-
1
-
-
25444474703
-
Mitochondria take center stage in aging and neurodegeneration
-
DOI 10.1002/ana.20624
-
Beal M. F., Mitochondria take center stage in aging and neurodegeneration Annals of Neurology 2005 58 4 495 505 (Pubitemid 41377212)
-
(2005)
Annals of Neurology
, vol.58
, Issue.4
, pp. 495-505
-
-
Beal, M.F.1
-
2
-
-
0034961888
-
Role of reactive oxygen species in cell signalling pathways
-
DOI 10.1042/0300-5127:0290345
-
Hancock J. T., Desikan R., Neill S. J., Role of reactive oxygen species in cell signalling pathways Biochemical Society Transactions 2001 29 2 345 350 (Pubitemid 32587530)
-
(2001)
Biochemical Society Transactions
, vol.29
, Issue.2
, pp. 345-350
-
-
Hancock, J.T.1
Desikan, R.2
Neill, S.J.3
-
3
-
-
0028068186
-
Free radicals, antioxidants, and human disease: Curiosity, cause, or consequence?
-
Halliwell B., Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 1994 344 8924 721 724
-
(1994)
Lancet
, vol.344
, Issue.8924
, pp. 721-724
-
-
Halliwell, B.1
-
4
-
-
0010471495
-
Cellular defenses against damage from reactive oxygen species
-
Yu B. P., Cellular defenses against damage from reactive oxygen species Physiological Reviews 1994 74 1 139 162 (Pubitemid 24045676)
-
(1994)
Physiological Reviews
, vol.74
, Issue.1
, pp. 139-162
-
-
Yu, B.P.1
-
5
-
-
0031980388
-
Role of oxidative DNA damage in cancer initiation and promotion
-
Poulsen H. E., Prieme H., Loft S., Role of oxidative DNA damage in cancer initiation and promotion European Journal of Cancer Prevention 1998 7 1 9 16 (Pubitemid 28164131)
-
(1998)
European Journal of Cancer Prevention
, vol.7
, Issue.1
, pp. 9-16
-
-
Poulsen, H.E.1
Prieme, H.2
Loft, S.3
-
6
-
-
0001047585
-
Reactive oxygen species: Oxidative damage and pathogenesis
-
Uday B., Dipak D., Ranajit B. K., Reactive oxygen species: oxidative damage and pathogenesis Current Science 1999 77 5 658 666
-
(1999)
Current Science
, vol.77
, Issue.5
, pp. 658-666
-
-
Uday, B.1
Dipak, D.2
Ranajit, B.K.3
-
7
-
-
33750347347
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
-
DOI 10.1038/nature05292, PII NATURE05292
-
Lin M. T., Beal M. F., Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases Nature 2006 443 7113 787 795 (Pubitemid 44622683)
-
(2006)
Nature
, vol.443
, Issue.7113
, pp. 787-795
-
-
Lin, M.T.1
Beal, M.F.2
-
8
-
-
0031694722
-
Chronic lung disease: The role of oxidative stress
-
DOI 10.1159/000047031
-
Saugstad O. D., Chronic lung disease: the role of oxidative stress Biology of the Neonate 1998 74 1 21 28 (Pubitemid 28425288)
-
(1998)
Biology of the Neonate
, vol.74
, Issue.SUPPL. 1
, pp. 21-28
-
-
Saugstad, O.D.1
-
9
-
-
23444438707
-
Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms
-
DOI 10.1016/j.freeradbiomed.2005.04.020, PII S0891584905002121
-
Kennedy G., Spence V. A., McLaren M., Hill A., Underwood C., Belch J. J. F., Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms Free Radical Biology and Medicine 2005 39 5 584 589 (Pubitemid 41112100)
-
(2005)
Free Radical Biology and Medicine
, vol.39
, Issue.5
, pp. 584-589
-
-
Kennedy, G.1
Spence, V.A.2
McLaren, M.3
Hill, A.4
Underwood, C.5
Belch, J.J.F.6
-
10
-
-
67650601390
-
Biomarkers of oxidative stress in heart failure
-
Trachtenberg B. H., Hare J. M., Biomarkers of oxidative stress in heart failure Heart Failure Clinics 2009 5 4 561 577
-
(2009)
Heart Failure Clinics
, vol.5
, Issue.4
, pp. 561-577
-
-
Trachtenberg, B.H.1
Hare, J.M.2
-
11
-
-
43249112515
-
Role of inflammatory markers in brain ischemia
-
DOI 10.1097/WCO.0b013e3282ffafbf, PII 0001905220080600000022
-
Rodrguez-Yez M., Castillo J., Role of inflammatory markers in brain ischemia Current Opinion in Neurology 2008 21 3 353 357 (Pubitemid 351653988)
-
(2008)
Current Opinion in Neurology
, vol.21
, Issue.3
, pp. 353-357
-
-
Rodriguez-Yanez, M.1
Castillo, J.2
-
12
-
-
0030048496
-
Oxidative stress and diabetic vascular complications
-
Giugliano D., Ceriello A., Paolisso G., Oxidative stress and diabetic vascular complications Diabetes Care 1996 19 3 257 267 (Pubitemid 26070354)
-
(1996)
Diabetes Care
, vol.19
, Issue.3
, pp. 257-267
-
-
Giugliano, D.1
Ceriello, A.2
Paolisso, G.3
-
13
-
-
0023024981
-
Aldose reductase in the diabetic eye. XLIII Edward Jackson Memorial Lecture
-
Kinoshita J. H., Aldose reductase in the diabetic eye. XLIII Edward Jackson Memorial Lecture American Journal of Ophthalmology 1986 102 6 685 692 (Pubitemid 17196264)
-
(1986)
American Journal of Ophthalmology
, vol.102
, Issue.6
, pp. 685-692
-
-
Kinoshita, J.H.1
-
14
-
-
0026703165
-
Lipoprotein glycation and its metabolic consequences
-
Lyons T. J., Lipoprotein glycation and its metabolic consequences Diabetes 1992 41 2 67 73
-
(1992)
Diabetes
, vol.41
, Issue.2
, pp. 67-73
-
-
Lyons, T.J.1
-
15
-
-
0027183867
-
Glycosylated low density lipoprotein is more sensitive to oxidation: Implications for the diabetic patient?
-
Bowie A., Owens D., Collins P., Johnson A., Tomkin G. H., Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient? Atherosclerosis 1993 102 1 63 67 (Pubitemid 23269731)
-
(1993)
Atherosclerosis
, vol.102
, Issue.1
, pp. 63-67
-
-
Bowie, A.1
Owens, D.2
Collins, P.3
Johnson, A.4
Tomkin, G.H.5
-
16
-
-
0025732948
-
Role of oxidative stress in development of complications in diabetes
-
Baynes J. W., Role of oxidative stress in development of complications in diabetes Diabetes 1991 40 4 405 412
-
(1991)
Diabetes
, vol.40
, Issue.4
, pp. 405-412
-
-
Baynes, J.W.1
-
17
-
-
33746868374
-
Oxidative damage to RNA in neurodegenerative diseases
-
Nunomura A., Honda K., Takeda A., Hirai K., Zhu X., Smith M., Perry G., Oxidative damage to RNA in neurodegenerative diseases Journal of Biomedicine and Biotechnology 2006 2006 6
-
(2006)
Journal of Biomedicine and Biotechnology
, vol.2006
, pp. 6
-
-
Nunomura, A.1
Honda, K.2
Takeda, A.3
Hirai, K.4
Zhu, X.5
Smith, M.6
Perry, G.7
-
18
-
-
18744374615
-
Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?
-
DOI 10.1016/S0891-5849(02)01113-9, PII S0891584902011139
-
Perry G., Nunomura A., Hirai K., Zhu X., Prez M., Avila J., Castellani R. J., Atwood C. S., Aliev G., Sayre L. M., Takeda A., Smith M. A., Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radical Biology and Medicine 2002 33 11 1475 1479 (Pubitemid 35351590)
-
(2002)
Free Radical Biology and Medicine
, vol.33
, Issue.11
, pp. 1475-1479
-
-
Perry, G.1
Nunomura, A.2
Hirai, K.3
Zhu, X.4
Prez, M.5
Avila, J.6
Castellani, R.J.7
Atwood, C.S.8
Aliev, G.9
Sayre, L.M.10
Takeda, A.11
Smith, M.A.12
-
19
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe D. J., Alzheimer's disease: genes, proteins, and therapy Physiological Reviews 2001 81 2 741 766 (Pubitemid 32267077)
-
(2001)
Physiological Reviews
, vol.81
, Issue.2
, pp. 741-766
-
-
Selkoe, D.J.1
-
20
-
-
79959886270
-
Amyloid precursor protein processing and Alzheimers disease
-
O'Brien R. J., Wong P. C., Amyloid precursor protein processing and Alzheimers disease Annual Review of Neuroscience 2010 22 36 185 204
-
(2010)
Annual Review of Neuroscience
, vol.22
, Issue.36
, pp. 185-204
-
-
O'Brien, R.J.1
Wong, P.C.2
-
21
-
-
0036379174
-
A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells
-
Zheng Y. L., Li B. S., Amin N. D., Albers W., Pant H. C., A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells European Journal of Biochemistry 2002 269 18 4427 4434
-
(2002)
European Journal of Biochemistry
, vol.269
, Issue.18
, pp. 4427-4434
-
-
Zheng, Y.L.1
Li, B.S.2
Amin, N.D.3
Albers, W.4
Pant, H.C.5
-
22
-
-
0031741247
-
New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry
-
Hanger D. P., Betts J. C., Loviny T. L. F., Blackstock W. P., Anderton B. H., New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry Journal of Neurochemistry 1998 71 6 2465 2476 (Pubitemid 28531257)
-
(1998)
Journal of Neurochemistry
, vol.71
, Issue.6
, pp. 2465-2476
-
-
Hanger, D.P.1
Betts, J.C.2
Loviny, T.L.F.3
Blackstock, W.P.4
Anderton, B.H.5
-
24
-
-
55549124552
-
Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein
-
Rudrabhatla P., Zheng Y. L., Amin N. D., Kesavapany S., Albers W., Pant H. C., Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein Journal of Biological Chemistry 2008 283 39 26737 26747
-
(2008)
Journal of Biological Chemistry
, vol.283
, Issue.39
, pp. 26737-26747
-
-
Rudrabhatla, P.1
Zheng, Y.L.2
Amin, N.D.3
Kesavapany, S.4
Albers, W.5
Pant, H.C.6
-
25
-
-
43049143027
-
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy
-
DOI 10.1172/JCI34308
-
