-
1
-
-
0028931830
-
Advances in the biology and treatment of B-cell chronic lymphocytic leukemia
-
O'Bien S, del Giglio A, Keating M. Advances in the biology and treatment of B-cell chronic lymphocytic leukemia. Blood. 1995;85:306-318.
-
(1995)
Blood
, vol.85
, pp. 306-318
-
-
O'Bien, S.1
Del Giglio, A.2
Keating, M.3
-
2
-
-
0033011755
-
Molecular pathogenesis of chronic lymphocytic leukemia: Factors and signaling pathways regulating cell growth and survival
-
Meinhardt G, Wendtner CM, Hallek M. Molecular pathogenesis of chronic lymphocytic leukemia: Factors and signaling pathways regulating cell growth and survival. J Mol Med. 1999;77:282-293.
-
(1999)
J Mol Med
, vol.77
, pp. 282-293
-
-
Meinhardt, G.1
Wendtner, C.M.2
Hallek, M.3
-
3
-
-
0034727833
-
Genomic aberrations and survival in chronic lymphocytic leukemia
-
Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000;343:1910-1916.
-
(2000)
N Engl J Med
, vol.343
, pp. 1910-1916
-
-
Dohner, H.1
Stilgenbauer, S.2
Benner, A.3
-
4
-
-
0031890032
-
Molecular biology of chronic lymphocytic leukemia
-
Reed JC. Molecular biology of chronic lymphocytic leukemia. Semin Oncol. 1998;25:11-18.
-
(1998)
Semin Oncol
, vol.25
, pp. 11-18
-
-
Reed, J.C.1
-
5
-
-
0027239823
-
Bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
-
Hanada M, Delia D, Aiello A, Stadtmauer E, Reed JC. Bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood. 1993;82:1820-1828.
-
(1993)
Blood
, vol.82
, pp. 1820-1828
-
-
Hanada, M.1
Delia, D.2
Aiello, A.3
Stadtmauer, E.4
Reed, J.C.5
-
6
-
-
0032079746
-
Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations with in vitro and in vivo chemoresponses
-
Kitada S, Andersen J, Akar S, et al. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations with in vitro and in vivo chemoresponses. Blood. 1998;91:3379-3389.
-
(1998)
Blood
, vol.91
, pp. 3379-3389
-
-
Kitada, S.1
Andersen, J.2
Akar, S.3
-
7
-
-
0031436969
-
B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT)1 and STAT3 constitutively phosphorylated on serine residues
-
Frank DA, Mahajan S, Ritz J. B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT)1 and STAT3 constitutively phosphorylated on serine residues. J Clin Invest. 1997;100:3140-3148.
-
(1997)
J Clin Invest
, vol.100
, pp. 3140-3148
-
-
Frank, D.A.1
Mahajan, S.2
Ritz, J.3
-
8
-
-
0034651739
-
Modulation of NF-κB activity and apoptosis in chronic lymphocytic leukemia
-
Furman RR, Asgary Z, Mascarenhas JO, Liou HC, Schattner EJ. Modulation of NF-κB activity and apoptosis in chronic lymphocytic leukemia. J Immunol. 2000;164:2200-2206.
-
(2000)
J Immunol
, vol.164
, pp. 2200-2206
-
-
Furman, R.R.1
Asgary, Z.2
Mascarenhas, J.O.3
Liou, H.C.4
Schattner, E.J.5
-
9
-
-
0030790548
-
Using structure to define the function of phosphoinositide 3-kinase family members
-
Domin J, Waterfield MD. Using structure to define the function of phosphoinositide 3-kinase family members. FEBS Lett. 1997;410:91-95.
-
(1997)
FEBS Lett
, vol.410
, pp. 91-95
-
-
Domin, J.1
Waterfield, M.D.2
-
10
-
-
0034292331
-
Phosphatidylinositol 3-kinase and NF-kappa B/Rel are at the divergence of CD40 mediated proliferation and survival pathways
-
Andjelic S, Hsia C, Suzuki H, Kadowaki T, Koyasu S, Liou HC. Phosphatidylinositol 3-kinase and NF-kappa B/Rel are at the divergence of CD40 mediated proliferation and survival pathways. J Immunol. 2000;165:3860-3867.
