-
1
-
-
0020534965
-
Somatic generation of antibody diversity
-
Tonegawa, S. Somatic generation of antibody diversity. Nature 302, 575-581 (1983).
-
(1983)
Nature
, vol.302
, pp. 575-581
-
-
Tonegawa, S.1
-
2
-
-
0026708716
-
V(D)J recombination: Molecular biology and regulation
-
Schatz, D. G., Oettinger, M. A. & Schlissel, M. S. V(D)J recombination: molecular biology and regulation. Ann. Rev. Immunol. 10, 359-383 (1992).
-
(1992)
Ann. Rev. Immunol.
, vol.10
, pp. 359-383
-
-
Schatz, D.G.1
Oettinger, M.A.2
Schlissel, M.S.3
-
3
-
-
0024691453
-
V(D)J recombination: A functional definition of the joining signals
-
Hesse, J. E., Lieber, M. R., Mizuuchi, K. & Gellert, M. V(D)J recombination: a functional definition of the joining signals. Genes Dev. 3, 1053-1061 (1989).
-
(1989)
Genes Dev.
, vol.3
, pp. 1053-1061
-
-
Hesse, J.E.1
Lieber, M.R.2
Mizuuchi, K.3
Gellert, M.4
-
4
-
-
0034094425
-
The RAG proteins and V(D)J recombination: Complexes, ends, and transposition
-
Fugmann, S. D., Lee, A. I., Shookett, P. E., Villey, I. J. & Schatz, D. G. The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu. Rev. Immunol. 18, 495-527 (2000).
-
(2000)
Annu. Rev. Immunol.
, vol.18
, pp. 495-527
-
-
Fugmann, S.D.1
Lee, A.I.2
Shookett, P.E.3
Villey, I.J.4
Schatz, D.G.5
-
5
-
-
0013816340
-
Cellular localization of immunoglobulins with different allotype specificities in rabbit lymphoid tissue
-
Pernis, B. G., Chiappino, G., Kelus, A. S. & Gell, P. G. H. Cellular localization of immunoglobulins with different allotype specificities in rabbit lymphoid tissue. J. Exp. Med. 122, 853-875 (1965).
-
(1965)
J. Exp. Med.
, vol.122
, pp. 853-875
-
-
Pernis, B.G.1
Chiappino, G.2
Kelus, A.S.3
Gell, P.G.H.4
-
6
-
-
0027156278
-
Impairment of V(D)J recombination in double-strand break repair mutants
-
Taccioli, G. E. et al. Impairment of V(D)J recombination in double-strand break repair mutants. Science 260, 207-210 (1993).
-
(1993)
Science
, vol.260
, pp. 207-210
-
-
Taccioli, G.E.1
-
7
-
-
0029983727
-
Accessibility control of antigen-receptor variable-region gene assembly: Role of cisacting elements
-
Sleckman, B. P., Gorman, J. R. & Alt, F. W. Accessibility control of antigen-receptor variable-region gene assembly: role of cisacting elements. Ann. Rev. Immunol. 14, 459-481 (1996).
-
(1996)
Ann. Rev. Immunol.
, vol.14
, pp. 459-481
-
-
Sleckman, B.P.1
Gorman, J.R.2
Alt, F.W.3
-
8
-
-
0021983551
-
Developmentally controlled and tissue-specific expression of unrearranged VH gene segments
-
Yancopoulos, G. & Alt, F. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell 40, 271-281 (1985).
-
(1985)
Cell
, vol.40
, pp. 271-281
-
-
Yancopoulos, G.1
Alt, F.2
-
9
-
-
0024435908
-
Activation of immunoglobulin κ gene rearrangement correlates with induction of germline κ gene transcription
-
Schlissel, M. & Baltimore, D. Activation of immunoglobulin κ gene rearrangement correlates with induction of germline κ gene transcription. Cell 58, 1001-1007 (1989).
-
(1989)
Cell
, vol.58
, pp. 1001-1007
-
-
Schlissel, M.1
Baltimore, D.2
-
10
-
-
0036669273
-
Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow
-
Igarashi, H., Gregory, S. C., Yokota, T., Sakaguchi, N. & Kincade, P. W. Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. Immunity 17, 117-130 (2002).
-
(2002)
Immunity
, vol.17
, pp. 117-130
-
-
Igarashi, H.1
Gregory, S.C.2
Yokota, T.3
Sakaguchi, N.4
Kincade, P.W.5
-
11
-
-
0028256203
-
Two waves of recombinase gene expression in developing thymocytes
-
Wilson, A., Held, W. & MacDonald, H. R. Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 179, 1355-1360 (1994).