Lim J., Balastik M., Lee T. H., Nakamura K., Liou Y. C., Sun A., Finn G., Pastorino L., Lee V. M. Y., Lu K. P., Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy Journal of Clinical Investigation 2008 118 5 1877 1889 (Pubitemid 351632390)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.5
, pp. 1877-1889
-
-
Lim, J.1
Balastik, M.2
Lee, T.H.3
Nakamura, K.4
Liou, Y.-C.5
Sun, A.6
Finn, G.7
Pastorino, L.8
Lee, V.M.-Y.9
Lu, K.P.10
-
26
-
-
0043069764
-
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
-
DOI 10.1038/nature01832
-
Liou Y. C., Sun A., Ryo A., Zhou X. Z., Yu Z. X., Huang H. K., Uchida T., Bronson R., Bing G., Li X., Hunter T., Lu K. P., Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration Nature 2003 424 6948 556 561 (Pubitemid 36975777)
-
(2003)
Nature
, vol.424
, Issue.6948
, pp. 556-561
-
-
Liou, Y.-C.1
Sun, A.2
Ryo, A.3
Zhou, X.Z.4
Yu, Z.-X.5
Huang, H.-K.6
Uchida, T.7
Bronson, R.8
Bing, G.9
Li, X.10
Hunter, T.11
Lu, K.P.12
-
27
-
-
0028361538
-
Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation
-
Iqbal K., Zaidi T., Bancher C., Grundke-Iqbal I., Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation FEBS Letters 1994 349 1 104 108
-
(1994)
FEBS Letters
, vol.349
, Issue.1
, pp. 104-108
-
-
Iqbal, K.1
Zaidi, T.2
Bancher, C.3
Grundke-Iqbal, I.4
-
28
-
-
19944375450
-
Tau pathology in Alzheimer disease and other tauopathies
-
DOI 10.1016/j.bbadis.2004.09.008, PII S0925443904001784
-
Iqbal K., Del C. Alonso A., Chen S., Chohan M. O., El-Akkad E., Gong C.-X., Khatoon S., Li B., Liu F., Rahman A., Tanimukai H., Grundke-Iqbal I., Tau pathology in Alzheimer disease and other tauopathies Biochimica et Biophysica Acta 2005 1739 2 198 210 (Pubitemid 40018538)
-
(2005)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1739
, Issue.2
, pp. 198-210
-
-
Iqbal, K.1
Del C. Alonso, A.2
Chen, S.3
Chohan, M.O.4
El-Akkad, E.5
Gong, C.-X.6
Khatoon, S.7
Li, B.8
Liu, F.9
Rahman, A.10
Tanimukai, H.11
Grundke-Iqbal, I.12
-
29
-
-
0037381710
-
Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease
-
Keck S., Nitsch R., Grune T., Ullrich O., Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease Journal of Neurochemistry 2003 85 1 115 122 (Pubitemid 36389701)
-
(2003)
Journal of Neurochemistry
, vol.85
, Issue.1
, pp. 115-122
-
-
Keck, S.1
Nitsch, R.2
Grune, T.3
Ullrich, O.4
-
30
-
-
0028918383
-
Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross linking in Alzheimer disease
-
Cras P., Smith M. A., Richey P. L., Siedlak S. L., Mulvihill P., Perry G., Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross linking in Alzheimer disease Acta Neuropathologica 1995 89 4 291 295
-
(1995)
Acta Neuropathologica
, vol.89
, Issue.4
, pp. 291-295
-
-
Cras, P.1
Smith, M.A.2
Richey, P.L.3
Siedlak, S.L.4
Mulvihill, P.5
Perry, G.6
-
32
-
-
43049165571
-
Current approaches in the treatment of Alzheimer's disease
-
DOI 10.1016/j.biopha.2008.02.005, PII S0753332208000401
-
Shah R. S., Lee H.-G., Xiongwei Z., Perry G., Smith M. A., Castellani R. J., Current approaches in the treatment of Alzheimer's disease Biomedicine and Pharmacotherapy 2008 62 4 199 207 (Pubitemid 351635842)
-
(2008)
Biomedicine and Pharmacotherapy
, vol.62
, Issue.4
, pp. 199-207
-
-
Shah, R.S.1
Lee, H.-G.2
Xiongwei, Z.3
Perry, G.4
Smith, M.A.5
Castellani, R.J.6
-
33
-
-
0035978743
-
Amyotrophic lateral sclerosis
-
DOI 10.1056/NEJM200105313442207
-
Rowland L. P., Shneider N. A., Amyotrophic lateral sclerosis New England Journal of Medicine 2001 344 22 1688 1700 (Pubitemid 32479968)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.22
, pp. 1688-1700
-
-
Rowland, L.P.1
Shneider, N.A.2
-
34
-
-
0035992927
-
Detection of N -(carboxymethyl)lysine (CML) and non-CML advanced glycation end-products in the anterior horn of amyotrophic lateral sclerosis spinal cord
-
Kikuchi S., Shinpo K., Ogata A., Tsuji S., Takeuchi M., Makita Z., Tashiro K., Detection of N -(carboxymethyl)lysine (CML) and non-CML advanced glycation end-products in the anterior horn of amyotrophic lateral sclerosis spinal cord Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 2002 3 2 63 68
-
(2002)
Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
, vol.3
, Issue.2
, pp. 63-68
-
-
Kikuchi, S.1
Shinpo, K.2
Ogata, A.3
Tsuji, S.4
Takeuchi, M.5
Makita, Z.6
Tashiro, K.7
-
35
-
-
0031768026
-
Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients
-
Pedersen W. A., Fu W., Keller J. N., Markesbery W. R., Appel S., Smith R. G., Kasarskis E., Mattson M. P., Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients Annals of Neurology 1998 44 5 819 824 (Pubitemid 28516055)
-
(1998)
Annals of Neurology
, vol.44
, Issue.5
, pp. 819-824
-
-
Pedersen, W.A.1
Fu, W.2
Keller, J.N.3
Markesbery, W.R.4
Appel, S.5
Smith, R.G.6
Kasarskis, E.7
Mattson, M.P.8
-
36
-
-
0030813067
-
Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis
-
Ferrante R. J., Browne S. E., Shinobu L. A., Bowling A. C., Baik M. J., MacGarvey U., Kowall N. W., Brown R. H., Beal M. F., Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis Journal of Neurochemistry 1997 69 5 2064 2074 (Pubitemid 27452754)
-
(1997)
Journal of Neurochemistry
, vol.69
, Issue.5
, pp. 2064-2074
-
-
Ferrante, R.J.1
Browne, S.E.2
Shinobu, L.A.3
Bowling, A.C.4
Baik, M.J.5
MacGarvey, U.6
Kowall, N.W.7
Brown Jr., R.H.8
Beal, M.F.9
-
37
-
-
33751003518
-
Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target
-
DOI 10.1016/j.bbadis.2006.03.008, PII S0925443906000524
-
Barber S. C., Mead R. J., Shaw P. J., Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target Biochimica et Biophysica Acta 2006 1762 11-12 1051 1067 (Pubitemid 44750575)
-
(2006)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1762
, Issue.11-12
, pp. 1051-1067
-
-
Barber, S.C.1
Mead, R.J.2
Shaw, P.J.3
-
39
-
-
0037119407
-
Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice
-
DOI 10.1074/jbc.M203065200
-
Mattiazzi M., D'Aurelio M., Gajewski C. D., Martushova K., Kiaei M., Flint Beal M., Manfredi G., Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice Journal of Biological Chemistry 2002 277 33 29626 29633 (Pubitemid 41079252)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.33
, pp. 29626-29633
-
-
Mattiazzi, M.1
D'Aurelio, M.2
Gajewski, C.D.3
Martushova, K.4
Kiaei, M.5
Flint Beal, M.6
Manfredi, G.7
-
40
-
-
0032079517
-
Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1
-
Kong J., Xu Z., Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1 Journal of Neuroscience 1998 18 9 3241 3250 (Pubitemid 28186017)
-
(1998)
Journal of Neuroscience
, vol.18
, Issue.9
, pp. 3241-3250
-
-
Kong, J.1
Xu, Z.2
-
41
-
-
3242701496
-
Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria
-
DOI 10.1016/j.neuron.2004.06.016, PII S0896627304003630
-
Liu J., Lillo C., Jonsson P. A., Velde C. V., Ward C. M., Miller T. M., Subramaniam J. R., Rothstein J. D., Marklund S., Andersen P. M., Brnnstrm T., Gredal O., Wong P. C., Williams D. S., Cleveland D. W., Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria Neuron 2004 43 1 5 17 (Pubitemid 38952815)
-
(2004)
Neuron
, vol.43
, Issue.1
, pp. 5-17
-
-
Liu, J.1
Lillo, C.2
Jonsson, P.A.3
Velde, C.V.4
Ward, C.M.5
Miller, T.M.6
Subramaniam, J.R.7
Rothstein, J.D.8
Marklund, S.9
Andersen, P.M.10
Brannstrom, T.11
Gredal, O.12
Wong, P.C.13
Williams, D.S.14
Cleveland, D.W.15
-
42
-
-
0039251419
-
Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase
-
Estévez A. C., Crow J. P., Sampson J. B., Reiter C., Zhuang Y., Richardson G. J., Tarpey M. M., Barbeito L., Beckman J. S., Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase Science 1999 286 5449 2498 2500
-
(1999)
Science
, vol.286
, Issue.5449
, pp. 2498-2500
-
-
Estévez, A.C.1
Crow, J.P.2
Sampson, J.B.3
Reiter, C.4
Zhuang, Y.5
Richardson, G.J.6
Tarpey, M.M.7
Barbeito, L.8
Beckman, J.S.9
-
43
-
-
0037119407
-
Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice
-
DOI 10.1074/jbc.M203065200
-
Mattiazzi M., D'Aurelio M., Gajewski C. D., Martushova K., Kiaei M., Flint Beal M., Manfredi G., Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice Journal of Biological Chemistry 2002 277 33 29626 29633 (Pubitemid 41079252)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.33
, pp. 29626-29633
-
-
Mattiazzi, M.1
D'Aurelio, M.2
Gajewski, C.D.3
Martushova, K.4
Kiaei, M.5
Flint Beal, M.6
Manfredi, G.7
-
44
-
-
33751212177
-
Structure, folding, and misfolding of Cu,Zn superoxide dismutase in amyotrophic lateral sclerosis
-
DOI 10.1016/j.bbadis.2006.05.004, PII S0925443906000846
-
Rakhit R., Chakrabartty A., Structure, folding, and misfolding of Cu,Zn superoxide dismutase in amyotrophic lateral sclerosis Biochimica et Biophysica Acta 2006 1762 11-12 1025 1037 (Pubitemid 44781177)