-
(2000)
J Immunol
, vol.165
, pp. 3860-3867
-
-
Andjelic, S.1
Hsia, C.2
Suzuki, H.3
Kadowaki, T.4
Koyasu, S.5
Liou, H.C.6
-
11
-
-
0029882545
-
Phosphatidylinositol 3-kinase activation in normal human B lymphocytes
-
Aagaard-Tillery KM, Jelinek DF. Phosphatidylinositol 3-kinase activation in normal human B lymphocytes. J Immunol. 1996;156:4543-4554.
-
(1996)
J Immunol
, vol.156
, pp. 4543-4554
-
-
Aagaard-Tillery, K.M.1
Jelinek, D.F.2
-
12
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi DR, Andejelkovic M, Caudwell B, et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 1996;15:6541-6551.
-
(1996)
EMBO J
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andejelkovic, M.2
Caudwell, B.3
-
13
-
-
0034092571
-
The catalytic subunit of phosphoinositide 3-kinase: Requirements for oncogenicity
-
Aoki M, Schetter C, Himly M, Batista O, Chang HW, Vogt PK. The catalytic subunit of phosphoinositide 3-kinase: Requirements for oncogenicity. J Biol Chem. 2000;275:6267-6275.
-
(2000)
J Biol Chem
, vol.275
, pp. 6267-6275
-
-
Aoki, M.1
Schetter, C.2
Himly, M.3
Batista, O.4
Chang, H.W.5
Vogt, P.K.6
-
14
-
-
0026667730
-
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinase, is amplified in human ovarian carcinomas
-
Cheng JQ, Godwin AK, Bellacosa A, et al. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinase, is amplified in human ovarian carcinomas. Proc Natl Acad Sci U S A. 1992;89:9267-9271.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 9267-9271
-
-
Cheng, J.Q.1
Godwin, A.K.2
Bellacosa, A.3
-
15
-
-
0034742120
-
Akt1/PKBα kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells
-
Sun M, Wang G, Paciga JE, et al. Akt1/PKBα kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol. 2001;159:431-437.
-
(2001)
Am J Pathol
, vol.159
, pp. 431-437
-
-
Sun, M.1
Wang, G.2
Paciga, J.E.3
-
16
-
-
0033604585
-
The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
-
Kandel ES, Hay N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res. 1999;253:210-229.
-
(1999)
Exp Cell Res
, vol.253
, pp. 210-229
-
-
Kandel, E.S.1
Hay, N.2
-
17
-
-
0033517190
-
NF-κB is a target of Akt in anti-apoptotic PDGF signaling
-
Romashkova JA, Makarov SS. NF-κB is a target of Akt in anti-apoptotic PDGF signaling. Nature. 1999;401:86-90.
-
(1999)
Nature
, vol.401
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
18
-
-
0035793086
-
A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3K and Akt
-
Aoki M, Blazek E, Vogt K. A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3K and Akt. Proc Natl Acad Sci U S A. 2001;98:136-141.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 136-141
-
-
Aoki, M.1
Blazek, E.2
Vogt, K.3
-
20
-
-
0033387429
-
Activation and tyrosine phosphorylation of proteinkinase Cδ in response to B cell antigen receptor stimulation
-
Popoff IJ, Deans JP. Activation and tyrosine phosphorylation of proteinkinase Cδ in response to B cell antigen receptor stimulation. Mol Immunol. 1999;36:1005-1016.
-
(1999)
Mol Immunol
, vol.36
, pp. 1005-1016
-
-
Popoff, I.J.1
Deans, J.P.2
-
21
-
-
0030014746
-
Protein kinase Cδ specifically associates with phosphathidyinositol 3-kinase following cytokine stimulation
-
Ettinger SL, Lauener RW, Duronio V. Protein kinase Cδ specifically associates with phosphathidyinositol 3-kinase following cytokine stimulation. J Biol Chem. 1996;271:14514-14518.
-
(1996)
J Biol Chem
, vol.271
, pp. 14514-14518
-
-
Ettinger, S.L.1
Lauener, R.W.2
Duronio, V.3
-
22
-
-
0033597645
-
Protein kinase Cδ inhibition of S-phase transition in capillary endothelial cell involves the cyclin-dependent kinase inhibitor p27
-
Ashton AW, Watanabe G, Albanese C, Harrington EO, Ware JA, Pestell RG. Protein kinase Cδ inhibition of S-phase transition in capillary endothelial cell involves the cyclin-dependent kinase inhibitor p27. J Biol Chem. 1999;274:20805-20811.
