Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38

Journal of Biological Chemistry

Volumn 284, Issue 40, 2009, Pages 27629-27636

  Graeff, Richard ^a   Liu, Qun ^b   Kriksunov, Irina A ^b   Kotaka, Masayo ^c   Oppenheimer, Norman ^d   Hao, Quan ^b,c   Lee, Hon Cheung ^a,c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Department of Molecular Biology and Genetics   (United States)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE RING; ADP-RIBOSE; APLYSIA; CATALYTIC RESIDUE; CELLULAR FUNCTION; CYCLASES; CYCLIC ADP-RIBOSE (CADPR); DINUCLEOTIDES; DOUBLE MUTATION; IN-VIVO; LINEAR SUBSTRATES; STABLE COMPLEXES;

AMIDES; BIOCHEMICAL ENGINEERING; BIOLOGICAL RADIATION EFFECTS; CALCIUM; CATALYSTS; CRYSTAL STRUCTURE; ENZYMES; MAMMALS;

SUBSTRATES;

ADENOSINE DIPHOSPHATE RIBOSYL CYCLASE; CD38 ANTIGEN; CYCLIC ADENOSINE DIPHOSPHATE RIBOSE; NICOTINAMIDE ADENINE DINUCLEOTIDE; CALCIUM;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; ENZYME SUBSTRATE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; ANIMAL; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MUTATION; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

APLYSIA; MAMMALIA;

ANIMALS; ANTIGENS, CD38; BIOCATALYSIS; CALCIUM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; CYCLIC ADP-RIBOSE; CYCLIZATION; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NAD; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SUBSTRATE SPECIFICITY;

EID: 70350453607     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.030965     Document Type: Article

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