-
(2006)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1762
, Issue.11-12
, pp. 1025-1037
-
-
Rakhit, R.1
Chakrabartty, A.2
-
45
-
-
33745889333
-
Folding of Cu/Zn superoxide dismutase suggests structural hotspots for gain of neurotoxic function in ALS: Parallels to precursors in amyloid disease
-
DOI 10.1073/pnas.0601696103
-
Nordlund A., Oliveberg M., Folding of Cu/Zn superoxide dismutase suggests structural hotspots for gain of neurotoxic function in ALS: parallels to precursors in amyloid disease Proceedings of the National Academy of Sciences of the United States of America 2006 103 27 10218 10223 (Pubitemid 44051147)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.27
, pp. 10218-10223
-
-
Nordlund, A.1
Oliveberg, M.2
-
46
-
-
33750975902
-
Failure of protein quality control in amyotrophic lateral sclerosis
-
DOI 10.1016/j.bbadis.2006.06.006, PII S0925443906001141
-
Kabashi E., Durham H. D., Failure of protein quality control in amyotrophic lateral sclerosis Biochimica et Biophysica Acta 2006 1762 11-12 1038 1050 (Pubitemid 44750579)
-
(2006)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1762
, Issue.11-12
, pp. 1038-1050
-
-
Kabashi, E.1
Durham, H.D.2
-
47
-
-
33645225597
-
Pathogenic superoxide dismutase structure, folding, aggregation and turnover
-
Hart P. J., Pathogenic superoxide dismutase structure, folding, aggregation and turnover Current Opinion in Chemical Biology 2006 10 2 131 138
-
(2006)
Current Opinion in Chemical Biology
, vol.10
, Issue.2
, pp. 131-138
-
-
Hart, P.J.1
-
49
-
-
3242703300
-
Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
-
DOI 10.1016/j.neuron.2004.06.021, PII S0896627304003915
-
Pasinelli P., Belford M. E., Lennon N., Bacskai B. J., Hyman B. T., Trotti D., Brown R. H., Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria Neuron 2004 43 1 19 30 (Pubitemid 38952816)
-
(2004)
Neuron
, vol.43
, Issue.1
, pp. 19-30
-
-
Pasinelli, P.1
Belford, M.E.2
Lennon, N.3
Bacskai, B.J.4
Hyman, B.T.5
Trotti, D.6
Brown Jr., R.H.7
-
50
-
-
51349120583
-
Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS
-
Chang Y., Kong Q., Shan X., Tian G., Ilieva H., Cleveland D. W., Rothstein J. D., Borchelt D. R., Wong P. C., Lin C. L. G., Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS PLoS ONE 2008 3 8
-
(2008)
PLoS ONE
, vol.3
, Issue.8
-
-
Chang, Y.1
Kong, Q.2
Shan, X.3
Tian, G.4
Ilieva, H.5
Cleveland, D.W.6
Rothstein, J.D.7
Borchelt, D.R.8
Wong, P.C.9
Lin, C.L.G.10
-
51
-
-
71049166754
-
The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS)
-
Strong M. J., The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS) Journal of the Neurological Sciences 2010 288 1-2 1 12
-
(2010)
Journal of the Neurological Sciences
, vol.288
, Issue.1-2
, pp. 1-12
-
-
Strong, M.J.1
-
52
-
-
33749632259
-
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
DOI 10.1126/science.1134108
-
Neumann M., Sampathu D. M., Kwong L. K., Truax A. C., Micsenyi M. C., Chou T. T., Bruce J., Schuck T., Grossman M., Clark C. M., McCluskey L. F., Miller B. L., Masliah E., Mackenzie I. R., Feldman H., Feiden W., Kretzschmar H. A., Trojanowski J. Q., Lee V. M. Y., Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Science 2006 314 5796 130 133 (Pubitemid 44547757)
-
(2006)
Science
, vol.314
, Issue.5796
, pp. 130-133
-
-
Neumann, M.1
Sampathu, D.M.2
Kwong, L.K.3
Truax, A.C.4
Micsenyi, M.C.5
Chou, T.T.6
Bruce, J.7
Schuck, T.8
Grossman, M.9
Clark, C.M.10
McCluskey, L.F.11
Miller, B.L.12
Masliah, E.13
Mackenzie, I.R.14
Feldman, H.15
Feiden, W.16
Kretzschmar, H.A.17
Trojanowski, J.Q.18
Lee, V.M.-Y.19
-
53
-
-
73249152831
-
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
-
Wegorzewska I., Bell S., Cairns N. J., Miller T. M., Baloh R. H., TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration Proceedings of the National Academy of Sciences of the United States of America 2009 106 44 18809 18814
-
(2009)
Proceedings of the National Academy of Sciences of the United States of America
, vol.106
, Issue.44
, pp. 18809-18814
-
-
Wegorzewska, I.1
Bell, S.2
Cairns, N.J.3
Miller, T.M.4
Baloh, R.H.5
-
54
-
-
70449528427
-
TARDBP 3′-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy
-
Gitcho M. A., Bigio E. H., Mishra M., Johnson N., Weintraub S., Mesulam M., Rademakers R., Chakraverty S., Cruchaga C., Morris J. C., Goate A. M., Cairns N. J., TARDBP 3′-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy Acta Neuropathologica 2009 118 5 633 645
-
(2009)
Acta Neuropathologica
, vol.118
, Issue.5
, pp. 633-645
-
-
Gitcho, M.A.1
Bigio, E.H.2
Mishra, M.3
Johnson, N.4
Weintraub, S.5
Mesulam, M.6
Rademakers, R.7
Chakraverty, S.8
Cruchaga, C.9
Morris, J.C.10
Goate, A.M.11
Cairns, N.J.12
-
55
-
-
76149120427
-
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery
-
Freibaum B. D., Chitta R. K., High A. A., Taylor J. P., Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery Journal of Proteome Research 2010 9 2 1104 1120
-
(2010)
Journal of Proteome Research
, vol.9
, Issue.2
, pp. 1104-1120
-
-
Freibaum, B.D.1
Chitta, R.K.2
High, A.A.3
Taylor, J.P.4
-
56
-
-
70350135049
-
TDP-43 is recruited to stress granules in conditions of oxidative insult
-
Colombrita C., Zennaro E., Fallini C., Weber M., Sommacal A., Buratti E., Silani V., Ratti A., TDP-43 is recruited to stress granules in conditions of oxidative insult Journal of Neurochemistry 2009 111 4 1051 1061
-
(2009)
Journal of Neurochemistry
, vol.111
, Issue.4
, pp. 1051-1061
-
-
Colombrita, C.1
Zennaro, E.2
Fallini, C.3
Weber, M.4
Sommacal, A.5
Buratti, E.6
Silani, V.7
Ratti, A.8
-
57
-
-
62149141328
-
Rethinking ALS: The FUS about TDP-43
-
Lagier-Tourenne C., Cleveland D. W., Rethinking ALS: the FUS about TDP-43 Cell 2009 136 6 1001 1004
-
(2009)
Cell
, vol.136
, Issue.6
, pp. 1001-1004
-
-
Lagier-Tourenne, C.1
Cleveland, D.W.2
-
58
-
-
77956199371
-
Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice
-
Xu Y. F., Gendron T. F., Zhang Y. J., Lin W. L., D'Alton S., Sheng H., Casey M. C., Tong J., Knight J., Yu X., Rademakers R., Boylan K., Hutton M., McGowan E., Dickson D. W., Lewis J., Petrucelli L., Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice Journal of Neuroscience 2010 30 32 10851 10859
-
(2010)
Journal of Neuroscience
, vol.30
, Issue.32
, pp. 10851-10859
-
-
Xu, Y.F.1
Gendron, T.F.2
Zhang, Y.J.3
Lin, W.L.4
D'Alton, S.5
Sheng, H.6
Casey, M.C.7
Tong, J.8
Knight, J.9
Yu, X.10
Rademakers, R.11
Boylan, K.12
Hutton, M.13
McGowan, E.14
Dickson, D.W.15
Lewis, J.16
Petrucelli, L.17
-
59
-
-
0037378026
-
Oxidative stress in Parkinson's disease
-
DOI 10.1002/ana.10483
-
Jenner P., Hunot, Olanow, Beal, Kordower, Tatton, Schapira, Oxidative stress in Parkinson's disease Annals of Neurology 2003 53 3 S26 S38 (Pubitemid 36368560)
-
(2003)
Annals of Neurology
, vol.53
, Issue.SUPPL. 3
-
-
Jenner, P.1
Hunot2
Olanow3
Beal4
Kordower5
Tatton6
Schapira7
-
60
-
-
0036197296
-
Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy
-
DOI 10.1006/nbdi.2002.0466
-
Kikuchi A., Takeda A., Onodera H., Kimpara T., Hisanaga K., Sato N., Nunomura A., Castellani R. J., Perry G., Smith M. A., Itoyama Y., Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy Neurobiology of Disease 2002 9 2 244 248 (Pubitemid 34261218)
-
(2002)
Neurobiology of Disease
, vol.9
, Issue.2
, pp. 244-248
-
-
Kikuchi, A.1
Takeda, A.2
Onodera, H.3
Kimpara, T.4
Hisanaga, K.5
Sato, N.6
Nunomura, A.7
Castellani, R.J.8
Perry, G.9
Smith, M.A.10
Itoyama, Y.11
-
61
-
-
0026563548
-
Filaments of Lewy bodies contain insoluble cytoskeletal elements
-
Galloway P. G., Mulvihill P., Perry G., Filaments of Lewy bodies contain insoluble cytoskeletal elements American Journal of Pathology 1992 140 4 809 822
-
(1992)
American Journal of Pathology
, vol.140
, Issue.4
, pp. 809-822
-
-
Galloway, P.G.1
Mulvihill, P.2
Perry, G.3
-
62
-
-
4344681293
-
Pathogenetic mechanisms of parkin in Parkinson's disease
-
DOI 10.1016/S0140-6736(04)16901-8, PII S0140673604169018
-
Hattori N., Mizuno P. Y., Pathogenetic mechanisms of parkin in Parkinson's disease Lancet 2004 364 9435 722 724 (Pubitemid 39140630)
-
(2004)
Lancet
, vol.364
, Issue.9435
, pp. 722-724
-
-
Hattori, N.1
Mizuno, P.Y.2
-
63
-
-
33750370804
-
Understanding the molecular causes of Parkinson's disease
-
DOI 10.1016/j.molmed.2006.09.007, PII S147149140600219X
-
Wood-Kaczmar A., Gandhi S., Wood N. W., Understanding the molecular causes of Parkinson's disease Trends in Molecular Medicine 2006 12 11 521 528 (Pubitemid 44633809)