-
(1994)
J. Exp. Med.
, vol.179
, pp. 1355-1360
-
-
Wilson, A.1
Held, W.2
MacDonald, H.R.3
-
12
-
-
0028828269
-
Downregulation of RAG1 and RAG2 gene expression in pre-B cells after functional immunoglobulin heavy chain rearrangement
-
Grawunder, U. et al. Downregulation of RAG1 and RAG2 gene expression in pre-B cells after functional immunoglobulin heavy chain rearrangement. Immunity 3, 601-608 (1995). This paper describes in detail the pattern of expression of recombination-activating gene (RAG) messenger RNA and protein in primary developing B cells.
-
(1995)
Immunity
, vol.3
, pp. 601-608
-
-
Grawunder, U.1
-
13
-
-
0033919659
-
Pre-B and pre-T-cell receptors: Conservation of strategies in regulating early lymphocyte development
-
Muljo, S. A. & Schlissel, M. S. Pre-B and pre-T-cell receptors: conservation of strategies in regulating early lymphocyte development. Immunol. Rev. 175, 80-93 (2000).
-
(2000)
Immunol. Rev.
, vol.175
, pp. 80-93
-
-
Muljo, S.A.1
Schlissel, M.S.2
-
14
-
-
0026661878
-
Engagement of the T-cell receptor during positive selection in the thymus downregulates RAG-1 expression
-
Brandle, D., Muller, C., Rulicke, T., Hengartner, H. & Pircher, H. Engagement of the T-cell receptor during positive selection in the thymus downregulates RAG-1 expression. Proc. Natl Acad. Sci. USA 89, 9529-9533 (1992).
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 9529-9533
-
-
Brandle, D.1
Muller, C.2
Rulicke, T.3
Hengartner, H.4
Pircher, H.5
-
15
-
-
0027478391
-
Receptor editing in self-reactive bone marrow B cells
-
Tiegs, S. S., Russell, D. M. & Nemazee, D. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177, 1009-1020 (1993).
-
(1993)
J. Exp. Med.
, vol.177
, pp. 1009-1020
-
-
Tiegs, S.S.1
Russell, D.M.2
Nemazee, D.3
-
16
-
-
0027499537
-
Receptor editing: An approach by autoreactive B cells to escape tolerance
-
Gay, D., Saunders, T., Camper, S. & Weigert, M. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177, 999-1008 (1993).
-
(1993)
J. Exp. Med.
, vol.177
, pp. 999-1008
-
-
Gay, D.1
Saunders, T.2
Camper, S.3
Weigert, M.4
-
17
-
-
0025785134
-
Thymocyte expression of RAG-1 and RAG-2: Termination by T cell receptor crosslinking
-
Turka, L. A. et al. Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor crosslinking. Science 253, 778-781 (1991).
-
(1991)
Science
, vol.253
, pp. 778-781
-
-
Turka, L.A.1
-
18
-
-
0033611469
-
Secondary V(D)J recombination in B-1 cells
-
Qin, X. F. et al. Secondary V(D)J recombination in B-1 cells. Nature 397, 355-359 (1999).
-
(1999)
Nature
, vol.397
, pp. 355-359
-
-
Qin, X.F.1
-
19
-
-
0030475466
-
Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells
-
Hikida, M. et al. Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science 274, 2092-2094 (1996).
-
(1996)
Science
, vol.274
, pp. 2092-2094
-
-
Hikida, M.1
-
20
-
-
0030764978
-
V(D)J recombinase activity in a subset of germinal center B lymphocytes
-
Han, S. et al. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science 278, 301-305 (1997).
-
(1997)
Science
, vol.278
, pp. 301-305
-
-
Han, S.1
-
21
-
-
0033180183
-
RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues
-
Monroe, R. J. et al. RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity 11, 201-212 (1999).
-
(1999)
Immunity
, vol.11
, pp. 201-212
-
-
Monroe, R.J.1
-
22
-
-
0032740593
-
Cutting edge: Absence of expression of RAG1 in peritoneal B-1 cells detected by knocking into RAG1 locus with green fluorescent protein gene
-
Kuwata, N., Igarashi, H., Ohmura, T., Aizawa, S. & Sakaguchi, N. Cutting edge: absence of expression of RAG1 in peritoneal B-1 cells detected by knocking into RAG1 locus with green fluorescent protein gene. J. Immunol. 163, 6355-6359 (1999).
-
(1999)
J. Immunol.
, vol.163
, pp. 6355-6359
-
-
Kuwata, N.1
Igarashi, H.2
Ohmura, T.3
Aizawa, S.4
Sakaguchi, N.5
-
24
-
-
0028223271
-
Cell cycle regulation of V(D)J recombination-activating protein RAG-2
-
Lin, W. C. & Desiderio, S. Cell cycle regulation of V(D)J recombination-activating protein RAG-2. Proc. Natl Acad. Sci. USA 91, 2733-2737 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 2733-2737
-
-
Lin, W.C.1
Desiderio, S.2
-
25
-
-
0029978830
-
The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression
-
Grawunder, U., Schatz, D. G., Leu, T. M., Rolink, A. & Melchers, F. The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression. J. Exp. Med. 183, 1731-1737 (1996).
