Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats

British Journal of Pharmacology

Volumn 142, Issue 6, 2004, Pages 953-960

  Ferrandi, Chiara ^a   Ballerio, Rossana ^a   Gaillard, Pascale ^b   Giachetti, Claudio ^a   Carboni, Sonia ^b   Vitte, Pierre Alain ^b   Gotteland, Jean Pierre ^b   Cirillo, Rocco ^a  

^a Merck Serono SpA   (Italy)

^b SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

Author keywords

Apoptosis; JNK; JNK inhibitor; Myocardial ischemia reperfusion

Indexed keywords

1,3 BENZOTHIAOL 2 YL [2 [[2 (3 PYRIDINYL)ETHYL]AMINO] 4 PYRIMIDINYL]ACETONITRILE; 3 AMINOBENZAMIDE; AS 601245; DNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEART HEMODYNAMICS; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ST SEGMENT ELEVATION;

ACETONITRILES; ANESTHESIA; ANIMALS; APOPTOSIS; BENZOTHIAZOLES; BLOOD PRESSURE; BLOTTING, WESTERN; CORONARY DISEASE; DNA FRAGMENTATION; ENZYME ACTIVATION; HEART RATE; HEMODYNAMIC PHENOMENA; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; THIAZOLES;

EID: 3843090683     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705873     Document Type: Article

References (23)

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