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Volumn 184, Issue 2, 2010, Pages 746-756

Neuroprotective activities of CEP-1347 in models of neuroAIDS

Author keywords

[No Author keywords available]

Indexed keywords

CEP 1347; 3,9 BIS((ETHYLTHIO)METHYL) K 252A; 3,9-BIS((ETHYLTHIO)METHYL)-K-252A; CARBAZOLE DERIVATIVE; CYTOKINE; NEUROPROTECTIVE AGENT; PROTEIN KINASE INHIBITOR;

EID: 76249099852     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902962     Document Type: Article
Times cited : (39)

References (86)
  • 1
    • 0028909868 scopus 로고
    • Dementia associated with the acquired immunodeficiency syndrome
    • Lipton, S. A., and H. E. Gendelman. 1995. Dementia associated with the acquired immunodeficiency syndrome. N. Engl. J. Med. 332: 934-940.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 934-940
    • Lipton, S.A.1    Gendelman, H.E.2
  • 2
    • 0024264066 scopus 로고
    • Human immunodeficiency virus type 1 (HIV-1) infection of the nervous system: A review
    • Michaels, J., L. R. Sharer, and L. G. Epstein. 1988. Human immunodeficiency virus type 1 (HIV-1) infection of the nervous system: a review. Immunodefic. Rev. 1: 71-104.
    • (1988) Immunodefic. Rev. , vol.1 , pp. 71-104
    • Michaels, J.1    Sharer, L.R.2    Epstein, L.G.3
  • 3
    • 0025728281 scopus 로고
    • Neuronal loss in the frontal cortex in HIV infection
    • see comments
    • Everall, I. P., P. J. Luthert, and P. L. Lantos. 1991. Neuronal loss in the frontal cortex in HIV infection. [see comments] Lancet 337: 1119-1121.
    • (1991) Lancet , vol.337 , pp. 1119-1121
    • Everall, I.P.1    Luthert, P.J.2    Lantos, P.L.3
  • 4
    • 0032943694 scopus 로고    scopus 로고
    • HIV-associated dementia: New insights into disease pathogenesis and therapeutic interventions
    • Swindells, S., J. Zheng, and H. E. Gendelman. 1999. HIV-associated dementia: new insights into disease pathogenesis and therapeutic interventions. AIDS Patient Care STDS 13: 153-163. (Pubitemid 29155983)
    • (1999) AIDS Patient Care and STDs , vol.13 , Issue.3 , pp. 153-163
    • Swindells, S.1    Zheng, J.2    Gendelman, H.E.3
  • 5
    • 0025787561 scopus 로고
    • Human immunodeficiency virus-1 infection of the nervous system: An autopsy study of 268 adult, pediatric, and fetal brains
    • Kure, K., J. F. Llena, W. D. Lyman, R. Soeiro, K. M. Weidenheim, A. Hirano, and D. W. Dickson. 1991. Human immunodeficiency virus-1 infection of the nervous system: an autopsy study of 268 adult, pediatric, and fetal brains. Hum. Pathol. 22: 700-710.
    • (1991) Hum. Pathol. , vol.22 , pp. 700-710
    • Kure, K.1    Llena, J.F.2    Lyman, W.D.3    Soeiro, R.4    Weidenheim, K.M.5    Hirano, A.6    Dickson, D.W.7
  • 6
    • 0030922857 scopus 로고    scopus 로고
    • Early HIV-1 infection of the central nervous system
    • An, S. F., and F. Scaravilli. 1997. Early HIV-1 infection of the central nervous system. Arch. Anat. Cytol. Pathol. 45: 94-105.
    • (1997) Arch. Anat. Cytol. Pathol. , vol.45 , pp. 94-105
    • An, S.F.1    Scaravilli, F.2
  • 9
    • 34447540064 scopus 로고    scopus 로고
    • Neurologic complications of HIV disease and their treatment
    • Letendre, S., B. Ances, S. Gibson, and R. J. Ellis. 2007. Neurologic complications of HIV disease and their treatment. Top. HIV Med. 15: 32-39.
