deaglio S, Vaisitti T, Aydin S, et al. CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential. Blood 2007; 110: 4012-21.
-
(2007)
Blood
, vol.110
, pp. 4012-4021
-
-
Deaglio, S.1
Vaisitti, T.2
Aydin, S.3
-
237
-
-
33750057683
-
Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status
-
Huttmann A, Klein-Hitpass L, Thomale J, et al. Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status. Leukemia 2006; 20: 1774-82.
-
(2006)
Leukemia
, vol.20
, pp. 1774-1782
-
-
Huttmann, A.1
Klein-Hitpass, L.2
Thomale, J.3
-
238
-
-
33646487923
-
CD38+ chronic lymphocytic leukaemia cells co-express high levels of ZAP-70 and are functionally distinct from their CD38-counter-parts
-
Pepper C, Brennan P, Alghazal S, et al. CD38+ chronic lymphocytic leukaemia cells co-express high levels of ZAP-70 and are functionally distinct from their CD38-counter-parts. Leukemia 2006; 20: 743-4.
-
(2006)
Leukemia
, vol.20
, pp. 743-744
-
-
Pepper, C.1
Brennan, P.2
Alghazal, S.3
-
239
-
-
18644382787
-
Combined analysis of ZAP-70 and CD38 expression as a predictor of disease progression in B-cell chronic lymphocytic leukemia
-
Schroers R, Griesinger F, Trumper L, et al. Combined analysis of ZAP-70 and CD38 expression as a predictor of disease progression in B-cell chronic lymphocytic leukemia. Leukemia 2005; 19: 750-8.
-
(2005)
Leukemia
, vol.19
, pp. 750-758
-
-
Schroers, R.1
Griesinger, F.2
Trumper, L.3
-
240
-
-
35748939418
-
Prognostic significance of combined analysis of ZAP-70 and CD38 in chronic lymphocytic leukemia
-
D'Arena G, Tarnani M, Rumi C, et al. Prognostic significance of combined analysis of ZAP-70 and CD38 in chronic lymphocytic leukemia. Am J Hematol 2007; 82: 787-91.
-
(2007)
Am J Hematol
, vol.82
, pp. 787-791
-
-
D'Arena, G.1
Tarnani, M.2
Rumi, C.3
-
241
-
-
33947389299
-
Highly purified CD38+ and CD38-sub-clones derived from the same chronic lymphocytic leukemia patient have distinct gene expression signatures despite their monoclonal origin
-
Pepper C, Ward R, Lin TT, et al. Highly purified CD38+ and CD38-sub-clones derived from the same chronic lymphocytic leukemia patient have distinct gene expression signatures despite their monoclonal origin. Leukemia 2007; 21: 687-96.
-
(2007)
Leukemia
, vol.21
, pp. 687-696
-
-
Pepper, C.1
Ward, R.2
Lin, T.T.3
-
242
-
-
36148992239
-
CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells
-
Damle RN, Temburni S, Calissano C, et al. CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells. Blood 2007; 110: 3352-9.
-
(2007)
Blood
, vol.110
, pp. 3352-3359
-
-
Damle, R.N.1
Temburni, S.2
Calissano, C.3
-
243
-
-
77952419807
-
CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells
-
Vaisitti T, Aydin S, Rossi D, et al. CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells. Leukemia 2010; 24: 958-69.
-
(2010)
Leukemia
, vol.24
, pp. 958-969
-
-
Vaisitti, T.1
Aydin, S.2
Rossi, D.3
-
244
-
-
78649774633
-
CD38 as a molecular compass guiding topographical decisions of chronic lymphocytic leukemia cells
-
Deaglio S, Vaisitti T, Zucchetto A, Gattei V, Malavasi F. CD38 as a molecular compass guiding topographical decisions of chronic lymphocytic leukemia cells. Semin Cancer Biol 2010; 20: 416-23.
-
(2010)
Semin Cancer Biol
, vol.20
, pp. 416-423
-
-
Deaglio, S.1
Vaisitti, T.2
Zucchetto, A.3
Gattei, V.4
Malavasi, F.5
-
245
-
-
80053350162
-
CD38 and chronic lymphocytic leukemia: A decade later
-
Malavasi F, Deaglio S, Damle R, Cutrona G, Ferrarini M, Chiorazzi N. CD38 and chronic lymphocytic leukemia: a decade later. Blood 2011.
