Role of the JNK Pathway in human diseases

Progress in Molecular Biology and Translational Science

Volumn 106, Issue , 2012, Pages 145-169

  Sabapathy, Kanaga ^a,b,c  

^a DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Apoptosis; c Jun; Disease; Inhibitors; JNK; Phosphorylation; Substrates

Indexed keywords

EID: 84857216258     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-396456-4.00013-4     Document Type: Chapter

References (139)

1. L. Chang, and M. Karin Mammalian MAP kinase signalling cascades Nature 410 2001 37 40 (Pubitemid 32225829)
2. M. Karin, and E. Gallagher From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance IUBMB Life 57 2005 283 295 (Pubitemid 40904256)
3. A. Minden, and M. Karin Regulation and function of the JNK subgroup of MAP kinases Biochim Biophys Acta 24 1997 F85 F104
4. M. Karin Mitogen-activated protein kinase cascades as regulators of stress responses Ann NY Acad Sci 851 1998 139 146 (Pubitemid 28370374)
5. C.R. Weston, and R.J. Davis The JNK signal transduction pathway Curr Opin Cell Biol 19 2007 142 149 (Pubitemid 46386399)
6. K. Sabapathy JNK signalling 2005 Landes BioSciences Texas pp. 29-39
7. R.K. Barr, and M.A. Bogoyevitch The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs) Int J Biochem Cell Biol 33 2001 1047 1063 (Pubitemid 32817087)
8. M.A. Bogoyevitch, and B. Kobe Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases Microbiol Mol Biol Rev 70 2006 1061 1095 (Pubitemid 44958264)
9. S. Gupta, T. Barrett, A.J. Whitmarsh, J. Cavanagh, H.K. Sluss, and B. Dérijard Selective interaction of JNK protein kinase isoforms with transcription factors EMBO J 15 1996 2760 2770 (Pubitemid 26176253)
10. A.A. Mohit, J.H. Martin, and C.A. Miller p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system Neuron 14 1995 67 78
11. B. Dérijard, M. Hibi, I.H. Wu, T. Barrett, B. Su, and T. Deng JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain Cell 76 1994 1025 1037 (Pubitemid 24106383)
12. M. Hibi, A. Lin, T. Smeal, A. Minden, and M. Karin Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain Genes Dev 11 1993 2135 2148 (Pubitemid 23336140)
13. T. Kallunki, T. Deng, M. Hibi, and M. Karin c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions Cell 87 1996 929 939 (Pubitemid 26404291)
14. T. Kallunki, B. Su, I. Tsigelny, H.K. Sluss, B. Dérijard, and G. Moore JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation Genes Dev 24 1994 2996 3007
15. M.A. Bogoyevitch The isoform-specific functions of the c-Jun N-terminal kinases (JNKs): differences revealed by gene targeting Bioessays 9 2006 923 934 (Pubitemid 44433755)
16. K. Sabapathy, K. Hochedlinger, S.Y. Nam, A. Bauer, M. Karin, and E.F. Wagner Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation Mol Cell 15 2004 713 725 (Pubitemid 39194902)
17. A.M. Musti, M. Treier, and D. Bohmann Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases Science 275 1997 400 402 (Pubitemid 27051620)
18. S.Y. Fuchs, V.A. Fried, and Z. Ronai Stress-activated kinases regulate protein stability Oncogene 17 1998 1483 1490 (Pubitemid 28458417)
19. A. Behrens, M. Sibilia, and E.F. Wagner Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation Nat Genet 21 1999 326 329 (Pubitemid 29124945)