    • (2007) Top. HIV Med. , vol.15 , pp. 32-39
    • Letendre, S.1    Ances, B.2    Gibson, S.3    Ellis, R.J.4
  • 11
    • 0036800457 scopus 로고    scopus 로고
    • HIV-1-associated dementia: A metabolic encephalopathy perpetrated by virus-infected and immune-competent mononuclear phagocytes
    • Anderson, E., W. Zink, H. Xiong, and H. E. Gendelman. 2002. HIV-1-associated dementia: a metabolic encephalopathy perpetrated by virus-infected and immune-competent mononuclear phagocytes. J. Acquir. Immune Defic. Syndr. 31 (Suppl 2): S43-S54.
    • (2002) J. Acquir. Immune Defic. Syndr. , vol.31 , Issue.SUPPL. 2
    • Anderson, E.1    Zink, W.2    Xiong, H.3    Gendelman, H.E.4
  • 12
    • 1542285311 scopus 로고    scopus 로고
    • Levels of human immunodeficiency virus type 1 (HIV-1) replication in macrophages determines the severity of murine HIV-1 encephalitis
    • Nukuna, A., H. E. Gendelman, J. Limoges, J. Rasmussen, L. Poluektova, A. Ghorpade, and Y. Persidsky. 2004. Levels of human immunodeficiency virus type 1 (HIV-1) replication in macrophages determines the severity of murine HIV-1 encephalitis. J. Neurovirol. 10(Suppl 1): 82-90.
    • (2004) J. Neurovirol. , vol.10 , Issue.SUPPL. 1 , pp. 82-90
    • Nukuna, A.1    Gendelman, H.E.2    Limoges, J.3    Rasmussen, J.4    Poluektova, L.5    Ghorpade, A.6    Persidsky, Y.7
  • 13
    • 0029086519 scopus 로고
    • Unraveling the neuroimmune mechanisms for the HIV-1-associated cognitive/motor complex
    • Nottet, H. S., and H. E. Gendelman. 1995. Unraveling the neuroimmune mechanisms for the HIV-1-associated cognitive/motor complex. Immunol. Today 16: 441-448.
    • (1995) Immunol. Today , vol.16 , pp. 441-448
    • Nottet, H.S.1    Gendelman, H.E.2
  • 14
    • 0031974964 scopus 로고    scopus 로고
    • Neurobiological aspects of human immunodeficiency virus infection: Neurotoxic mechanisms
    • Nath, A., and J. Geiger. 1998. Neurobiological aspects of human immunodeficiency virus infection: neurotoxic mechanisms. Prog. Neurobiol. 54: 19-33.
    • (1998) Prog. Neurobiol. , vol.54 , pp. 19-33
    • Nath, A.1    Geiger, J.2
  • 15
    • 0029960647 scopus 로고    scopus 로고
    • Human microglia convert l-tryptophan into the neurotoxin quinolinic acid
    • Heyes, M. P., C. L. Achim, C. A. Wiley, E. O. Major, K. Saito, and S. P. Markey. 1996. Human microglia convert l-tryptophan into the neurotoxin quinolinic acid. Biochem. J. 320: 595-597.
    • (1996) Biochem. J. , vol.320 , pp. 595-597
    • Heyes, M.P.1    Achim, C.L.2    Wiley, C.A.3    Major, E.O.4    Saito, K.5    Markey, S.P.6
  • 16
    • 33644845532 scopus 로고    scopus 로고
    • Adjunctive therapies for HIV-1 associated neurologic disease
    • Perry, S. W., J. P. Norman, and H. A. Gelbard. 2005. Adjunctive therapies for HIV-1 associated neurologic disease. Neurotox. Res. 8: 161-166.