-
(1999)
J Biol Chem
, vol.274
, pp. 20805-20811
-
-
Ashton, A.W.1
Watanabe, G.2
Albanese, C.3
Harrington, E.O.4
Ware, J.A.5
Pestell, R.G.6
-
23
-
-
0026472991
-
Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-δ subspecies
-
Watanabe T, Ono Y, Taniyama Y, Hazama K, et al. Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-δ subspecies. Proc Natl Acad Sci U S A. 1992;89:10159-10163.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 10159-10163
-
-
Watanabe, T.1
Ono, Y.2
Taniyama, Y.3
Hazama, K.4
-
24
-
-
0030973402
-
Protein kinase Cδ inhibits the proliferation of vascular smooth muscle cells by suppressing G1 cyclin expression
-
Fukumoto S, Nishizawa Y, Hosoi M, et al. Protein kinase Cδ inhibits the proliferation of vascular smooth muscle cells by suppressing G1 cyclin expression. J Biol Chem. 1997;272:13816-13822.
-
(1997)
J Biol Chem
, vol.272
, pp. 13816-13822
-
-
Fukumoto, S.1
Nishizawa, Y.2
Hosoi, M.3
-
25
-
-
0037171731
-
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ
-
Miyamoto A, Nakayama K, Imaki H, et al. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ. Nature. 2002;416:865-869.
-
(2002)
Nature
, vol.416
, pp. 865-869
-
-
Miyamoto, A.1
Nakayama, K.2
Imaki, H.3
-
26
-
-
13344259987
-
Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells
-
Emoto Y, Manome G, Meinhard G, et al. Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells. EMBO J. 1995;14:6148-6156.
-
(1995)
EMBO J
, vol.14
, pp. 6148-6156
-
-
Emoto, Y.1
Manome, G.2
Meinhard, G.3
-
27
-
-
0029063970
-
Phosphatidylinositol-3 kinase activity is regulated by BRC/ABL and is required for growth of Philadelphia chromosome-positive cells
-
Skorski T, Kanakarai P, Nieborowska-Skorska M, et al. Phosphatidylinositol-3 kinase activity is regulated by BRC/ABL and is required for growth of Philadelphia chromosome-positive cells. Blood. 1995;86:726-736.
-
(1995)
Blood
, vol.86
, pp. 726-736
-
-
Skorski, T.1
Kanakarai, P.2
Nieborowska-Skorska, M.3
-
28
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol-3 kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos CJ, Matter WF, Hui KY, Brown RF. A specific inhibitor of phosphatidylinositol-3 kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem. 1994;269:5241-5248.
-
(1994)
J Biol Chem
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
29
-
-
0034796549
-
Homotypic interactions protect chronic lymphocytic leukemia cells from spontaneous death in vitro
-
Pettitt AR, Moran EC, Cawley JC. Homotypic interactions protect chronic lymphocytic leukemia cells from spontaneous death in vitro. Leuk Res. 2001;25:1003-1012.
-
(2001)
Leuk Res
, vol.25
, pp. 1003-1012
-
-
Pettitt, A.R.1
Moran, E.C.2
Cawley, J.C.3
-
30
-
-
0028880006
-
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
-
Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 1995;270;1326-1331.
-
(1995)
Science
, vol.270
, pp. 1326-1331
-
-
Xia, Z.1
Dickens, M.2
Raingeaud, J.3
Davis, R.J.4
Greenberg, M.E.5
-
31
-
-
0034629345
-
The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation and retinoblastoma hyperphosphorylation in interleukin-2 stimulated T-cells independently of p38 MAP kinase
-
Lali FV, Hunt AE, Turner SJ, Foxwell B. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation and retinoblastoma hyperphosphorylation in interleukin-2 stimulated T-cells independently of p38 MAP kinase. J Biol Chem. 2000;275:7395-7402.