-
(2011)
Blood
-
-
Malavasi, F.1
Deaglio, S.2
Damle, R.3
Cutrona, G.4
Ferrarini, M.5
Chiorazzi, N.6
-
246
-
-
0025973190
-
Inducible nuclear expression of NF-kappa B in primary B cells stimulated through the surface Ig receptor
-
Liu JL, Chiles TC, Sen RJ, Rothstein TL. Inducible nuclear expression of NF-kappa B in primary B cells stimulated through the surface Ig receptor. J Immunol 1991; 146: 1685-91.
-
(1991)
J Immunol
, vol.146
, pp. 1685-1691
-
-
Liu, J.L.1
Chiles, T.C.2
Sen, R.J.3
Rothstein, T.L.4
-
247
-
-
0030966218
-
Different nuclear signals are activated by the B cell receptor during positive versus negative signaling
-
Healy JI, Dolmetsch RE, Timmerman LA, et al. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity 1997; 6: 419-28.
-
(1997)
Immunity
, vol.6
, pp. 419-428
-
-
Healy, J.I.1
Dolmetsch, R.E.2
Timmerman, L.A.3
-
248
-
-
77957201023
-
Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
-
Herman SE, Gordon AL, Wagner AJ, et al. Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood 2010; 116: 2078-88.
-
(2010)
Blood
, vol.116
, pp. 2078-2088
-
-
Herman, S.E.1
Gordon, A.L.2
Wagner, A.J.3
-
249
-
-
0037089403
-
Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells
-
Barragan M, Bellosillo B, Campas C, Colomer D, Pons G, Gil J. Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells. Blood 2002; 99: 2969-76.
-
(2002)
Blood
, vol.99
, pp. 2969-2976
-
-
Barragan, M.1
Bellosillo, B.2
Campas, C.3
Colomer, D.4
Pons, G.5
Gil, J.6
-
250
-
-
80053345977
-
The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
-
Hoellenriegel J, Meadows SA, Sivina M, et al. The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood 2011.
-
(2011)
Blood
-
-
Hoellenriegel, J.1
Meadows, S.A.2
Sivina, M.3
-
251
-
-
73949119120
-
Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: The therapeutic potential of Akt inhibition
-
Zhuang J, Hawkins SF, Glenn MA, et al. Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition. Haematologica 2010; 95: 110-8.
-
(2010)
Haematologica
, vol.95
, pp. 110-118
-
-
Zhuang, J.1
Hawkins, S.F.2
Glenn, M.A.3
-
252
-
-
38349107623
-
The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells
-
Longo PG, Laurenti L, Gobessi S, Sica S, Leone G, Efremov DG. The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells. Blood 2008; 111: 846-55.
-
(2008)
Blood
, vol.111
, pp. 846-855
-
-
Longo, P.G.1
Laurenti, L.2
Gobessi, S.3
Sica, S.4
Leone, G.5
Efremov, D.G.6
-
253
-
-
0033636528
-
The protooncogene TCL1 is an Akt kinase coactivator
-
Laine J, Kunstle G, Obata T, Sha M, Noguchi M. The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell 2000; 6: 395-407.
-
(2000)
Mol Cell
, vol.6
, pp. 395-407
-
-
Laine, J.1
Kunstle, G.2
Obata, T.3
Sha, M.4
Noguchi, M.5
-
254
-
-
0034724199
-
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation
-
Pekarsky Y, Koval A, Hallas C, et al. Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. Proc Natl Acad Sci USA 2000; 97: 3028-33.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3028-3033
-
-
Pekarsky, Y.1
Koval, A.2
Hallas, C.3
-
255
-
-
0031454756
-
TCL1 is overexpressed in patients affected by adult T-cell leukemias
-
Narducci MG, Stoppacciaro A, Imada K, et al. TCL1 is overexpressed in patients affected by adult T-cell leukemias. Cancer Res 1997; 57: 5452-6.
-
(1997)
Cancer Res
, vol.57
, pp. 5452-5456
-
-
Narducci, M.G.1
Stoppacciaro, A.2
Imada, K.3
-
256
-
-
0034655156
-
Regulation of TCL1 expression in B-and T-cell lymphomas and reactive lymphoid tissues
-
Narducci MG, Pescarmona E, Lazzeri C, et al. Regulation of TCL1 expression in B-and T-cell lymphomas and reactive lymphoid tissues. Cancer Res 2000; 60: 2095-100.