    • (2005) Neurotox. Res. , vol.8 , pp. 161-166
    • Perry, S.W.1    Norman, J.P.2    Gelbard, H.A.3
  • 18
    • 33748668056 scopus 로고    scopus 로고
    • A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathy
    • Adult AIDS Clinical Trials Group (ACTG) 301 tEAM
    • Schifitto, G., C. T. Yiannoutsos, D. M. Simpson, C. M. Marra, E. J. Singer, D. L. Kolson, A. Nath, J. R. Berger, and B. Navia; Adult AIDS Clinical Trials Group (ACTG) 301 tEAM. 2006. A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathy. J. Neurovirol. 12: 328-331.
    • (2006) J. Neurovirol. , vol.12 , pp. 328-331
    • Schifitto, G.1    Yiannoutsos, C.T.2    Simpson, D.M.3    Marra, C.M.4    Singer, E.J.5    Kolson, D.L.6    Nath, A.7    Berger, J.R.8    Navia, B.9
  • 19
    • 0033595183 scopus 로고    scopus 로고
    • Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment
    • Neurological AIDS Research Consortium
    • Schifitto, G., N. Sacktor, K. Marder, M. P. McDermott, J. C. McArthur, K. Kieburtz, S. Small, and L. G. Epstein; Neurological AIDS Research Consortium. 1999. Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurology 53: 391-396.
    • (1999) Neurology , vol.53 , pp. 391-396
    • Schifitto, G.1    Sacktor, N.2    Marder, K.3    McDermott, M.P.4    McArthur, J.C.5    Kieburtz, K.6    Small, S.7    Epstein, L.G.8
  • 20
    • 0035198010 scopus 로고    scopus 로고
    • HIV inhibitors: Problems and reality
    • Tözsér, J. 2001. HIV inhibitors: problems and reality. Ann. N. Y. Acad. Sci. 946: 145-159.
    • (2001) Ann. N. Y. Acad. Sci. , vol.946 , pp. 145-159
    • Tözsér, J.1
  • 21
    • 27144549662 scopus 로고    scopus 로고
    • Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection
    • Deeks, S. G., R. Hoh, T. B. Neilands, T. Liegler, F. Aweeka, C. J. Petropoulos, R. M. Grant, and J. N. Martin. 2005. Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection. J. Infect. Dis. 192: 1537-1544.
    • (2005) J. Infect. Dis. , vol.192 , pp. 1537-1544
    • Deeks, S.G.1    Hoh, R.2    Neilands, T.B.3    Liegler, T.4    Aweeka, F.5    Petropoulos, C.J.6    Grant, R.M.7    Martin, J.N.8
  • 22
    • 0034622946 scopus 로고    scopus 로고
    • Evidence for independent development of resistance to HIV-1 reverse transcriptase inhibitors in the cerebrospinal fluid
    • Cunningham, P. H., D. G. Smith, C. Satchell, D. A. Cooper, and B. Brew. 2000. Evidence for independent development of resistance to HIV-1 reverse transcriptase inhibitors in the cerebrospinal fluid. AIDS 14: 1949-1954.
    • (2000) AIDS , vol.14 , pp. 1949-1954
    • Cunningham, P.H.1    Smith, D.G.2    Satchell, C.3    Cooper, D.A.4    Brew, B.5
  • 24
    • 0032814250 scopus 로고    scopus 로고
    • Changes to AIDS dementia complex in the era of highly active anti-retroviral therapy
    • Dore, G. J., P. K. Correll, Y. Li, J. M. Kaldor, D. A. Cooper, and B. J. Brew. 1999. Changes to AIDS dementia complex in the era of highly active anti-retroviral therapy. AIDS 13: 1249-1253.
    • (1999) AIDS , vol.13 , pp. 1249-1253
    • Dore, G.J.1    Correll, P.K.2    Li, Y.3    Kaldor, J.M.4    Cooper, D.A.5    Brew, B.J.6
  • 25
    • 33751359822 scopus 로고    scopus 로고
    • HIV and aging: Implications for patient management
    • Gebo, K. A. 2006. HIV and aging: implications for patient management. Drugs Aging 23: 897-913.