20. M. Schreiber, A. Kolbus, F. Piu, A. Szabowski, U. Möhle-Steinlein, and J. Tian Control of cell cycle progression by c-Jun is p53 dependent Genes Dev 13 1999 607 619 (Pubitemid 29131884)
21. A. Behrens, K. Sabapathy, I. Graef, M. Cleary, G.R. Crabtree, and E.F. Wagner Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT) Proc Natl Acad Sci USA 98 2001 1769 1774 (Pubitemid 32165573)
22. C.W. Chow, M. Rincón, J. Cavanagh, M. Dickens, and R.J. Davis Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway Science 278 1997 1638 1641 (Pubitemid 27516286)
23. Y.H. Han, X. Cao, B. Lin, F. Lin, S.K. Kolluri, and J. Stebbins Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt Oncogene 25 2006 2974 2986 (Pubitemid 43780462)
24. H. Yoshida, C.J. Hastie, H. McLauchlan, P. Cohen, and M. Goedert Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK) J Neurochem 90 2004 352 358 (Pubitemid 38938221)
25. K. Sabapathy, and E.F. Wagner JNK2: a negative regulator of cellular proliferation Cell Cycle 3 2004 1520 1523 (Pubitemid 40521404)
26. M. Gao, T. Labuda, Y. Xia, E. Gallagher, D. Fang, and Y.C. Liu Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch Science 306 2004 271 275 (Pubitemid 39336871)
27. C. Ducret, S.M. Maira, Y. Lutz, and B. Wasylyk The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signaling cascades Oncogene 19 2000 5063 5072
28. M.D. Boppart, D. Aronson, L. Gibson, R. Roubenoff, L.W. Abad, and J. Bean Eccentric exercise markedly increases c-Jun NH(2)-terminal kinase activity in human skeletal muscle J Appl Physiol 87 1999 1668 1673
29. M.D. Boppart, S. Asp, J.F. Wojtaszewski, R.A. Fielding, T. Mohr, and L.J. Goodyear Marathon running transiently increases c-Jun NH2-terminal kinase and p38 activities in human skeletal muscle J Physiol 526 2000 663 669 (Pubitemid 30654769)
30. S. Hunot, M. Vila, P. Teismann, R.J. Davis, E.C. Hirsch, and S. Przedborski JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease Proc Natl Acad Sci USA 101 2004 665 670 (Pubitemid 38084694)
31. L.R. White, M. Toft, S.N. Kvam, M.J. Farrer, and J.O. Aasly MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease J Neurosci Res 85 2007 1288 1294 (Pubitemid 46724372)
32. X. Zhu, A.K. Raina, C.A. Rottkamp, G. Aliev, G. Perry, and H. Boux Activation and redistribution of c jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease J Neurochem 76 2001 435 441 (Pubitemid 32097021)
33. M. Shoji, N. Iwakami, S. Takeuchi, M. Waragai, M. Suzuki, and I. Kanazawa JNK activation is associated with intracellular beta-amyloid accumulation Brain Res Mol Brain Res 85 2000 221 233 (Pubitemid 32056254)
34. A. Thakur, X. Wang, S.L. Siedlak, G. Perry, M.A. Smith, and X. Zhu c-Jun phosphorylation in Alzheimer disease J Neurosci Res 85 2007 1668 1673 (Pubitemid 46849614)
35. N. Mitsios, J. Gaffney, J. Krupinski, R. Mathias, Q. Wang, and S. Hayward Expression of signaling molecules associated with apoptosis in human ischemic stroke tissue Cell Biochem Biophys 47 2007 73 86
36. A.R. Baker, A.L. Harte, N. Howell, D.C. Pritlove, A.M. Ranasinghe, and N.F. da Silva Epicardial adipose tissue as a source of nuclear factor-kappaB and c-Jun N-terminal kinase mediated inflammation in patients with coronary artery disease J Clin Endocrinol Metab 94 2009 261 267
