-
1
-
-
0033567907
-
Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
-
Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848-1854. (Pubitemid 29430400)
-
(1999)
Blood
, vol.94
, Issue.6
, pp. 1848-1854
-
-
Hamblin, T.J.1
Davis, Z.2
Gardiner, A.3
Oscier, D.G.4
Stevenson, F.K.5
-
2
-
-
0037406968
-
ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia
-
DOI 10.1056/NEJMoa023143
-
Crespo M, Bosch F, Villamor N, Bellosillo B, Colomer D, Rozman M et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003; 348: 1764-1775. (Pubitemid 36514707)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.18
, pp. 1764-1775
-
-
Crespo, M.1
Bosch, F.2
Villamor, N.3
Bellosillo, B.4
Colomer, D.5
Rozman, M.6
Marce, S.7
Lopez-Guillermo, A.8
Campo, E.9
Montserrat, E.10
-
3
-
-
0026038974
-
B-cell chronic lymphocytic leukemia: Present status and future directions
-
Dighiero G, Travade P, Chevret S, Fenaux P, Chastang C, Binet JL. B-cell chronic lymphocytic leukemia: present status and future directions. French Cooperative Group on CLL. Blood 1991; 78: 1901-1914.
-
(1991)
French Cooperative Group on CLL. Blood
, vol.78
, pp. 1901-1914
-
-
Dighiero, G.1
Travade, P.2
Chevret, S.3
Fenaux, P.4
Chastang, C.5
Binet, J.L.6
-
4
-
-
20044372326
-
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
-
DOI 10.1172/JCI200523409
-
Messmer BT, Messmer D, Allen SL, Kolitz JE, Kudalkar P, Cesar D et al. In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest 2005; 115: 755-764. (Pubitemid 40322252)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.3
, pp. 755-764
-
-
Messmer, B.T.1
Messmer, D.2
Allen, S.L.3
Kolitz, J.E.4
Kudalkar, P.5
Cesar, D.6
Murphy, E.J.7
Koduru, P.8
Ferrarini, M.9
Zupo, S.10
Cutrona, G.11
Damle, R.N.12
Wasil, T.13
Rai, K.R.14
Hellerstein, M.K.15
Chiorazzi, N.16
-
5
-
-
0035353212
-
Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia
-
Granziero L, Ghia P, Circosta P, Gottardi D, Strola G, Geuna M et al. Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. Blood 2001; 97: 2777-2783.
-
(2001)
Blood
, vol.97
, pp. 2777-2783
-
-
Granziero, L.1
Ghia, P.2
Circosta, P.3
Gottardi, D.4
Strola, G.5
Geuna, M.6
-
6
-
-
38049054087
-
What is the optimal initial treatment for chronic lymphocytic leukemia?
-
Lin TS. What is the optimal initial treatment for chronic lymphocytic leukemia? Oncology (Williston Park) 2007; 21: 1641-1649.
-
(2007)
Oncology (Williston Park)
, vol.21
, pp. 1641-1649
-
-
Lin, T.S.1
-
7
-
-
33747875167
-
Phase II study of single-agent bortezomib for the treatment of patients with fludarabine-refractory B-cell chronic lymphocytic leukemia
-
DOI 10.1002/cncr.22097
-
Faderl S, Rai K, Gribben J, Byrd JC, Flinn IW, O'Brien S et al. Phase II study of single-agent bortezomib for the treatment of patients with fludarabine-refractory B-cell chronic lymphocytic leukemia. Cancer 2006; 107: 916-924. (Pubitemid 44291139)
-
(2006)
Cancer
, vol.107
, Issue.5
, pp. 916-924
-
-
Faderl, S.1
Rai, K.2
Gribben, J.3
Byrd, J.C.4
Flinn, I.W.5
O'Brien, S.6
Sheng, S.7
Esseltine, D.-L.8
Keating, M.J.9
-
8
-
-
33846219417
-
Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
-
DOI 10.1182/blood-2006-05-020735
-
Byrd JC, Lin TS, Dalton JT, Wu D, Phelps MA, Fischer B et al. Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood 2007; 109: 399-404. (Pubitemid 46105932)
-
(2007)
Blood
, vol.109
, Issue.2
, pp. 399-404
-
-
Byrd, J.C.1
Lin, T.S.2
Dalton, J.T.3
Wu, D.4
Phelps, M.A.5
Fischer, B.6
Moran, M.7
Blum, K.A.8
Rovin, B.9
Brooker-McEldowney, M.10
Broering, S.11
Schaaf, L.J.12
Johnson, A.J.13
Lucas, D.M.14
Heerema, N.A.15
Lozanski, G.16
Young, D.C.17
Suarez, J.-R.18
Colevas, A.D.19
Grever, M.R.20
more..