    • (2006) Drugs Aging , vol.23 , pp. 897-913
    • Gebo, K.A.1
  • 27
    • 33747476112 scopus 로고    scopus 로고
    • Protecting the synapse: Evidence for a rational strategy to treat HIV-1 associated neurologic disease
    • Bellizzi, M. J., S. M. Lu, and H. A. Gelbard. 2006. Protecting the synapse: evidence for a rational strategy to treat HIV-1 associated neurologic disease. J. Neuroimmune Pharmacol. 1: 20-31.
    • (2006) J. Neuroimmune Pharmacol. , vol.1 , pp. 20-31
    • Bellizzi, M.J.1    Lu, S.M.2    Gelbard, H.A.3
  • 30
    • 27144489077 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis
    • Potula, R., L. Poluektova, B. Knipe, J. Chrastil, D. Heilman, H. Dou, O. Takikawa, D. H. Munn, H. E. Gendelman, and Y. Persidsky. 2005. Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis. Blood 106: 2382-2390.
    • (2005) Blood , vol.106 , pp. 2382-2390
    • Potula, R.1    Poluektova, L.2    Knipe, B.3    Chrastil, J.4    Heilman, D.5    Dou, H.6    Takikawa, O.7    Munn, D.H.8    Gendelman, H.E.9    Persidsky, Y.10
  • 32
    • 14344262713 scopus 로고    scopus 로고
    • Mixed-lineage kinase inhibitors require the activation of Trk receptors to maintain long-term neuronal trophism and survival
    • Wang, L. H., A. J. Paden, and E. M. Johnson, Jr. 2005. Mixed-lineage kinase inhibitors require the activation of Trk receptors to maintain long-term neuronal trophism and survival. J. Pharmacol. Exp. Ther. 312: 1007-1019.
    • (2005) J. Pharmacol. Exp. Ther. , vol.312 , pp. 1007-1019
    • Wang, L.H.1    Paden, A.J.2    Johnson Jr., E.M.3
  • 33
    • 1542269020 scopus 로고    scopus 로고
    • Targeting the JNK MAPK cascade for inhibition: Basic science and therapeutic potential
    • Bogoyevitch, M. A., I. Boehm, A. Oakley, A. J. Ketterman, and R. K. Barr. 2004. Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential. Biochim. Biophys. Acta 1697: 89-101.
    • (2004) Biochim. Biophys. Acta , vol.1697 , pp. 89-101
    • Bogoyevitch, M.A.1    Boehm, I.2    Oakley, A.3    Ketterman, A.J.4    Barr, R.K.5
  • 34
    • 0035019371 scopus 로고    scopus 로고
    • CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis
    • Bozyczko-Coyne, D., T. M. O'Kane, Z. L. Wu, P. Dobrzanski, S. Murthy, J. L. Vaught, and R. W. Scott. 2001. CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis. J. Neurochem. 77: 849-863.
    • (2001) J. Neurochem. , vol.77 , pp. 849-863
    • Bozyczko-Coyne, D.1    O'Kane, T.M.2    Wu, Z.L.3    Dobrzanski, P.4    Murthy, S.5    Vaught, J.L.6    Scott, R.W.7
  • 35
    • 0034281386 scopus 로고    scopus 로고
    • Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase
    • Namgung, U., and Z. Xia. 2000. Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. J. Neurosci. 20: 6442-6451.
    • (2000) J. Neurosci. , vol.20 , pp. 6442-6451
    • Namgung, U.1    Xia, Z.2
  • 42
    • 0032851787 scopus 로고    scopus 로고
    • Lymphotropic virions affect chemokine receptor-mediated neural signaling and apoptosis: Implications for human immunodeficiency virus type 1-associated dementia
    • Zheng, J., A. Ghorpade, D. Niemann, R. L. Cotter, M. R. Thylin, L. Epstein, J. M. Swartz, R. B. Shepard, X. Liu, A. Nukuna, and H. E. Gendelman. 1999. Lymphotropic virions affect chemokine receptor-mediated neural signaling and apoptosis: implications for human immunodeficiency virus type 1-associated dementia. J. Virol. 73: 8256-8267.
