Selective interaction of JNK protein kinase isoforms with transcription factors

EMBO Journal

Volumn 15, Issue 11, 1996, Pages 2760-2770

  Gupta, Shashi ^a   Barrett, Tamera ^a   Whitmarsh, Alan J ^a   Cavanagh, Julie ^a   Sluss, Hayla K ^a   Dérijard, Benoit ^a   Davis, Roger J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

ATF2; c Jun; Elk 1; JNK; MAP kinase

Indexed keywords

BRAIN ENZYME; INTERLEUKIN 1; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; TRANSCRIPTION FACTOR;

ALTERNATIVE RNA SPLICING; ARTICLE; BINDING AFFINITY; BRAIN; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SUBSTRATE; FETUS; HUMAN; HUMAN TISSUE; MOLECULAR CLONING; NONHUMAN; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

EID: 0029885419     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00636.x     Document Type: Article

References (57)

1. Adler,V., Franklin,C.C. and Kraft,A.S. (1992a) Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain. Proc. Natl Acad. Sci. USA, 89, 5341-5345.
2. Adler,V., Polotskaya,A., Wagner,F. and Kraft,A.S. (1992b) Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity. J. Biol. Chem., 267, 17001-17005.
3. Adler,V., Unlap,T. and Kraft,A.S. (1994) A peptide encoding the c-Jun δ domain inhibits the activity of a c-Jun amino-terminal protein kinase. J. Biol. Chem., 269, 11186-11191.
4. Alessi,D.R., Smythe,C. and Keyse,S.M. (1993) The human CL100 gene encodes a Tyr/Thr phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. Oncogene, 8, 992-999.
5. Andersson,S., Davis,D.L., Dahlbäck,H., Jörnvall,H. and Russell,D.W. (1989) Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J. Biol. Chem., 264, 8222-8229.
6. Bagrodia,S., Derijard,B., Davis,R.J. and Cerione,R. (1995) Cdc42 and PAK-mediated signaling leads to JNK and p38 MAP kinase activation. J. Biol. Chem., 270, 27995-27998.
7. Charles,C.H., Abler,A.S. and Lau,L.F. (1992) cDNA sequence of a growth factor inducible immediate-early gene and characterization of its encoded protein. Oncogene. 7, 187-190.
8. Chiu,R., Angel,P. and Karin,M. (1989) Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell, 59, 979-986.
9. Coso,O.A., Chiariello,M., Yu,J.-C., Teramoto,H., Crespo,P., Xu,N., Miki,T. and Gutkind,J.S. (1995) The small GTP-binding proteins rac1 and cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell, 81, 1137-1146.
10. Curran,T., Abate,C., Baker,S., Kerppola,T. and Xanthoudakis,S. (1993) The regulation of c-fos: too much is never enough. Adv. Second Messenger Phosphoprotein Res., 28, 271-277.
11. Davis,R.J. (1994) MAP kinases: new JNK expands the group. Trends. Biochem. Sci., 19, 470-473.
12. Deng,T. and Karin,M. (1993) JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers. Genes Dev., 7, 479-490.
13. Deng,T. and Karin,M. (1994) c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK. Nature, 371, 171-175.
14. Dérijard,B., Hibi,M., Wu,I.-H., Barrett,T., Su,B., Deng,T., Karin,M. and Davis,R.J. (1994) JNKI: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell, 76, 1025-1037.
15. Dérijard,B., Raingeaud,J., Barrett,T., Wu,I.-H., Han,J., Ulevitch,R.J. and Davis,R.J. (1995) Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science, 267, 682-685.
16. Franklin,C.C., Sanchez,V., Wagner,F., Woodgett,J.R. and Kraft,A.S. (1992) Phorbol ester-induced amino-terminal phosphorylation of human Jun but not JunB regulates transcriptional activity. Proc. Natl Acad. Sci. USA, 89, 7247-7251.