-
9
-
-
39749092014
-
Thalidomide-induced partial stable remission in a case of refractory progressive B Cell Chronic Lymphoid Leukemia
-
DOI 10.1016/j.leukres.2007.04.005, PII S0145212607001385
-
Morotti A, Cilloni D, Parvis G, Guerrasio A, Saglio G. Thalidomide-induced partial stable remission in a case of refractory progressive B cell chronic lymphoid leukemia. Leuk Res 2008; 32: 506-507. (Pubitemid 351295902)
-
(2008)
Leukemia Research
, vol.32
, Issue.3
, pp. 506-507
-
-
Morotti, A.1
Cilloni, D.2
Parvis, G.3
Guerrasio, A.4
Saglio, G.5
-
10
-
-
33947243663
-
Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase II study
-
DOI 10.1200/JCO.2005.05.0401
-
Chanan-Khan A, Miller KC, Musial L, Lawrence D, Padmanabhan S, Takeshita K et al. Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study. J Clin Oncol 2006; 24: 5343-5349. (Pubitemid 46623164)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.34
, pp. 5343-5349
-
-
Chanan-Khan, A.1
Miller, K.C.2
Musial, L.3
Lawrence, D.4
Padmanabhan, S.5
Takeshita, K.6
Porter, C.W.7
Goodrich, D.W.8
Bernstein, Z.P.9
Wallace, P.10
Spaner, D.11
Mohr, A.12
Byrne, C.13
Hernandez-Ilizaliturri, F.14
Chrystal, C.15
Starostik, P.16
Czuczman, M.S.17
-
11
-
-
0030752756
-
Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance
-
Pepper C, Hoy T, Bentley DP. Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance. Br J Cancer 1997; 76: 935-938. (Pubitemid 27401947)
-
(1997)
British Journal of Cancer
, vol.76
, Issue.7
, pp. 935-938
-
-
Pepper, C.1
Hoy, T.2
Bentley, D.P.3
-
12
-
-
0036304760
-
Histone deacetylase inhibitors: A new class of potential therapeutic agents for cancer treatment
-
Richon VM, O'Brien JP. Histone deacetylase inhibitors: a new class of potential therapeutic agents for cancer treatment. Clin Cancer Res 2002; 8: 662-664. (Pubitemid 34742091)
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.3
, pp. 662-664
-
-
Richon, V.M.1
O'Brien, J.P.2
-
13
-
-
3843141804
-
Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells
-
Thelen P, Schweyer S, Hemmerlein B, Wuttke W, Seseke F, Ringert RH. Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells. Int J Oncol 2004; 24: 25-31.
-
(2004)
Int J Oncol
, vol.24
, pp. 25-31
-
-
Thelen, P.1
Schweyer, S.2
Hemmerlein, B.3
Wuttke, W.4
Seseke, F.5
Ringert, R.H.6
-
14
-
-
1142267455
-
Antiepileptic drugs inhibit cell growth in the human breast cancer cell line MCF7
-
DOI 10.1016/j.mce.2003.10.032
-
Olsen CM, Meussen-Elholm ET, Roste LS, Tauboll E. Antiepileptic drugs inhibit cell growth in the human breast cancer cell line MCF7. Mol Cell Endocrinol 2004; 213: 173-179. (Pubitemid 38213144)
-
(2004)
Molecular and Cellular Endocrinology
, vol.213
, Issue.2
, pp. 173-179
-
-
Olsen, C.M.1
Meussen-Elholm, E.T.M.2
Roste, L.S.3
Tauboll, E.4
-
15
-
-
0036204738
-
Histone acetylation may suppress human glioma cell proliferation when p21WAF/Cip1 and gelsolin are induced
-
DOI 10.1215/S1522851701000564
-
Kamitani H, Taniura S, Watanabe K, Sakamoto M, Watanabe T, Eling T. Histone acetylation may suppress human glioma cell proliferation when p21 WAF/Cip1 and gelsolin are induced. Neuro Oncol 2002; 4: 95-101. (Pubitemid 34285063)
-
(2002)
Neuro-Oncology
, vol.4
, Issue.2
, pp. 95-101
-
-
Kamitani, H.1
Taniura, S.2
Watanabe, K.3
Sakamoto, M.4
Watanabe, T.5
Eling, T.6
-
16
-
-
0036134288
-
Induction of differentiation and suppression of malignant phenotype of human neuroblastoma BE(2)-C cells by valproic acid: Enhancement by combination with interferon-alpha
-
Cinatl Jr J, Kotchetkov R, Blaheta R, Driever PH, Vogel JU, Cinatl J. Induction of differentiation and suppression of malignant phenotype of human neuroblastoma BE(2)-C cells by valproic acid: enhancement by combination with interferon-alpha. Int J Oncol 2002; 20: 97-106.