-
(1996)
J. Exp. Med.
, vol.183
, pp. 1731-1737
-
-
Grawunder, U.1
Schatz, D.G.2
Leu, T.M.3
Rolink, A.4
Melchers, F.5
-
26
-
-
0033427205
-
Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair
-
Lee, J. & Desiderio, S. Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair. Immunity 11, 771-781 (1999). These authors describe the mechanism by which recombinase activity is limited to cells in the G1 stage of the cell cycle. A cyclin-dependent kinase (CDK) phosphorylates Thr490 in RAG2 resulting in its ubiquitin-dependent degradation.
-
(1999)
Immunity
, vol.11
, pp. 771-781
-
-
Lee, J.1
Desiderio, S.2
-
27
-
-
0028425466
-
A regulatory role for recombinase activating genes, RAG-1 and RAG-2, in T cell development
-
Wayne, J. et al. A regulatory role for recombinase activating genes, RAG-1 and RAG-2, in T cell development. Immunity 1, 95-107 (1994).
-
(1994)
Immunity
, vol.1
, pp. 95-107
-
-
Wayne, J.1
-
28
-
-
0032551829
-
Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
-
Agrawal, A., Eastman, Q. M. & Schatz, D. G. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature 394, 744-751 (1998).
-
(1998)
Nature
, vol.394
, pp. 744-751
-
-
Agrawal, A.1
Eastman, Q.M.2
Schatz, D.G.3
-
29
-
-
0031279369
-
Cloning and characterization of the human recombination activating gene 1 (RAG 1) and RAG2 promoter regions
-
Zarrin, A. A., Fong, I., Malkin, L., Marsden, P. A. & Berinstein, N. L. Cloning and characterization of the human recombination activating gene 1 (RAG 1) and RAG2 promoter regions. J. Immunol. 159, 4382-4394 (1997).
-
(1997)
J. Immunol.
, vol.159
, pp. 4382-4394
-
-
Zarrin, A.A.1
Fong, I.2
Malkin, L.3
Marsden, P.A.4
Berinstein, N.L.5
-
30
-
-
0030237233
-
Isolation and characterization of a TATA-less promoter for the human RAG-1 gene
-
Kurioka, H. et al. Isolation and characterization of a TATA- less promoter for the human RAG-1 gene. Mol. Immunol. 33, 1059-1066 (1996).
-
(1996)
Mol. Immunol.
, vol.33
, pp. 1059-1066
-
-
Kurioka, H.1
-
31
-
-
0031417336
-
Identification and characterization of the murine Rag1 promoter
-
Fuller, K. & Storb, U. Identification and characterization of the murine Rag1 promoter. Mol. Immunol. 34, 939-954 (1997).
-
(1997)
Mol. Immunol.
, vol.34
, pp. 939-954
-
-
Fuller, K.1
Storb, U.2
-
32
-
-
0032958092
-
Distinct factors regulate the murine RAG-2 promoter in B- and T-cell lines
-
Lauring, J. & Schlissel, M. S. Distinct factors regulate the murine RAG-2 promoter in B- and T-cell lines. Mol. Cell. Biol. 19, 2601-2612 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 2601-2612
-
-
Lauring, J.1
Schlissel, M.S.2
-
33
-
-
0037079724
-
Cooperative binding of c-Myb and Pax-5 activates the RAG-2 promoter in immature B cells
-
Kishi, H. et al. Cooperative binding of c-Myb and Pax-5 activates the RAG-2 promoter in immature B cells. Blood 99, 576-583 (2002).
-
(2002)
Blood
, vol.99
, pp. 576-583
-
-
Kishi, H.1
-
34
-
-
0036784604
-
Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells
-
Jin, Z. X. et al. Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells. J. Immunol. 169, 3783-3792 (2002).
-
(2002)
J. Immunol.
, vol.169
, pp. 3783-3792
-
-
Jin, Z.X.1
-
35
-
-
0034660269
-
Lineage-specific regulation of the murine RAG-2 promoter: GATA-3 in T cells and Pax-5 in B cells
-
Kishi, H. et al. Lineage-specific regulation of the murine RAG-2 promoter: GATA-3 in T cells and Pax-5 in B cells. Blood 95, 3845-3852 (2000).
-
(2000)
Blood
, vol.95
, pp. 3845-3852
-
-
Kishi, H.1
-
36
-
-
0033763621
-
Functional analysis of the human RAG 2 promoter
-
Fong, I. C., Zarrin, A. A., Wu, G. E. & Berinstein, N. L. Functional analysis of the human RAG 2 promoter. Mol. Immunol. 37, 391-402 (2000).
-
(2000)
Mol. Immunol.