37. S.A. Cook, P.H. Sugden, and A. Clerk Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease J Mol Cell Cardiol 31 1999 1429 1434 (Pubitemid 29361110)
38. K. Yoshimura, H. Aoki, Y. Ikeda, A. Furutani, K. Hamano, and M. Matsuzaki Identification of c-Jun N-terminal kinase as a therapeutic target for abdominal aortic aneurysm Ann NY Acad Sci 1085 2006 403 406 (Pubitemid 47092020)
39. N. Diehm, S. Di Santo, T. Schaffner, J. Schmidli, J. Völzmann, and P. Jüni Severe structural damage of the seemingly non-diseased infrarenal aortic aneurysm neck J Vasc Surg 48 2008 425 434
40. M. Longoni, S. Moncini, M. Cisternino, I.M. Morella, S. Ferraiuolo, and S. Russo Noonan syndrome associated with both a new Jnk-activating familial SOS1 and a de novo RAF1 mutations Am J Med Genet 152A 2010 2176 2184
41. J. Kluwe, J.P. Pradere, G.Y. Gwak, A. Mencin, S. De Minicis, and C.H. Osterreicher Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition Gastroenterology 138 2011 347 359
42. P. Hasselblatt, M. Rath, V. Komnenovic, K. Zatloukal, and E.F. Wagner Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase Proc Natl Acad Sci USA 104 2007 17105 17110 (Pubitemid 350210999)
43. D.M. Ferreira, R.E. Castro, M.V. Machado, T. Evangelista, A. Silvestre, and A. Costa Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease Diabetologia 54 2011 1788 1798
44. W. Liu, Q. Liang, S. Balzar, S. Wenzel, M. Gorska, and R. Alam Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways J Allergy Clin Immunol 121 2008 893 902
45. L. Rumora, L. Milevoj, S. Popović-Grle, K. Barisić, I. Cepelak, and T.Z. Grubisić Levels changes of blood leukocytes and intracellular signalling pathways in COPD patients with respect to smoking attitude Clin Biochem 41 2008 387 394
46. K. Mitsuyama, A. Suzuki, N. Tomiyasu, O. Tsuruta, S. Kitazaki, and T. Takeda Pro-inflammatory signaling by Jun-N-terminal kinase in inflammatory bowel disease Int J Mol Med 17 2006 449 455
47. G. Malamut, C. Cabane, L. Dubuquoy, M. Malapel, B. Dérijard, and J. Gay No evidence for an involvement of the p38 and JNK mitogen-activated protein in inflammatory bowel diseases Dig Dis Sci 51 2006 1443 1453 (Pubitemid 44315815)
48. D. Hommes, B. van den Blink, T. Plasse, J. Bartelsman, C. Xu, and B. Macpherson Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease Gastroenterology 122 2002 7 14 (Pubitemid 34049188)
49. G. Schett, M. Tohidast-Akrad, J.S. Smolen, B.J. Schmid, C.W. Steiner, and P. Bitzan Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis Arthritis Rheum 43 2000 2501 2512
50. S.H. Mun, J.W. Kim, S.S. Nah, N.Y. Ko, J.H. Lee, and J.D. Kim Tumor necrosis factor alpha-induced interleukin-32 is positively regulated via the Syk/protein kinase Cdelta/JNK pathway in rheumatoid synovial fibroblasts Arthritis Rheum 60 2009 678 685
51. Y. Molad, M. Amit-Vasina, O. Bloch, E. Yona, and M.J. Rapoport Increased ERK and JNK activities correlate with disease activity in patients with systemic lupus erythematosus Ann Rheum Dis 69 2010 175 180
52. M. Nakou, G. Bertsias, I. Stagakis, M. Centola, I. Tassiulas, and M. Hatziapostolou Gene network analysis of bone marrow mononuclear cells reveals activation of multiple kinase pathways in human systemic lupus erythematosus PLoS One 5 2010 e13351
