Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats

Immunology

Volumn 112, Issue 3, 2004, Pages 446-453

  Eynott, Paul R ^a   Xu, Li ^b   Bennett, Brydon L ^b   Noble, Alistair ^c   Leung, Sum Yee ^a   Nath, Puneeta ^a   Groneberg, David A ^a   Adcock, Ian M ^a   Chung, K Fan ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b CELGENE CORPORATION   (United States)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Asthma; Bronchial hyperresponsiveness; Enzymes; Inflammation; Inhibitors; Jun N terminal kinase; SP600125

Indexed keywords

ALLERGEN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; IMMUNOGLOBULIN E; INTERLEUKIN 1BETA; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

AIRWAY; ALLERGY; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DRUG EFFECT; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME INHIBITION; EOSINOPHIL; EXPOSURE; HYPERSENSITIVITY; LUNG LAVAGE; MACROPHAGE; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROVOCATION TEST; RAT; SENSITIZATION; T LYMPHOCYTE ACTIVATION;

ALLERGENS; ANIMALS; ANTHRACENES; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CYTOKINES; ENZYME ACTIVATION; EOSINOPHILS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKOCYTE COUNT; LEUKOCYTES, MONONUCLEAR; LUNG; MACROPHAGES; MALE; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, ANIMAL; NEUTROPHILS; OVALBUMIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, INBRED BN;

EID: 3042752921     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2004.01887.x     Document Type: Article

References (33)

1. Chung KF. Role played by inflammation in the hyperreactivity of the airways in asthma. Thorax 1986; 41:657-62.
2. Robinson DS, Hamid Q, Ying S et al. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326:298-304.
3. Gavett SH, O'Hearn DJ, Li X, Huang SK, Finkelman FD, Wills Karp M. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J Exp Med 1995; 182:1527-36.
4. Foster PS, Hogan SP, Ramsay AJ, Matthaei KI, Young IG. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model [see comments]. J Exp Med 1996; 183:195-201.
5. Huang TJ, Macary PA, Eynott P et al. Allergen-specific Th1 cells counteract efferent Th2 cell-dependent bronchial hyperresponsiveness and eosinophilic inflammation partly via IFN-gamma. J Immunol 2001; 166:207-17.
6. Davis RJ. Signal transduction by the c-Jun N-terminal kinase. Biochem Soc Symp 1999; 64:1-12.
7. Whitmarsh AJ, Davis RJ. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 1996; 74:589-607.
8. Zhang P, Miller BS, Rosenzweig SA, Bhat NR. Activation of C-jun N-terminal kinase/stress-activated protein kinase in primary glial cultures. J Neurosci Res 1996; 46:114-21.
9. Kallunki T, Deng T, Hibi M, Karin M. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell 1996; 87:929-39.
10. Chung KF, Barnes PJ. Cytokines in asthma. Thorax 1999; 54:825-57.
11. Su B, Jacinto E, Hibi M, Kallunki T, Karin M, Ben-Neriah Y. JNK is involved in signal integration during co-stimulation of T lymphocytes. Cell 1994; 77:727-36.
12. Nishina H, Bachmann M, Oliveira-dos-Santos AJ et al. Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J Exp Med 1997; 186:941-53.
13. Dong C, Yang DD, Wysk M, Whitmarsh AJ, Davis RJ, Flavell RA. Defective T cell differentiation in the absence of Ink1. Science 1998; 282:2092-5.
14. Kawakami Y, Hartman SE, Holland PM, Cooper JA, Kawakami T. Multiple signaling pathways for the activation of JNK in mast cells: involvement of Bruton's tyrosine kinase, protein kinase C, and JNK kinases, SEK1 and MKK7. J Immunol 1998; 161:1795-802.
15. Kontoyiannis D, Pasparakis M, Pizarro TT, Cominelli F, Kollias G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 1999; 10:387-98.
16. Min W, Pober JS. TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ ATF2 pathways. J Immunol 1997; 159:3508-18.
17. Haczku A, Moqbel R, Sun J et al. T-cell subsets and activation in bronchial mucosa of sensitised Brown-Norway rats after single allergen exposure. Immunol 1995; 85:598-603.
18. Bennett BL, Sasaki DT, Murray BW et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 2001; 98:13681-6.
19. Han Z, Boyle DL, Chang L et al. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 2001; 108:73-81.
20. Huang TJ, Adcock IM, Chung KF. A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat. Br J Pharmacol 2001; 134: 1029-36.
21. Haczku A, Chung KF, Barnes PJ, Kay AB, Moqbel R. Airway hyperresponsiveness, elevation of serum IgE and activation of T cells in Brown-Norway rats. Immunol 1995; 85:598-603.
22. Nonaka T, Mitsuhashi H, Takahashi K, Sugiyama H, Kishimoto T. Effect of TEI-9874, an inhibitor of immunoglobulin E production, on allergen-induced asthmatic model in rats. Eur J Pharmacol 2000; 402:287-95.
23. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nat 1970; 227:680-5.
24. Sanderson CJ. Interleukin-5, eosinophils and disease. Blood 1992; 79:3101-9.
25. Hamelmann E, Oshiba A, Loader J et al. Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization. Am J Respir Crit Care Med 1997; 155:819-25.
26. Snapper CM, Finkelman FD, Paul WE. Regulation of IgG1 and IgE production by interleukin-4. Immunol Rev 1988; 102:51-75.
27. Sakata N, Patel HR, Terada N, Aruffo A, Johnson GL, Gelfand EW. Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells. J Biol Chem 1995; 270:30823-8.
28. Liu SF, Haddad E-B, Adcock IA et al. Inducible nitric oxide synthase after sensitisation and allergen challenge of Brown-Norway rat lung. Br J Pharmacol 1997; 159:1241-6.
29. De Cesaris P, Starace D, Starace G, Filippini A, Stefanini M, Ziparo E. Activation of Jun N-terminal kinase/stress-activated protein kinase pathway by tumor necrosis factor alpha leads to intercellular adhesion molecule-1 expression. J Biol Chem 1999; 274:28978-82.
30. Nakajima H, Sano H, Nishimura T, Yoshida S, Iwamoto I. Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. J Exp Med 1994; 179:1145-54.
31. Escott KJ, Belvisi MG, Birrell MA, Webber SE, Foster ML, Sargent CA. Effect of p38 kinase inhibitor, SB 203580, on allergic airway inflammation in the rat. Br J Pharmacol 2000; 131:173-6.
32. Adachi T, Choudhury BK, Stafford S, Sur S, Alam R. The differential role of extracellular signal-regulated kinases and p38 mitogen-activated protein kinase in eosinophil functions. J Immunol 2000; 165:2198-204.
33. Eynott PR, Nath P, Leung SY, Adcock IM, Bennett BL, Chung KF. Allergen-induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N-terminal kinase. Br J Pharmacol 2003; 140:1371-80.