, vol.37
, pp. 391-402
-
-
Fong, I.C.1
Zarrin, A.A.2
Wu, G.E.3
Berinstein, N.L.4
-
37
-
-
0031157582
-
Regulation of the RAG-1 promoter by the NF-Y transcription factor
-
Brown, S. T. et al. Regulation of the RAG-1 promoter by the NF-Y transcription factor. J. Immunol. 158, 5071-5074 (1997).
-
(1997)
J. Immunol.
, vol.158
, pp. 5071-5074
-
-
Brown, S.T.1
-
38
-
-
0034461254
-
c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells
-
Wang, Q. F., Lauring, J. & Schlissel, M. S. c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells. Mol. Cell. Biol. 20, 9203-9211 (2000).
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 9203-9211
-
-
Wang, Q.F.1
Lauring, J.2
Schlissel, M.S.3
-
39
-
-
0033551866
-
Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5′ of RAG2
-
Yu, W. et al. Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5′ of RAG2. Science 285, 1080-1084 (1999). Using a RAG locus bacterial artificial chromosome (BAC) transgenic reporter construct, these authors show that sequences required for developmentally regulated transcription of RAG reside 5′ of RAG2 and that different sequences are important for expression at distinct stages of B- and T-cell development.
-
(1999)
Science
, vol.285
, pp. 1080-1084
-
-
Yu, W.1
-
40
-
-
0033607175
-
RAG2 is regulated differentially in B and T cells by elements 5′ of the promoter
-
Monroe, R. J., Chen, F., Ferrini, R., Davidson, L. & Alt, F. W. RAG2 is regulated differentially in B and T cells by elements 5′ of the promoter. Proc. Natl Acad. Sci. USA 96, 12713-12718 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 12713-12718
-
-
Monroe, R.J.1
Chen, F.2
Ferrini, R.3
Davidson, L.4
Alt, F.W.5
-
41
-
-
0037100436
-
Characterization of chromatin structure and enhancer elements for murine recombination activating gene-2
-
Wei, X. C. et al. Characterization of chromatin structure and enhancer elements for murine recombination activating gene-2. J. Immunol. 169, 873-881 (2002).
-
(2002)
J. Immunol.
, vol.169
, pp. 873-881
-
-
Wei, X.C.1
-
42
-
-
0038783576
-
A conserved transcriptional enhancer regulates RAG gene expression in developing B cells
-
Hsu, L.-Y. et al. A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. Immunity 19, 105-117 (2003). This paper describes the discovery and analysis by targeted deletion of a new RAG locus transcriptional enhancer. Deletion of this element affects B- but not T-cell development.
-
(2003)
Immunity
, vol.19
, pp. 105-117
-
-
Hsu, L.-Y.1
-
43
-
-
0027992622
-
E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
-
Bain, G. et al. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 79, 885-892 (1994).
-
(1994)
Cell
, vol.79
, pp. 885-892
-
-
Bain, G.1
-
44
-
-
0034616398
-
Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons
-
Loots, G. G. et al. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science 288, 136-140 (2000).
-
(2000)
Science
, vol.288
, pp. 136-140
-
-
Loots, G.G.1
-
45
-
-
0025301095
-
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
-
Oettinger, M. A., Schatz, D. G., Gorka, C. & Baltimore, D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517-1523 (1990). A classic paper reporting the cloning of RAG2 and its synergy in V(D)J recombination with RAG1. The unusual structure of the RAG locus is also shown.
-
(1990)
Science
, vol.248
, pp. 1517-1523
-
-
Oettinger, M.A.1
Schatz, D.G.2
Gorka, C.3
Baltimore, D.4
-
46
-
-
0033871151
-
E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells
-
Romanow, W. J. et al. E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells Mol. Cell 5, 343-353 (2000). Stable expression of either E2A or EBF (lymphoid-lineage transcription factors) in non-lymphoid cells is sufficient to allow transfected RAG expression vectors to activate rearrangement of endogenous immunoglobulin genes.
-
(2000)
Mol. Cell
, vol.5
, pp. 343-353
-
-
Romanow, W.J.1
-
47
-
-
0029894165
-
Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro
-
Stanhope-Baker, P., Hudson, K., Shaffer, A., Constantinescu, A. & Schlissel, M. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro. Cell 85, 887-897 (1996). These investigators used purified nuclear substrates and recombinant RAG proteins to directly show developmentally regulated changes in recombination signal sequence (RSS) accessibility within chromatin.
-
(1996)
Cell
, vol.85
, pp. 887-897
-
-
Stanhope-Baker, P.1
Hudson, K.2
Shaffer, A.3
Constantinescu, A.4
Schlissel, M.5
-
48
-
-
0031171282
-
Accessibility and the developmental regulation of V(D)J recombination
-
Schlissel, M. S. & Stanhope-Baker, P. Accessibility and the developmental regulation of V(D)J recombination. Semin. Immunol. 9, 161 (1997).