-
(2006)
Trends in Molecular Medicine
, vol.12
, Issue.11
, pp. 521-528
-
-
Wood-Kaczmar, A.1
Gandhi, S.2
Wood, N.W.3
-
64
-
-
0037010312
-
Role of mitochondrial dysfunction in Alzheimer's disease
-
DOI 10.1002/jnr.10389
-
Castellani R., Hirai K., Aliev G., Drew K. L., Nunomura A., Takeda A., Cash A. D., Obrenovich M. E., Perry G., Smith M. A., Role of mitochondrial dysfunction in Alzheimer's disease Journal of Neuroscience Research 2002 70 3 357 360 (Pubitemid 35222373)
-
(2002)
Journal of Neuroscience Research
, vol.70
, Issue.3
, pp. 357-360
-
-
Castellani, R.1
Hirai, K.2
Aliev, G.3
Drew, K.L.4
Nunomura, A.5
Takeda, A.6
Cash, A.D.7
Obrenovich, M.E.8
Perry, G.9
Smith, M.A.10
-
65
-
-
0030297454
-
Mitochondrial encephalopathy with multiple mitochondrial DNA deletions: A report of two families and two sporadic cases with unusual clinical and neuropathological features
-
DOI 10.1016/S0022-510X(96)00032-9, PII S0022510X96000329
-
Chalmers R. M., Brockington M., Howard R. S., Lecky B. R. F., Morgan-Hughes J. A., Harding A. E., Mitochondrial encephalopathy with multiple mitochondrial DNA deletions: a report of two families and two sporadic cases with unusual clinical and neuropathological features Journal of the Neurological Sciences 1996 143 1-2 41 45 (Pubitemid 26402784)
-
(1996)
Journal of the Neurological Sciences
, vol.143
, Issue.1-2
, pp. 41-45
-
-
Chalmers, R.M.1
Brockington, M.2
Howard, R.S.3
Lecky, B.R.F.4
Morgan-Hughes, J.A.5
Harding, A.E.6
-
66
-
-
0034776305
-
Mitochondrial DNA rearrangements in young onset parkinsonism: Two case reports
-
DOI 10.1136/jnnp.71.5.685
-
Siciliano G., Mancuso M., Ceravolo R., Lombardi V., Iudice A., Bonuccelli U., Mitochondrial DNA rearrangements in young onset parkinsonismml: two case reports Journal of Neurology Neurosurgery and Psychiatry 2001 71 5 685 687 (Pubitemid 33010588)
-
(2001)
Journal of Neurology Neurosurgery and Psychiatry
, vol.71
, Issue.5
, pp. 685-687
-
-
Siciliano, G.1
Mancuso, M.2
Ceravolo, R.3
Lombardi, V.4
Iudice, A.5
Bonuccelli, U.6
-
67
-
-
0032899012
-
A 4-base pair deletion in the mitochondrial cytochrome b gene associated with Parkinsonism/MELAS overlap syndrome
-
DOI 10.1002/1531-8249(199901)45:1<130::AID-ART21>3.0.CO;2-Z
-
De Coo I. F. M., Renier W. O., Ruitenbeek W., Ter Laak H. J., Bakker M., Schgger H., Van Oost B. A., Smeets H. J. M., A 4-base pair deletion in the mitochondrial cytochrome b gene associated with Parkinsonism/MELAS overlap syndrome Annals of Neurology 1999 45 1 130 133 (Pubitemid 29036443)
-
(1999)
Annals of Neurology
, vol.45
, Issue.1
, pp. 130-133
-
-
De Coo, I.F.M.1
Renier, W.O.2
Ruitenbeek, W.3
Ter Laak, H.J.4
Bakker, M.5
Schagger, H.6
Van Oost, B.A.7
Smeets, H.J.M.8
-
68
-
-
0033768121
-
A novel mitochondrial 12SrRNA point mutation in parkinsonism, deafness, and neuropathy
-
Thyagarajan D., Bressman S., Bruno C., Przedborski S., Shanske S., Lynch T., Fahn S., Dimauro S., A novel mitochondrial 12SrRNA point mutation in parkinsonism, deafness, and neuropathy Annals of Neurology 2000 48 5 730 736
-
(2000)
Annals of Neurology
, vol.48
, Issue.5
, pp. 730-736
-
-
Thyagarajan, D.1
Bressman, S.2
Bruno, C.3
Przedborski, S.4
Shanske, S.5
Lynch, T.6
Fahn, S.7
Dimauro, S.8
-
69
-
-
0034595728
-
Overexpression of human -synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells
-
DOI 10.1016/S0006-8993(00)02215-0, PII S0006899300022150
-
Zhou W., Huribert M. S., Schaack J., Prasad K. N., Freed C. R., Overexpression of human -synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells Brain Research 2000 866 1-2 33 43 (Pubitemid 30313005)
-
(2000)
Brain Research
, vol.866
, Issue.1-2
, pp. 33-43
-
-
Zhou, W.1
Huribert, M.S.2
Schaack, J.3
Prasad, K.N.4
Freed, C.R.5
-
70
-
-
0035109909
-
Effect of the overexpression of wild-type or mutant -synuclein on cell susceptibility to insult
-
DOI 10.1046/j.1471-4159.2001.00149.x
-
Lee M., Hyun D. H., Halliwell B., Jenner P., Effect of the overexpression of wild-type or mutant -synuclein on cell susceptibility to insult Journal of Neurochemistry 2001 76 4 998 1009 (Pubitemid 32167373)
-
(2001)
Journal of Neurochemistry
, vol.76
, Issue.4
, pp. 998-1009
-
-
Lee, M.1
Hyun, D.-H.2
Halliwell, B.3
Jenner, P.4
-
71
-
-
0037466656
-
Initiation and synergistic fibrillization of tau and alpha-synuctein
-
DOI 10.1126/science.1082324
-
Giasson B. I., Forman M. S., Higuchi M., Golbe L. I., Graves C. L., Kotzbauer P. T., Trojanowski J. Q., Lee V. M. Y., Initiation and synergistic fibrillization of tau and alpha-synuctein Science 2003 300 5619 636 640 (Pubitemid 36520587)
-
(2003)
Science
, vol.300
, Issue.5619
, pp. 636-640
-
-
Giasson, B.I.1
Forman, M.S.2
Higuchi, M.3
Golbe, L.I.4
Graves, C.L.5
Kotzbauer, P.T.6
Trojanowski, J.Q.7
Lee, V.M.-Y.8
-
72
-
-
0033537922
-
Frequent coexistence of Lewy bodies and neurofibrillary tangles in the same neurons of patients with diffuse Lewy body disease
-
DOI 10.1016/S0304-3940(99)00178-0, PII S0304394099001780
-
Iseki E., Marui W., Kosaka K., Uéda K., Frequent coexistence of Lewy bodies and neurofibrillary tangles in the same neurons of patients with diffuse Lewy body disease Neuroscience Letters 1999 265 1 9 12 (Pubitemid 29210185)
-
(1999)
Neuroscience Letters
, vol.265
, Issue.1
, pp. 9-12
-
-
Iseki, E.1
Marui, W.2
Kosaka, K.3
Ueda, K.4
-
73
-
-
1342321775
-
More than just two peas in a pod: Common amyloidogenic properties of tau and -synuclein in neurodegenerative diseases
-
DOI 10.1016/j.tins.2004.01.007
-
Lee V. M. Y., Giasson B. I., Trojanowski J. Q., More than just two peas in a pod: common amyloidogenic properties of tau and -synuclein in neurodegenerative diseases Trends in Neurosciences 2004 27 3 129 134 (Pubitemid 38251512)
-
(2004)
Trends in Neurosciences
, vol.27
, Issue.3
, pp. 129-134
-
-
Lee, V.M.-Y.1
Giasson, B.I.2
Trojanowski, J.Q.3
-
74
-
-
0242363670
-
Molecular Pathways of Neurodegeneration in Parkinson's Disease
-
DOI 10.1126/science.1087753
-
Dawson T. M., Dawson V. L., Molecular pathways of neurodegeneration in Parkinson's disease Science 2003 302 5646 819 822 (Pubitemid 37339614)
-
(2003)
Science
, vol.302
, Issue.5646
, pp. 819-822
-
-
Dawson, T.M.1
Dawson, V.L.2
-
75
-
-
0035233083
-
Causes of neuronal death in Parkinson's disease
-
Schapira A. H., Causes of neuronal death in Parkinson's disease Advances in neurology 2001 86 155 162
-
(2001)
Advances in Neurology
, vol.86
, pp. 155-162
-
-
Schapira, A.H.1
-
76
-
-
10244246626
-
10 as a potential treatment
-
DOI 10.1023/B:JOBB.0000041772.74810.92
-
Beal M. F., Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment Journal of Bioenergetics and Biomembranes 2004 36 4 381 386 (Pubitemid 39619845)
-
(2004)
Journal of Bioenergetics and Biomembranes
, vol.36
, Issue.SPEC.ISS. 4
, pp. 381-386
-
-
Beal, M.F.1
-
77
-
-
33646948530
-
Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled
-
DOI 10.1523/JNEUROSCI.0984-06.2006
-
Keeney P. M., Xie J., Capaldi R. A., Bennett J. P. Jr., Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled Journal of Neuroscience 2006 26 19 5256 5264 (Pubitemid 44315308)
-
(2006)
Journal of Neuroscience
, vol.26
, Issue.19
, pp. 5256-5264
-
-
Keeney, P.M.1
Xie, J.2
Capaldi, R.A.3
Bennett Jr., J.P.4
-
78
-
-
0000232034
-
A marker of oxyradical-mediated DNA damage (8-hydroxy- 2′ -deoxyguanosine) is increased in nigro-striatum of Parkinsons disease brain
-
Sanchez-Ramos J., Overvik E., Ames B., A marker of oxyradical-mediated DNA damage (8-hydroxy- 2′ -deoxyguanosine) is increased in nigro-striatum of Parkinsons disease brain Neurodegeneration 1994 3 197 204
-
(1994)
Neurodegeneration
, vol.3
, pp. 197-204
-
-
Sanchez-Ramos, J.1
Overvik, E.2
Ames, B.3
-
79
-
-
0032911488
-
Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons
-
Zhang J., Perry G., Smith M. A., Robertson D., Olson S. J., Graham D. G., Montine T. J., Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons American Journal of Pathology 1999 154 5 1423 1429 (Pubitemid 29226437)
-
(1999)
American Journal of Pathology
, vol.154
, Issue.5
, pp. 1423-1429
-
-
Zhang, J.1
Perry, G.2
Smith, M.A.3
Robertson, D.4
Olson, S.J.5
Graham, D.G.6
Montine, T.J.7
-
80
-
-
0030805622
-
A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease
-
Alam Z. I., Daniel S. E., Lees A. J., Marsden D. C., Jenner P., Halliwell B., A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease Journal of Neurochemistry 1997 69 3 1326 1329 (Pubitemid 27364859)
-
(1997)
Journal of Neurochemistry
, vol.69
, Issue.3
, pp. 1326-1329
-
-
Alam, Z.I.1
Daniel, S.E.2
Lees, A.J.3
