Anti-endothelial cell autoantibodies selectively activate SAPK/JNK signalling in Wegener's granulomatosis

Journal of the American Society of Nephrology

Volumn 18, Issue 9, 2007, Pages 2497-2508

  Holmén, Carolina ^a   Elsheikh, Elzafir ^a   Christensson, Marta ^a   Liu, Jining ^a   Johansson, Anne Sofie ^a   Qureshi, Abdul Rashid ^a   Jalkanen, Sirpa ^b   Sumitran Holgersson, Suchitra ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; AUTOANTIBODY; CALCIUM ION; CHEMOKINE; IMMUNOGLOBULIN G; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MONOCYTE CHEMOTACTIC PROTEIN 1; NATURAL KILLER CELL RECEPTOR NKG2D; STRESS ACTIVATED PROTEIN KINASE; VASCULAR ADHESION PROTEIN 1;

ADULT; AGED; ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; KIDNEY; MALE; MICROVASCULATURE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WEGENER GRANULOMATOSIS; WESTERN BLOTTING;

EID: 34548513029     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2006111286     Document Type: Article

References (40)

1. Lamprecht P, Gross WL: Wegener's granulomatosis. Herz 29: 47-56, 2004
2. Reumaux D, Duthilleul P, Roos D: Pathogenesis of diseases associated with antineutrophil cytoplasm autoantibodies. Hum Immunol 65: 1-12, 2004
3. Pettersson E, Heigl Z: Antineutrophil cytoplasmic antibody (cANCA and pANCA) titers in relation to disease activity in patients with necrotizing vasculitis: A longitudinal study. Clin Nephrol 37: 219-228, 1992
4. Cid MC: Endothelial cell biology, perivascular inflammation, and vasculitis. Cleve Clin J Med 69[Suppl 2]: SII45-SII49, 2002
5. Gobel U, Eichhorn J, Kettritz R, Briedigkeit L, Sima D, Lindschau C, Haller H, Luft FC: Disease activity and autoantibodies to endothelial cells in patients with Wegener's granulomatosis. Am J Kidney Dis 28: 186-194, 1996
6. Belizna C, Duijvestijn A, Hamidou M, Cohen Tervaert JW: Antiendothelial cell antibodies in vasculitis and connective tissue disease. Ann Rheum Dis 65: 1545-1550, 2006
7. Damianovich M, Gilburd B, George J, Del Papa N, Afek A, Goldberg I, Kopolovic Y, Roth D, Barkai G, Meroni PL, Shoenfeld Y: Pathogenic role of anti-endothelial cell antibodies in vasculitis: An idiotypic experimental model. J Immunol 156: 4946-4951, 1996
8. Hazzalin CA, Cano E, Cuenda A, Barratt MJ, Cohen P, Mahadevan LC: p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient. Curr Biol 6: 1028-1031, 1996
9. Karin M: The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 270: 16483-16486, 1995
10. Whitmarsh AJ, Davis RJ: Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 74: 589-607, 1996
11. Kettritz R, Schreiber A, Luft FC, Haller H: Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies. J Am Soc Nephrol 12: 37-46, 2001
12. Holmen C, Christensson M, Pettersson E, Bratt J, Stjarne P, Karrar A, Sumitran-Holgersson S: Wegener's granulomatosis is associated with organ-specific antiendothelial cell antibodies. Kidney Int 66: 1049-1060, 2004
13. Holmen C, Elsheikh E, Stenvinkel P, Qureshi AR, Pettersson E, Jalkanen S, Sumitran-Holgersson S: Circulating inflammatory endothelial cells contribute to endothelial progenitor cell dysfunction in patients with vasculitis and kidney involvement. J Am Soc Nephrol 16: 3110-3120, 2005
14. Merinen M, Irjala H, Salmi M, Jaakkola I, Hanninen A, Jalkanen S: Vascular adhesion protein-1 is involved in both acute and chronic inflammation in the mouse. Am J Pathol 166: 793-800, 2005
15. Koskinen K, Vainio PJ, Smith DJ, Pihlavisto M, Yla-Herttuala S, Jalkanen S, Salmi M: Granulocyte transmigration through the endothelium is regulated by the oxidase activity of vascular adhesion protein-1 (VAP-1). Blood 103: 3388-3395, 2004
16. Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T: Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc Natl Acad Sci U S A 100: 9452-9457, 2003
17. Collins RW: Human MHC class I chain related (MIC) genes: Their biological function and relevance to disease and transplantation. Eur J Immunogenet 31: 105-114, 2004
18. Wu J, Groh V, Spies T: T cell antigen receptor engagement and specificity in the recognition of stress-inducible MHC class I-related chains by human epithelial gamma delta T cells. J Immunol 169: 1236-1240, 2002
19. Recht PA, Tepedino GJ, Siecke NW, Buckley MT, Mandeville JT, Maxfield FR, Levin RI: Oxalic acid alters intracellular calcium in endothelial cells. Atherosclerosis 173: 321-328, 2004