    • (1999) J. Virol. , vol.73 , pp. 8256-8267
    • Zheng, J.1    Ghorpade, A.2    Niemann, D.3    Cotter, R.L.4    Thylin, M.R.5    Epstein, L.6    Swartz, J.M.7    Shepard, R.B.8    Liu, X.9    Nukuna, A.10    Gendelman, H.E.11
  • 43
    • 0031611295 scopus 로고    scopus 로고
    • Tetrazolium (MTT) assay for cellular viability and activity
    • Morgan, D. M. 1998. Tetrazolium (MTT) assay for cellular viability and activity. Methods Mol. Biol. 79: 179-183.
    • (1998) Methods Mol. Biol. , vol.79 , pp. 179-183
    • Morgan, D.M.1
  • 45
    • 2942615005 scopus 로고    scopus 로고
    • Neuroregulatory events follow adaptive immune-mediated elimination of HIV-1-infected macrophages: Studies in a murine model of viral encephalitis
    • Poluektova, L., S. Gorantla, J. Faraci, K. Birusingh, H. Dou, and H. E. Gendelman. 2004. Neuroregulatory events follow adaptive immunemediated elimination of HIV-1-infected macrophages: studies in a murine model of viral encephalitis. J. Immunol. 172: 7610-7617. (Pubitemid 38747625)
    • (2004) Journal of Immunology , vol.172 , Issue.12 , pp. 7610-7617
    • Poluektova, L.1    Gorantla, S.2    Faraci, J.3    Birusingh, K.4    Dou, H.5    Gendelman, H.E.6
  • 46
    • 0031447215 scopus 로고    scopus 로고
    • An analysis of HIV-1-associated inflammatory products in brain tissue of humans and SCID mice with HIV-1 encephalitis
    • Persidsky, Y., M. Buttini, J. Limoges, P. Bock, and H. E. Gendelman. 1997. An analysis of HIV-1-associated inflammatory products in brain tissue of humans and SCID mice with HIV-1 encephalitis. J. Neurovirol. 3: 401-416. (Pubitemid 28041140)
    • (1997) Journal of NeuroVirology , vol.3 , Issue.6 , pp. 401-416
    • Persidsky, Y.1    Buttini, M.2    Limoges, J.3    Bock, P.4    Gendelman, H.E.5
  • 47
    • 0036731701 scopus 로고    scopus 로고
    • Mixed-lineage kinase control of JNK and p38 MAPK pathways
    • Gallo, K. A., and G. L. Johnson. 2002. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat. Rev. Mol. Cell Biol. 3: 663-672.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 663-672
    • Gallo, K.A.1    Johnson, G.L.2
  • 48
    • 0037147130 scopus 로고    scopus 로고
    • K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK
    • Roux, P. P., G. Dorval, M. Boudreau, A. Angers-Loustau, S. J. Morris, J. Makkerh, and P. A. Barker. 2002. K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK. J. Biol. Chem. 277: 49473-49480.
    • (2002) J. Biol. Chem. , vol.277 , pp. 49473-49480
    • Roux, P.P.1    Dorval, G.2    Boudreau, M.3    Angers-Loustau, A.4    Morris, S.J.5    Makkerh, J.6    Barker, P.A.7
  • 51
    • 0034092005 scopus 로고    scopus 로고
    • Human immunodeficiency virus-associated dementia
    • Clifford, D. B. 2000. Human immunodeficiency virus-associated dementia. Arch. Neurol. 57: 321-324.
    • (2000) Arch. Neurol. , vol.57 , pp. 321-324
    • Clifford, D.B.1
  • 52
    • 0030849538 scopus 로고    scopus 로고
    • Treating AIDS dementia
    • Lipton, S. A. 1997. Treating AIDS dementia. Science 276: 1629-1630.
