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Volumn 54, Issue 7, 2011, Pages 1788-1798

Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease

Author keywords

Caspase 2; Cell death; Insulin resistance; JNK; Non alcoholic steatohepatitis; Obesity; Steatosis

Indexed keywords

CASPASE 2; CASPASE 3; INSULIN; INSULIN RECEPTOR SUBSTRATE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TYROSINE;

EID: 79959755613     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2130-8     Document Type: Article
Times cited : (87)

References (47)
  • 1
    • 77951648486 scopus 로고    scopus 로고
    • From the metabolic syndrome to NAFLD or vice versa?
    • 20207596 10.1016/j.dld.2010.01.016 1:CAS:528:DC%2BC3cXotVejt78%3D
    • E Vanni E Bugianesi A Kotronen S de Minicis H Yki-Jarvinen G Svegliati-Baroni 2010 From the metabolic syndrome to NAFLD or vice versa? Dig Liver Dis 42 320 330 20207596 10.1016/j.dld.2010.01.016 1:CAS:528: DC%2BC3cXotVejt78%3D
    • (2010) Dig Liver Dis , vol.42 , pp. 320-330
    • Vanni, E.1    Bugianesi, E.2    Kotronen, A.3    De Minicis, S.4    Yki-Jarvinen, H.5    Svegliati-Baroni, G.6
  • 4
    • 70449133334 scopus 로고    scopus 로고
    • Diabetes and apoptosis: Lipotoxicity
    • 19421860 10.1007/s10495-009-0352-8 1:CAS:528:DC%2BD1MXhtlKjsrnJ
    • CM Kusminski S Shetty L Orci RH Unger PE Scherer 2009 Diabetes and apoptosis: lipotoxicity Apoptosis 14 1484 1495 19421860 10.1007/s10495-009-0352- 8 1:CAS:528:DC%2BD1MXhtlKjsrnJ
    • (2009) Apoptosis , vol.14 , pp. 1484-1495
    • Kusminski, C.M.1    Shetty, S.2    Orci, L.3    Unger, R.H.4    Scherer, P.E.5
  • 6
    • 38649124615 scopus 로고    scopus 로고
    • Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease
    • DOI 10.1053/j.gastro.2007.10.039, PII S0016508507019191
    • P Puri F Mirshahi O Cheung, et al. 2008 Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease Gastroenterology 134 568 576 18082745 10.1053/j.gastro.2007.10.039 1:CAS:528:DC%2BD1cXivFOjs7w%3D (Pubitemid 351173040)
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 568-576
    • Puri, P.1    Mirshahi, F.2    Cheung, O.3    Natarajan, R.4    Maher, J.W.5    Kellum, J.M.6    Sanyal, A.J.7
  • 7
    • 77951634226 scopus 로고    scopus 로고
    • Insulin resistance, adipose depots and gut: Interactions and pathological implications
    • 20194050 10.1016/j.dld.2010.01.013 1:CAS:528:DC%2BC3cXotVejt74%3D
    • A Gastaldelli A Natali R Vettor SG Corradini 2010 Insulin resistance, adipose depots and gut: interactions and pathological implications Dig Liver Dis 42 310 319 20194050 10.1016/j.dld.2010.01.013 1:CAS:528:DC%2BC3cXotVejt74%3D
    • (2010) Dig Liver Dis , vol.42 , pp. 310-319
    • Gastaldelli, A.1    Natali, A.2    Vettor, R.3    Corradini, S.G.4
  • 9
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance
    • GS Hotamisligil P Peraldi A Budavari R Ellis MF White BM Spiegelman 1996 IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance Science 271 665 668 8571133 10.1126/science.271.5249.665 1:CAS:528:DyaK28XptVyhtQ%3D%3D (Pubitemid 26052915)
    • (1996) Science , vol.271 , Issue.5249 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 10
    • 4544259980 scopus 로고    scopus 로고
    • Cytokine regulation of skeletal muscle fatty acid metabolism: Effect of interleukin-6 and tumor necrosis factor-α
    • DOI 10.1152/ajpendo.00150.2004
    • CR Bruce DJ Dyck 2004 Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-alpha Am J Physiol Endocrinol Metab 287 E616 E621 15149950 10.1152/ajpendo.00150.2004 1:CAS:528:DC%2BD2cXptVyitLg%3D (Pubitemid 39237888)