-
(2000)
Cancer Res
, vol.60
, pp. 2095-2100
-
-
Narducci, M.G.1
Pescarmona, E.2
Lazzeri, C.3
-
257
-
-
31444446831
-
TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state
-
Herling M, Patel KA, Khalili J, et al. TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state. Leukemia 2006; 20: 280-5.
-
(2006)
Leukemia
, vol.20
, pp. 280-285
-
-
Herling, M.1
Patel, K.A.2
Khalili, J.3
-
258
-
-
77957011677
-
Modifying akt signaling in B-cell chronic lymphocytic leukemia cells
-
Hofbauer SW, Pinon JD, Brachtl G, et al. Modifying akt signaling in B-cell chronic lymphocytic leukemia cells. Cancer Res 2010; 70: 7336-44.
-
(2010)
Cancer Res
, vol.70
, pp. 7336-7344
-
-
Hofbauer, S.W.1
Pinon, J.D.2
Brachtl, G.3
-
259
-
-
0037076279
-
Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression
-
Bichi R, Shinton SA, Martin ES, et al. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci USA 2002; 99: 6955-60.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 6955-6960
-
-
Bichi, R.1
Shinton, S.A.2
Martin, E.S.3
-
260
-
-
33746817989
-
B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia
-
Yan XJ, Albesiano E, Zanesi N, et al. B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2006; 103: 11713-8.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 11713-11718
-
-
Yan, X.J.1
Albesiano, E.2
Zanesi, N.3
-
261
-
-
34548128321
-
Molecular heterogeneity in chronic lymphocytic leukemia is dependent on BCR signaling: Clinical correlation
-
Rodriguez A, Villuendas R, Yanez L, et al. Molecular heterogeneity in chronic lymphocytic leukemia is dependent on BCR signaling: clinical correlation. Leukemia 2007; 21: 1984-91.
-
(2007)
Leukemia
, vol.21
, pp. 1984-1991
-
-
Rodriguez, A.1
Villuendas, R.2
Yanez, L.3
-
262
-
-
33846883742
-
B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CbetaII
-
Abrams ST, Lakum T, Lin K, et al. B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CbetaII. Blood 2007; 109: 1193-201.
-
(2007)
Blood
, vol.109
, pp. 1193-1201
-
-
Abrams, S.T.1
Lakum, T.2
Lin, K.3
-
263
-
-
17944377368
-
PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization
-
Kang SW, Wahl MI, Chu J, et al. PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization. EMBO J 2001; 20: 5692-702.
-
(2001)
EMBO J
, vol.20
, pp. 5692-5702
-
-
Kang, S.W.1
Wahl, M.I.2
Chu, J.3
-
264
-
-
63849093256
-
PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: Validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia
-
Holler C, Pinon JD, Denk U, et al. PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia. Blood 2009; 113: 2791-4.
-
(2009)
Blood
, vol.113
, pp. 2791-2794
-
-
Holler, C.1
Pinon, J.D.2
Denk, U.3
-
265
-
-
77950926863
-
Proliferation centers in chronic lymphocytic leukemia: The niche where NFkappaB activation takes place
-
Herreros B, Rodriguez-Pinilla SM, Pajares R, et al. Proliferation centers in chronic lymphocytic leukemia: the niche where NFkappaB activation takes place. Leukemia 2010; 24: 872-6.
-
(2010)
Leukemia
, vol.24
, pp. 872-876
-
-
Herreros, B.1
Rodriguez-Pinilla, S.M.2
Pajares, R.3
-
266
-
-
6044254953
-
Variability in the degree of expression of phosphorylated IkappaBalpha in chronic lymphocytic leukemia cases with nodal involvement
-
Rodriguez A, Martinez N, Camacho FI, et al. Variability in the degree of expression of phosphorylated IkappaBalpha in chronic lymphocytic leukemia cases with nodal involvement. Clin Cancer Res 2004; 10: 6796-806.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6796-6806
-
-
Rodriguez, A.1
Martinez, N.2
Camacho, F.I.3
-
267
-
-
77957366071
-
Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription
-
Buggins AG, Pepper C, Patten PE, et al. Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription. Cancer Res 2010; 70: 7523-33.
-
(2010)
Cancer Res
, vol.70
, pp. 7523-7533
-
-
Buggins, A.G.1
Pepper, C.2
Patten, P.E.3
-
268
-
-
47149090375
-
The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target
-
Hewamana S, Alghazal S, Lin TT, et al. The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. Blood 2008; 111: 4681-9.