    • (1997) Science , vol.276 , pp. 1629-1630
    • Lipton, S.A.1
  • 54
    • 0032574890 scopus 로고    scopus 로고
    • Highly active antiretroviral treatment in HIV infection: Benefits for neuropsychological function
    • Ferrando, S., W. van Gorp, M. McElhiney, K. Goggin, M. Sewell, and J. Rabkin. 1998. Highly active antiretroviral treatment in HIV infection: benefits for neuropsychological function. AIDS 12: F65-F70.
    • (1998) AIDS , vol.12
    • Ferrando, S.1    Van Gorp, W.2    McElhiney, M.3    Goggin, K.4    Sewell, M.5    Rabkin, J.6
  • 55
    • 0028909868 scopus 로고
    • Seminars in medicine of the Beth Israel Hospital, Boston. Dementia associated with the acquired immunodeficiency syndrome
    • Lipton, S. A., and H. E. Gendelman. 1995. Seminars in medicine of the Beth Israel Hospital, Boston. Dementia associated with the acquired immunodeficiency syndrome. N. Engl. J. Med. 332: 934-940.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 934-940
    • Lipton, S.A.1    Gendelman, H.E.2
  • 56
    • 0035912198 scopus 로고    scopus 로고
    • Pathways to neuronal injury and apoptosis in HIV-associated dementia
    • Kaul, M., G. A. Garden, and S. A. Lipton. 2001. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410: 988-994.
    • (2001) Nature , vol.410 , pp. 988-994
    • Kaul, M.1    Garden, G.A.2    Lipton, S.A.3
  • 57
    • 0034723366 scopus 로고    scopus 로고
    • HIV infection and dementia
    • Gartner, S. 2000. HIV infection and dementia. Science 287: 602-604.
    • (2000) Science , vol.287 , pp. 602-604
    • Gartner, S.1
  • 58
    • 0007220909 scopus 로고    scopus 로고
    • Prospects for neuropharmacological intervention in AIDS dementia
    • H. Gendelman, S. Lipton, L. Epstein, and S. Swindells, eds. Chapman-Hall, N Y.
    • Lipton, S., and K. Kieburtz. 1998. Prospects for neuropharmacological intervention in AIDS dementia. In The Neurology of AIDS. H. Gendelman, S. Lipton, L. Epstein, and S. Swindells, eds. Chapman-Hall, N Y., pp. 377-381.
    • (1998) The Neurology of AIDS , pp. 377-381
    • Lipton, S.1    Kieburtz, K.2
  • 59
    • 0031748172 scopus 로고    scopus 로고
    • Neuronal injury associated with HIV-1: Approaches to treatment
    • Lipton, S. A. 1998. Neuronal injury associated with HIV-1: approaches to treatment. Annu. Rev. Pharmacol. Toxicol. 38: 159-177.
    • (1998) Annu. Rev. Pharmacol. Toxicol. , vol.38 , pp. 159-177
    • Lipton, S.A.1
  • 62
    • 22844445441 scopus 로고    scopus 로고
    • Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: A new therapeutic target in Parkinson's disease
    • Silva, R. M., C. Y. Kuan, P. Rakic, and R. E. Burke. 2005. Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease. Mov. Disord. 20: 653-664.
    • (2005) Mov. Disord. , vol.20 , pp. 653-664
    • Silva, R.M.1    Kuan, C.Y.2    Rakic, P.3    Burke, R.E.4
  • 63
    • 0031442550 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons
    • Lannuzel, A., J. V. Barnier, C. Hery, V. T. Huynh, B. Guibert, F. Gray, J. D. Vincent, and M. Tardieu. 1997. Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons. Ann. Neurol. 42: 847-856.