    • (2004) American Journal of Physiology - Endocrinology and Metabolism , vol.287 , Issue.4
    • Bruce, C.R.1    Dyck, D.J.2
  • 11
    • 0029906375 scopus 로고    scopus 로고
    • Effects of an engineered human anti-TNF-α antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM
    • F Ofei S Hurel J Newkirk M Sopwith R Taylor 1996 Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM Diabetes 45 881 885 8666137 10.2337/diabetes.45. 7.881 (Pubitemid 26225502)
    • (1996) Diabetes , vol.45 , Issue.3 SUPPL. , pp. 881-885
    • Ofei, F.1    Hurel, S.2    Newkirk, J.3    Sopwith, M.4    Taylor, R.5
  • 12
    • 0030864185 scopus 로고    scopus 로고
    • Targeted disruption of the tumor necrosis factor-α gene: Metabolic consequences in obese and nonobese mice
    • J Ventre T Doebber M Wu, et al. 1997 Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice Diabetes 46 1526 1531 9287059 10.2337/diabetes.46.9.1526 1:CAS:528: DyaK2sXlvFemsro%3D (Pubitemid 27369096)
    • (1997) Diabetes , vol.46 , Issue.9 , pp. 1526-1531
    • Ventre, J.1    Doebber, T.2    Wu, M.3    MacNaul, K.4    Stevens, K.5    Pasparakis, M.6    Kollias, G.7    Moller, D.E.8
  • 13
    • 51349156218 scopus 로고    scopus 로고
    • Insulin sensitivity: Modulation by nutrients and inflammation
    • 18769626 10.1172/JCI34260 1:CAS:528:DC%2BD1cXhtV2isb%2FE
    • S Schenk M Saberi JM Olefsky 2008 Insulin sensitivity: modulation by nutrients and inflammation J Clin Invest 118 2992 3002 18769626 10.1172/JCI34260 1:CAS:528:DC%2BD1cXhtV2isb%2FE
    • (2008) J Clin Invest , vol.118 , pp. 2992-3002
    • Schenk, S.1    Saberi, M.2    Olefsky, J.M.3
  • 14
    • 57349101675 scopus 로고    scopus 로고
    • A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
    • 19056984 10.1126/science.1160794 1:CAS:528:DC%2BD1cXhsVGltb%2FM
    • G Sabio M Das A Mora, et al. 2008 A stress signaling pathway in adipose tissue regulates hepatic insulin resistance Science 322 1539 1543 19056984 10.1126/science.1160794 1:CAS:528:DC%2BD1cXhsVGltb%2FM
    • (2008) Science , vol.322 , pp. 1539-1543
    • Sabio, G.1    Das, M.2    Mora, A.3
  • 16
    • 70449927269 scopus 로고    scopus 로고
    • Prevention of steatosis by hepatic JNK1
    • 19945406 10.1016/j.cmet.2009.09.007 1:CAS:528:DC%2BC3cXks1Clsro%3D
    • G Sabio J Cavanagh-Kyros HJ Ko, et al. 2009 Prevention of steatosis by hepatic JNK1 Cell Metab 10 491 498 19945406 10.1016/j.cmet.2009.09.007 1:CAS:528:DC%2BC3cXks1Clsro%3D
    • (2009) Cell Metab , vol.10 , pp. 491-498
    • Sabio, G.1    Cavanagh-Kyros, J.2    Ko, H.J.3
  • 18
    • 30944455145 scopus 로고    scopus 로고
    • Insulin resistance: A metabolic pathway to chronic liver disease
    • DOI 10.1002/hep.20920
    • E Bugianesi AJ McCullough G Marchesini 2005 Insulin resistance: a metabolic pathway to chronic liver disease Hepatology 42 987 1000 16250043 10.1002/hep.20920 1:CAS:528:DC%2BD2MXht1amtb3E (Pubitemid 43112663)
    • (2005) Hepatology , vol.42 , Issue.5 , pp. 987-1000
    • Bugianesi, E.1    McCullough, A.J.2    Marchesini, G.3
  • 19
    • 0344844379 scopus 로고    scopus 로고
    • Diagnosing Insulin Resistance by Simple Quantitative Methods in Subjects with Normal Glucose Metabolism
    • DOI 10.2337/diacare.26.12.3320
    • JF Acaso S Pardo JT Real, et al. 2003 Diagnosing insulin resistance by simple quantitative methods in subjects with normal glucose metabolism Diabetes Care 26 3320 3325 10.2337/diacare.26.12.3320 (Pubitemid 37466894)