53. C.K. Wong, P.T. Wong, L.S. Tam, E.K. Li, D.P. Chen, and C.W. Lam Activation profile of intracellular mitogen-activated protein kinases in peripheral lymphocytes of patients with systemic lupus erythematosus J Clin Immunol 29 2009 738 746
54. O. Oikonomidou, P.G. Vlachoyiannopoulos, A. Kominakis, A. Kalofoutis, H.M. Moutsopoulos, and P. Moutsatsou Glucocorticoid receptor, nuclear factor kappaB, activator protein-1 and C-jun N-terminal kinase in systemic lupus erythematosus patients Neuroimmunomodulation 13 2006 194 204 (Pubitemid 46474692)
55. E. Broide, E. Scapa, O. Bloch, M. Shapiro, N.A. Kimchi, and G. Ben-Yehudah Evidence for aberrant regulation of MAP kinase signal transduction pathway in peripheral blood mononuclear cells in patients with active celiac disease Dig Dis Sci 54 2009 1270 1275
56. C. Gulmann, K.M. Sheehan, R.M. Conroy, J.D. Wulfkuhle, V. Espina, and M.J. Mullarkey Quantitative cell signalling analysis reveals down-regulation of MAPK pathway activation in colorectal cancer J Pathol 218 2009 514 519
57. Z. Chen, A. Yang, C. Xu, Y. Xing, W. Gong, and J. Li c-Jun N-terminal kinase is involved in the regulation of proliferation and apoptosis by integrin-linked kinase in human retinoblastoma cells Graefes Arch Clin Exp Ophthalmol 249 2011 1399 1407
58. K. Jørgensen, B. Davidson, and V.A. Flørenes Activation of c-jun N-terminal kinase is associated with cell proliferation and shorter relapse-free period in superficial spreading malignant melanoma Mod Pathol 19 2006 1446 1455 (Pubitemid 44624163)
59. X. Wang, L. Chao, X. Li, G. Ma, L. Chen, and Y. Zang Elevated expression of phosphorylated c-Jun NH2-terminal kinase in basal-like and "triple-negative" breast cancers Hum Pathol 41 2010 401 406
60. E. Ødegaard, A.C. Staff, V.M. Abeler, J. Kopolovic, M. Onsrud, and P. Lazarovici The activated nerve growth factor receptor p-TrkA is selectively expressed in advanced-stage ovarian carcinoma Hum Pathol 38 2007 140 146 (Pubitemid 44895445)
61. J. Chung, A.K. Nguyen, D.C. Henstridge, A.G. Holmes, M.H. Chan, and J.L. Mesa HSP72 protects against obesity-induced insulin resistance Proc Natl Acad Sci USA 105 2008 1739 1744 (Pubitemid 351346584)
62. T. Takamura, M. Honda, Y. Sakai, H. Ando, A. Shimizu, and T. Ota Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes Biochem Biophys Res Commun 361 2007 379 384 (Pubitemid 47187270)
63. G. Boden, X. Duan, C. Homko, E.J. Molina, W. Song, and O. Perez Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals Diabetes 57 2008 2438 2444
64. P. Margutti, P. Matarrese, F. Conti, T. Colasanti, F. Delunardo, and A. Capozzi Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis Blood 111 2008 4559 4570
65. K. Sabapathy, W. Jochum, K. Hochedlinger, L. Chang, M. Karin, and E.F. Wagner Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2 Mech Dev 89 1999 115 124 (Pubitemid 29528280)
66. C.R. Weston, A. Wong, J.P. Hall, M.E. Goad, R.A. Flavell, and R.J. Davis The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis Proc Natl Acad Sci USA 28 2004 14114 14119 (Pubitemid 39305039)
67. J.T. Chen, D.H. Lu, C.P. Chia, D.Y. Ruan, K. Sabapathy, and Z.C. Xiao Impaired long-term potentiation in c Jun N-terminal kinase 2-deficient mice J Neurochem 93 2005 463 473 (Pubitemid 40547503)
68. K. Sabapathy, Y. Hu, T. Kallunki, M. Schreiber, J.P. David, and W. Jochum JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development Curr Biol 9 1999 116 125 (Pubitemid 29087541)
