Identification of c-Jun N-terminal kinase as a therapeutic target for abdominal aortic aneurysm

Annals of the New York Academy of Sciences

Volumn 1085, Issue , 2006, Pages 403-406

  Yoshimura, Koichi ^a   Aoki, Hiroki ^a   Ikeda, Yasuhiro ^a   Furutani, Akira ^a   Hamano, Kimikazu ^a   Matsuzaki, Masunori ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

AAA; Abdominal aortic aneurysm; c Jun N terminal kinase; ECM; Extracellular matrix; JNK; Matrix metalloproteinase; MMP

Indexed keywords

MATRIX METALLOPROTEINASE; STRESS ACTIVATED PROTEIN KINASE; PROTEIN KINASE INHIBITOR;

ABDOMINAL AORTA ANEURYSM; ANIMAL CELL; BIOSYNTHESIS; CELL METABOLISM; CONFERENCE PAPER; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; NONHUMAN; RAT; RNA ANALYSIS; SCREENING; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM;

AORTIC ANEURYSM, ABDOMINAL; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS;

EID: 34447635066     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1383.049     Document Type: Conference Paper

References (4)

1. THOMPSON, R.W., P.J. GERAGHTY & J.K. LEE. 2002. Abdominal aortic aneurysms: basic mechanisms and clinical implications. Curr. Probl. Surg. 39: 110-230.
2. YOSHIMURA, K. et al. 2005. Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Nat. Med. 11: 1330-1338.
3. BENNETT, B.L. et al. 2001. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. USA 98: 13681-13686.
4. YOSHIMURA, K. et al. Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase in mice. Ann. N. Y. Acad. Sci. This volume.