-
(2000)
J Biol Chem
, vol.275
, pp. 7395-7402
-
-
Lali, F.V.1
Hunt, A.E.2
Turner, S.J.3
Foxwell, B.4
-
32
-
-
0029166667
-
A synthetic inhibitor of the mitogen-activated protein kinase cascade
-
Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A. 1995;92:7686-7689.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 7686-7689
-
-
Dudley, D.T.1
Pang, L.2
Decker, S.J.3
Bridges, A.J.4
Saltiel, A.R.5
-
33
-
-
0030740005
-
The molecular phosphorylation and activation of p70S6kinase
-
Pullen N, Thomas G. The molecular phosphorylation and activation of p70S6kinase. FEBS Lett. 1997;410:78-82.
-
(1997)
FEBS Lett
, vol.410
, pp. 78-82
-
-
Pullen, N.1
Thomas, G.2
-
34
-
-
0030060075
-
Requirement of an ICE-like protease for induction of apoptosis and ceramide generation by REAPER
-
Pronk GJ, Ramer K, Amiri P, Williams LT. Requirement of an ICE-like protease for induction of apoptosis and ceramide generation by REAPER. Science. 1996;271:808-810.
-
(1996)
Science
, vol.271
, pp. 808-810
-
-
Pronk, G.J.1
Ramer, K.2
Amiri, P.3
Williams, L.T.4
-
35
-
-
0030905543
-
Involvement of CED-3/ICE proteases in the apoptosis of B-chronic lymphocytic leukemia cells
-
Bellosillo B, Dalmau M, Colomer D, Gil J. Involvement of CED-3/ICE proteases in the apoptosis of B-chronic lymphocytic leukemia cells. Blood. 1997;89:3378-3384.
-
(1997)
Blood
, vol.89
, pp. 3378-3384
-
-
Bellosillo, B.1
Dalmau, M.2
Colomer, D.3
Gil, J.4
-
37
-
-
0033566911
-
The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase
-
Gold MR, Scheid MP, Santos L, et al. The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase. J Immunol. 1999;163:1894-1905.
-
(1999)
J Immunol
, vol.163
, pp. 1894-1905
-
-
Gold, M.R.1
Scheid, M.P.2
Santos, L.3
-
38
-
-
0028339457
-
Rottlerin, a novel protein kinase inhibitor
-
Gschwendt M, Muller HJ, Kielbassa K, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994;199:93-98.
-
(1994)
Biochem Biophys Res Commun
, vol.199
, pp. 93-98
-
-
Gschwendt, M.1
Muller, H.J.2
Kielbassa, K.3
-
39
-
-
0030603158
-
Inhibition of protein kinase Cμ by various inhibitors: Differentiation from protein kinase c isoenzymes
-
Gschwendt M, Dieterich S, Rennecke J, Kittstein W, Mueller HJ, Johannes FJ. Inhibition of protein kinase Cμ by various inhibitors: differentiation from protein kinase c isoenzymes. FEBS Lett. 1996;392:77-80.
-
(1996)
FEBS Lett
, vol.392
, pp. 77-80
-
-
Gschwendt, M.1
Dieterich, S.2
Rennecke, J.3
Kittstein, W.4
Mueller, H.J.5
Johannes, F.J.6
-
40
-
-
0036093058
-
Constitutive activation of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival
-
Benekli M, Xia Z, Donohue KA, et al. Constitutive activation of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival. Blood. 2002;99:252-257.
-
(2002)
Blood
, vol.99
, pp. 252-257
-
-
Benekli, M.1
Xia, Z.2
Donohue, K.A.3
-
41
-
-
0033820091
-
Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation
-
Tse KF, Mukheriee G, Small D. Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation. Leukemia. 2000;14:1766-1776.
-
(2000)
Leukemia
, vol.14
, pp. 1766-1776
-
-
Tse, K.F.1
Mukheriee, G.2
Small, D.3
-
42
-
-
0034823632
-
Therapeutic targeting of MEK/MAPK signal transduction module in acute myeloid leukemia
-
Milella M, Kornblau SM, Estrov Z, et al. Therapeutic targeting of MEK/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest. 2001;108:851-859.
-
(2001)
J Clin Invest
, vol.108
, pp. 851-859
-
-
Milella, M.1
Kornblau, S.M.2
Estrov, Z.3
-
43
-
-
0033556333
-
Impaired B cell development and proliferation in absence of phosphoinositide 3 kinase p85α
-
Fruman DA, Snapper SB, Yballe CM, et al. Impaired B cell development and proliferation in absence of phosphoinositide 3 kinase p85α. Science. 1999;283:393-397.