69. K. Sabapathy, T. Kallunki, J.P. David, I. Graef, M. Karin, and E.F. Wagner c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation J Exp Med 193 2001 317 328 (Pubitemid 32524515)
70. J.P. David, K. Sabapathy, O. Hoffmann, M.H. Idarraga, and E.F. Wagner JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms J Cell Sci 115 2002 4317 4325 (Pubitemid 35460702)
71. D.D. Yang, D. Conze, A.J. Whitmarsh, T. Barrett, R.J. Davis, and M. Rincón Differentiation of CD4 + T cells to Th1 cells requires MAP kinase JNK2 Immunity 9 1998 575 585 (Pubitemid 28499208)
72. C. Dong, D.D. Yang, M. Wysk, A.J. Whitmarsh, R.J. Davis, and R.A. Flavell Defective T cell differentiation in the absence of Jnk1 Science 282 1998 2092 2095 (Pubitemid 29001267)
73. D.D. Yang, C.Y. Kuan, A.J. Whitmarsh, M. Rincón, T.S. Zheng, and R.J. Davis Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene Nature 389 1997 865 870 (Pubitemid 27462982)
74. J. Hirosumi, G. Tuncman, L. Chang, C.Z. Görgün, K.T. Uysal, and K. Maeda A central role for JNK in obesity and insulin resistance Nature 420 2002 333 336 (Pubitemid 35398190)
75. X.M. Li, C.C. Li, S.S. Yu, J.T. Chen, K. Sabapathy, and D.Y. Ruan JNK1 contributes to metabotropic glutamate receptor-dependent long-term depression and short-term synaptic plasticity in the mice area hippocampal CA1 Eur J Neurosci 25 2007 391 396
76. P. Xu, and R.J. Davis c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal Mol Cell Biol 30 2010 1329 1340
77. V. Ries, R.M. Silva, T.F. Oo, H.C. Cheng, M. Rzhetskaya, and N. Kholodilov JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration J Neurochem 107 2008 1578 1588
78. C. Dong, D.D. Yang, C. Tournier, A.J. Whitmarsh, J. Xu, and R.J. Davis JNK is required for effector T-cell function but not for T-cell activation Nature 405 2000 91 94 (Pubitemid 30321821)
79. E. Tafolla, S. Wang, B. Wong, J. Leong, and Y.L. Kapila JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53 J Biol Chem 280 2005 19992 19999 (Pubitemid 41379528)
80. M. Gururajan, R. Chui, A.K. Karuppannan, J. Ke, C.D. Jennings, and S. Bondada c-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells Blood 106 2005 1382 1391 (Pubitemid 41129605)
81. R. Lizundia, M. Chaussepied, M. Huerre, D. Werling, J.P. Di Santo, and G. Langsley c-Jun NH2-terminal kinase/c-Jun signaling promotes survival and metastasis of B lymphocytes transformed by Theileria Cancer Res 66 2006 6105 6110
82. Y. Galley, G. Hagens, I. Glaser, W. Davis, M. Eichhorn, and D. Dobbelaere Jun NH2-terminal kinase is constitutively activated in T cells transformed by the intracellular parasite Theileria parva Proc Natl Acad Sci USA 94 1997 5119 5124 (Pubitemid 27214746)
83. Z. Han, D.L. Boyle, L. Chang, B. Bennett, M. Karin, and L. Yang c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis J Clin Invest 108 2001 73 81 (Pubitemid 32634924)
84. T. Shin, M. Ahn, K. Jung, S. Heo, D. Kim, and Y. Jee Activation of mitogen-activated protein kinases in experimental autoimmune encephalomyelitis J Neuroimmunol 14 2003 118 125 (Pubitemid 36840905)
85. C. Stambe, R.C. Atkins, P.A. Hill, and D.J. Nikolic-Paterson Activation and cellular localization of the p38 and JNK MAPK pathways in rat crescentic glomerulonephritis Kidney Int 64 2003 2121 2132 (Pubitemid 37449546)