Marsden, D.C.4
Jenner, P.5
Halliwell, B.6
-
81
-
-
0031962268
-
Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay
-
Floor E., Wetzel M. G., Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay Journal of Neurochemistry 1998 70 1 268 275 (Pubitemid 28020852)
-
(1998)
Journal of Neurochemistry
, vol.70
, Issue.1
, pp. 268-275
-
-
Floor, E.1
Wetzel, M.G.2
-
82
-
-
0031939204
-
Protein nitration in Parkinson's disease
-
Good P. F., Hsu A., Werner P., Perl D. P., Warren Olanow C., Protein nitration in Parkinson's disease Journal of Neuropathology and Experimental Neurology 1998 57 4 338 342 (Pubitemid 28182632)
-
(1998)
Journal of Neuropathology and Experimental Neurology
, vol.57
, Issue.4
, pp. 338-342
-
-
Good, P.F.1
Hsu, A.2
Werner, P.3
Perl, D.P.4
Warren Olanow, C.5
-
83
-
-
0030597071
-
Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease
-
DOI 10.1016/0006-8993(96)00729-9, PII S0006899396007299
-
Castellani R., Smith M. A., Richey P. L., Perry G., Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease Brain Research 1996 737 1-2 195 200 (Pubitemid 26366614)
-
(1996)
Brain Research
, vol.737
, Issue.1-2
, pp. 195-200
-
-
Castellani, R.1
Smith, M.A.2
Richey, P.L.3
Perry, G.4
-
84
-
-
0029917194
-
Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease
-
DOI 10.1073/pnas.93.7.2696
-
Yoritaka A., Hattori N., Uchida K., Tanaka M., Stadtman E. R., Mizuno Y., Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease Proceedings of the National Academy of Sciences of the United States of America 1996 93 7 2696 2701 (Pubitemid 26114311)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.7
, pp. 2696-2701
-
-
Yoritaka, A.1
Hattori, N.2
Uchida, K.3
Tanaka, M.4
Stadtman, E.R.5
Mizuno, Y.6
-
85
-
-
0037039837
-
Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans
-
DOI 10.1016/S0304-3940(01)02514-9, PII S0304394001025149
-
Castellani R. J., Perry G., Siedlak S. L., Nunomura A., Shimohama S., Zhang J., Montine T., Sayre L. M., Smith M. A., Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans Neuroscience Letters 2002 319 1 25 28 (Pubitemid 34117635)
-
(2002)
Neuroscience Letters
, vol.319
, Issue.1
, pp. 25-28
-
-
Castellani, R.J.1
Perry, G.2
Siedlak, S.L.3
Nunomura, A.4
Shimohama, S.5
Zhang, J.6
Montine, T.7
Sayre, L.M.8
Smith, M.A.9
-
86
-
-
34250796802
-
The impact of the E46K mutation on the properties of -synuclein in its monomelic and oligomeric states
-
DOI 10.1021/bi7000246
-
Fredenburg R. A., Rospigliosi C., Meray R. K., Kessler J. C., Lashuel H. A., Eliezer D., Lansbury P. T. Jr., The impact of the E46K mutation on the properties of -synuclein in its monomelic and oligomeric states Biochemistry 2007 46 24 7107 7118 (Pubitemid 46973985)
-
(2007)
Biochemistry
, vol.46
, Issue.24
, pp. 7107-7118
-
-
Fredenburg, R.A.1
Rospigliosi, C.2
Meray, R.K.3
Kessler, J.C.4
Lashuel, H.A.5
Eliezer, D.6
Lansbury Jr., P.T.7
-
87
-
-
1542617769
-
Enhanced substantia nigra mitochondrial pathology in human -synuclein transgenic mice after treatment with MPTP
-
DOI 10.1016/S0014-4886(03)00342-X, PII S001448860300342X
-
Song D. D., Shults C. W., Sisk A., Rockenstein E., Masliah E., Enhanced substantia nigra mitochondrial pathology in human -synuclein transgenic mice after treatment with MPTP Experimental Neurology 2004 186 2 158 172 (Pubitemid 38333191)
-
(2004)
Experimental Neurology
, vol.186
, Issue.2
, pp. 158-172
-
-
Song, D.D.1
Shults, C.W.2
Sisk, A.3
Rockenstein, E.4
Masliah, E.5
-
88
-
-
33244460534
-
Mice lacking alpha-synuclein are resistant to mitochondrial toxins
-
DOI 10.1016/j.nbd.2005.08.018, PII S0969996105002421
-
Klivenyi P., Siwek D., Gardian G., Yang L., Starkov A., Cleren C., Ferrante R. J., Kowall N. W., Abeliovich A., Beal M. F., Mice lacking alpha-synuclein are resistant to mitochondrial toxins Neurobiology of Disease 2006 21 3 541 548 (Pubitemid 43277537)
-
(2006)
Neurobiology of Disease
, vol.21
, Issue.3
, pp. 541-548
-
-
Klivenyi, P.1
Siwek, D.2
Gardian, G.3
Yang, L.4
Starkov, A.5
Cleren, C.6
Ferrante, R.J.7
Kowall, N.W.8
Abeliovich, A.9
Beal, M.F.10
-
89
-
-
0037227397
-
Altered proteasomal function in sporadic Parkinson's disease
-
DOI 10.1006/exnr.2002.8050
-
McNaught K. S. P., Belizaire R., Isacson O., Jenner P., Olanow C. W., Altered proteasomal function in sporadic Parkinson's disease Experimental Neurology 2003 179 1 38 46 (Pubitemid 36062617)
-
(2003)
Experimental Neurology
, vol.179
, Issue.1
, pp. 38-46
-
-
McNaught, K.St.P.1
Belizaire, R.2
Isacson, O.3
Jenner, P.4
Olanow, C.W.5
-
90
-
-
2542560342
-
Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
-
DOI 10.1242/dev.01095
-
Pesah Y., Pham T., Burgess H., Middlebrooks B., Verstreken P., Zhou Y., Harding M., Bellen H., Mardon G., Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress Development 2004 131 9 2183 2194 (Pubitemid 38702049)
-
(2004)
Development
, vol.131
, Issue.9
, pp. 2183-2194
-
-
Pesah, Y.1
Pham, T.2
Burgess, H.3
Middlebrooks, B.4
Verstreken, P.5
Zhou, Y.6
Harding, M.7
Bellen, H.8
Mardon, G.9
-
91
-
-
2442481789
-
Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice
-
DOI 10.1074/jbc.M401135200
-
Palacino J. J., Sagi D., Goldberg M. S., Krauss S., Motz C., Wacker M., Klose J., Shen J., Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice Journal of Biological Chemistry 2004 279 18 18614 18622 (Pubitemid 38623283)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.18
, pp. 18614-18622
-
-
Palacino, J.J.1
Sagi, D.2
Goldberg, M.S.3
Krauss, S.4
Motz, C.5
Wacker, M.6
Klose, J.7
Shen, J.8
-
92
-
-
0037428241
-
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
-
DOI 10.1126/science.1077209
-
Bonifati V., Rizzu P., Van Baren M. J., Schaap O., Breedveld G. J., Krieger E., Dekker M. C. J., Squitieri F., Ibanez P., Joosse M., Van Dongen J. W., Vanacore N., Van Swieten J. C., Brice A., Meco G., Van Duijn C. M., Oostra B. A., Heutink P., Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism Science 2003 299 5604 256 259 (Pubitemid 36131051)
-
(2003)
Science
, vol.299
, Issue.5604
, pp. 256-259
-
-
Bonifati, V.1
Rizzu, P.2
Van Baren, M.J.3
Schaap, O.4
Breedveld, G.J.5
Krieger, E.6
Dekker, M.C.J.7
Squitieri, F.8
Ibanez, P.9
Joosse, M.10
Van Dongen, J.W.11
Vanacore, N.12
Van Swieten, J.C.13
Brice, A.14
Meco, G.15
Van Duijn, C.M.16
Oostra, B.A.17
Heutink, P.18
-
93
-
-
20144389422
-
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6- tetrahydropyrindine (MPTP) and oxidative stress
-
Kim R. H., Smith P. D., Aleyasin H., Hayley S., Mount M. P., Pownall S., Wakeham A., You-Ten A. J., Kalia S. K., Horne P., Westaway D., Lozano A. M., Anisman H., Park D. S., Mak T. W., Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6- tetrahydropyrindine (MPTP) and oxidative stress Proceedings of the National Academy of Sciences of the United States of America 2005 102 14 5215 5220
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.14
, pp. 5215-5220
-
-
Kim, R.H.1
Smith, P.D.2
Aleyasin, H.3
Hayley, S.4
Mount, M.P.5
Pownall, S.6
Wakeham, A.7
You-Ten, A.J.8
Kalia, S.K.9
Horne, P.10
Westaway, D.11
Lozano, A.M.12
Anisman, H.13
Park, D.S.14
Mak, T.W.15
-
94
-
-
33747611218
-
Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging
-
DOI 10.1073/pnas.0601891103
-
Meulener M. C., Xu K., Thompson L., Ischiropoulos H., Bonini N. M., Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging Proceedings of the National Academy of Sciences of the United States of America 2006 103 33 12517 12522 (Pubitemid 44267290)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.33
, pp. 12517-12522
-
-
Meulener, M.C.1
Xu, K.2
Thompson, L.3
Ischiropoulos, H.4
Bonini, N.M.5
-
95
-
-
2442668926
-
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
-
DOI 10.1126/science.1096284
-
Valente E. M., Abou-Sleiman P. M., Caputo V., Muqit M. M. K., Harvey K., Gispert S., Ali Z., Del Turco D., Bentivoglio A. R., Healy D. G., Albanese A., Nussbaum R., Gonzlez-Maldonado R., Deller T., Salvi S., Cortelli P., Gilks W. P., Latchman D. S., Harvey R. J., Dallapiccola B., Auburger G., Wood N. W., Hereditary early-onset Parkinson's disease caused by mutations in PINK1 Science 2004 304 5674 1158 1160 (Pubitemid 38661852)
-
(2004)
Science
, vol.304
, Issue.5674
, pp. 1158-1160
-
-
Valente, E.M.1
Abou-Sleiman, P.M.2
Caputo, V.3
Muqit, M.M.K.4
Harvey, K.5
Gispert, S.6
Ali, Z.7
Del Turco, D.8
Bentivoglio, A.R.9
Healy, D.G.10
Albanese, A.11
Nussbaum, R.12
Gonzalez-Maldonado, R.13
Deller, T.14
Salvi, S.15
Cortelli, P.16
Gilks, W.P.17
Latchman, D.S.18
Harvey, R.J.19
Dallapiccola, B.20
Auburger, G.21
Wood, N.W.22
more..
