Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease

Journal of Molecular and Cellular Cardiology

Volumn 31, Issue 8, 1999, Pages 1429-1434

  Cook, Stuart A ^a,b   Sugden, Peter H ^a   Clerk, Angela ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b NHLI Division (Cardiac Medicine)   (United Kingdom)

Author keywords

c Jun N terminal kinases; Heart failure; Human; Ischemic heart disease; p38 mitogen activated protein kinases

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXPLANT; HEART; HEART FAILURE; HEART LEFT VENTRICLE; HUMAN; HUMAN TISSUE; ISCHEMIC HEART DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; RABBIT; RODENT; WESTERN BLOTTING;

EID: 0033179153     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1999.0979     Document Type: Article

References (20)

1. Aikawa R, Komuro I, Yamazaki T, Zou Y, Kudoh S, Tanaka M, Shiojima I, Hiroi Y, Yazaki Y, 1997. Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest 100: 1813-1821.
2. Bogoyevitch MA, Parker PJ, Sugden PH, 1993. Characterization of protein kinase C isotype expression in adult rat heart. Protein kinase C-ε is a major isotype present, and it is activated by phorbol esters, epinephrine and endothelin. Circ Res 72: 757-767.
3. Bogoyevitch MA, Gillespie-Brown J, Ketterman AJ, Fuller SJ, Ben-Levy R, Ashworth A, Marshall CJ, Sugden PH, 1996. Stimulation of the stress-activated mitogen-activated protein kinases subfamilies in perfused heart. p38/RK (HOG-1-related) kinases and c-Jun N-terminal kinases (JNK/SAPKs) are activated by ischemia-reperfusion. Circ Res 79: 162-173.
4. Bradford MM, 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
5. Clerk A, Bogoyevitch MA, Andersson MB, Sugden PH, 1994. Differential activation of protein kinase C iso-forms by endothelin-1 and phenylephrine, and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts. J Biol Chem 269: 32848-32857.
6. Clerk A, Fuller SJ, Michael A, Sugden PH, 1998a. Stimulation of "stress-regulated" mitogen-activated protein kinases (SAPKs/JNKs and p38-MAPKs) in perfused rat hearts by oxidative and other stresses. J Biol Chem 273: 7228-7234.
7. Clerk A, Michael A, Sugden PH, 1998b. Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes. Biochem J 333: 581-589.
8. Cohen P, 1997. The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol 7: 353-361.
9. Knight RJ, Buxton DB, 1996. Stimulation of c-Jun kinase and mitogen-activated protein kinase by ischemia and reperfusion in the perfused rat heart. Biochem Biophys Res Commun 218: 83-88.
10. Krown KA, Page MT, Nguyen C, Zechner D, Gutierrez V, Comstock KL, Glembotski CC, Quintana PJE, Sabbadini RA, 1996. Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death. J Clin Invest 98: 2854-2865.
11. Lazou A, Bogoyevitch MA, Clerk A, Fuller SJ, Marshall CJ, Sugden PH, 1994. Regulation of the mitogen-activated protein kinase cascade in adult rat heart preparations in vitro. Circ Res 75: 932-941.
12. Narula J, Haider N, Virmani R, DiSalvo TG, Kolodgie FD, Hajjar RJ, Schmidt U, Semigran MJ, Dec GW, Khaw BA, 1996. Apoptosis in myocytes in end-stage heart failure. N Engl J Med 335: 1182-1189.
13. Nemoto S, Sheng Z, Lin A, 1998a. Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy. Mol Cell Biol 18: 3518-3526.
14. Nemoto S, Xiang J, Huang S, Lin A, 1998b. Induction of apoptosis by SB202190 through inhibition of p38β mitogen-activated protein kinase. J Biol Chem 273: 16415-16420.
15. Olivetti G, Abbi R, Quaini F, Kajstura J, Cheng W, Nitahara JA, Quaini E, Di Loreto C, Beltrami CA, Krajewski S, Reed JC, Anversa P, 1997. Apoptosis in the failing human heart. N Engl J Med 336: 1131-1141.
16. Smith SB, Johnson KS, 1988. Single step purification of polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase. Gene 67: 31-40.
17. Sugden PH, Clerk A, 1998a. Cellular mechanisms of cardiac hypertrophy. J Mol Med 76: 725-746.
18. Sugden PH, Clerk A, 1998b. "Stress-responsive" mitogen-activated protein kinases in the myocardium. Circ Res 83: 345-352.
19. Wang Y, Huang S, Sah VP, Ross J, Brown JH, Han J, Chien KR, 1998. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem 273: 2161-2168.
20. Zechner D, Craig R, Hanford DS, McDonough PM, Sabbadini RA, Glembotski CC, 1998. MKK6 activates myocardial cell NF-κB and inhibits apoptosis in a p38 mitogen-activated protein kinase-dependent manner. J Biol Chem 273: 8232-8239.