86. Y. Kawakami, J. Kitaura, D. Hata, L. Yao, and T. Kawakami Functions of Bruton's tyrosine kinase in mast and B cells J Leukoc Biol 65 1999 86 90
87. S.L. Constant, C. Dong, D.D. Yang, M. Wysk, R.J. Davis, and R.A. Flavell JNK1 is required for T cell-mediated immunity against Leishmania major infection J Immunol 165 2000 2671 2676 (Pubitemid 30660716)
88. Y. Morishima, Y. Gotoh, J. Zieg, T. Barrett, H. Takano, and R. Flavell Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand J Neurosci 21 2001 7551 7560 (Pubitemid 32904954)
89. G. Sumara, M. Belwal, and R. Ricci "Jnking" atherosclerosis Cell Mol Life Sci 62 2005 487 494
90. R. Ricci, G. Sumara, I. Sumara, I. Rozenberg, M. Kurrer, and A. Akhmedov Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis Science 306 2004 1558 1561 (Pubitemid 39564952)
91. V. Aguirre, T. Uchida, L. Yenush, R. Davis, and M.F. White The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307) J Biol Chem 275 2000 9047 9054 (Pubitemid 30180265)
92. J.M. Schattenberg, R. Singh, Y. Wang, J.H. Lefkowitch, R.M. Rigoli, and P.E. Scherer JNK1 but not JNK2 promotes the development of steatohepatitis in mice Hepatology 43 2006 163 172 (Pubitemid 43733603)
93. J. Kluwe, J.P. Pradere, G.Y. Gwak, A. Mencin, S. De Minicis, and C.H. Osterreicher Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition Gastroenterology 138 2010 347 359
94. Q. Liang, O.F. Bueno, B.J. Wilkins, C.Y. Kuan, Y. Xia, and J.D. Molkentin c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling EMBO J 22 2003 5079 5089 (Pubitemid 37222028)
95. H. Tachibana, C. Perrino, H. Takaoka, R.J. Davis, S.V. Naga Prasad, and H.A. Rockman JNK1 is required to preserve cardiac function in the early response to pressure overload Biochem Biophys Res Commun 343 2006 1060 1066
96. E.F. Wagner, and A.R. Nebreda Signal integration by JNK and p38 MAPK pathways in cancer development Nat Rev Cancer 9 2009 537 549
97. A. Behrens, W. Jochum, M. Sibilia, and E.F. Wagner Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation Oncogene 19 2000 2657 2663 (Pubitemid 30326415)
98. A.S. Nateri, B. Spencer-Dene, and A. Behrens Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development Nature 437 2005 281 285 (Pubitemid 41294493)
99. M.A. Bogoyevitch, and P.G. Arthur Inhibitors of c-Jun N-terminal kinases: JuNK no more? Biochim Biophys Acta 1784 2008 76 93
100. V. Vukic, D. Callaghan, D. Walker, L.F. Lue, Q.Y. Liu, and P.O. Couraud Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway Neurobiol Dis 34 2009 95 106
101. S. Mishra, J.P. Mishra, and A. Kumar Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes J Biol Chem 282 2007 4288 4300 (Pubitemid 47100979)
102. J.C. Zheng, Y. Huang, K. Tang, M. Cui, D. Niemann, and A. Lopez HIV-1-infected and/or immune-activated macrophages regulate astrocyte CXCL8 production through IL-1beta and TNF-alpha: involvement of mitogen-activated protein kinases and protein kinase R J Neuroimmunol 200 2008 100 110
103. C. Holmén, E. Elsheikh, M. Christensson, J. Liu, A.S. Johansson, and A.R. Qureshi Anti endothelial cell autoantibodies electively activate SAPK/JNK signalling in Wegener's granulomatosis J Am Soc Nephrol 18 2007 2497 2508 (Pubitemid 47378866)