-
96
-
-
26644440926
-
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations
-
DOI 10.1074/jbc.M505143200
-
Petit A., Kawarai T., Paitel E., Sanjo N., Maj M., Scheid M., Chen F., Gu Y., Hasegawa H., Salehi-Rad S., Wang L., Rogaeva E., Fraser P., Robinson B., George -. P. S., Tandon A., Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations Journal of Biological Chemistry 2005 280 40 34025 34032 (Pubitemid 41443124)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.40
, pp. 34025-34032
-
-
Petit, A.1
Kawarai, T.2
Paitel, E.3
Sanjo, N.4
Maj, M.5
Scheid, M.6
Chen, F.7
Gu, Y.8
Hasegawa, H.9
Salehi-Rad, S.10
Wang, L.11
Rogaeva, E.12
Fraser, P.13
Robinson, B.14
St. George-Hyslop, P.15
Tandon, A.16
-
97
-
-
0034025513
-
Dopamine-induced apoptosis is mediated by oxidative stress and is enhanced by cyanide in differentiated PC12 cells
-
DOI 10.1046/j.1471-4159.2000.0742296.x
-
Jones D. C., Gunasekar P. G., Borowitz J. L., Isom G. E., Dopamine-induced apoptosis is mediated by oxidative stress and is enhanced by cyanide in differentiated PC12 cells Journal of Neurochemistry 2000 74 6 2296 2304 (Pubitemid 30314204)
-
(2000)
Journal of Neurochemistry
, vol.74
, Issue.6
, pp. 2296-2304
-
-
Jones, D.C.1
Gunasekar, P.G.2
Borowitz, J.L.3
Isom, G.E.4
-
98
-
-
0028914437
-
Generation of the neurotoxin 6-hydroxydopamine by peroxidase/H2O2 oxidation of dopamine
-
Napolitano A., Crescenzi O., Pezzella A., Prota G., Generation of the neurotoxin 6-hydroxydopamine by peroxidase/H2O2 oxidation of dopamine Journal of Medicinal Chemistry 1995 38 6 917 922
-
(1995)
Journal of Medicinal Chemistry
, vol.38
, Issue.6
, pp. 917-922
-
-
Napolitano, A.1
Crescenzi, O.2
Pezzella, A.3
Prota, G.4
-
99
-
-
0034939055
-
Methamphetamine-induced dopaminergic neurotoxicity: Role of peroxynitrite and neuroprotective role of antioxidants and peroxynitrite decomposition catalysts
-
Imam S. Z., El-Yazal J., Newport G. D., Itzhak Y., Cadet J. L., Slikker W., Ali S. F., Methamphetamine-induced dopaminergic neurotoxicity: role of peroxynitrite and neuroprotective role of antioxidants and peroxynitrite decomposition catalysts Annals of the New York Academy of Sciences 2001 939 366 380 (Pubitemid 32620088)
-
(2001)
Annals of the New York Academy of Sciences
, vol.939
, pp. 366-380
-
-
Imam, S.Z.1
El-Yazal, J.2
Newport, G.D.3
Itzhak, Y.4
Cadet, J.L.5
Slikker Jr., W.6
Ali, S.F.7
-
100
-
-
11144353557
-
The relevance of iron in the pathogenesis of Parkinson's disease
-
DOI 10.1196/annals.1306.017
-
Gtz M. E., Double K., Gerlach M., Youdim M. B. H., Riederer P., The relevance of iron in the pathogenesis of Parkinson's disease Annals of the New York Academy of Sciences 2004 1012 193 208 (Pubitemid 38455479)
-
(2004)
Annals of the New York Academy of Sciences
, vol.1012
, pp. 193-208
-
-
Gotz, M.E.1
Double, K.2
Gerlach, M.3
Youdim, M.B.H.4
Riederer, P.5
-
101
-
-
3042654997
-
Does cellular iron dysregulation play a causative role in Parkinson's disease?
-
DOI 10.1016/j.arr.2004.01.003, PII S1568163704000145
-
Kaur D., Andersen J., Does cellular iron dysregulation play a causative role in Parkinson's disease? Ageing Research Reviews 2004 3 3 327 343 (Pubitemid 38844698)
-
(2004)
Ageing Research Reviews
, vol.3
, Issue.3
, pp. 327-343
-
-
Kaur, D.1
Andersen, J.2
-
103
-
-
0021028244
-
A polymorphic DNA marker genetically linked to Huntington's disease
-
Gusella J. F., Wexler N. S., Conneally P. M., A polymorphic DNA marker genetically linked to Huntington's disease Nature 1983 306 5940 234 238 (Pubitemid 14232350)
-
(1983)
Nature
, vol.306
, Issue.5940
, pp. 234-238
-
-
Gusella, J.F.1
Wexler, N.S.2
Conneally, P.M.3
-
104
-
-
0141705360
-
Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: Implications for the pathogenesis of neurodegenerative diseases
-
DOI 10.1023/A:1025682611389
-
Rego A. C., Oliveira C. R., Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases Neurochemical Research 2003 28 10 1563 1574 (Pubitemid 37193539)
-
(2003)
Neurochemical Research
, vol.28
, Issue.10
, pp. 1563-1574
-
-
Rego, A.C.1
Oliveira, C.R.2
-
106
-
-
0030919567
-
Oxidative damage and metabolic dysfunction in huntington's disease: Selective vulnerability of the basal ganglia
-
DOI 10.1002/ana.410410514
-
Browne S. E., Bowling A. C., MacGarvey U., Baik M. J., Berger S. C., Muqit M. M. K., Bird E. D., Beal M. F., Oxidative damage and metabolic dysfunction in huntington's disease: selective vulnerability of the basal ganglia Annals of Neurology 1997 41 5 646 653 (Pubitemid 27212659)
-
(1997)
Annals of Neurology
, vol.41
, Issue.5
, pp. 646-653
-
-
Browne, S.E.1
Bowling, A.C.2
MacGarvey, U.3
Baik, M.J.4
Berger, S.C.5
Muqit, M.M.K.6
Bird, E.D.7
Beal, M.F.8
-
107
-
-
0027741301
-
1H NMR spectroscopy
-
Jenkins B. G., Koroshetz W. J., Beal M. F., Rosen B. R., Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy Neurology 1993 43 12 I 2689 2695 (Pubitemid 24004570)
-
(1993)
Neurology
, vol.43
, Issue.12
, pp. 2689-2695
-
-
Jenkins, B.G.1
Koroshetz, W.J.2
Beal, M.F.3
Rosen, B.R.4
-
108
-
-
0031044805
-
10
-
DOI 10.1002/ana.410410206
-
Koroshetz W. J., Jenkins B. G., Rosen B. R., Flint Beal M., Energy metabolism defects in Huntington's disease and effects of coenzyme Q10 Annals of Neurology 1997 41 2 160 165 (Pubitemid 27082096)
-
(1997)
Annals of Neurology
, vol.41
, Issue.2
, pp. 160-165
-
-
Koroshetz, W.J.1
Jenkins, B.G.2
Rosen, B.R.3
Flint Beal, M.4
-
109
-
-
0025087726
-
Evidence for a defect in NADH:ubiquinone oxidoreductase (complex I) in Huntington's disease
-
Parker W. D., Boyson S. J., Luder A. S., Parks J. K., Evidence for a defect in NADH:ubiquinone oxidoreductase (complex I) in Huntington's disease Neurology 1990 40 8 1231 1234 (Pubitemid 20244981)
-
(1990)
Neurology
, vol.40
, Issue.8
, pp. 1231-1234
-
-
Parker Jr., W.D.1
Boyson, S.J.2
Luder, A.S.3
Parks, J.K.4
-
110
-
-
0021917344
-
Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and -glutamyl transpeptidase in post-mortem brain from Huntington's disease and agonal cases
-
DOI 10.1016/0022-510X(85)90112-1
-
Butterworth J., Yates C. M., Reynolds G. P., Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and -glutamyl transpeptidase in post-mortem brain from Huntington's disease and agonal cases Journal of the Neurological Sciences 1985 67 2 161 171 (Pubitemid 15130758)
-
(1985)
Journal of the Neurological Sciences
, vol.67
, Issue.2
, pp. 161-171
-
-
Butterworth, J.1
Yates, C.M.2
Reynolds, G.P.3
-
111
-
-
0025078573
-
Mitochondrial function and parental sex effect in Huntington's disease
-
Mann V. M., Cooper J. M., Javoy-Agid F., Agid Y., Jenner P., Schapira A. H.V., Mitochondrial function and parental sex effect in Huntington's disease Lancet 1990 336 8717 749 (Pubitemid 20309171)
-
(1990)
Lancet
, vol.336
, Issue.8717
, pp. 749
-
-
Mann, V.M.1
Cooper, J.M.2
Javoy-Agid, F.3
Agid, Y.4
Jenner, P.5
Schapira, A.H.V.6
-
112
-
-
0017839485
-
Juvenile Huntington chorea: Clinical, ultrastructural, and biochemical studies
-
Goebel H. H., Heipertz R., Scholz W., Juvenile Huntington chorea: clinical, ultrastructural, and biochemical studies Neurology 1978 28 1 23 31 (Pubitemid 8272515)
-
(1978)
Neurology
, vol.28
, Issue.1
, pp. 23-31
-
-
Goebel, H.H.1
Heipertz, R.2
Scholz, W.3
-
113
-
-
7944224718
-
Huntington's disease: Pathomechanism and therapeutic perspectives
-
DOI 10.1007/s00702-004-0201-4, Parkinson's Research in Progress
-
Grdin G., Vécsei L., Huntington's disease: pathomechanism and therapeutic perspectives Journal of Neural Transmission 2004 111 10-11 1485 1494 (Pubitemid 39468401)
-
(2004)
Journal of Neural Transmission
, vol.111
, Issue.10-11
, pp. 1485-1494
-
-
Gardian, G.1
Vecsei, L.2
-
114
-
-
33748591092
-
Oxidative stress in skin fibroblasts cultures of patients with Huntington's disease
-
DOI 10.1007/s11064-006-9110-2
-
Del Hoyo P., Garca-Redondo A., De Bustos F., Molina J. A., Sayed Y., Alonso-Navarro H., Caballero L., Arenas J., Jiménez-Jiménez F. J., Oxidative stress in skin fibroblasts cultures of patients with Huntington's disease Neurochemical Research 2006 31 9 1103 1109 (Pubitemid 44379670)
-
(2006)
Neurochemical Research
, vol.31
, Issue.9
, pp. 1103-1109
-
-
Del Hoyo, P.1
Garcia-Redondo, A.2
De Bustos, F.3
Molina, J.A.4
Sayed, Y.5
Alonso-Navarro, H.6
Caballero, L.7
Arenas, J.8
Jimenez-Jimenez, F.J.9
-
115
-
-
24744444740
-
Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin
-
DOI 10.1074/jbc.M504749200
-
Milakovic T., Johnson G. V. W., Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin Journal of Biological Chemistry 2005 280 35 30773 30782 (Pubitemid 41291807)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.35
, pp. 30773-30782
-
-
Milakovic, T.1
Johnson, G.V.W.2
-
116
-
-
0034663040
-
11-mediated activation of cyclin-dependent kinase 5 activity is involved in neurite outgrowth and human neurofilament protein H Lys-Ser-Pro tail domain phosphorylation
-
Li B.-S., Zhang L., Gu J., Amin N. D., Pant H. C., Integrin 1 1-mediated activation of cyclin-dependent kinase 5 activity is involved in neurite outgrowth and human neurofilament protein H Lys-Ser-Pro tail domain phosphorylation Journal of Neuroscience 2000 20 16 6055 6062 (Pubitemid 30658399)
-
(2000)
Journal of Neuroscience
, vol.20
, Issue.16
, pp. 6055-6062
-
-
Li, B.-S.1
Zhang, L.2
Gu, J.3
Amin, N.D.4
Pant, H.C.5
-
117
-
-
0036169172
-
Cdk5 behind the wheel: A role in trafficking and transport?