-
(2002)
Int J Oncol
, vol.20
, pp. 97-106
-
-
Cinatl Jr., J.1
Kotchetkov, R.2
Blaheta, R.3
Driever, P.H.4
Vogel, J.U.5
Cinatl, J.6
-
17
-
-
3142692649
-
Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1
-
DOI 10.1038/sj.leu.2403390
-
Tang R, Faussat AM, Majdak P, Perrot JY, Chaoui D, Legrand O et al. Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1. Leukemia 2004; 18: 1246-1251. (Pubitemid 39023135)
-
(2004)
Leukemia
, vol.18
, Issue.7
, pp. 1246-1251
-
-
Tang, R.1
Faussat, A.-M.2
Majdak, P.3
Perrot, J.-Y.4
Chaoui, D.5
Legrand, O.6
Marie, J.-P.7
-
18
-
-
34447096461
-
HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway
-
DOI 10.1016/j.biocel.2007.03.009, PII S1357272507000866
-
Tsapis M, Lieb M, Manzo F, Shankaranarayanan P, Herbrecht R, Lutz P et al. HDAC inhibitors induce apoptosis in glucocorticoidresistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway. Int J Biochem Cell Biol 2007; 39: 1500-1509. (Pubitemid 47031039)
-
(2007)
International Journal of Biochemistry and Cell Biology
, vol.39
, Issue.7-8
, pp. 1500-1509
-
-
Tsapis, M.1
Lieb, M.2
Manzo, F.3
Shankaranarayanan, P.4
Herbrecht, R.5
Lutz, P.6
Gronemeyer, H.7
-
19
-
-
34548176264
-
Valproic acid for the treatment of myeloid malignancies
-
DOI 10.1002/cncr.22891
-
Kuendgen A, Gattermann N. Valproic acid for the treatment of myeloid malignancies. Cancer 2007; 110: 943-954. (Pubitemid 47312858)
-
(2007)
Cancer
, vol.110
, Issue.5
, pp. 943-954
-
-
Kuendgen, A.1
Gattermann, N.2
-
20
-
-
34548703581
-
Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response
-
DOI 10.1016/j.exphem.2007.06.014, PII S0301472X07003852
-
Lagneaux L, Gillet N, Stamatopoulos B, Delforge A, Dejeneffe M, Massy M et al. Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response. Exp Hematol 2007; 35: 1527-1537. (Pubitemid 47419135)
-
(2007)
Experimental Hematology
, vol.35
, Issue.10
, pp. 1527-1537
-
-
Lagneaux, L.1
Gillet, N.2
Stamatopoulos, B.3
Delforge, A.4
Dejeneffe, M.5
Massy, M.6
Meuleman, N.7
Kentos, A.8
Martiat, P.9
Willems, L.10
Bron, D.11
-
21
-
-
40349100607
-
Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- and antiapoptotic proteins
-
DOI 10.2119/2007-00084.Bokelmann
-
Bokelmann I, Mahlknecht U. Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro-and antiapoptotic proteins. Mol Med 2008; 14: 20-27. (Pubitemid 351356882)
-
(2008)
Molecular Medicine
, vol.14
, Issue.1-2
, pp. 20-27
-
-
Bokelmann, I.1
Mahlknecht, U.2
-
22
-
-
57449103563
-
Valproate synergizes with purine nucleoside analogues to induce apoptosis of B-chronic lymphocytic leukaemia cells
-
Bouzar AB, Boxus M, Defoiche J, Berchem G, Macallan D, Pettengell R et al. Valproate synergizes with purine nucleoside analogues to induce apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol 2009; 144: 41-52.
