Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Science

Volumn 315, Issue 5813, 2007, Pages 856-859

  Willis, Simon N ^a   Fletcher, Jamie I ^a   Kaufmann, Thomas ^a   Van Delft, Mark F ^a,b   Chen, Lin ^a   Czabotar, Peter E ^a   Ierino, Helen ^a   Lee, Erinna F ^a,b   Fairlie, W Douglas ^a   Bouillet, Philippe ^a   Strasser, Andreas ^a   Kluck, Ruth M ^a   Adams, Jerry M ^a   Huang, David C S ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; BIM PROTEIN; PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN PUMA; UNCLASSIFIED DRUG;

APOPTOSIS; GENE EXPRESSION; LIGAND; PROTEIN;

APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN FUNCTION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; BCL-X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CELL LINE; CELLS, CULTURED; HUMANS; LIGANDS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MUTATION; NEOPLASM PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEINS;

EID: 33846964621     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1133289     Document Type: Article

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