CD19 as a membrane-anchored adaptor protein of B lymphocytes: Costimulation of lipid and protein kinases by recruitment of Vav

Immunity

Volumn 8, Issue 5, 1998, Pages 635-645

  O'Rourke, Lorraine M ^a   Tooze, Reuben ^a   Turner, Martin ^c,d   Sandoval, David M ^b   Carter, Robert H ^b   Tybulewicz, Victor L J ^c   Fearon, Douglas T ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CD19 ANTIGEN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; IMMUNOGLOBULIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DAUDI CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 0032076954     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80568-3     Document Type: Article

References (52)

1. Aktories, K., and Hall, A. (1989). Botulinum ADP-ribosylation transferase: a new tool to study low molecular weight GTP-binding proteins. Trends Pharmacol. Sci. 10, 415-418.
2. Alexander, D.R., Hexham, J.M., Lucas, S.C., Graves, J.D., Cantrell, D.A., and Crumpton, M.J. (1989). A protein kinase C pseudosubstrate peptide inhibits phosphorylation of CD3 antigen in streptolysin-O-permeabilized human T cells. Biochem. J. 260, 893-901.
3. Billips, L.G., Nunez C. A., Bertrand, F.E., Stankovic, A.K., Gartland, G.L., Burrows, P.D., and Cooper, M.D. (1995). Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors. J. Exp. Med. 182, 973-982.
4. Bradbury, L.E., Goldmacher, V.S., and Tedder, T.F. (1993). The CD19 signal transduction complex of B lymphocytes: deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13. J. Immunol. 151, 2915-2927.
5. 2+ mobilization. J. Exp. Med. 186, 1897-1910.
6. Bustelo, X.R., and Barbacid, M. (1992). Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells. Science 256, 1196-1199.
7. Bustelo, X.R., Ledbetter, J.A., and Barbacid, M. (1992). Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates. Nature 356, 68-71.
8. Bustelo, X.R., Suen, K.L., Leftheris, K., Meyers, C.A., and Barbacid, M. (1994). Vav cooperates with Ras to transform rodent fibroblasts but is not a ras GDP/GTP exchange factor. Oncogene 9, 2405-2413.
9. Carter, R.H., and Fearon, D.T. (1992). CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 256, 105-107.
10. Carter, R.H., Tuveson, D.A., Park, D.J., Rhee, S.G., and Fearon, D.T. (1991). The CD19 complex of B lymphocytes: activation of phospholipase C by a protein tyrosine kinase-dependent pathway that can be enhanced by the membrane IgM complex. J. Immunol. 147, 3663-3671.
11. Chong, L.D., Traynor-Kaplan, A., Bokoch, G.M., and Schwartz, M.A. (1994). The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell 79, 507-513.
12. Coso, O.A., Chiariello, M., Yu, J.C., Teramoto, H., Crespo, P., Xu, N., Miki,T., and Gutkind, J.S. (1995). The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81, 1137-1146.
13. Crespo, P., Bustelo, X.R., Aaronson, D.S., Coso, O.A., Lopez-Barahona, M., Barbacid, M., and Gutkind, J.S. (1996). Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. Oncogene 13, 455-460.
14. Crespo, P., Schuebel, K.E., Ostrom, A.A., Gutkind, J.S., and Bustelo, X.R. (1997). Phosphotyrosine-dependent activation of Rac-1 GDP/ GTP exchange by the vav proto-oncogene product. Nature 385, 169-172.
15. Delibrias, C.C., Floettmann, J.E., Rowe, M., and Fearon, D.T. (1997). Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes. J. Exp. Med. 186, 1575-1583.
16. Dempsey, P.W., Allison, M.E., Akkaraju, S., Goodnow, C.C., and Fearon, DT. (1996). C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271, 348-350.
17. Engel, P., Zhou, L.J., Ord, D.C., Sato, S., Koller, B., and Tedder, T.F. (1995). Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity 3, 39-50.
18. Gold, M.R., Jakway, J.P., and DeFranco, A.L. (1987). Involvement of aguanine-nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdown. J. Immunol. 139, 3604-3613.
19. Man, J., Balaka, D., Wei, W., van Aelst, L., Mosteller, R.D., Khosravi-Far, R., Westwick, J.K., Der, C.J., and Broek, D. (1997). Lck regulates Vav activation of members of the Rho family of GTPases. Mol. Cell Biol. 17, 1346-1353.
20. Man, J., Luby-Phelps, K., Das, B., Shu, X., Xia, Y., Mosteller, R.D., Krishna, M., Falck, J.R., White, M.A., and Broek, D. (1998). Role of the substrates and products of PI3-kinase in the regulating activation of the rac-related guanosine triphosphateses by Vav. Science 279, 558-560.
21. Harnett, M.M., and Klaus, G.G. (1988). G protein coupling of antigen receptor-stimulated polyphosphoinositide hydrolysis in B cells. J. Immunol. 140, 3135-3139.
22. Hartwig, J.H., Bokoch, G.M., Carpenter, C.L., Janmey, P.A., Taylor, L.A., Toker, A., and Stossel, T.P. (1995). Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 82, 643-653.
23. Janmey, P.A. (1994). Phosphoinositides and calcium as regulators of cellular actin assembly and disassembly. Annu. Rev. Physiol. 56, 169-191.
24. Katzav, S., Martin-Zanca, D., and Barbacid, M. (1989). vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 8, 2283-2290.
25. Khosravi-Far, R., Chrzanowska-Wodnicka, M., Solski, P.A., Eva, A., Burridge, K., and Der, C.J. (1994). Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras. Mol. Cell. Biol. 14, 6848-6857.