-
(2009)
Br J Haematol
, vol.144
, pp. 41-52
-
-
Bouzar, A.B.1
Boxus, M.2
Defoiche, J.3
Berchem, G.4
MacAllan, D.5
Pettengell, R.6
-
23
-
-
33750530675
-
Phase 1/2 study of the combination of 5-aza-20-deoxycytidine with valproic acid in patients with leukemia
-
Garcia-Manero G, Kantarjian HM, Sanchez-Gonzalez B, Yang H, Rosner G, Verstovsek S et al. Phase 1/2 study of the combination of 5-aza-20-deoxycytidine with valproic acid in patients with leukemia. Blood 2006; 108: 3271-3279.
-
(2006)
Blood
, vol.108
, pp. 3271-3279
-
-
Garcia-Manero, G.1
Kantarjian, H.M.2
Sanchez-Gonzalez, B.3
Yang, H.4
Rosner, G.5
Verstovsek, S.6
-
24
-
-
34548529948
-
Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia
-
DOI 10.1200/JCO.2006.09.4169
-
Blum W, Klisovic RB, Hackanson B, Liu Z, Liu S, Devine H et al. Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia. J Clin Oncol 2007; 25: 3884-3891. (Pubitemid 47477265)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.25
, pp. 3884-3891
-
-
Blum, W.1
Klisovic, R.B.2
Hackanson, B.3
Liu, Z.4
Liu, S.5
Devine, H.6
Vukosavljevic, T.7
Huynh, L.8
Lozanski, G.9
Kefauver, C.10
Plass, C.11
Devine, S.M.12
Heerema, N.A.13
Murgo, A.14
Chan, K.K.15
Grever, M.R.16
Byrd, J.C.17
Marcucci, G.18
-
25
-
-
34249937594
-
Phase I trial of histone deacetylase inhibition by valproic acid followed by the topoisomerase II inhibitor epirubicin in advanced solid tumors: A clinical and translational study
-
DOI 10.1200/JCO.2006.08.6165
-
Munster P, Marchion D, Bicaku E, Schmitt M, Lee JH, DeConti R et al. Phase I trial of histone deacetylase inhibition by valproic acid followed by the topoisomerase II inhibitor epirubicin in advanced solid tumors: a clinical and translational study. J Clin Oncol 2007; 25: 1979-1985. (Pubitemid 46972780)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.15
, pp. 1979-1985
-
-
Munster, P.1
Marchion, D.2
Bicaku, E.3
Schmitt, M.4
Ji, H.L.5
DeConti, R.6
Simon, G.7
Fishman, M.8
Minton, S.9
Garrett, C.10
Chiappori, A.11
Lush, R.12
Sullivan, D.13
Daud, A.14
-
26
-
-
58149263278
-
A phase I-II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma
-
Rocca A, Minucci S, Tosti G, Croci D, Contegno F, Ballarini M et al. A phase I-II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma. Br J Cancer 2009; 100: 28-36.
-
(2009)
Br J Cancer
, vol.100
, pp. 28-36
-
-
Rocca, A.1
Minucci, S.2
Tosti, G.3
Croci, D.4
Contegno, F.5
Ballarini, M.6
-
27
-
-
33846502110
-
The histone deacetylase inhibitor valproic acid potently augments gemtuzumab ozogamicin-induced apoptosis in acute myeloid leukemic cells
-
DOI 10.1038/sj.leu.2404477, PII 2404477
-
Ten Cate B, Samplonius DF, Bijma T, de Leij LF, Helfrich W, Bremer E. The histone deacetylase inhibitor valproic acid potently augments gemtuzumab ozogamicin-induced apoptosis in acute myeloid leukemic cells. Leukemia 2007; 21: 248-252. (Pubitemid 46158116)
-
(2007)
Leukemia
, vol.21
, Issue.2
, pp. 248-252
-
-
Ten Cate, B.1
Samplonius, D.F.2
Bijma, T.3
De Leij, L.F.M.H.4
Helfrich, W.5
Bremer, E.6
-
28
-
-
33644505789
-
Valproate enhances imatinib-induced growth arrest and apoptosis in chronic myeloid leukemia cells
-
Morotti A, Cilloni D, Messa F, Arruga F, Defilippi I, Carturan S et al. Valproate enhances imatinib-induced growth arrest and apoptosis in chronic myeloid leukemia cells. Cancer 2006; 106: 1188-1196.