-
(1997)
Semin. Immunol.
, vol.9
, pp. 161
-
-
Schlissel, M.S.1
Stanhope-Baker, P.2
-
49
-
-
0036097492
-
Essential roles of the κ light chain intronic enhancer and 3′ enhancer in κ rearrangement and demethylation
-
Inlay, M., Alt, F. W., Baltimore, D. & Xu, Y. Essential roles of the κ light chain intronic enhancer and 3′ enhancer in κ rearrangement and demethylation. Nature Immunol. 3, 463-468 (2002).
-
(2002)
Nature Immunol.
, vol.3
, pp. 463-468
-
-
Inlay, M.1
Alt, F.W.2
Baltimore, D.3
Xu, Y.4
-
50
-
-
0033635229
-
Deletion of germline promoter PDβ1 from the TCRβ locus causes hypermethylation that impairs dβ1 recombination by multiple mechanisms
-
Whitehurst, C. E., Schlissel, M. S. & Chen, J. Deletion of germline promoter PDβ1 from the TCRβ locus causes hypermethylation that impairs dβ1 recombination by multiple mechanisms. Immunity 13, 703-714 (2000).
-
(2000)
Immunity
, vol.13
, pp. 703-714
-
-
Whitehurst, C.E.1
Schlissel, M.S.2
Chen, J.3
-
51
-
-
0034934221
-
T early α (TEA) regulates initial TCRVAJA rearrangements and leads to TCRJA coincidence
-
Mauvieux, L., Villey, I. & de Villartay, J. P. T early α (TEA) regulates initial TCRVAJA rearrangements and leads to TCRJA coincidence. Eur. J. Immunol. 31, 2080-2086 (2001).
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 2080-2086
-
-
Mauvieux, L.1
Villey, I.2
De Villartay, J.P.3
-
52
-
-
0030273709
-
Defect in rearrangement of the most 5′ TCR-J α following targeted deletion of T early α (TEA): Implications for TCRα locus accessibility
-
Villey, I., Caillol, D., Selz, F., Ferrier, P. & de Villartay, J. P. Defect in rearrangement of the most 5′ TCR-J α following targeted deletion of T early α (TEA): implications for TCRα locus accessibility. Immunity 5, 331-342 (1996).
-
(1996)
Immunity
, vol.5
, pp. 331-342
-
-
Villey, I.1
Caillol, D.2
Selz, F.3
Ferrier, P.4
De Villartay, J.P.5
-
53
-
-
0035999828
-
+ thymocytes
-
+ thymocytes. Nature Immunol. 3, 469-476 (2002).
-
(2002)
Nature Immunol.
, vol.3
, pp. 469-476
-
-
Guo, J.1
-
54
-
-
0033152430
-
A developmental switch from TCR delta enhancer to TCRα enhancer function during thymocyte maturation
-
Hernandez-Munain, C., Sleckman, B. P. & Krangel, M. S. A developmental switch from TCR delta enhancer to TCRα enhancer function during thymocyte maturation. Immunity 10, 723-733 (1999).
-
(1999)
Immunity
, vol.10
, pp. 723-733
-
-
Hernandez-Munain, C.1
Sleckman, B.P.2
Krangel, M.S.3
-
55
-
-
0030958199
-
In vivo occupancy of the κ light chain enhancers in primary pro- and pre-B cells: A model for κ locus activation
-
Shaffer, A. L., Peng, A. & Schlissel, M. S. In vivo occupancy of the κ light chain enhancers in primary pro- and pre-B cells: a model for κ locus activation. Immunity 6, 131-143 (1997).
-
(1997)
Immunity
, vol.6
, pp. 131-143
-
-
Shaffer, A.L.1
Peng, A.2
Schlissel, M.S.3
-
56
-
-
0033515093
-
Induction of Ig light chain gene rearrangemant in heavy chain-deficient B cells by activated Ras
-
Shaw, A. C., Swat, W., Davidson, L. & Alt, F. W. Induction of Ig light chain gene rearrangemant in heavy chain-deficient B cells by activated Ras. Proc. Natl Acad. Sci. USA 96, 2239-2243 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 2239-2243
-
-
Shaw, A.C.1
Swat, W.2
Davidson, L.3
Alt, F.W.4
-
57
-
-
0030664126
-
Control of B cell development by Ras-mediated activation of Raf
-
Iritani, B. M., Forbush, K. A., Farrar, M. A. & Perlmutter, R. M. Control of B cell development by Ras-mediated activation of Raf. EMBO J. 16, 7019-7031 (1997).
-
(1997)
EMBO J.
, vol.16
, pp. 7019-7031
-
-
Iritani, B.M.1
Forbush, K.A.2
Farrar, M.A.3
Perlmutter, R.M.4
-
58
-
-
0032429254
-
The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells
-
Dinkel, A. et al. The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells. J. Exp. Med. 188, 2215-2224 (1998).