26. Krop, I., de Fougerolles, A.R., Hardy, R.R., Allison, M., Schlissel, M.S., and Fearon, D.T. (1996). Self-renewal of B-1 lymphocytes is dependent on CD19. Eur. J. Immunol. 26, 238-242.
27. Li, X., Sandoval, D., Freeberg, L., and Carter, R.H. (1997). Role of CD19 tyrosine 391 in the synergistic activation of B lymphocytes by coligating of CD19 and membrane Ig. J. Immunol. 158, 5649-5657.
28. Margolis, B., Hu, P., Katzav, S., Li, W., Oliver, J.M., Ullrich, A., Weiss, A., and Schlessinger, J. (1992). Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature 356, 71-74.
29. Matsumoto, A.K., Martin, D.R., Carter, R.H., Klickstein, L.B., Ahearn, J.M., and Fearon, D.T. (1993). Functional dissection of the CD21/ CD19/TAPA-1/Leu-13 complex of B lymphocytes. J. Exp. Med. 178, 1407-1417.
30. Minden, A., Lin, A., Claret, F.X., Abo, A., and Karin, M. (1995). Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81, 1147-1157.
31. Pezzutto, A., Dorken, B., Rabinovitch, P.S., Led better, J. A., Moldenhauer, G., and Clark, E.A. (1987). CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation. J. Immunol. 138, 2793-2799.
32. Raab, M., da Silva, A.J., Findell, P.R., and Rudd, C.E. (1997). Regulation of Vav-SLP-76 binding by ZAP-70 and its revelance to TCRz/ CDS induction of interleukin-2. Immunity 6, 155-164.
33. Rameh, L.E., Tolias, K.F., Duckworth, B.C., and Cantley, L.C. (1997). A new pathway for the synthesis of phosphatidylinositol-4,5-bisphosphate. Nature 390, 192-196.
34. Reif, K., Buday, L., Downward, J., and Cantrell, D.A. (1994). SH3 domains of the adaptor molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sosand a75-kDa protein that is a substrate for the T cell antigen receptor-activated tyrosine kinases. J. Biol. Chem. 269, 14081-14087.
35. Ren, X.-D., Bokoch, G.M., Traylor-Kaplan, A., Jenkins, G.H., Anderson, R.A., and Schwartz, M.A. (1996). Physical association of small GTPase Rho with a 68kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. Mol. Biol. Cell. 7, 435-442.
36. Rickert, R.C., Rajewsky, K., and Roes, J. (1995). Impairment of T cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376, 352-355.
37. Sato, S., Steeber, D.A., and Tedder, T.F. (1995). The CD19 signal transduction molecule is a response regulator of B lymphocyte differentiation. Proc. Natl. Acad. Sci. USA 92, 11558-11562.
38. Sato, S., Jansen, P.J., and Tedder, T.F. (1997). CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. Proc. Natl. Acad. Sci. USA 94, 13158-13162.
39. Schuebel, K.E., Bustelo, X.R., Nielsen, D.A., Song, B.J., Barbacid, M., Goldman, D., and Lee, I.J. (1996). Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes. Oncogene 13, 363-371.
40. Songyang, Z., Shoelson, S.E., McGlade J., Oliver, P., Pawson T., Bustelo, X.R., Barbacid M., Sabe, H., Yi, T., Ren, R., et al. (1994). Specific motifs recognised by the SH2 domains of Csk, 3BP2, fps/ fes, Grb2, HCP, SHC, Syk and Vav. Mol. Cell. Biol. 14, 2777-2785.
41. Stephens, L., Jackson, T.R., and Hawkins, P.T. (1993). Activation of phosphatidylinositol 4,5-bisphosphate supply by agonists and non-hydrolysable GTP analogues. Biochem. J. 296, 481-488.
42. Tarakhovsky, A., Turner, M., Schaal, S., Mee, P.J., Duddy, L.P., Rajewsky, K., and Tybulewicz, V.L. (1995). Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374, 467-470.
43. Tedder, T.F., and Isaacs, C.M. (1989). Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes: a new member of the immunoglobulin superfamily. J. Immunol. 143, 712-717.
44. Tolias, K.F., Cantley, L.C., and Carpenter, C.L. (1995). Rho family GTPases bind to phosphoinositide kinases. J. Biol. Chem. 270, 17656-17659.
45. Tooze, R.M., Doody, G.M., and Fearon, D.T. (1997). Counterregulation by coreceptors CD19 and CD22 of MAP kinase activation by membrane immunoglobulin. Immunity 7, 59-67.
46. Turner, M., Mee, J.P., Walters, A.E., Quinn, M.E., Mellor, A.L., Zamoyska, R., and Tybulewicz, V.L.J. (1997). A requirement for Rhofamily GTP exchange factor Vav in positive and negative selecton of thymocytes. Immunity 7, 451-460.
47. Tuveson, D.A., Carter, R.H., Soltoff, S.P., and Fearon, D.T. (1993). CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science 260, 986-989.
48. Weng, W.K., Jarvis, L., and LeBien, T.W. (1994). Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors. J. Biol. Chem. 269, 32514-32521.
49. Woscholski, R., Waterfield, M.D., and Parker, P. (1995). Purification and biochemical characterization of the mammalian phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. J. Biol. Chem. 270, 31001-31007.
50. Wu, J., Motto, D.G., Koretzky, G.A., and Weiss, A. (1996). Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity 4, 593-602.
51. Yamamoto, M., Marui, N., Sakai, T., Morii, N., Kozaki, S., Ikai, K., Imamura, S., and Narumiya, S. (1993). ADP-ribosylation of rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle. Oncogene 8, 1449-1455.
52. Zhang, R., Alt, F.W., Davidson, L., Orkin, S.H., and Swat, W. (1995). Defective signalling through the T-and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374, 470-473.