-
(1999)
Science
, vol.283
, pp. 393-397
-
-
Fruman, D.A.1
Snapper, S.B.2
Yballe, C.M.3
-
44
-
-
0030962582
-
Interleukin-4 (IL-4) induces phosphatidylinositol 3 kinase (p85) dephosphorylation: Implications for the role of SHP-1 in the IL-4-induced signals in human B cells
-
Imani F, Rager KJ, Catipovic B, Marsh DG. Interleukin-4 (IL-4) induces phosphatidylinositol 3 kinase (p85) dephosphorylation: Implications for the role of SHP-1 in the IL-4-induced signals in human B cells. J Biol Chem. 1997;272:7927-7931.
-
(1997)
J Biol Chem
, vol.272
, pp. 7927-7931
-
-
Imani, F.1
Rager, K.J.2
Catipovic, B.3
Marsh, D.G.4
-
45
-
-
0037089403
-
Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia
-
Barragan M, Bellosillo B, Campas C, Colomer D, Pons G, Gil J. Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia. Blood. 2002;99:2969-2976.
-
(2002)
Blood
, vol.99
, pp. 2969-2976
-
-
Barragan, M.1
Bellosillo, B.2
Campas, C.3
Colomer, D.4
Pons, G.5
Gil, J.6
-
46
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restaining the phophoinositol-3 kinase/AKT pathway
-
Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restaining the phophoinositol-3 kinase/AKT pathway. Proc Natl Acad Sci U S A. 1999;96:4240-4245.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
47
-
-
0034548453
-
The phosphatidylinositol-3 kinase/Akt pathway in multiple myeloma plasma cells: Role in cytokine-dependent survival and proliferation responses
-
Tu Y, Gardner A, Lichtenstein A. The phosphatidylinositol-3 kinase/Akt pathway in multiple myeloma plasma cells: Role in cytokine-dependent survival and proliferation responses. Cancer Res. 2000;60:6763-6770.
-
(2000)
Cancer Res
, vol.60
, pp. 6763-6770
-
-
Tu, Y.1
Gardner, A.2
Lichtenstein, A.3
-
48
-
-
0034791463
-
Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage-induced apoptosis in B-chronic lymphocytic leukemia cells
-
Wickremasinghe RG, Ganeshaguru K, Jones DT, et al. Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage-induced apoptosis in B-chronic lymphocytic leukemia cells. Br J Haematol. 2001;114:608-615.
-
(2001)
Br J Haematol
, vol.114
, pp. 608-615
-
-
Wickremasinghe, R.G.1
Ganeshaguru, K.2
Jones, D.T.3
-
49
-
-
0035892106
-
Survival of leukemic B cells promoted by engagement of antigen receptor
-
Bernal A, Pastore RD, Asgary Z, et al. Survival of leukemic B cells promoted by engagement of antigen receptor. Blood. 2001;98:3050-3057.
-
(2001)
Blood
, vol.98
, pp. 3050-3057
-
-
Bernal, A.1
Pastore, R.D.2
Asgary, Z.3
-
50
-
-
0032566691
-
Protein kinase C isotypes controlled by phosphoinositide 3 kinase through the protein kinase PDK1
-
Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ. Protein kinase C isotypes controlled by phosphoinositide 3 kinase through the protein kinase PDK1. Science 1998;281:2042-2045.
-
(1998)
Science
, vol.281
, pp. 2042-2045
-
-
Good, J.A.1
Ziegler, W.H.2
Parekh, D.B.3
Alessi, D.R.4
Cohen, P.5
Parker, P.J.6
-
51
-
-
0030894024
-
Phosphorylation of protein kinase Cδ (PKCδ) at threonine 505 is not a prerequisite for enzymatic activity: Expression of rat PKCdelta and an alanine 505 mutant in bacteria in a functional form
-
Stempka L, Girod A, Muller HJ, et al. Phosphorylation of protein kinase Cδ (PKCδ) at threonine 505 is not a prerequisite for enzymatic activity: Expression of rat PKCdelta and an alanine 505 mutant in bacteria in a functional form. J Biol Chem. 1997;272:6805-6811.