-
(1998)
J. Exp. Med.
, vol.188
, pp. 2215-2224
-
-
Dinkel, A.1
-
59
-
-
0035881676
-
Differential roles of cytokine receptors in the development of epidermal γδ T cells
-
Ye, S. K. et al. Differential roles of cytokine receptors in the development of epidermal γδ T cells. J. Immunol. 167, 1929-1934 (2001).
-
(2001)
J. Immunol.
, vol.167
, pp. 1929-1934
-
-
Ye, S.K.1
-
60
-
-
0033180184
-
Induction of germline transcription in the TCRγ locus by Stat5: Implications for accessibility control by the IL-7 receptor
-
Ye, S. K. et al. Induction of germline transcription in the TCRγ locus by Stat5: implications for accessibility control by the IL-7 receptor. Immunity 11, 213-223 (1999).
-
(1999)
Immunity
, vol.11
, pp. 213-223
-
-
Ye, S.K.1
-
61
-
-
0037372003
-
Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
-
Jaenisch, R. & Bird, A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nature Genet. 33 Suppl. 245-254 (2003).
-
(2003)
Nature Genet.
, vol.33
, Issue.SUPPL.
, pp. 245-254
-
-
Jaenisch, R.1
Bird, A.2
-
62
-
-
0032526136
-
κ chain monoallelic demethylation and the establishment of allelic exclusion
-
Mostoslavsky, R. et al. κ chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 12, 1801-1811 (1998). The authors found that DNA in the Igκ locus was CpG methylated in non-lymphoid and pro-B cells, but underwent progressive, monoallelic demethylation with the progression of B-cell development. They proposed that methylation was important for allelic exclusion.
-
(1998)
Genes Dev.
, vol.12
, pp. 1801-1811
-
-
Mostoslavsky, R.1
-
63
-
-
0036792721
-
Differential accessibility at the kappa chain locus plays a role in allelic exclusion
-
Goldmit, M., Schlissel, M., Cedar, H. & Bergman, Y. Differential accessibility at the kappa chain locus plays a role in allelic exclusion. EMBO J. 21, 5255-5261 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 5255-5261
-
-
Goldmit, M.1
Schlissel, M.2
Cedar, H.3
Bergman, Y.4
-
64
-
-
18244365863
-
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
-
Lee, P. P. et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15, 763-774 (2001).
-
(2001)
Immunity
, vol.15
, pp. 763-774
-
-
Lee, P.P.1
-
65
-
-
0030873630
-
Germ-line transcription and methylation status of the TCR-Jα locus in its accessible configuration
-
Villey, I., Quartier, P., Selz. F. & de Villartay, J. P. Germ-line transcription and methylation status of the TCR-Jα locus in its accessible configuration. Eur. J. Immunol. 27, 1619-1625 (1997).
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 1619-1625
-
-
Villey, I.1
Quartier, P.2
Selz, F.3
De Villartay, J.P.4
-
66
-
-
0032574977
-
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
-
Nan, X. et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386-389 (1998).
-
(1998)
Nature
, vol.393
, pp. 386-389
-
-
Nan, X.1
-
67
-
-
0033168204
-
Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase
-
Golding, A., Chandler, S., Ballestar, E., Wolffe, A. P. & Schlissel, M. S. Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase. EMBO J. 18, 3712-3723 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 3712-3723
-
-
Golding, A.1
Chandler, S.2
Ballestar, E.3
Wolffe, A.P.4
Schlissel, M.S.5
-
68
-
-
0032239155
-
Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1
-
Kwon, J., Imbalzano, A. N., Matthews, A. & Oettinger, M. A. Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1. Mol. Cell 2, 829-839 (1998).
-
(1998)
Mol. Cell
, vol.2
, pp. 829-839
-
-
Kwon, J.1
Imbalzano, A.N.2
Matthews, A.3
Oettinger, M.A.4
-
69
-
-
0034175813
-
Stimulation of V(D)J recombination by histone acetylation
-
McBlane, F. & Boyes, J. Stimulation of V(D)J recombination by histone acetylation. Curr. Biol. 10, 483-486 (2000).
-
(2000)
Curr. Biol.
, vol.10
, pp. 483-486
-
-
McBlane, F.1
Boyes, J.2
-
70
-
-
85015069067
-
Controlling the double helix
-
Felsenfeld, G. & Groudine, M. Controlling the double helix. Nature 421, 448-453 (2003).
