Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2

Immunity

Volumn 9, Issue 4, 1998, Pages 575-585

  Yang, Derek D ^a,b,e   Conze, Dietrich ^c   Whitmarsh, Alan J ^b,d   Barrett, Tamera ^b,d   Davis, Roger J ^b,d   Rincón, Mercedes ^c   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; MITOGEN ACTIVATED PROTEIN KINASE; RECOMBINANT GAMMA INTERFERON; RECOMBINANT INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; EFFECTOR CELL; ENZYME ACTIVATION; GENE EXPRESSION; HELPER CELL; IMMUNE RESPONSE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 0032191173     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80640-8     Document Type: Article

References (40)

1. Alberola-lla, J., Forbush, K.A., Seger, R., Krebs, E.G., and Perlmutter, R.M. (1995). Selective requirement for MAP kinase activation in thymocytes differentiation. Nature 373, 620-623.
2. Bradley, L.M., Dalton, D.K., and Croft, M. (1996). A direct rolefor IFNγ in regulation of Th1 cell development. J. Immunol. 157, 1350-1358.
3. Chomczynski, P., and Sacchi, N. (1987). Single-step method of RNA extraction by acid guanidinium thiocyanate-phenol-chloroform. Anal. Biochem. 162, 156-159.
4. Chow, C.-W., Rincon, M., Cavanagh, J., Dickens, M., and Davis, R.J. (1997). Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. Science 278, 1638-1641.
5. + T cell responses: the alternative approaches. Annu. Rev. Immunol. 15, 297-322.
6. Dérijard, B., Hibi, M., Wu, I.-H., Barret, T., Su, B., Deng, T., Karin, M., and Davis, R.J. (1994). JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025-1037.
7. Gillis, S., Ferm, M.N., and Smith, K.A. (1978). T cell growth factor: parameters of production and quantitative microassay for activity. J. Immunol. 120, 1109-1113.
8. Gupta, S., Campbell, D., Dérijard, B., and Davis, R.J. (1995). Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267, 389-393.
9. Gupta, S., Barret, T., Whitmarsh, A.J., Cavanagh, J., Sluss, H.K., Deacute;rijard, B., and Davis, R.J. (1996). Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15, 2760-2770.
10. + Tcellsthrough IL-12 produced by Listeria-induced macrophages. Science 260, 547-549.
11. Ip, Y.T., and Davis, R.J. (1998). Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development. Curr. Opin. Cell. Biol. 10, 205-219.
12. Kamogawa, Y., Minasi, L-A.E., Carding, S., Bottomly, K., and Flavell, R.A. (1993). The relationship of IL-4 and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells. Cell 75, 985-995.
13. Kyriakis, J.M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E.A., Ahmad, M.F., Avruch, J., and Woodgett, J.R. (1994). The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369, 156-160.
14. Le Gros, G., Ben-Sasson, S.Z., Seder, R., Finkelman, F.D., and Paul, W.E. (1990). Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4 producing cells. J. Exp. Med. 172, 921-929.
15. Linsley, P.S., and Ledbetter, J.A. (1993). The role of the CD28 receptor during T cell responses. Annu. Rev. Immunol. 11, 191-212.
16. Nishina, H., Bachmann, M., Oliveira-dos-Santos, A.J., Odermatt, B., Wakeham, A., Shahinian, A., Takimoto, H., Bernstein, A., Mak, T.M., Woodgett, J.R., et al. (1997). Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J. Exp. Med. 186, 941-953.
17. Paul, W.E., and Seder, R.A. (1994). Lymphocyte response and cytokines. Cell 76, 241-251.
18. Penix, L., Weaver, W.M., Pang, Y., Young, H.A., and Wilson, C.B. (1993). Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells. J. Exp. Med. 178, 1483-1496.
19. Penix, L.A., Sweetser, M.T., Weaver, W.M., Hoey, T., Hoeffler, J.P., Kerpolla, T.K., and Wilson, C.B. (1996). The proximal regulatory element of the interferon-γ promoter mediates selective expression in T cells. J. Biol. Chem. 271, 31964-31972.
20. Presky, D.H., Yang, H., Minetti, L.J., Chua, A.O., Nabavi, N., Wu, C.-Y., Gately, M.K., and Gubler, U. (1996). A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 93, 14002-14002.
21. Reiner, S.L., Zheng, S., Corry, D.B., and Locksley, R.M. (1993). Constructing polycompetitor cDNAs for quantitative PCR. J. Immunol. Methods 165, 37-46.
22. Rincón, M., and Flavell, R.A. (1994). AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO J. 13, 4370-4381.
23. Rincón, M., and Flavell, R.A. (1997). Transcriptional control of Th1/ Th2 polarization. Curr. Biol. 7, R729-R732.
24. + T cells. J. Exp. Med. 185, 461-469.
25. + T cells to effector Th1 and Th2 cells. Genes Function 1, 51-68.
26. Rincón, M., Enslen, H., Raingeaud, J., Recht, M., Zapton, T., Su, M. S.-S., Penix, L.A., Davis, R.J., and Flavell, R.A. (1998). Interferon-γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J. 17, 2817-2829.
27. Rogge, L., Barberis-Maino, L., Biffi, M., Passini, N., Presky, D.H., Gubler, U., and Sinegaglia, F. (1997). Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185, 825-831.
28. + Tcells. Annu. Rev. Immunol 12, 635-637.
29. + T cells to enhance priming for IFNγ production and diminish IL-4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90, 10188-10192.
30. Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y. (1994). JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77, 727-736.
31. Swain, S.L. (1995). Who does the polarizing? Curr. Biol. 5, 849-851.
32. Swain, S.L., Weinberg, A.D., English, M., and Huston, G. (1990). IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145, 3796-3806.
33. Swat, W., Fujikawa, K., Ganiatsas, S., Yang, D.D., Xavier, R.J., Harris, N.L., Davidson, L., Ferrini, R., Davis, R.J., Labow, M.A., et al. (1998). SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for T lymphocyte development. Immunity 8, 625-634.
34. Szabo, S.J., Dighe, A.S., Gubler, U., and Murphy, K.M. (1997). Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper (Th1) and Th2 cells. J. Exp. Med. 185, 817-824.
35. 2-terminal kinase. Proc. Natl. Acad. Sci. USA 94, 7337-7342.
36. Trinchieri, G. (1995). Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13, 251-276.
37. Wenner, C.A., Güler, M.L., Macatonia, S.E., O'Garra, A., and Murphy, K.M. (1996). Roles of IFNγ and IFNα in IL-12-induced T helper cell-1 development. J. Immunol. 156, 1442-1447.
38. Whitmarsh, A.J., and Davis, R.J. (1996). Transcription factor AP-1: regulation by mitogen activated protein kinases signal transduction pathways. J. Mol. Med. 17, 2360-2371.
39. 2 terminal kinase activation, and defects in AP-1 transcriptional activity. Proc. Natl. Acad. Sci. USA 94, 3004-3009.
40. Yang, D.D., Kuan, C.-Y., Whitmarsh, A.J., Rincón, M., Zheng, T.S., Davis, R.J., Rakic, P., and Flavell, R.A. (1997b). Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389, 865-870.