Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus

European Journal of Immunology

Volumn 34, Issue 10, 2004, Pages 2740-2749

  Wen, Xiangshu ^a   Zhang, Danqing ^a   Kikuchi, Yuji ^b   Jiang, Yi ^a,c   Nakamura, Kazuhiro ^a   Xiu, Yan ^a   Tsurui, Hiromichi ^a   Takahashi, Kazuko ^a   Abe, Masaaki ^a   Ohtsuji, Mareki ^a   Nishimura, Hiroyuki ^d   Takatsu, Kiyoshi ^e   Shirai, Toshikazu ^a   Hirose, Sachiko ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c CHINA MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF TOKYO   (Japan)

^e TOIN UNIVERSITY OF YOKOHAMA   (Japan)

Author keywords

B cell chronic lymphocytic leukemia; B1 cells; IL 5; SLE; Transgenic mice

Indexed keywords

AUTOANTIBODY; CROSS REACTING ANTIBODY; DNA ANTIBODY; IMMUNOGLOBULIN; INTERLEUKIN 5; POLYCLONAL ANTIBODY;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE DISEASE; B CELL LEUKEMIA; B LYMPHOCYTE ACTIVATION; CANCER RISK; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; FLOW CYTOMETRY; FREQUENCY ANALYSIS; GENE EXPRESSION; IN VITRO STUDY; LEUKEMOGENESIS; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLEEN CELL; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSGENE;

ANIMALS; ANTIBODIES, ANTINUCLEAR; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; BLOTTING, SOUTHERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN-5; LEUKEMIA, B-CELL, CHRONIC; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS NEPHRITIS; MICE; MICE, TRANSGENIC; TRANSGENES;

EID: 7244229674     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425267     Document Type: Article

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