Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

Nature

Volumn 437, Issue 7056, 2005, Pages 281-285

  Nateri, Abdolrahman S ^a   Spencer Dene, Bradley ^a,b   Behrens, Axel ^a  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOLOGICAL ORGANS; GENETIC ENGINEERING; PHOSPHORS; PROTEINS;

C-JUN N-TERMINAL KINASES (JNK); GENETIC ABROGATION; PHOSPHORYLATED; TUMORIGENESIS;

TUMORS;

BETA CATENIN; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; T CELL FACTOR 4; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; APC PROTEIN; CATNB PROTEIN, MOUSE; CTNNB1 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; DNA BINDING PROTEIN; SIGNAL PEPTIDE; TCF4 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; WNT PROTEIN;

MEDICINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GENETICS; CARCINOGENESIS; CHROMATIN; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HOMEOBOX; IMMUNOPRECIPITATION; INTESTINE CARCINOMA; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REPORTER GENE; ANIMAL; C57BL MOUSE; CELL LINE; CELL STRAIN 3T3; CHROMATIN IMMUNOPRECIPITATION; DRUG ANTAGONISM; GENETICS; HUMAN; INTESTINE TUMOR; METABOLISM; ONCOGENE; PATHOLOGY; PHOSPHORYLATION; PROTEIN BINDING; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; BETA CATENIN; CELL LINE; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; GENES, APC; GENES, JUN; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTESTINAL NEOPLASMS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, INBRED C57BL; NIH 3T3 CELLS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-JUN; SIGNAL TRANSDUCTION; TCF TRANSCRIPTION FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; WNT PROTEINS;

EID: 24644478136     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03914     Document Type: Article

References (24)

1. Eferl, R. & Wagner, E. F. AP-1: a double-edged sword in tumorigenesis. Nature Rev. Cancer 3, 859-868 (2003).
2. Davis, R. J. Signal transduction by the JNK group of MAP kinases. Cell 103, 239-252 (2000).
3. Behrens, A., Sibilia, M. & Wagner, E. F. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nature Genet. 21, 326-329 (1999).
4. Behrens, A. et al. Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J. 21, 1782-1790 (2002).
5. el Marjou, F. et al. Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 39, 186-193 (2004).
6. Moser, A. R. et al. ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias. Proc. Natl Acad. Sci. USA 90, 8977-8981 (1993).
7. Giles, R. H., van Es, J. H. & Clevers, H. Caught up in a Wnt storm: Wnt signalling in cancer. Biochim. Biophys. Acta 1653, 1-24 (2003).
8. Fodde, R. The APC gene in colorectal cancer. Eur. J. Cancer 38, 867-871 (2002).
9. Veeman, M. T., Axelrod, J. D. & Moon, R. T. A second canon. Functions and mechanisms of β-catenin-independent Wnt signalling. Dev. Cell 5, 367-377 (2003).
10. Angel, P., Hattori, K., Smeal, T. & Karin, M. The jun proto-oncogene is positively autoregulated by its product, Jun/AP1. Cell 55, 875-885 (1988).
11. Behrens, A., Jochum, W., Sibilia, M. & Wagner, E. F. Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation. Oncogene 19, 2657-2663 (2000).
12. Nateri, A. S., Riera-Sans, L., Da Costa, C. & Behrens, A. The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signalling. Science 303, 1374-1378 (2004).
13. Stein, B. et al. Ultraviolet-radiation induced c-jun gene transcription: two AP-1 like binding sites mediate the response. Photochem. Photobiol. 55, 409-415 (1992).
14. Staal, F. J. et al. Wnt target genes identified by DNA microarrays in immature CD34+ thymocytes regulate proliferation and cell adhesion. J. Immunol. 172, 1099-1108 (2004).
15. Mann, B. et al. Target genes of β-catenin-T cell-factor/lymphoid- enhancer-factor signalling in human colorectal carcinomas. Proc. Natl Acad. Sci. USA 96, 1603-1608 (1999).
16. He, T. C. et al. Identification of C-MYC as a target of the APC pathway. Science 281, 1509-1512 (1998).
17. Wada, T. et al. MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nature Cell Biol. 6, 215-226 (2004).
18. Tetsu, O. & McCormick, F. β-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 422-426 (1999).
19. Raivich, G. et al. The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron 43, 57-67 (2004).
20. Wielenga, V. J. et al. Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am. J. Pathol. 154, 515-523 (1999).
21. Sansom, O. J. et al. Loss of Apc in vivo immediately perturbs Wnt signalling, differentiation, and migration. Genes Dev. 18, 1385-1390 (2004).
22. Bogoyevitch, M. A., Boehm, I., Oakley, A., Ketterman, A. J. & Barr, R. K. Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential. Biochim. Biophys. Acta 1697, 89-101 (2004).
23. Borsello, T. et al. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nature Med 9, 1180-1186 (2003).
24. Alberts, A. S., Geneste, O. & Treisman, R. Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation. Cell 92, 475-487 (1998).