-
(2006)
Cancer
, vol.106
, pp. 1188-1196
-
-
Morotti, A.1
Cilloni, D.2
Messa, F.3
Arruga, F.4
Defilippi, I.5
Carturan, S.6
-
29
-
-
34848886101
-
Quantification of ZAP70 mRNA in B cells by real-time PCR is a powerful prognostic factor in chronic lymphocytic leukemia
-
DOI 10.1373/clinchem.2007.089326
-
Stamatopoulos B, Meuleman N, Haibe-Kains B, Duvillier H, Massy M, Martiat P et al. Quantification of ZAP70 mRNA in B cells by real-time PCR is a powerful prognostic factor in chronic lymphocytic leukemia. Clin Chem 2007; 53: 1757-1766. (Pubitemid 47509668)
-
(2007)
Clinical Chemistry
, vol.53
, Issue.10
, pp. 1757-1766
-
-
Stamatopoulos, B.1
Meuleman, N.2
Haibe-Kains, B.3
Duvillier, H.4
Massy, M.5
Martiat, P.6
Bron, D.7
Lagneaux, L.8
-
30
-
-
0031661841
-
Alveolar soft-part sarcoma: Further evidence by FISH for the involvement of chromosome band 17q25
-
DOI 10.1002/(SICI)1098-2264(199810)23:2<194::AID-GCC14>3.0.CO;2-O
-
Heimann P, Devalck C, Debusscher C, Sariban E, Vamos E. Alveolar soft-part sarcoma: further evidence by FISH for the involvement of chromosome band 17q25. Genes Chromosomes Cancer 1998; 23: 194-197. (Pubitemid 28402347)
-
(1998)
Genes Chromosomes and Cancer
, vol.23
, Issue.2
, pp. 194-197
-
-
Heimann, P.1
Devalck, C.2
Debusscher, C.3
Sariban, E.4
Vamos, E.5
-
31
-
-
0026567277
-
Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoire
-
Campbell MJ, Zelenetz AD, Levy S, Levy R. Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoire. Mol Immunol 1992; 29: 193-203.
-
(1992)
Mol Immunol
, vol.29
, pp. 193-203
-
-
Campbell, M.J.1
Zelenetz, A.D.2
Levy, S.3
Levy, R.4
-
32
-
-
20944441116
-
New method to detect histone acetylation levels by flow cytometry
-
DOI 10.1002/cyto.a.20151
-
Ronzoni S, Faretta M, Ballarini M, Pelicci P, Minucci S. New method to detect histone acetylation levels by flow cytometry. Cytometry A 2005; 66: 52-61. (Pubitemid 40868919)
-
(2005)
Cytometry Part A
, vol.66
, Issue.1
, pp. 52-61
-
-
Ronzoni, S.1
Faretta, M.2
Ballarini, M.3
Pelicci, P.4
Minucci, S.5
-
33
-
-
0036939240
-
Growth arrest of HPV-positive cells after histone deacetylase inhibition is independent of E6/E7 oncogene expression
-
DOI 10.1006/viro.2002.1667
-
Finzer P, Ventz R, Kuntzen C, Seibert N, Soto U, Rosl F. Growth arrest of HPV-positive cells after histone deacetylase inhibition is independent of E6/E7 oncogene expression. Virology 2002; 304: 265-273. (Pubitemid 36069168)
-
(2002)
Virology
, vol.304
, Issue.2
, pp. 265-273
-
-
Finzer, P.1
Ventz, R.2
Kuntzen, C.3
Seibert, N.4
Soto, U.5
Rosl, F.6
-
34
-
-
38349107623
-
The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells
-
Longo PG, Laurenti L, Gobessi S, Sica S, Leone G, Efremov DG. The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells. Blood 2008; 111: 846-855.
-
(2008)
Blood
, vol.111
, pp. 846-855
-
-
Longo, P.G.1
Laurenti, L.2
Gobessi, S.3
Sica, S.4
Leone, G.5
Efremov, D.G.6
-
35
-
-
33846707942
-
Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B
-
Chen J, Ghazawi FM, Bakkar W, Li Q. Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B. Mol Cancer 2006; 5: 71.