-
(1997)
J Biol Chem
, vol.272
, pp. 6805-6811
-
-
Stempka, L.1
Girod, A.2
Muller, H.J.3
-
52
-
-
0028229299
-
Tyrosine phosphorylation and stimulation of protein kinase Cδ from porcine spleen by src in vitro: Dependence on the activated state of protein kinase Cδ
-
Gschwendt M, Kielbassa K, Kittstein W, Marks F. Tyrosine phosphorylation and stimulation of protein kinase Cδ from porcine spleen by src in vitro: Dependence on the activated state of protein kinase Cδ. FEBS Lett. 1994;347:85-89.
-
(1994)
FEBS Lett
, vol.347
, pp. 85-89
-
-
Gschwendt, M.1
Kielbassa, K.2
Kittstein, W.3
Marks, F.4
-
53
-
-
0033588229
-
Protein kinase Cδ associates with phosphorylates Stat3 in an interleukin-6 dependent manner
-
Jain N, Zhang T, Kee WH, Li W, Cao X. Protein kinase Cδ associates with phosphorylates Stat3 in an interleukin-6 dependent manner. J Biol Chem. 1999;274:24392-24400.
-
(1999)
J Biol Chem
, vol.274
, pp. 24392-24400
-
-
Jain, N.1
Zhang, T.2
Kee, W.H.3
Li, W.4
Cao, X.5
-
54
-
-
0035827660
-
NF-κB activation in tumor necrosis factor α-stimulated neutrophils is mediated by protein kinase Cδ: Correlation to nuclear Ikappa Balpha
-
Vancurova I, Miskolci V, Davidson D. NF-κB activation in tumor necrosis factor α-stimulated neutrophils is mediated by protein kinase Cδ: Correlation to nuclear Ikappa Balpha. J Biol Chem. 2001;276:19746-19752.
-
(2001)
J Biol Chem
, vol.276
, pp. 19746-19752
-
-
Vancurova, I.1
Miskolci, V.2
Davidson, D.3
-
56
-
-
0032851693
-
Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-CLL
-
Kitada S, Zapata JM, Andreeff M, Reed JC. Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-CLL. Br J Haematol. 1999;106:995-1004.
-
(1999)
Br J Haematol
, vol.106
, pp. 995-1004
-
-
Kitada, S.1
Zapata, J.M.2
Andreeff, M.3
Reed, J.C.4
-
57
-
-
0034661538
-
Protein kinase inhibitors flavopiddol and 7-hydroxystaurosporine down-regulate antiapoptosis proteins in B-CLL
-
Kitada S, Zapata JM, Andreeff M, Reed JC. Protein kinase inhibitors flavopiddol and 7-hydroxystaurosporine down-regulate antiapoptosis proteins in B-CLL. Blood. 2000;96:393-397.
-
(2000)
Blood
, vol.96
, pp. 393-397
-
-
Kitada, S.1
Zapata, J.M.2
Andreeff, M.3
Reed, J.C.4
-
58
-
-
0035496899
-
Chronic myeloid leukemia: Current treatment options
-
Goldman JM, Druker BJ. Chronic myeloid leukemia: Current treatment options. Blood. 2001;98:2039-2042.
-
(2001)
Blood
, vol.98
, pp. 2039-2042
-
-
Goldman, J.M.1
Druker, B.J.2
-
59
-
-
0035281737
-
Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C
-
Propper DJ, McDonald AC, Man A, et al. Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C. J Clin Oncol. 2001;19:1485-1492.
-
(2001)
J Clin Oncol
, vol.19
, pp. 1485-1492
-
-
Propper, D.J.1
McDonald, A.C.2
Man, A.3
-
60
-
-
0024379951
-
A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity
-
Meyer T, Regenass U, Fabbro D, et al. A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity. Int J Cancer. 1989;43:851-859.
-
(1989)
Int J Cancer
, vol.43
, pp. 851-859
-
-
Meyer, T.1
Regenass, U.2
Fabbro, D.3
-
61
-
-
12944249449
-
Phase II trial of bryostatin 1 in patients with relapsed low-grade non-Hodgkin's lymphoma and chronic lymphocytic leukemia
-
Varterasian ML, Mohammad RM, Shurafa S, et al. Phase II trial of bryostatin 1 in patients with relapsed low-grade non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Clin Cancer Res. 2000;6:825-828.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 825-828
-
-
Varterasian, M.L.1
Mohammad, R.M.2
Shurafa, S.3
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