    • (2003) Diabetes Care , vol.26 , Issue.12 , pp. 3320-3325
    • Ascaso, J.F.1    Pardo, S.2    Real, J.T.3    Lorente, R.I.4    Priego, A.5    Carmena, R.6
  • 21
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference
    • DOI 10.1053/jhep.2003.50193
    • BA Neuschwander-Tetri SH Caldwell 2003 Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference Hepatology 37 1202 1219 12717402 10.1053/jhep.2003.50193 (Pubitemid 36538699)
    • (2003) Hepatology , vol.37 , Issue.5 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 23
    • 56649094325 scopus 로고    scopus 로고
    • Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
    • 18956292 10.1055/s-0028-1091980 1:CAS:528:DC%2BD1cXhsVKju7fF
    • H Malhi GJ Gores 2008 Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease Semin Liver Dis 28 360 369 18956292 10.1055/s-0028-1091980 1:CAS:528:DC%2BD1cXhsVKju7fF
    • (2008) Semin Liver Dis , vol.28 , pp. 360-369
    • Malhi, H.1    Gores, G.J.2
  • 24
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis
    • DOI 10.1016/S0016-5085(03)00907-7
    • AE Feldstein A Canbay P Angulo, et al. 2003 Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis Gastroenterology 125 437 443 12891546 10.1016/S0016-5085(03)00907-7 (Pubitemid 36929425)
    • (2003) Gastroenterology , vol.125 , Issue.2 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3    Taniai, M.4    Burgart, L.J.5    Lindor, K.D.6    Gores, G.J.7
  • 25
    • 0028903232 scopus 로고
    • Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects
    • 7537758 10.1172/JCI117909 1:CAS:528:DyaK2MXltlWrtLg%3D
    • LJ Goodyear F Giorgino LA Sherman J Carey RJ Smith GL Dohm 1995 Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects J Clin Invest 95 2195 2204 7537758 10.1172/JCI117909 1:CAS:528:DyaK2MXltlWrtLg%3D
    • (1995) J Clin Invest , vol.95 , pp. 2195-2204
    • Goodyear, L.J.1    Giorgino, F.2    Sherman, L.A.3    Carey, J.4    Smith, R.J.5    Dohm, G.L.6
  • 26
    • 51249114837 scopus 로고    scopus 로고
    • Molecular determinants of insulin resistance, cell apoptosis and lipid accumulation in non-alcoholic steatohepatitis
    • 18063353 10.1016/j.numecd.2007.08.002 1:CAS:528:DC%2BD1cXhsV2htL7J
    • S Piro L Spadaro M Russello, et al. 2008 Molecular determinants of insulin resistance, cell apoptosis and lipid accumulation in non-alcoholic steatohepatitis Nutr Metab Cardiovasc Dis 18 545 552 18063353 10.1016/j.numecd.2007.08.002 1:CAS:528:DC%2BD1cXhsV2htL7J
    • (2008) Nutr Metab Cardiovasc Dis , vol.18 , pp. 545-552
    • Piro, S.1    Spadaro, L.2    Russello, M.3
  • 27
    • 77149168465 scopus 로고    scopus 로고
    • Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease
    • 20176643 10.1136/gut.2009.190801 1:CAS:528:DC%2BC3cXjsFeqsb8%3D
    • P Dongiovanni L Valenti R Rametta, et al. 2010 Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease Gut 59 267 273 20176643 10.1136/gut.2009.190801 1:CAS:528:DC%2BC3cXjsFeqsb8%3D
    • (2010) Gut , vol.59 , pp. 267-273
    • Dongiovanni, P.1    Valenti, L.2    Rametta, R.3
  • 28
    • 33845244172 scopus 로고    scopus 로고
    • Pathophysiology of insulin resistance
    • DOI 10.1016/j.beem.2006.09.007, PII S1521690X06000789, Hormone Resistance Syndromes
    • G Sesti 2006 Pathophysiology of insulin resistance Best Pract Res Clin Endocrinol Metab 20 665 679 17161338 10.1016/j.beem.2006.09.007 1:CAS:528:DC%2BD28Xht12ksb%2FO (Pubitemid 44856489)