17. Gille,H., Strahl,T. and Shaw,P.E. (1995) Activation of ternary complex factor Elk-1 by stress-activated protein kinases. Curr. Biol., 5, 1191-1200.
18. Gupta,S., Seth,A. and Davis,R.J. (1993) Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62. Proc. Natl Acad. Sci. USA, 90, 3216-3220.
19. Gupta,S., Campbell,D., Derijard,B. and Davis,R.J. (1995) Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science, 267, 389-393.
20. Hanks,S.K., Quinn,A.M. and Hunter,T. (1988) The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science, 241, 42-52.
21. Hibi,M., Lin,A., Smeal,T., Minden,A. and Karin,M. (1993) Identification of an oncoprotein-and UV-responsive protein kinase that bind and potentiate the c-Jun activation domain. Genes Dev., 7, 2135-2148.
22. Hirai,S.-I., Ryseck,R.-P., Mechta,F., Bravo,R. and Yaniv,M. (1989) Characterization of JunD: a new member of the jun proto-oncogene family. EMBO J., 8, 1433-1439.
23. Hirai,S.-I., Bourachot,B. and Yaniv,M. (1990) Both Fos and Jun contribute to transcription activation by the heterodimer. Oncogene, 5, 39-46.
24. Ho,S.N., Hunt,H.D., Horton,R.M., Pullen,J.K. and Pease,L.R. (1989) Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene, 77, 51-59.
25. Hunter,T. and Karin,M. (1992) The regulation of transcription by phosphorylation. Cell, 70, 375-387.
26. Ishibashi,T., Bottaro,D.P., Michieli,P., Kelley,C.A. and Aaronson,S.A. (1994) A novel dual specificity phosphatase induced by serum stimulation and heat shock. J. Biol. Chem., 269, 29897-29902.
27. Kallunki,T., Su,B., Tsigelny,I., Sluss,H.K., Dérijard,B., Moore,G., Davis,R.J. and Karin,M. (1994) JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev., 8, 2996-3007.
28. Keyse,S.M. and Emslie,E.A. (1992) Oxidative stress and heat shock induce a human gene encoding a protein tyrosine phosphatase. Nature, 359, 644-647.
29. Kyriakis,J.M., Banerjee,P., Nikolakaki,E., Dai,T., Rubie,E.A., Ahmad,M.F., Avruch,J. and Woodgett,J.R. (1994) The stress-activated protein kinase subfamily of c-Jun kinases. Nature, 369, 156-160.
30. Lin,A., Minden,A., Martinetto,H., Claret,F.-X., Lange-Carter,C., Mercurio,F., Johnson,G.L. and Karin,M. (1995) Identification of a dual specificity kinase that activates Jun kinases and p38-Mpk2. Science, 268, 286-290.
31. Liu,Y., Goroscope,M., Yang,C. and Holbrook,N.J. (1995) Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. J. Biol. Chem., 270, 8377-8380.
32. Livingstone,C., Patel,G. and Jones,N. (1995) ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J., 14, 1785-1797.
33. Minden,A., Lin,A., McMahon,M., Lange-Carter,C., Derijard,B., Davis,R.J., Johnson,G.L. and Karin,M. (1994) Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science, 266, 1719-1723.
34. Minden,A., Lin,A., Claret,F.-X., Abo,A. and Karin,M. (1995) Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and cdc42Hs. Cell, 81, 1147-1157.
35. Misra-Press,A., Rim,C.S., Yao,H., Roberson,M.S. and Stork,P.J.S. (1995) A novel mitogen-activated protein kinase phosphatase. Structure, expression, and regulation. J. Biol Chem., 270, 14587-14596.
36. Olson,M.F., Ashworth,A. and Hall,A. (1995) An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science, 269, 1270-1272.
37. Pfarr,C.M., Mechta,F., Spyrou,G., Lallemand,D., Carillo,S. and Yaniv,M. (1994) Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras. Cell, 76, 747-760.
