Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis

Nature Chemical Biology

Volumn 7, Issue 1, 2011, Pages 41-50

  Di Paolo, Julie A ^a,d,e   Huang, Tao ^b   Balazs, Mercedesz ^b   Barbosa, James ^b,d,e   Barck, Kai H ^b   Bravo, Brandon J ^b   Carano, Richard A D ^b   Darrow, James ^a,d,e   Davies, Douglas R ^c   Deforge, Laura E ^b   Diehl, Lauri ^b   Ferrando, Ronald ^b   Gallion, Steven L ^a,d,e   Giannetti, Anthony M ^b   Gribling, Peter ^b   Hurez, Vincent ^b,d,e   Hymowitz, Sarah G ^b   Jones, Randall ^a,d,e   Kropf, Jeffrey E ^a,d,e   Lee, Wyne P ^b   MacIejewski, Patricia M ^a,d,e   Mitchell, Scott A ^a,d,e   Rong, Hong ^a,d,e   Staker, Bart L ^c   Whitney, J Andrew ^a,d,e   Yeh, Sherry ^b   Young, Wendy B ^a   Yu, Christine ^b   Zhang, Juan ^b   Reif, Karin ^b   Currie, Kevin S ^a,d,e   more..

^a CGI Pharmaceuticals Inc   (United States)

^b GENENTECH INC   (United States)

^c Emerald BioStructures   (United States)

^d Gilead Sciences   (United States)

^e UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; BRUTON TYROSINE KINASE; CGI 1746; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTHRITIS; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; BONE MARROW CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG POTENCY; ENZYME ACTIVATION; ENZYME CONFORMATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 78650433517     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.481     Document Type: Article

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