    • (1997) Ann. Neurol. , vol.42 , pp. 847-856
    • Lannuzel, A.1    Barnier, J.V.2    Hery, C.3    Huynh, V.T.4    Guibert, B.5    Gray, F.6    Vincent, J.D.7    Tardieu, M.8
  • 65
    • 0034041752 scopus 로고    scopus 로고
    • HIV-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: Relevance for HIV-1-associated dementia
    • Xiong, H., Y. C. Zeng, T. Lewis, J. Zheng, Y. Persidsky, and H. E. Gendelman. 2000. HIV-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: relevance for HIV-1-associated dementia. J. Neurovirol. 6(Suppl 1): S14-S23. (Pubitemid 30342773)
    • (2000) Journal of NeuroVirology , vol.6 , Issue.SUPPL. 1
    • Xiong, H.1    Zeng, Y.-C.2    Lewis, T.3    Zheng, J.4    Persidsky, Y.5    Gendelman, H.E.6
  • 66
    • 0032733230 scopus 로고    scopus 로고
    • Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis
    • Persidsky, Y., A. Ghorpade, J. Rasmussen, J. Limoges, X. J. Liu, M. Stins, M. Fiala, D. Way, K. S. Kim, M. H. Witte, et al. 1999. Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis. Am. J. Pathol. 155: 1599-1611.
    • (1999) Am. J. Pathol. , vol.155 , pp. 1599-1611
    • Persidsky, Y.1    Ghorpade, A.2    Rasmussen, J.3    Limoges, J.4    Liu, X.J.5    Stins, M.6    Fiala, M.7    Way, D.8    Kim, K.S.9    Witte, M.H.10
  • 67
    • 25444453444 scopus 로고    scopus 로고
    • Neuroprotective role of microglia expressing interleukin-4
    • Park, K. W., D. Y. Lee, E. H. Joe, S. U. Kim, and B. K. Jin. 2005. Neuroprotective role of microglia expressing interleukin-4. J. Neurosci. Res. 81: 397-402.
    • (2005) J. Neurosci. Res. , vol.81 , pp. 397-402
    • Park, K.W.1    Lee, D.Y.2    Joe, E.H.3    Kim, S.U.4    Jin, B.K.5
  • 69
    • 0347362913 scopus 로고    scopus 로고
    • Loss of TGF-β 1 leads to increased neuronal cell death and microgliosis in mouse brain
    • Brionne, T. C., I. Tesseur, E. Masliah, and T. Wyss-Coray. 2003. Loss of TGF-β 1 leads to increased neuronal cell death and microgliosis in mouse brain. Neuron 40: 1133-1145.
    • (2003) Neuron , vol.40 , pp. 1133-1145
    • Brionne, T.C.1    Tesseur, I.2    Masliah, E.3    Wyss-Coray, T.4
  • 74
    • 17344367099 scopus 로고    scopus 로고
    • The neuroprotective function of vascular endothelial growth factor (VEGF)
    • Góra-Kupilas, K., and J. Jośko. 2005. The neuroprotective function of vascular endothelial growth factor (VEGF). Folia Neuropathol. 43: 31-39. (Pubitemid 40533190)
    • (2005) Folia Neuropathologica , vol.43 , Issue.1 , pp. 31-39
    • Gora-Kupilas, K.1    Josko, J.2
  • 75
    • 1542319928 scopus 로고    scopus 로고
    • Dysregulation of mitogen-activated protein kinase signaling pathways in simian immunodeficiency virus encephalitis
    • Barber, S. A., J. L. Uhrlaub, J. B. DeWitt, P. M. Tarwater, and M. C. Zink. 2004. Dysregulation of mitogen-activated protein kinase signaling pathways in simian immunodeficiency virus encephalitis. Am. J. Pathol. 164: 355-362.
    • (2004) Am. J. Pathol. , vol.164 , pp. 355-362
    • Barber, S.A.1    Uhrlaub, J.L.2    DeWitt, J.B.3    Tarwater, P.M.4    Zink, M.C.5
  • 76
    • 34247179074 scopus 로고    scopus 로고
    • Identification of novel therapeutic targets for HIV infection through functional genomic cDNA screening
    • Nguyen, D. G., H. Yin, Y. Zhou, K. C. Wolff, K. L. Kuhen, and J. S. Caldwell. 2007. Identification of novel therapeutic targets for HIV infection through functional genomic cDNA screening. Virology 362: 16-25.
