Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis

Science

Volumn 306, Issue 5701, 2004, Pages 1558-1561

  Ricci, Romeo ^a,b   Sumara, Grzegorz ^a,b   Sumara, Izabela ^b   Rozenberg, Izabela ^a   Kurrer, Michael ^a   Akhmedov, Alexander ^a   Hersberger, Martin ^c   Eriksson, Urs ^d   Eberli, Franz R ^a   Becher, Burkhard ^a   Borén, Jan ^e   Chen, Mian ^f   Cybulsky, Myron I ^f   Moore, Kathryn J ^g   Freeman, Mason W ^g   Wagner, Erwin F ^h   Matter, Christian M ^a   Lüscher, Thomas F ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d UNIVERSITY HOSPITAL BASEL   (Switzerland)

^e UNIVERSITY OF GOTHENBURG   (Sweden)

^f UNIVERSITY OF TORONTO   (Canada)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

^h RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; FOAMS; LIPIDS; PROTEINS;

CELLULAR PROCESSES; JUN N-TERMINAL KINASES (JNKS); LIPOPROTEINS;

GENES;

APOLIPOPROTEIN E; CD36 ANTIGEN; CHOLESTEROL; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLYCOPROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR; SCAVENGER RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; TRIACYLGLYCEROL; VASCULAR CELL ADHESION MOLECULE 1;

ENZYME;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; ENZYME ACTIVITY; FOAM CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGENS, CD36; AORTA; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; BONE MARROW TRANSPLANTATION; CELLS, CULTURED; CHOLESTEROL; CHOLESTEROL, DIETARY; DIET, ATHEROGENIC; ENDOTHELIAL CELLS; FOAM CELLS; LIPOPROTEINS, LDL; MACROPHAGES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; RECEPTORS, IMMUNOLOGIC; RECEPTORS, SCAVENGER; SCAVENGER RECEPTORS, CLASS A; T-LYMPHOCYTES;

CELLS; FOAM; GENES; LIPIDS; PHOSPHORYLATION; PROTEINS;

ANIMALIA;

EID: 9444277846     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1101909     Document Type: Article

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29. We thank P. Lerch who provided us with oxLDL; D. Zhang and P. Meier, who helped us with isolation of aortas; H. Joch and A. Jaschko, who helped us with smooth muscle cell isolation; P. Bargsten, who helped us with bone marrow transplantation experiments; W. Krek and P. J. Gough, with whom we had very fruitful scientific discussions; and R. Eferl, for critical reading. Supported by the Swiss National Science Foundation (grant no. 3100-068118), the European Union (grant no. G5RD-CT-2001-00532), the Bundesamt für Bildung und Wissenschaft, and the Swiss Heart Foundation, and the "Forschungskredit 2003" of the University of Zurich.