A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss

Journal of Neuroscience

Volumn 23, Issue 24, 2003, Pages 8596-8607

  Wang, J ^a   Van De Water, T R ^b   Bonny, C ^c   De Ribaupierre, F ^d   Puel, J L ^a   Zine, Azel ^a,d  

^a INSERM   (France)

^b UNIVERSITY OF MIAMI EAR INSTITUTE   (United States)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Acoustic trauma; Apoptosis of hair cells; c Jun N terminal kinase (JNK); JNK inhibition; Neomycin; Noise induced hearing loss; Organ of Corti; Ototoxicity

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; C JUN N TERMIMINAL KINASE INHIBITOR; D JUN N TERMINAL KINASE I 1; MITOGEN ACTIVATED PROTEIN KINASE; NEOMYCIN; PEPTIDE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; COCHLEA; CONTROLLED STUDY; CORTI ORGAN; DOSE RESPONSE; GUINEA PIG; HAIR CELL; HEARING LOSS; MOUSE; NOISE INJURY; NONHUMAN; ORGAN CULTURE; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0141457877     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-24-08596.2003     Document Type: Article

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