104. P.R. Eynott, L. Xu, B.L. Bennett, A. Noble, S.Y. Leung, and P. Nath Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats Immunology 112 2004 446 453 (Pubitemid 38859523)
105. A. Colombo, M. Repici, M. Pesaresi, S. Santambrogio, G. Forloni, and T. Borsello The TAT-JNK inhibitor peptide interferes with beta amyloid protein stability Cell Death Differ 14 2007 1845 1848 (Pubitemid 47423652)
106. J.D. Beckham, R.J. Goody, P. Clarke, C. Bonny, and K.L. Tyler Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase J Virol 81 2007 6984 6992 (Pubitemid 46986634)
107. Z.Y. Zhuang, Y.R. Wen, D.R. Zhang, T. Borsello, C. Bonny, and G.R. Strichartz A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance J Neurosci 26 2006 3551 3560
108. E. Touchard, S. Omri, M.C. Naud, M. Berdugo, C. Deloche, and C. Abadie A peptide inhibitor of c-Jun N-terminal kinase for the treatment of endotoxin-induced uveitis Invest Ophthalmol Vis Sci 51 2010 4683 4693
109. K.R. Ngoei, B. Catimel, N. Church, D.S. Lio, C. Dogovski, and M.A. Perugini Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide Biochem J 24 2011 399 413
110. K. Maedler, F.T. Schulthess, C. Bielman, T. Berney, C. Bonny, and M. Prentki Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases FASEB J 22 2008 1905 1913 (Pubitemid 351811467)
111. M.S. Saporito, E.M. Brown, M.S. Miller, and S. Carswell CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo J Pharmacol Exp Ther 288 1999 421 427 (Pubitemid 29119647)
112. D. Eggert, P.K. Dash, S. Gorantla, H. Dou, G. Schifitto, and S.B. Maggirwar Neuroprotective activities of CEP-1347 in models of neuroAIDS J Immunol 184 2010 746 756
113. L. Chialda, M. Zhang, K. Brune, and A. Pahl Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia Respir Res 15 2005 6 36
114. H. Toyoda, M.G. Zhao, H. Xu, L.J. Wu, M. Ren, and M. Zhuo Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex Mol Pain 3 2007 36
115. Q.H. Guan, D.S. Pei, X.M. Liu, X.T. Wang, T.L. Xu, and G.Y. Zhang Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis Brain Res 1092 2006 36 46
116. J. Dou, X. Li, Y. Cai, H. Chen, S. Zhu, and Q. Wang Human cytomegalovirus induces caspase-dependent apoptosis of megakaryocytic CHRF-288-11 cells by activating the JNK pathway Int J Hematol 91 2010 620 629
117. Y. Wang, Y. Zhang, Z. Wei, H. Li, H. Zhou, and Z. Zhang JNK inhibitor protects dopaminergic neurons by reducing COX-2 expression in the MPTP mouse model of subacute Parkinson's disease J Neurol Sci 285 2009 172 177
118. H. Cho, S.C. Black, D. Looper, M. Shi, D. Kelly-Sullivan, and S. Timofeevski Pharmacological characterization of a small molecule inhibitor of c-Jun kinase Am J Physiol Endocrinol Metab 295 2008 1142 1151
119. C. Ferrandi, R. Ballerio, P. Gaillard, C. Giachetti, S. Carboni, and P.A. Vitte Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats Br J Pharmacol 142 2004 953 960 (Pubitemid 39037045)
120. S. Carboni, U. Boschert, P. Gaillard, J.P. Gotteland, J.Y. Gillon, and P.A. Vitte AS601245, a c-Jun NH2-terminal kinase (JNK) inhibitor, reduces axon/dendrite damage and cognitive deficits after global cerebral ischaemia in gerbils Br J Pharmacol 153 2008 157 163
121. S. Carboni, A. Hiver, C. Szyndralewiez, P. Gaillard, J.P. Gotteland, and P.A. Vitte AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties J Pharmacol Exp Ther 310 2004 25 32 (Pubitemid 38812691)