38. Pulverer,B.J., Kyriakis,J.M., Avruch,J., Nikolakaki,E. and Woodgett,J.R. (1991) Phosphorylation of c-Jun mediated by MAP kinases. Nature, 353, 670-674.
39. Raingeaud,J., Gupta,S., Rogers,J., Dickens,M., Han,J., Ulevitch,R.J. and Davis,R.J. (1995) Pro-inflammatory cytokines and environmental stress cause p38 MAP kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem., 270, 7420-7426.
40. Rohan,P.J., Davis,P., Moskaluk,C.A., Kearns,M., Krutzsch,H., Siebenlist,U. and Kelly,K. (1993) PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science, 259, 1763-1766.
41. Russell,M., Lange-Carter,C.A. and Johnson,G.L. (1995) Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1). J. Biol. Chem., 270, 11757-11760.
42. Sanchez,I., Hughes,R.T., Mayer,B.J., Yee,K., Woodgett,J.R., Avruch,J., Kyriakis,J.M. and Zon,L.I. (1994) Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature, 372, 794-798.
43. Schütte,J., Minna,J.D. and Birrer,M.J. (1989a) Deregulated expression of human c-Jun transforms primary rat embryo cells in cooperation with an activated Ha-ras gene and transforms Rat-1a cells as a single gene. Proc. Natl Acad. Sci. USA, 86, 2257-2261.
44. Schütte,J., Viallet,J., Nau,M., Segal,S., Fedorko,J. and Minna,J. (1989b) JunB inhibits and c-Fos stimulates the transforming and transactivating activities of c-Jun. Cell, 59, 987-997.
45. Seth,A., Gonzalez,F.A., Gupta,S., Raden,D.L. and Davis,R.J. (1992) Signal transduction within the nucleus by mitogen-activated protein kinase. J. Biol. Chem., 267, 24796-24804.
46. Sluss,H.K., Barrett,T., Dérijard,B. and Davis,R.J. (1994) Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol. Cell. Biol., 14, 8376-8384.
47. Smeal,T., Binetruy,B., Mercola,D.A., Birrer,M. and Karin,M. (1991) Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature, 354, 494-496.
48. Smith,S.B. and Johnson,K.S. (1988) Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase. Gene, 67, 31-40.
49. Sun,H., Charles,C.H., Lau,L.F. and Tonks,N.K. (1993) MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell, 75, 487-493.
50. Sun,H., Tonks,N.K. and Bar-Sagi,D. (1994) Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1. Science, 266, 285-288.
51. van Dam,H., Wilhelm,D., Herr,I., Steffen,A., Herrlich,P. and Angel,P. (1995) ATF2 is preferentially activated by stress-activated protein kinases to mediate c-Jun induction in response to genotoxic agents. EMBO J., 14, 1798-1811.
52. Vogt,P.K. and Bos,T.J. (1990) Jun: oncogene and transcription factor. Adv. Cancer Res., 55, 1-35.
53. Ward,Y., Gupta,S., Jensen,P., Wartmann,M., Davis,R.J. and Kelly,K. (1994) Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1. Nature, 367, 651-654.
54. Whitmarsh,A.J., Shore,P., Sharrocks,A.D. and Davis,R.J. (1995) Integration of MAP kinase signal transduction pathways at the serum response element. Science, 269, 403-407.
55. Yan,M., Dai,T., Deak,J.C., Kyriakis,J.M., Zon,L.I., Woodgett,J.R. and Templeton,D.J. (1994) Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature, 372, 798-800.
56. Zheng,C.-F. and Guan,K.L. (1993) Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase. J. Biol. Chem., 268, 16116-16119.
57. Zinck,R., Cahill,M.A., Kracht,M., Sachsenmaier,C., Hipskind,R.A. and Nordheim,A. (1995) Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1. Mol. Cell Biol., 15, 4930-4938.