    • (2007) Virology , vol.362 , pp. 16-25
    • Nguyen, D.G.1    Yin, H.2    Zhou, Y.3    Wolff, K.C.4    Kuhen, K.L.5    Caldwell, J.S.6
  • 77
    • 4043136542 scopus 로고    scopus 로고
    • Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347
    • Falsig, J., P. Pörzgen, J. Lotharius, and M. Leist. 2004. Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347. J. Immunol. 173: 2762-2770. (Pubitemid 39063138)
    • (2004) Journal of Immunology , vol.173 , Issue.4 , pp. 2762-2770
    • Falsig, J.1    Porzgen, P.2    Lotharius, J.3    Leist, M.4
  • 79
    • 0036845266 scopus 로고    scopus 로고
    • Identification of JNK-dependent and -independent components of cerebellar granule neuron apoptosis
    • Harris, C., A. C. Maroney, and E. M. Johnson, Jr. 2002. Identification of JNK-dependent and -independent components of cerebellar granule neuron apoptosis. J. Neurochem. 83: 992-1001.
    • (2002) J. Neurochem. , vol.83 , pp. 992-1001
    • Harris, C.1    Maroney, A.C.2    Johnson Jr., E.M.3
  • 80
    • 24944455016 scopus 로고    scopus 로고
    • Phosphatidylserinespecific receptor contributes to TGF-β production in macrophages through a MAP kinase, ERK
    • Otsuka, M., K. Goto, S. Tsuchiya, and Y. Aramaki. 2005. Phosphatidylserinespecific receptor contributes to TGF-β production in macrophages through a MAP kinase, ERK. Biol. Pharm. Bull. 28: 1707-1710.
    • (2005) Biol. Pharm. Bull. , vol.28 , pp. 1707-1710
    • Otsuka, M.1    Goto, K.2    Tsuchiya, S.3    Aramaki, Y.4
  • 81
    • 0035033952 scopus 로고    scopus 로고
    • Signalling for survival and death in neurones: The role of stress-activated kinases, JNK and p38
    • Harper, S. J., and P. LoGrasso. 2001. Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38. Cell. Signal. 13: 299-310.
    • (2001) Cell. Signal. , vol.13 , pp. 299-310
    • Harper, S.J.1    LoGrasso, P.2
  • 82
    • 33947541266 scopus 로고    scopus 로고
    • Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: Involvement of antiapoptotic BCL2 and c-IAP1 genes
    • Mishra, S., J. P. Mishra, and A. Kumar. 2007. Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes. J. Biol. Chem. 282: 4288-4300.
    • (2007) J. Biol. Chem. , vol.282 , pp. 4288-4300
    • Mishra, S.1    Mishra, J.P.2    Kumar, A.3
  • 85
    • 0035283335 scopus 로고    scopus 로고
    • Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis
    • Persidsky, Y., J. Limoges, J. Rasmussen, J. Zheng, A. Gearing, and H. E. Gendelman. 2001. Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis. J. Neuroimmunol. 114: 57-68.
    • (2001) J. Neuroimmunol. , vol.114 , pp. 57-68
    • Persidsky, Y.1    Limoges, J.2    Rasmussen, J.3    Zheng, J.4    Gearing, A.5    Gendelman, H.E.6
  • 86
    • 49049083497 scopus 로고    scopus 로고
    • Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease
    • Wang, L. H., E. M. Johnson, Jr., I. Shoulson, A. E. Lang, and D. Bozyczko-Coyne. 2008. Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease. Neurology 71: 462-463, author reply 462-463.
    • (2008) Neurology , vol.71 , Issue.462-463 , pp. 462-463
    • Wang, L.H.1    Johnson Jr., E.M.2    Shoulson, I.3    Lang, A.E.4    Bozyczko-Coyne, D.5


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