-
(2006)
Mol Cancer
, vol.5
, pp. 71
-
-
Chen, J.1
Ghazawi, F.M.2
Bakkar, W.3
Li, Q.4
-
36
-
-
34447304130
-
Valproic acid (VPA) in patients with refractory advanced cancer: A dose escalating phase I clinical trial
-
DOI 10.1038/sj.bjc.6603851, PII 6603851
-
Atmaca A, Al Batran SE, Maurer A, Neumann A, Heinzel T, Hentsch B et al. Valproic acid (VPA) in patients with refractory advanced cancer: a dose escalating phase I clinical trial. Br J Cancer 2007; 97: 177-182. (Pubitemid 47057472)
-
(2007)
British Journal of Cancer
, vol.97
, Issue.2
, pp. 177-182
-
-
Atmaca, A.1
Al-Batran, S.-E.2
Maurer, A.3
Neumann, A.4
Heinzel, T.5
Hentsch, B.6
Schwarz, S.E.7
Hovelmann, S.8
Gottlicher, M.9
Knuth, A.10
Jager, E.11
-
37
-
-
0242539836
-
Cancer epigenetics
-
Momparler RL. Cancer epigenetics. Oncogene 2003; 22: 6479-6483. (Pubitemid 37372327)
-
(2003)
Oncogene
, vol.22
, Issue.43
, pp. 6479-6483
-
-
Momparler, R.L.1
-
38
-
-
10244224128
-
Differences in gene expression between B-cell chronic lymphocytic leukemia and normal B cells: A meta-analysis of three microarray studies
-
DOI 10.1093/bioinformatics/bth381
-
Wang J, Coombes KR, Highsmith WE, Keating MJ, Abruzzo LV. Differences in gene expression between B-cell chronic lymphocytic leukemia and normal B cells: a meta-analysis of three microarray studies. Bioinformatics 2004; 20: 3166-3178. (Pubitemid 39619206)
-
(2004)
Bioinformatics
, vol.20
, Issue.17
, pp. 3166-3178
-
-
Wang, J.1
Coombes, K.R.2
Highsmith, W.E.3
Keating, M.J.4
Abruzzo, L.V.5
-
39
-
-
42649109021
-
Valproic acid as epigenetic cancer drug: Preclinical, clinical and transcriptional effects on solid tumors
-
Duenas-Gonzalez A, Candelaria M, Perez-Plascencia C, Perez-Cardenas E, Cruz-Hernandez E, Herrera LA. Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors. Cancer Treat Rev 2008; 34: 206-222.
-
(2008)
Cancer Treat Rev
, vol.34
, pp. 206-222
-
-
Duenas-Gonzalez, A.1
Candelaria, M.2
Perez-Plascencia, C.3
Perez-Cardenas, E.4
Cruz-Hernandez, E.5
Herrera, L.A.6
-
40
-
-
14144253823
-
In vitro drug resistance in B cell chronic lymphocytic leukemia: A comparison with acute myelocytic and acute lymphocytic leukemia
-
DOI 10.1097/00001813-200503000-00006
-
Aleskog A, Larsson R, Hoglund M, Kristensen J, Nygren P, Lindhagen E. In vitro drug resistance in B cell chronic lymphocytic leukemia: a comparison with acute myelocytic and acute lymphocytic leukemia. Anticancer Drugs 2005; 16: 277-283. (Pubitemid 40283942)
-
(2005)
Anti-Cancer Drugs
, vol.16
, Issue.3
, pp. 277-283
-
-
Aleskog, A.1
Larsson, R.2
Hoglund, M.3
Kristensen, J.4
Nygren, P.5
Lindhagen, E.6
-
41
-
-
0036335916
-
Results of first salvage therapy for patients refractory to a fludarabine regimen in chronic lymphocytic leukemia
-
DOI 10.1080/1042819021000006547
-
Keating MJ, O'Brien S, Kontoyiannis D, Plunkett W, Koller C, Beran M et al. Results of first salvage therapy for patients refractory to a fludarabine regimen in chronic lymphocytic leukemia. Leuk Lymphoma 2002; 43: 1755-1762. (Pubitemid 34874007)
-
(2002)
Leukemia and Lymphoma
, vol.43
, Issue.9
, pp. 1755-1762
-
-
Keating, M.J.1
O'Brien, S.2
Kontoyiannis, D.3
Plunkett, W.4
Koller, C.5
Beran, M.6
Lerner, S.7
Kantarjian, H.8
-
42
-
-
20344382459
-