-
DOI 10.1016/S0962-8924(01)02181-X, PII S096289240102181X
-
Smith D. S., Tsai L. H., Cdk5 behind the wheel: a role in trafficking and transport? Trends in Cell Biology 2002 12 1 28 36 (Pubitemid 34164154)
-
(2002)
Trends in Cell Biology
, vol.12
, Issue.1
, pp. 28-36
-
-
Smith, D.S.1
Tsai, L.-H.2
-
118
-
-
0034682414
-
Neurotoxicity induces cleavage of p35 to p25 by calpain
-
DOI 10.1038/35012636
-
Lee M. S., Kwon Y. T., Li M., Peng J., Friedlander R. M., Tsai L. H., Neurotoxicity induces cleavage of p35 to p25 by calpain Nature 2000 405 6784 360 364 (Pubitemid 30337070)
-
(2000)
Nature
, vol.405
, Issue.6784
, pp. 360-364
-
-
Lee, M.-S.1
Kwon, Y.T.2
Li, M.3
Peng, J.4
Friedlander, R.M.5
Tsai, L.-H.6
-
120
-
-
0036470547
-
Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35
-
DOI 10.1002/jnr.10116
-
Amin N. D., Albers W., Pant H. C., Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35 Journal of Neuroscience Research 2002 67 3 354 362 (Pubitemid 34137142)
-
(2002)
Journal of Neuroscience Research
, vol.67
, Issue.3
, pp. 354-362
-
-
Amin, N.D.1
Albers, W.2
Pant, H.C.3
-
121
-
-
0027978170
-
P35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
-
DOI 10.1038/371419a0
-
Tsai L. H., Delalle I., Caviness V. S., Chae T., Harlow E., p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 Nature 1994 371 6496 419 423 (Pubitemid 24302556)
-
(1994)
Nature
, vol.371
, Issue.6496
, pp. 419-423
-
-
Teai, L.-H.1
Delalle, I.2
Cavness Jr., V.S.3
Chae, T.4
Harlow, E.5
-
122
-
-
0033540060
-
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
-
Patrick G. N., Zukerberg L., Nikolic M., De La Monte S., Dikkes P., Tsai L. H., Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration Nature 1999 402 6762 615 622 (Pubitemid 129516324)
-
(1999)
Nature
, vol.402
, Issue.6762
, pp. 615-622
-
-
Patrick, G.N.1
Zukerberg, L.2
Nikolic, M.3
De La Monte, S.4
Dikkes, P.5
Tsai, L.-H.6
-
123
-
-
0034682414
-
Neurotoxicity induces cleavage of p35 to p25 by calpain
-
DOI 10.1038/35012636
-
Lee M. S., Kwon Y. T., Li M., Peng J., Friedlander R. M., Tsai L. H., Neurotoxicity induces cleavage of p35 to p25 by calpain Nature 2000 405 6784 360 364 (Pubitemid 30337070)
-
(2000)
Nature
, vol.405
, Issue.6784
, pp. 360-364
-
-
Lee, M.-S.1
Kwon, Y.T.2
Li, M.3
Peng, J.4
Friedlander, R.M.5
Tsai, L.-H.6
-
124
-
-
0037373079
-
Up-regulation of cDK5/p35 by oxidative stress in human neuroblastoma IMR-32 cells
-
DOI 10.1002/jcb.10391
-
Strocchi P., Pession A., Dozza B., Up-regulation of cDK5/p35 by oxidative stress in human neuroblastoma IMR-32 cells Journal of Cellular Biochemistry 2003 88 4 758 765 (Pubitemid 36258825)
-
(2003)
Journal of Cellular Biochemistry
, vol.88
, Issue.4
, pp. 758-765
-
-
Strocchi, P.1
Pession, A.2
Dozza, B.3
-
125
-
-
4444262625
-
Cdk5 deregulation in the pathogenesis of Alzheimer's disease
-
DOI 10.1016/j.molmed.2004.07.001, PII S1471491404001807
-
Cruz J. C., Tsai L. H., Cdk5 deregulation in the pathogenesis of Alzheimer's disease Trends in Molecular Medicine 2004 10 9 452 458 (Pubitemid 39209212)
-
(2004)
Trends in Molecular Medicine
, vol.10
, Issue.9
, pp. 452-458
-
-
Cruz, J.C.1
Tsai, L.-H.2
-
126
-
-
1642420308
-
Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway
-
DOI 10.1016/j.yexcr.2004.01.002, PII S0014482704000187
-
Quintanilla R. A., Orellana D. I., Gonzlez-Billault C., Maccioni R. B., Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway Experimental Cell Research 2004 295 1 245 257 (Pubitemid 38407361)
-
(2004)
Experimental Cell Research
, vol.295
, Issue.1
, pp. 245-257
-
-
Quintanilla, R.A.1
Orellana, D.I.2
Gonzalez-Billault, C.3
Maccioni, R.B.4
-
127
-
-
2642524580
-
Cyclin-dependent kinase 5 increases perikaryal neurofilament phosphorylation and inhibits neurofilament axonal transport in response to oxidative stress
-
DOI 10.1002/jnr.20099
-
Shea T. B., Zheng Y. L., Ortiz D., Pant H. C., Cyclin-dependent kinase 5 increases perikaryal neurofilament phosphorylation and inhibits neurofilament axonal transport in response to oxidative stress Journal of Neuroscience Research 2004 76 6 795 800 (Pubitemid 38720686)
-
(2004)
Journal of Neuroscience Research
, vol.76
, Issue.6
, pp. 795-800
-
-
Shea, T.B.1
Zheng, Y.-L.2
Ortiz, D.3
Pant, H.C.4
-
128
-
-
25644456097
-
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
-
DOI 10.1523/JNEUROSCI.2868-05.2005
-
Kitazawa M., Oddo S., Yamasaki T. R., Green K. N., LaFerla F. M., Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease Journal of Neuroscience 2005 25 39 8843 8853 (Pubitemid 41384452)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.39
, pp. 8843-8853
-
-
Kitazawa, M.1
Oddo, S.2
Yamasaki, T.R.3
Green, K.N.4
LaFerla, F.M.5
-
129
-
-
0036153235
-
Cdk5 sinks into ALS
-
DOI 10.1016/S0166-2236(00)02000-2, PII S0166223600020002
-
Patzke H., Tsai L. H., Cdk5 sinks into ALS Trends in Neurosciences 2002 25 1 8 10 (Pubitemid 34093773)
-
(2002)
Trends in Neurosciences
, vol.25
, Issue.1
, pp. 8-10
-
-
Patzke, H.1
Tsai, L.-H.2
-
130
-
-
0037125209
-
A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains
-
DOI 10.1016/S0014-5793(02)02934-4, PII S0014579302029344
-
Tseng H. C., Zhou Y., Shen Y., Tsai L. H., A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains FEBS Letters 2002 523 13 58 62 (Pubitemid 34786058)
-
(2002)
FEBS Letters
, vol.523
, Issue.1-3
, pp. 58-62
-
-
Tseng, H.-C.1
Zhou, Y.2
Shen, Y.3
Tsai, L.-H.4
-
131
-
-
0038705066
-
Cdk5: One of the links between senile plaques and neurofibrillary tangles?
-
Lee M. S., Tsai L. H., Cdk5: one of the links between senile plaques and neurofibrillary tangles? Journal of Alzheimer's Disease 2003 5 2 127 137
-
(2003)
Journal of Alzheimer's Disease
, vol.5
, Issue.2
, pp. 127-137
-
-
Lee, M.S.1
Tsai, L.H.2
-
132
-
-
0034489359
-
Oxygen free radical injury is sufficient to cause some Alzheimer-type molecular abnormalities in human CNS neuronal cells
-
De La Monte S. M., Ganju N., Feroz N., Luong T., Banerjee K., Cannon J., Wands J. R., Oxygen free radical injury is sufficient to cause some Alzheimer-type molecular abnormalities in human CNS neuronal cells Journal of Alzheimer's Disease 2000 2 3-4 261 281 (Pubitemid 32095611)
-
(2000)
Journal of Alzheimer's Disease
, vol.2
, Issue.3-4
, pp. 261-281
-
-
De La Monte, S.M.1
Ganju, N.2
Feroz, N.3
Luong, T.4
Banerjee, K.5
Cannon, J.6
Wands, J.R.7
-
133
-
-
0347785492
-
205 of human tau
-
DOI 10.1074/jbc.M207426200
-
Hashiguchi M., Saito T., Hisanaga S.-I., Hashiguchi T., Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau Journal of Biological Chemistry 2002 277 46 44525 44530 (Pubitemid 36157887)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.46
, pp. 44525-44530
-
-
Hashiguchi, M.1
Saito, T.2
Hisanaga, S.-I.3
Hashiguchi, T.4
-
134
-
-
0034923434
-
Oxidative damage is the earliest event in Alzheimer disease
-
Nunomura A., Perry G., Aliev G., Hirai K., Takeda A., Balraj E. K., Jones P. K., Ghanbari H., Wataya T., Shimohama S., Chiba S., Atwood C. S., Petersen R. B., Smith M. A., Oxidative damage is the earliest event in Alzheimer disease Journal of Neuropathology and Experimental Neurology 2001 60 8 759 767 (Pubitemid 32678256)
-
(2001)
Journal of Neuropathology and Experimental Neurology
, vol.60
, Issue.8
, pp. 759-767
-
-
Nunomura, A.1
Perry, G.2
Aliev, G.3
Hirai, K.4
Takeda, A.5
Balraj, E.K.6
Jones, P.K.7
Ghanbari, H.8
Wataya, T.9
Shimohama, S.10
Chiba, S.11
Atwood, C.S.12
Petersen, R.B.13
Smith, M.A.14
-
135
-
-
34548480683
-
Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5
-
DOI 10.1002/biot.200700057
-
Kesavapany S., Zheng Y. L., Amin N., Pant H. C., Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5 Biotechnology Journal 2007 2 8 978 987 (Pubitemid 47377105)
-
(2007)
Biotechnology Journal
, vol.2
, Issue.8
, pp. 978-987
-
-
Kesavapany, S.1
Zheng, Y.-L.2
Amin, N.3
Pant, H.C.4
-
136
-
-
13244264765
-
A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons
-
DOI 10.1038/sj.emboj.7600441
-
Zheng Y. L., Kesavapany S., Gravell M., Hamilton R. S., Schubert M., Amin N., Albers W., Grant P., Pant H. C., A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons EMBO Journal 2005 24 1 209 220 (Pubitemid 40188478)
-
(2005)
EMBO Journal
, vol.24
, Issue.1
, pp. 209-220
-
-
Zheng, Y.-L.1
Kesavapany, S.2
Gravell, M.3
Hamilton, R.S.4
Schubert, M.5
Amin, N.6
Albers, W.7
Grant, P.8
Pant, H.C.9
-
137
-
-
51849133140
-
Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction
-
Sun K. H., De Pablo Y., Vincent F., Shah K., Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction Journal of Neurochemistry 2008 107 1 265 278
-
(2008)
Journal of Neurochemistry
, vol.107
, Issue.1
, pp. 265-278
-
-
Sun, K.H.1
De Pablo, Y.2
Vincent, F.3
Shah, K.4
-
138
-
-
77951932919
-
Cdk5 is a major regulator of p38 cascade: Relevance to neurotoxicity in Alzheimer's disease
-
Chang K. H., De Pablo Y., Lee H. P., Lee H. G., Smith M. A., Shah K., Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease Journal of Neurochemistry 2010 113 5 1221 1229
-
(2010)