-
(2003)
Nature
, vol.421
, pp. 448-453
-
-
Felsenfeld, G.1
Groudine, M.2
-
71
-
-
0033638506
-
Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA
-
Kwon, J., Morshead, K. B., Guyon, J. R., Kingston, R. E. & Oettinger, M. A. Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA. Mol. Cell 6, 1037-1048 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 1037-1048
-
-
Kwon, J.1
Morshead, K.B.2
Guyon, J.R.3
Kingston, R.E.4
Oettinger, M.A.5
-
72
-
-
0034695501
-
A role for histone acetylation in the developmental regulation of VDJ recombination
-
McMurry, M. T. & Krangel, M. S. A role for histone acetylation in the developmental regulation of VDJ recombination. Science 287, 495-498 (2000). Using a chromatin immunoprecipitation assay, the authors uncovered developmentally regulated changes in the post-translational modification of histones, which correlate with RSS accessibility.
-
(2000)
Science
, vol.287
, pp. 495-498
-
-
McMurry, M.T.1
Krangel, M.S.2
-
73
-
-
0035890244
-
Stepwise activation of the immunoglobulin μ heavy chain gene locus
-
Chowdhury, D. & Sen, R. Stepwise activation of the immunoglobulin μ heavy chain gene locus. EMBO J. 20, 6394-6403 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 6394-6403
-
-
Chowdhury, D.1
Sen, R.2
-
74
-
-
0034605064
-
Chromatin remodeling by the T cell receptor (TCR)-β gene enhancer during early T cell development: Implications for the control of TCR-β locus recombination
-
Mathieu, N., Hempel, W. M., Spicuglia, S., Verthuy, C. & Ferrier, P. Chromatin remodeling by the T cell receptor (TCR)-β gene enhancer during early T cell development: implications for the control of TCR-β locus recombination. J. Exp. Med. 192, 625-636 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 625-636
-
-
Mathieu, N.1
Hempel, W.M.2
Spicuglia, S.3
Verthuy, C.4
Ferrier, P.5
-
75
-
-
0037320925
-
Ezh2 controls B cell development through histone H3 methylation and IgH rearrangement
-
Su, I. H. et al. Ezh2 controls B cell development through histone H3 methylation and IgH rearrangement. Nature Immunol. 4, 124-131 (2003).
-
(2003)
Nature Immunol.
, vol.4
, pp. 124-131
-
-
Su, I.H.1
-
76
-
-
0035839136
-
Translating the histone code
-
Jenuwein, T. & Allis, C. D. Translating the histone code. Science 293, 1074-1080 (2001).
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
77
-
-
0029030481
-
The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate
-
Fernex, C., Capone, M. & Ferrier, P. The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate. Mol. Cell. Biol. 15, 3217-3226 (1995).
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 3217-3226
-
-
Fernex, C.1
Capone, M.2
Ferrier, P.3
-
78
-
-
0037125979
-
Regulation of V(D)J recombination: A dominant role for promoter positioning in gene segment accessibility
-
Sikes, M. L., Meade, A., Tripathi, R., Krangel, M. S. & Oltz, E. M. Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility Proc. Natl Acad. Sci. USA 99, 12309-12314 (2002). Using a stably transfected recombination reporter construct, this study explored the roles of promoter sequences and germline transcripts in V(D)J recombination. They found that the position of the promoter was more important than its orientation, and that histone acetylation was not sufficient for recombinase accessibility.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 12309-12314
-
-
Sikes, M.L.1
Meade, A.2
Tripathi, R.3
Krangel, M.S.4
Oltz, E.M.5
-
79
-
-
0037229028
-
Pax5 is required for recombination of transcribed, acetylated, 5′ IgH V gene segments
-
Hesslein, D. G. et al. Pax5 is required for recombination of transcribed, acetylated, 5′ IgH V gene segments. Genes Dev. 17, 37-42 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 37-42
-
-
Hesslein, D.G.1
-
80
-
-
0035554683
-
Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes
-
Skok, J. A. et al. Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes. Nature Immunol. 2, 848-854 (2001).
-
(2001)
Nature Immunol.
, vol.2
, pp. 848-854
-
-
Skok, J.A.1
-
81
-
-
0037023361
-
Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development
-
Kosak, S. T. et al. Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science 296, 158-162 (2002).
-
(2002)
Science
, vol.296
, pp. 158-162
-
-
Kosak, S.T.1
-
82
-
-
0032007002
-
Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression
-
ten Boekel, E., Melchers, F. & Rolink, A. G. Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression. Immunity 8, 199-207 (1998).
-
(1998)
Immunity
, vol.8
, pp. 199-207
-
-
Ten Boekel, E.1
Melchers, F.2
Rolink, A.G.3
-
83
-
-
0030888193
-
B cell development under the condition of allelic inclusion
-
Sonoda, E. et al. B cell development under the condition of allelic inclusion. Immunity 6, 225-233 (1997).
-
(1997)
Immunity
, vol.6
, pp. 225-233
-
-
Sonoda, E.1
-
84
-
-
0019494043
-
Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
-
Coleclough, C., Perry, R. P., Karjalainen, K. & Weigert, M. Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature 290, 372-378 (1981).