    • (2006) Best Practice and Research: Clinical Endocrinology and Metabolism , vol.20 , Issue.4 , pp. 665-679
    • Sesti, G.1
  • 29
    • 70449724835 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance: Role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation
    • 19683471 10.1016/j.coph.2009.07.004 1:CAS:528:DC%2BD1MXhsVGqs7vJ
    • JF Tanti J Jager 2009 Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation Curr Opin Pharmacol 9 753 762 19683471 10.1016/j.coph.2009.07. 004 1:CAS:528:DC%2BD1MXhsVGqs7vJ
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 753-762
    • Tanti, J.F.1    Jager, J.2
  • 31
    • 54749148763 scopus 로고    scopus 로고
    • 2-terminal kinase activation and elevated proapoptotic Bax
    • 18806094 1:CAS:528:DC%2BD1cXht1Sgu7fK
    • 2-terminal kinase activation and elevated proapoptotic Bax J Nutr 138 1866 1871 18806094 1:CAS:528:DC%2BD1cXht1Sgu7fK
    • (2008) J Nutr , vol.138 , pp. 1866-1871
    • Wang, Y.1    Ausman, L.M.2    Russell, R.M.3    Greenberg, A.S.4    Wang, X.D.5
  • 32
    • 33744948514 scopus 로고    scopus 로고
    • Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
    • DOI 10.1074/jbc.M510660200
    • H Malhi SF Bronk NW Werneburg GJ Gores 2006 Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis J Biol Chem 281 12093 12101 16505490 10.1074/jbc.M510660200 1:CAS:528:DC%2BD28Xjslensb0%3D (Pubitemid 43855473)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.17 , pp. 12093-12101
    • Malhi, H.1    Bronk, S.F.2    Werneburg, N.W.3    Gores, G.J.4
  • 33
    • 21344458172 scopus 로고    scopus 로고
    • Apoptosis in alcoholic and nonalcoholic steatohepatitis
    • AE Feldstein GJ Gores 2005 Apoptosis in alcoholic and nonalcoholic steatohepatitis Front Biosci 10 3093 3099 15970563 10.2741/1765 1:CAS:528:DC%2BD2MXntFGit7c%3D (Pubitemid 40910547)
    • (2005) Frontiers in Bioscience , vol.10 , Issue.SUPPL. 3 , pp. 3093-3099
    • Feldstein, A.E.1    Gores, G.J.2
  • 34
    • 70449119226 scopus 로고    scopus 로고
    • Diabetes and apoptosis: Liver
    • 19544096 10.1007/s10495-009-0366-2 1:CAS:528:DC%2BD1MXhtlKjsrbM
    • JM Schattenberg M Schuchmann 2009 Diabetes and apoptosis: liver Apoptosis 14 1459 1471 19544096 10.1007/s10495-009-0366-2 1:CAS:528:DC%2BD1MXhtlKjsrbM
    • (2009) Apoptosis , vol.14 , pp. 1459-1471
    • Schattenberg, J.M.1    Schuchmann, M.2
  • 35
    • 77249156848 scopus 로고    scopus 로고
    • The unpredictable caspase-2: What can it do?
    • 20061149 10.1016/j.tcb.2009.12.006 1:CAS:528:DC%2BC3cXisFemu7w%3D
    • H Vakifahmetoglu-Norberg B Zhivotovsky 2010 The unpredictable caspase-2: what can it do? Trends Cell Biol 20 150 159 20061149 10.1016/j.tcb.2009.12.006 1:CAS:528:DC%2BC3cXisFemu7w%3D
    • (2010) Trends Cell Biol , vol.20 , pp. 150-159
    • Vakifahmetoglu-Norberg, H.1    Zhivotovsky, B.2
  • 37
    • 67349265126 scopus 로고    scopus 로고
    • High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue
    • 19212806 10.1007/s00726-009-0246-7 1:CAS:528:DC%2BD1MXltlemtLs%3D
    • W Jobgen WJ Fu H Gao, et al. 2009 High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue Amino Acids 37 187 198 19212806 10.1007/s00726-009-0246-7 1:CAS:528:DC%2BD1MXltlemtLs%3D
    • (2009) Amino Acids , vol.37 , pp. 187-198
    • Jobgen, W.1    Fu, W.J.2    Gao, H.3
  • 38
    • 79955787110 scopus 로고    scopus 로고
    • Octreotide induces caspase activation and apoptosis in human hepatoma HepG2 cells
    • 21253389 10.3748/wjg.v17.i3.313 1:CAS:528:DC%2BC3MXhvFOls78%3D