Flavopiridol administered as a 24-hour continuous infusion in chronic lymphocytic leukemia lacks clinical activity
-
DOI 10.1016/j.leukres.2005.03.010, PII S014521260500158X
-
Flinn IW, Byrd JC, Bartlett N, Kipps T, Gribben J, Thomas D et al. Flavopiridol administered as a 24 h continuous infusion in chronic lymphocytic leukemia lacks clinical activity. Leuk Res 2005; 29: 1253-1257. (Pubitemid 41297636)
-
(2005)
Leukemia Research
, vol.29
, Issue.11
, pp. 1253-1257
-
-
Flinn, I.W.1
Byrd, J.C.2
Bartlett, N.3
Kipps, T.4
Gribben, J.5
Thomas, D.6
Larson, R.A.7
Rai, K.8
Petric, R.9
Ramon-Suerez, J.10
Gabrilove, J.11
Grever, M.R.12
-
43
-
-
45149115902
-
Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia
-
Andritsos LA, Johnson AJ, Lozanski G, Blum W, Kefauver C, Awan F et al. Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia. J Clin Oncol 2008; 26: 2519-2525.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2519-2525
-
-
Andritsos, L.A.1
Johnson, A.J.2
Lozanski, G.3
Blum, W.4
Kefauver, C.5
Awan, F.6
-
44
-
-
0025341341
-
Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine
-
Herweijer H, Sonneveld P, Baas F, Nooter K. Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine. J Natl Cancer Inst 1990; 82: 1133-1140. (Pubitemid 20213254)
-
(1990)
Journal of the National Cancer Institute
, vol.82
, Issue.13
, pp. 1133-1140
-
-
Herweijer, H.1
Sonneveld, P.2
Baas, F.3
Nooter, K.4
-
45
-
-
0026610694
-
High expression of the mdr3 multidrug-resistance gene in advanced-stage chronic lymphocytic leukemia
-
Sonneveld P, Nooter K, Burghouts JT, Herweijer H, Adriaansen HJ, van Dongen JJ. High expression of the mdr3 multidrug-resistance gene in advanced-stage chronic lymphocytic leukemia. Blood 1992; 79: 1496-1500.
-
(1992)
Blood
, vol.79
, pp. 1496-1500
-
-
Sonneveld, P.1
Nooter, K.2
Burghouts, J.T.3
Herweijer, H.4
Adriaansen, H.J.5
Van Dongen, J.J.6
-
46
-
-
33644554220
-
The effects of the histone deacetylase inhibitor valproic acid on cell cycle, growth suppression and apoptosis in multiple myeloma
-
Kaiser M, Zavrski I, Sterz J, Jakob C, Fleissner C, Kloetzel PM et al. The effects of the histone deacetylase inhibitor valproic acid on cell cycle, growth suppression and apoptosis in multiple myeloma. Haematologica 2006; 91: 248-251.
-
(2006)
Haematologica
, vol.91
, pp. 248-251
-
-
Kaiser, M.1
Zavrski, I.2
Sterz, J.3
Jakob, C.4
Fleissner, C.5
Kloetzel, P.M.6
-
47
-
-
24744438875
-
Kip1 in acute myeloblastic leukemia cells
-
DOI 10.1016/j.leukres.2005.04.018, PII S0145212605001761
-
Siitonen T, Koistinen P, Savolainen ER. Increase in Ara-C cytotoxicity in the presence of valproate, a histone deacetylase inhibitor, is associated with the concurrent expression of cyclin D1 and p27(Kip 1) in acute myeloblastic leukemia cells. Leuk Res 2005; 29: 1335-1342. (Pubitemid 41297646)
-
(2005)
Leukemia Research
, vol.29
, Issue.11
, pp. 1335-1342
-
-
Siitonen, T.1
Koistinen, P.2
Savolainen, E.-R.3
-
48
-
-
0032535140
-
A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis
-
DOI 10.1093/emboj/17.24.7209
-
Gil-Gomez G, Berns A, Brady HJ. A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis. EMBO J 1998; 17: 7209-7218. (Pubitemid 29002690)
-
(1998)
EMBO Journal
, vol.17
, Issue.24
, pp. 7209-7218
-
-
Gil-Gomez, G.1
Berns, A.2
Brady, H.J.M.3
|