c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation

Journal of Experimental Medicine

Volumn 193, Issue 3, 2001, Pages 317-328

  Sabapathy, Kanaga ^a,d   Kallunki, Tuula ^b,e   David, Jean Pierre ^a   Graef, Isabella ^c   Karin, Michael ^b   Wagner, Erwin F ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^e DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

Apoptosis; JNK1; JNK2; Proliferation; T lymphocyte

Indexed keywords

CD28 ANTIGEN; INTERLEUKIN 2; NUCLEAR FACTOR; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; CD3 ANTIGEN; DNA BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 9; NUCLEAR PROTEIN; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL MATURATION; DNA BINDING; ENZYME ACTIVITY; IMMEDIATE EARLY GENE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; THYMOCYTE; ANIMAL; B LYMPHOCYTE; C57BL MOUSE; CELL DIFFERENTIATION; CELL DIVISION; CELL SURVIVAL; CYTOLOGY; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD3; APOPTOSIS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL DIVISION; CELL SURVIVAL; DNA-BINDING PROTEINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; MITOGEN-ACTIVATED PROTEIN KINASES; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PHOSPHORYLATION; T-LYMPHOCYTES; TRANSCRIPTION FACTORS;

EID: 0035808769     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.3.317     Document Type: Article

References (42)

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3. Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes
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5. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling
6. 2-terminal kinase and mitogen-activated protein kinase signaling pathways
7. + T cells
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26. + T cells to Th1 cells requires MAP kinase JNK2
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