20. Pfau S, Leitenberg D, Rinder H, Smith BR, Pardi R, Bender JR: Lymphocyte adhesion-dependent calcium signaling in human endothelial cells. J Cell Biol 128: 969-978, 1995
21. Charo IF, Taubman MB: Chemokines in the pathogenesis of vascular disease. Circ Res 95: 858-866, 2004
22. Van Damme J, Wuyts A, Froyen G, Van Coillie E, Struyf S, Billiau A, Proost P, Wang JM, Opdenakker G: Granulocyte chemotactic protein-2 and related CXC chemokines: From gene regulation to receptor usage. J Leukoc Biol 62: 563-569, 1997
23. Csernok E, Trabandt A, Muller A, Wang GC, Moosig F, Paulsen J, Schnabel A, Gross WL: Cytokine profiles in Wegener's granulomatosis: Predominance of type 1 (Th1) in the granulomatous inflammation. Arthritis Rheum 42: 742-750, 1999
24. Groh V, Rhinehart R, Randolph-Habecker J, Topp MS, Riddell SR, Spies T: Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat Immunol 2: 255-260, 2001
25. Snyder MR, Weyand CM, Goronzy JJ: The double life of NK receptors: Stimulation or co-stimulation? Trends Immunol 25: 25-32, 2004
26. Salmi M, Jalkanen S: Cell-surface enzymes in control of leukocyte trafficking. Nat Rev Immunol 5: 760-771, 2005
27. Salmi M, Kalimo K, Jalkanen S: Induction and function of vascular adhesion protein-1 at sites of inflammation. J Exp Med 178: 2255-2260, 1993
28. Praprotnik S, Rozman B, Blank M, Shoenfeld Y: Pathogenic role of anti-endothelial cell antibodies in systemic vasculitis. Wien Klin Wochenschr 112: 660-664, 2000
29. Yu F, Zhao MH, Zhang YK, Zhang Y, Wang HY: Anti-endothelial cell antibodies (AECA) in patients with propylthiouracil (PTU)-induced ANCA positive vasculitis are associated with disease activity. Clin Exp Immunol 139: 569-574, 2005
30. Kain R, Matsui K, Exner M, Binder S, Schaffner G, Sommer EM, Kerjaschki D: A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis: The lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells. J Exp Med 181: 585-597, 1995
31. Edmunds JW, Mahadevan LC: MAP kinases as structural adaptors and enzymatic activators in transcription complexes. J Cell Sci 117: 3715-3723, 2004
32. Carvalho D, Savage CO, Isenberg D, Pearson JD: IgG anti-endothelial cell autoantibodies from patients with systemic lupus erythematosus or systemic vasculitis stimulate the release of two endothelial cell-derived mediators, which enhance adhesion molecule expression and leukocyte adhesion in an autocrine manner. Arthritis Rheum 42: 631-640, 1999
33. Savage CO, Pottinger BE, Gaskin G, Lockwood CM, Pusey CD, Pearson JD: Vascular damage in Wegener's granulomatosis and microscopic polyarteritis: Presence of anti-endothelial cell antibodies and their relation to anti-neutrophil cytoplasm antibodies. Clin Exp Immunol 85: 14-19, 1991
34. Hoffman GS, Specks U: Antineutrophil cytoplasmic antibodies. Arthritis Rheum 41: 1521-1537, 1998
35. Del Papa N, Conforti G, Gambini D, La Rosa L, Tincani A, D'Cruz D, Khamashta M, Hughes GR, Balestrieri G, Meroni PL: Characterization of the endothelial surface proteins recognized by anti-endothelial antibodies in primary and secondary autoimmune vasculitis. Clin Immunol Immunopathol 70: 211-216, 1994
36. Del Papa N, Guidali L, Sironi M, Shoenfeld Y, Mantovani A, Tincani A, Balestrieri G, Radice A, Sinico RA, Meroni PL: Anti-endothelial cell IgG antibodies from patients with Wegener's granulomatosis bind to human endothelial cells in vitro and induce adhesion molecule expression and cytokine secretion. Arthritis Rheum 39: 758-766, 1996
37. Chan TM, Frampton G, Jayne DR, Perry GJ, Lockwood CM, Cameron JS: Clinical significance of anti-endothelial cell antibodies in systemic vasculitis: A longitudinal study comparing anti-endothelial cell antibodies and anti-neutrophil cytoplasm antibodies. Am J Kidney Dis 22: 387-392, 1993
38. Sumitran-Holgersson S, Wilczek HE, Holgersson J, Soderstrom K: Identification of the nonclassical HLA molecules, MICA, as targets for humoral immunity associated with irreversible rejection of kidney allografts. Transplantation 74: 268-277, 2002
39. Holmen C, Stjarne P, Sumitran-Holgersson S: Heterogeneity of human nasal vascular and sinusoidal endothelial cells from the inferior turbinate. Am J Respir Cell Mol Biol 32: 18-27, 2005
40. D'Amore PA, Shepro D: Calcium flux and ornithine decarboxylase activity in cultured endothelial cells. Life Sci 22: 571-576, 1978