-
(2008)
Blood
, vol.111
, pp. 4681-4689
-
-
Hewamana, S.1
Alghazal, S.2
Lin, T.T.3
-
269
-
-
60149094697
-
Rel a is an independent biomarker of clinical outcome in chronic lymphocytic leukemia
-
Hewamana S, Lin TT, Rowntree C, et al. Rel a is an independent biomarker of clinical outcome in chronic lymphocytic leukemia. J Clin Oncol 2009; 27: 763-9.
-
(2009)
J Clin Oncol
, vol.27
, pp. 763-769
-
-
Hewamana, S.1
Lin, T.T.2
Rowntree, C.3
-
270
-
-
33744480255
-
The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro
-
Steele AJ, Jones DT, Ganeshaguru K, et al. The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro. Leukemia 2006; 20: 1073-9.
-
(2006)
Leukemia
, vol.20
, pp. 1073-1079
-
-
Steele, A.J.1
Jones, D.T.2
Ganeshaguru, K.3
-
271
-
-
33847185843
-
Pharmacological inhibitors of NF-kappaB accelerate apoptosis in chronic lymphocytic leukaemia cells
-
Pickering BM, de Mel S, Lee M, et al. Pharmacological inhibitors of NF-kappaB accelerate apoptosis in chronic lymphocytic leukaemia cells. Oncogene 2007; 26: 1166-77.
-
(2007)
Oncogene
, vol.26
, pp. 1166-1177
-
-
Pickering, B.M.1
de Mel, S.2
Lee, M.3
-
272
-
-
65249086258
-
P65 activity and ZAP-70 status predict the sensitivity of chronic lymphocytic leukemia cells to the selective IkappaB kinase inhibitor BMS-345541
-
Lopez-Guerra M, Roue G, Perez-Galan P, et al. p65 activity and ZAP-70 status predict the sensitivity of chronic lymphocytic leukemia cells to the selective IkappaB kinase inhibitor BMS-345541. Clin Cancer Res 2009; 15: 2767-76.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2767-2776
-
-
Lopez-Guerra, M.1
Roue, G.2
Perez-Galan, P.3
-
273
-
-
0037300541
-
Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism
-
Pepper C, Thomas A, Fegan C, Hoy T, Bentley P. Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism. Leuk Lymphoma 2003; 44: 337-42.
-
(2003)
Leuk Lymphoma
, vol.44
, pp. 337-342
-
-
Pepper, C.1
Thomas, A.2
Fegan, C.3
Hoy, T.4
Bentley, P.5
-
274
-
-
0038107401
-
The vitamin D3 analog EB1089 induces apoptosis via a p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitro
-
Pepper C, Thomas A, Hoy T, Milligan D, Bentley P, Fegan C. The vitamin D3 analog EB1089 induces apoptosis via a p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitro. Blood 2003; 101: 2454-60.
-
(2003)
Blood
, vol.101
, pp. 2454-2460
-
-
Pepper, C.1
Thomas, A.2
Hoy, T.3
Milligan, D.4
Bentley, P.5
Fegan, C.6
-
275
-
-
11144268038
-
Constitutive activation of the MAPkinase p38 is critical for MMP-9 production and survival of B-CLL cells on bone marrow stromal cells
-
Ringshausen I, Dechow T, Schneller F, et al. Constitutive activation of the MAPkinase p38 is critical for MMP-9 production and survival of B-CLL cells on bone marrow stromal cells. Leukemia 2004; 18: 1964-70.
-
(2004)
Leukemia
, vol.18
, pp. 1964-1970
-
-
Ringshausen, I.1
Dechow, T.2
Schneller, F.3
-
276
-
-
84861661018
-
Systemic in vivo lentiviral delivery of miR-15a/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemia
-
Kasar S, Salerno E, Yuan Y, et al. Systemic in vivo lentiviral delivery of miR-15a/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemia. Genes Immun 2011.