    • NJ Tsagarakis I Drygiannakis AG Batistakis G Kolios EA Kouroumalis 2011 Octreotide induces caspase activation and apoptosis in human hepatoma HepG2 cells World J Gastroenterol 17 313 321 21253389 10.3748/wjg.v17.i3.313 1:CAS:528:DC%2BC3MXhvFOls78%3D
    • (2011) World J Gastroenterol , vol.17 , pp. 313-321
    • Tsagarakis, N.J.1    Drygiannakis, I.2    Batistakis, A.G.3    Kolios, G.4    Kouroumalis, E.A.5
  • 39
    • 40849099994 scopus 로고    scopus 로고
    • Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic beta-cell line NES2Y
    • 18272185 10.1016/j.lfs.2007.12.023
    • V Furstova T Kopska RF James J Kovar 2008 Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic beta-cell line NES2Y Life Sci 82 684 691 18272185 10.1016/j.lfs.2007.12.023
    • (2008) Life Sci , vol.82 , pp. 684-691
    • Furstova, V.1    Kopska, T.2    James, R.F.3    Kovar, J.4
  • 40
    • 64649104158 scopus 로고    scopus 로고
    • Banting Lecture. from the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
    • 19336687 10.2337/db09-9028 1:CAS:528:DC%2BD1MXktleitbw%3D
    • RA Defronzo 2009 Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus Diabetes 58 773 795 19336687 10.2337/db09-9028 1:CAS:528:DC%2BD1MXktleitbw%3D
    • (2009) Diabetes , vol.58 , pp. 773-795
    • Defronzo, R.A.1
  • 43
    • 65649098029 scopus 로고    scopus 로고
    • Phosphorylation of IRS proteins, insulin action, and insulin resistance
    • 18728222 10.1152/ajpendo.90437.2008 1:CAS:528:DC%2BD1MXkvVyhsbY%3D
    • S Boura-Halfon Y Zick 2009 Phosphorylation of IRS proteins, insulin action, and insulin resistance Am J Physiol Endocrinol Metab 296 E581 E591 18728222 10.1152/ajpendo.90437.2008 1:CAS:528:DC%2BD1MXkvVyhsbY%3D
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Boura-Halfon, S.1    Zick, Y.2
  • 44
    • 58949093454 scopus 로고    scopus 로고
    • Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance
    • 19053047 10.1002/hep.22578 1:CAS:528:DC%2BD1MXhsFGlt7Y%3D
    • R Singh Y Wang Y Xiang KE Tanaka WA Gaarde MJ Czaja 2009 Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance Hepatology 49 87 96 19053047 10.1002/hep.22578 1:CAS:528: DC%2BD1MXhsFGlt7Y%3D
    • (2009) Hepatology , vol.49 , pp. 87-96
    • Singh, R.1    Wang, Y.2    Xiang, Y.3    Tanaka, K.E.4    Gaarde, W.A.5    Czaja, M.J.6
  • 46
    • 44149119740 scopus 로고    scopus 로고
    • Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice
    • 18461459 10.1007/s10495-008-0216-7 1:CAS:528:DC%2BD1cXlvFaisrk%3D
    • M Braga AP Sinha Hikim S Datta, et al. 2008 Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice Apoptosis 13 822 832 18461459 10.1007/s10495-008-0216-7 1:CAS:528:DC%2BD1cXlvFaisrk%3D
    • (2008) Apoptosis , vol.13 , pp. 822-832
    • Braga, M.1    Sinha Hikim, A.P.2    Datta, S.3
  • 47
    • 78650814490 scopus 로고    scopus 로고
    • Modulation of amyloid-beta peptide-induced toxicity through inhibition of JNK nuclear localization and caspase-2 activation
    • 20847398 1:CAS:528:DC%2BC3cXhsVektLjN
    • RJ Viana RM Ramalho AF Nunes CJ Steer CM Rodrigues 2010 Modulation of amyloid-beta peptide-induced toxicity through inhibition of JNK nuclear localization and caspase-2 activation J Alzheimers Dis 22 557 568 20847398 1:CAS:528:DC%2BC3cXhsVektLjN
    • (2010) J Alzheimers Dis , vol.22 , pp. 557-568
    • Viana, R.J.1    Ramalho, R.M.2    Nunes, A.F.3    Steer, C.J.4    Rodrigues, C.M.5


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