122. T. Uehara, B. Bennett, S.T. Sakata, Y. Satoh, G.K. Bilter, and J.K. Westwick JNK mediates hepatic ischemia reperfusion injury J Hepatol 42 2005 850 859 (Pubitemid 40693202)
123. T. Borsello, P.G. Clarke, L. Hirt, A. Vercelli, M. Repici, and D.F. Schorderet A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia Nat Med 9 2003 1180 1186 (Pubitemid 37173703)
124. L. Hirt, J. Badaut, J. Thevenet, C. Granziera, L. Regli, and F. Maurer D-JNKI1, a cell-penetrating c-Jun-N-terminal kinase inhibitor, protects against cell death in severe cerebral ischemia Stroke 35 2004 1738 1743 (Pubitemid 38823657)
125. A. Ijaz, T. Tejada, P. Catanuto, X. Xia, S.J. Elliot, and O. Lenz Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes Kidney Int 75 2009 381 388
126. H. Kaneto, Y. Nakatani, T. Miyatsuka, D. Kawamori, T.A. Matsuoka, and M. Matsuhisa Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide Nat Med 10 2004 1128 1132 (Pubitemid 39424876)
127. G. Milano, S. Morel, C. Bonny, M. Samaja, L.K. von Segesser, and P. Nicod A peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo Am J Physiol Heart Circ Physiol 292 2007 H1828 H1835
128. J. Wang, T.R. Van De Water, C. Bonny, F. de Ribaupierre, J.L. Puel, and A. Zine A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss J Neurosci 23 2003 8596 8607 (Pubitemid 37158759)
129. J. Wang, J. Ruel, S. Ladrech, C. Bonny, T.R. van de Water, and J.L. Puel Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals Mol Pharmacol 71 2007 654 666 (Pubitemid 46294077)
130. B.K. Gunawan, Z.X. Liu, D. Han, N. Hanawa, W.A. Gaarde, and N. Kaplowitz c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity Gastroenterology 131 2006 165 178 (Pubitemid 44015744)
131. K.H. Lee, S.E. Kim, and Y.S. Lee SP600125, a selective JNK inhibitor, aggravate hepatic ischemia-reperfusion injury Exp Mol Med 31 2006 408 416
132. S. Kyoi, H. Otani, S. Matsuhisa, Y. Akita, K. Tatsumi, and C. Enoki Opposing effect of p38 MAP kinase and JNK inhibitors on the development of heart failure in the cardiomyopathic hamster Cardiovasc Res 69 2006 888 898 (Pubitemid 43227987)
133. X. Si, H. Luo, A. Morgan, J. Zhang, J. Wong, and J. Yuan Stress-activated protein kinases are involved in coxsackievirus B3 viral progeny release J Virol 79 2005 13875 13881 (Pubitemid 41552686)
134. S. Tanemura, H. Momose, N. Shimizu, D. Kitagawa, J. Seo, and T. Yamasaki Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway J Biochem 145 2009 345 354
135. J. Bain, H. McLauchlan, M. Elliott, and P. Cohen The specificities of protein kinase inhibitors: an update Biochem J 371 2003 199 204 (Pubitemid 36458094)
136. D. Holzberg, C.G. Knight, O. Dittrich-Breiholz, H. Schneider, A. Dörrie, and E. Hoffmann Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes J Biol Chem 278 2003 40213 40223 (Pubitemid 37248589)
137. M. Suckfuell, M. Canis, S. Strieth, H. Scherer, and A. Haisch Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study Acta Otolaryngolc 127 2007 938 942 (Pubitemid 47345817)
138. Parkinson Study Group PRECEPT Investigators Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease Neurology 9 2007 69480 69490
139. M. Xie, and K. Sabapathy Tyrosine 170 is dispensable for c-Jun turnover Cell Signal 22 2010 330 337