-
(2011)
Genes Immun
-
-
Kasar, S.1
Salerno, E.2
Yuan, Y.3
-
277
-
-
0037195092
-
Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma
-
Hoyer KK, French SW, Turner DE, et al. Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma. Proc Natl Acad Sci USA 2002; 99: 14392-7.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14392-14397
-
-
Hoyer, K.K.1
French, S.W.2
Turner, D.E.3
-
278
-
-
9344245131
-
TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice
-
Zapata JM, Krajewska M, Morse HC, 3rd, Choi Y, Reed JC. TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice. Proc Natl Acad Sci USA 2004; 101: 16600-5.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 16600-16605
-
-
Zapata, J.M.1
Krajewska, M.2
Morse III, H.C.3
Choi, Y.4
Reed, J.C.5
-
280
-
-
7244229674
-
Transgene-mediated hyperexpression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus
-
Wen X, Zhang D, Kikuchi Y, et al. Transgene-mediated hyperexpression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus. Eur J Immunol 2004; 34: 2740-9.
-
(2004)
Eur J Immunol
, vol.34
, pp. 2740-2749
-
-
Wen, X.1
Zhang, D.2
Kikuchi, Y.3
-
281
-
-
77952424509
-
CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation
-
Efanov A, Zanesi N, Nazaryan N, et al. CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Leukemia 2010; 24: 970-5.
-
(2010)
Leukemia
, vol.24
, pp. 970-975
-
-
Efanov, A.1
Zanesi, N.2
Nazaryan, N.3
-
282
-
-
77955435090
-
Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression
-
Santanam U, Zanesi N, Efanov A, et al. Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression. Proc Natl Acad Sci USA 2010; 107: 12210-5.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 12210-12215
-
-
Santanam, U.1
Zanesi, N.2
Efanov, A.3
-
283
-
-
79955513805
-
Phase II study of dasatinib in relapsed or refractory chronic lymphocytic leukemia
-
Amrein PC, Attar EC, Takvorian T, et al. Phase II study of dasatinib in relapsed or refractory chronic lymphocytic leukemia. Clin Cancer Res 2011; 17: 2977-86.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2977-2986
-
-
Amrein, P.C.1
Attar, E.C.2
Takvorian, T.3
-
284
-
-
79953072735
-
Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals
-
McCaig AM, Cosimo E, Leach MT, Michie AM. Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals. Br J Haematol 2011.
-
(2011)
Br J Haematol
-
-
McCaig, A.M.1
Cosimo, E.2
Leach, M.T.3
Michie, A.M.4
-
285
-
-
79951831707
-
Dasatinib plus Nutlin-3 shows synergistic antileukemic activity in both p53 wild-type and p53 mutated B chronic lymphocytic leukemias by inhibiting the Akt pathway
-
Zauli G, Voltan R, Bosco R, et al. Dasatinib plus Nutlin-3 shows synergistic antileukemic activity in both p53 wild-type and p53 mutated B chronic lymphocytic leukemias by inhibiting the Akt pathway. Clin Cancer Res 2011; 17: 762-70.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 762-770
-
-
Zauli, G.1
Voltan, R.2
Bosco, R.3
-
286
-
-
73849145729
-
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
-
Davis RE, Ngo VN, Lenz G, et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature 2010; 463: 88-92.
-
(2010)
Nature
, vol.463
, pp. 88-92
-
-
Davis, R.E.1
Ngo, V.N.2
Lenz, G.3
-
288
-
-
78751553221
-
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
-
Lannutti BJ, Meadows SA, Herman SE, et al. CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood 2011; 117: 591-4.
-
(2011)
Blood
, vol.117
, pp. 591-594
-
-
Lannutti, B.J.1
Meadows, S.A.2
Herman, S.E.3
-
289
-
-
77956592891
-
PI3K/p110δ is a novel therapeutic target in multiple myeloma
-
Ikeda H, Hideshima T, Fulciniti M, et al. PI3K/p110δ is a novel therapeutic target in multiple myeloma. Blood 2010; 116: 1460-8.
-
(2010)
Blood
, vol.116
, pp. 1460-1468
-
-
Ikeda, H.1
Hideshima, T.2
Fulciniti, M.3
-
290
-
-
77953664155
-
Clinical Roundtable Monograph: Current treatment options for NHL patients refractory to standard therapy: Recent data in single-agent and combination therapy
-
Kahl BS, Cheson BD, Friedberg JW. Clinical Roundtable Monograph: current treatment options for NHL patients refractory to standard therapy: recent data in single-agent and combination therapy. Clin Adv Hematol Oncol 2010; 8: 1-16.
-
(2010)
Clin Adv Hematol Oncol
, vol.8
, pp. 1-16
-
-
Kahl, B.S.1
Cheson, B.D.2
Friedberg, J.W.3
|