-
(1981)
Nature
, vol.290
, pp. 372-378
-
-
Coleclough, C.1
Perry, R.P.2
Karjalainen, K.3
Weigert, M.4
-
85
-
-
0036850786
-
The 'dispensable' portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development
-
Liang, H. E. et al. The 'dispensable' portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development. Immunity 17, 639-651 (2002).
-
(2002)
Immunity
, vol.17
, pp. 639-651
-
-
Liang, H.E.1
-
86
-
-
0035829551
-
Asynchronous replication and allelic exclusion in the immune system
-
Mostoslavsky, R. et al. Asynchronous replication and allelic exclusion in the immune system. Nature 414, 221-225 (2001).
-
(2001)
Nature
, vol.414
, pp. 221-225
-
-
Mostoslavsky, R.1
-
87
-
-
0029155607
-
Enhancers increase the probability but not the level of gene expression
-
Walters, M. C. et al. Enhancers increase the probability but not the level of gene expression. Proc. Natl Acad. Sci. USA 92, 7125-7129 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 7125-7129
-
-
Walters, M.C.1
-
88
-
-
0345268756
-
Biallelic germline transcription at the κ immunoglobulin locus
-
Singh, N., Bergman, Y., Cedar, H. & Chess, A. Biallelic germline transcription at the κ immunoglobulin locus. J. Exp. Med. 197, 743-750 (2003).
-
(2003)
J. Exp. Med.
, vol.197
, pp. 743-750
-
-
Singh, N.1
Bergman, Y.2
Cedar, H.3
Chess, A.4
-
89
-
-
1842411320
-
Crystal structure of the nucleosome core particle at 2. 8 A resolution
-
Luger, K., Mader, A. W., Richmond, R. K., Sargent, D. F. & Richmond, T. J. Crystal structure of the nucleosome core particle at 2. 8 A resolution. Nature 389, 251-260 (1997).
-
(1997)
Nature
, vol.389
, pp. 251-260
-
-
Luger, K.1
Mader, A.W.2
Richmond, R.K.3
Sargent, D.F.4
Richmond, T.J.5
-
90
-
-
0033843853
-
Factors that influence formation of B cell repertoire
-
Feeney, A. J. Factors that influence formation of B cell repertoire. Immunol. Res. 21, 195-202 (2000).
-
(2000)
Immunol. Res.
, vol.21
, pp. 195-202
-
-
Feeney, A.J.1
-
91
-
-
0025788230
-
Mouse κ light-chain recombination signal sequences mediate recombination more frequently than do those of λ light chain
-
Ramsden, D. A. & Wu, G. E. Mouse κ light-chain recombination signal sequences mediate recombination more frequently than do those of λ light chain. Proc. Natl Acad. Sci. USA 88, 10721-10725 (1991).
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, pp. 10721-10725
-
-
Ramsden, D.A.1
Wu, G.E.2
-
92
-
-
0034214049
-
Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule
-
Bassing, C. H. et al. Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule. Nature 405, 583-586 (2000). These investigators used a gene-targeting strategy to show the roles of particular RSSs in regulating rearrangement in the T-cell receptor β (TCRβ) locus. Before this study, it was thought that RSS involvement in recombinase regulation was limited to the restrictions in pairing imposed by the 12/23 rule.
-
(2000)
Nature
, vol.405
, pp. 583-586
-
-
Bassing, C.H.1
-
93
-
-
0034608888
-
Mechanisms that direct ordered assembly of T cell receptor β locus V, D, and J gene segments
-
Sleckman, B. P. et al. Mechanisms that direct ordered assembly of T cell receptor β locus V, D, and J gene segments. Proc. Natl Acad. Sci. USA 97, 7975-7980 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 7975-7980
-
-
Sleckman, B.P.1
-
94
-
-
0030889121
-
H, recombination and in the ordered rearrangement of the IgH locus
-
H, recombination and in the ordered rearrangement of the IgH locus. Int. Immunol. 9, 515-522 (1997).
-
(1997)
Int. Immunol.
, vol.9
, pp. 515-522
-
-
Pan, P.Y.1
Lieber, M.R.2
Teale, J.M.3
-
95
-
-
0037454957
-
Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling
-
Cowell, L. G., Davila, M., Yang, K., Kepler, T. B. & Kelsoe, G. Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling. J. Exp. Med. 197, 207-220 (2003).
-
(2003)
J. Exp. Med.
, vol.197
, pp. 207-220
-
-
Cowell, L.G.1
Davila, M.2
Yang, K.3
Kepler, T.B.4
Kelsoe, G.5
-
96
-
-
85015069067
-
Controlling the double helix
-
Felsenfeld, G. & Groudine, M. Controlling the double helix. Nature 421, 448-453 (2003).
-
(2003)
Nature
, vol.421
, pp. 448-453
-
-
Felsenfeld, G.1
Groudine, M.2
|