Journal of Neurochemistry
, vol.113
, Issue.5
, pp. 1221-1229
-
-
Chang, K.H.1
De Pablo, Y.2
Lee, H.P.3
Lee, H.G.4
Smith, M.A.5
Shah, K.6
-
139
-
-
0035087703
-
Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration
-
Pei J. J., Braak E., Braak H., Grundke-Iqbal I., Iqbal K., Winblad B., Cowburn R. F., Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration Journal of Alzheimer's Disease 2001 3 1 41 48 (Pubitemid 32238249)
-
(2001)
Journal of Alzheimer's Disease
, vol.3
, Issue.1
, pp. 41-48
-
-
Pei, J.-J.1
Braak, E.2
Braak, H.3
Grundke-Iqbal, I.4
Iqbal, K.5
Winblad, B.6
Cowburn, R.F.7
-
140
-
-
0034781046
-
Activation of MKK6, an upstream activator of p38, in Alzheimer's disease
-
DOI 10.1046/j.1471-4159.2001.00597.x
-
Zhu X., Rottkamp C. A., Hartzler A., Sun Z., Takeda A., Boux H., Shimohama S., Perry G., Smith M. A., Activation of MKK6, an upstream activator of p38, in Alzheimer's disease Journal of Neurochemistry 2001 79 2 311 318 (Pubitemid 32988947)
-
(2001)
Journal of Neurochemistry
, vol.79
, Issue.2
, pp. 311-318
-
-
Zhu, X.1
Rottkamp, C.A.2
Hartzler, A.3
Sun, Z.4
Takeda, A.5
Boux, H.6
Shimohama, S.7
Perry, G.8
Smith, M.A.9
-
141
-
-
0034737541
-
Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system
-
DOI 10.1016/S0304-3940(00)00910-1, PII S0304394000009101
-
Mizusawa H., Ishii T., Bannai S., Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system Neuroscience Letters 2000 283 1 57 60 (Pubitemid 30146735)
-
(2000)
Neuroscience Letters
, vol.283
, Issue.1
, pp. 57-60
-
-
Mizusawa, H.1
Ishii, T.2
Bannai, S.3
-
142
-
-
0037067763
-
Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation
-
DOI 10.1074/jbc.M110432200
-
Chang T. S., Jeong W., Choi S. Y., Yu S., Kang S. W., Rhee S. G., Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation Journal of Biological Chemistry 2002 277 28 25370 25376 (Pubitemid 34951848)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.28
, pp. 25370-25376
-
-
Chang, T.-S.1
Jeong, W.2
Choi, S.Y.3
Yu, S.4
Kang, S.W.5
Rhee, S.G.6
-
143
-
-
28244495868
-
2-Cys peroxiredoxin function in intracellular signal transduction: Therapeutic implications
-
DOI 10.1016/j.molmed.2005.10.006, PII S1471491405002406
-
Kang S. W., Rhee S. G., Chang T. S., Jeong W., Choi M. H., 2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic
-
(2005)
Trends in Molecular Medicine
, vol.11
, Issue.12
, pp. 571-578
-
-
Kang, S.W.1
Rhee, S.G.2
Chang, T.-S.3
Jeong, W.4
Choi, M.H.5
-
144
-
-
34147210988
-
Hydrogen Peroxide Sensing and Signaling
-
DOI 10.1016/j.molcel.2007.03.016, PII S1097276507001864
-
Veal E. A., Day A. M., Morgan B. A., Hydrogen peroxide sensing and signaling Molecular Cell 2007 26 1 1 14 (Pubitemid 46578115)
-
(2007)
Molecular Cell
, vol.26
, Issue.1
, pp. 1-14
-
-
Veal, E.A.1
Day, A.M.2
Morgan, B.A.3
-
145
-
-
77958608578
-
Silencing of CDK5 reduces neurofibrillary tangles in transgenic Alzheimer's mice
-
Piedrahita D., Hernndez I., Lpez-Tobn A., Fedorov D., Obara B., Manjunath B. S., Boudreau R. L., Davidson B., LaFerla F., Gallego-Gmez J. C., Kosik K. S., Cardona-Gmez G. P., Silencing of CDK5 reduces neurofibrillary tangles in transgenic Alzheimer's mice Journal of Neuroscience 2010 30 42 13966 13976
-
(2010)
Journal of Neuroscience
, vol.30
, Issue.42
, pp. 13966-13976
-
-
Piedrahita, D.1
Hernndez, I.2
Lpez-Tobn, A.3
Fedorov, D.4
Obara, B.5
Manjunath, B.S.6
Boudreau, R.L.7
Davidson, B.8
Laferla, F.9
Gallego-Gmez, J.C.10
Kosik, K.S.11
Cardona-Gmez, G.P.12
-
146
-
-
0033836219
-
Neuron-specific phosphorylation of Alzheimer's -amyloid precursor protein by cyclin-dependent kinase 5
-
DOI 10.1046/j.1471-4159.2000.0751085.x
-
Iijima K.-I., Ando K., Takeda S., Satoh Y., Seki T., Itohara S., Greengard P., Kirino Y., Nairn A. C., Suzuki T., Neuron-specific phosphorylation of Alzheimer's -amyloid precursor protein by cyclin-dependent kinase 5 Journal of Neurochemistry 2000 75 3 1085 1091 (Pubitemid 30660497)
-
(2000)
Journal of Neurochemistry
, vol.75
, Issue.3
, pp. 1085-1091
-
-
Iijima, K.-I.1
Ando, K.2
Takeda, S.3
Satoh, Y.4
Seki, T.5
Itohara, S.6
Greengard, P.7
Kirino, Y.8
Nairn, A.C.9
Suzuki, T.10
-
147
-
-
0345405447
-
Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
-
DOI 10.1016/S0896-6273(03)00627-5
-
Cruz J. C., Tseng H. C., Goldman J. A., Shih H., Tsai L. H., Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles Neuron 2003 40 3 471 483 (Pubitemid 37494698)
-
(2003)
Neuron
, vol.40
, Issue.3
, pp. 471-483
-
-
Cruz, J.C.1
Tseng, H.-C.2
Goldman, J.A.3
Shih, H.4
Tsai, L.-H.5
-
148
-
-
0343036220
-
Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5)
-
DOI 10.1016/S0006-8993(97)00561-1, PII S0006899397005611
-
Pant A. C., Veeranna, Pant H. C., Amin N., Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5) Brain Research 1997 765 2 259 266 (Pubitemid 27397621)
-
(1997)
Brain Research
, vol.765
, Issue.2
, pp. 259-266
-
-
Pant, A.C.1
Veeranna2
Pant, H.C.3
Amin, N.4
-
149
-
-
0033001435
-
CDK-5-mediated neurofilament phosphorylation in SHSY5Y human neuroblastoma cells
-
DOI 10.1046/j.1471-4159.1999.0730079.x
-
Sharma M., Sharma P., Pant H. C., CDK-5-mediated neurofilament phosphorylation in SHSY5Y human neuroblastoma cells Journal of Neurochemistry 1999 73 1 79 86 (Pubitemid 29289113)
-
(1999)
Journal of Neurochemistry
, vol.73
, Issue.1
, pp. 79-86
-
-
Sharma, M.1
Sharma, P.2
Pant, H.C.3
-
150
-
-
0034832115
-
Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism
-
DOI 10.1046/j.1432-1327.2001.02025.x
-
Grant P., Sharma P., Pant H. C., Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism European Journal of Biochemistry 2001 268 6 1534 1546 (Pubitemid 32862685)
-
(2001)
European Journal of Biochemistry
, vol.268
, Issue.6
, pp. 1534-1546
-
-
Grant, P.1
Sharma, P.2
Pant, H.C.3
-
151
-
-
0032949602
-
Oxidative stress and motor neurone disease
-
Cookson M. R., Shaw P. J., Oxidative stress and motor neurone disease Brain Pathology 1999 9 1 165 186 (Pubitemid 29056526)
-
(1999)
Brain Pathology
, vol.9
, Issue.1
, pp. 165-186
-
-
Cookson, M.R.1
Shaw, P.J.2
-
152
-
-
2642573146
-
The basics of therapeutics in amyotrophic lateral sclerosis
-
Strong M., The basics of therapeutics in amyotrophic lateral sclerosis Pharmacology Therapeutics 2003 5542 1 36
-
(2003)
Pharmacology Therapeutics
, vol.5542
, pp. 1-36
-
-
Strong, M.1
-
153
-
-
17744368458
-
Deregulation of Cdk5 in a mouse model of ALS: Toxicity alleviated by perikaryal neurofilament inclusions
-
DOI 10.1016/S0896-6273(01)00268-9
-
Nguyen M. D., Larivire R. C., Julien J. P., Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions Neuron 2001 30 1 135 147 (Pubitemid 32441682)
-
(2001)
Neuron
, vol.30
, Issue.1
, pp. 135-147
-
-
Nguyen, M.D.1
Lariviere, R.C.2
Julien, J.-P.3
-
154
-
-
0038632271
-
Defective neurofilament transport in mouse models of amyotrophic lateral sclerosis: A review
-
DOI 10.1023/A:1023259207015
-
Rao M. V., Nixon R. A., Defective neurofilament transport in mouse models of amyotrophic lateral sclerosis: a review Neurochemical Research 2003 28 7 1041 1047 (Pubitemid 36576201)
-
(2003)
Neurochemical Research
, vol.28
, Issue.7
, pp. 1041-1047
-
-
Rao, M.V.1
Nixon, R.A.2
-
155
-
-
44249113558
-
Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease
-
DOI 10.1016/j.parkreldis.2007.09.005, PII S1353802007002052
-
Alvira D., Ferrer I., Gutierrez-Cuesta J., Garcia-Castro B., Palls M., Camins A., Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease Parkinsonism and Related Disorders 2008 14 4 309 313 (Pubitemid 351726515)
-
(2008)
Parkinsonism and Related Disorders
, vol.14
, Issue.4
, pp. 309-313
-
-
Alvira, D.1
Ferrer, I.2
Gutierrez-Cuesta, J.3
Garcia-Castro, B.4
Pallas, M.5
Camins, A.6
-
156
-
-
34250344611
-
Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation
-
DOI 10.1074/jbc.M608243200
-
Avraham E., Rott R., Liani E., Szargel R., Engelender S., Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation Journal of Biological Chemistry 2007 282 17 12842 12850 (Pubitemid 47100582)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.17
, pp. 12842-12850
-
-
Avraham, E.1
Rott, R.2
Liani, E.3
Szargel, R.4
Engelender, S.5
-
157
-
-
18544379477
-
A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila
-
Kazantsev A., Walker H. A., Slepko N., Bear J. E., Preisinger E., Steffan J. S., Zhu Y. Z., Gertler F. B., Housman D. E., Marsh J. L., Thompson L. M., A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila Nature Genetics 2002 30 4 367 376
-
(2002)
Nature Genetics
, vol.30
, Issue.4
, pp. 367-376
-
-
Kazantsev, A.1
Walker, H.A.2
Slepko, N.3
Bear, J.E.4
Preisinger, E.5
Steffan, J.S.6
Zhu, Y.Z.7
Gertler, F.B.8
Housman, D.E.9
Marsh, J.L.10
Thompson, L.M.11
-
158
-
-
0037461730
-
Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders
-
DOI 10.1038/nature01301
-
Snchez I., Mahlke C., Yuan J., Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders Nature 2003 421 6921 373 379 (Pubitemid 36157935)
-
(2003)
Nature
, vol.421
, Issue.6921
, pp. 373-379
-
-
Sanchez, I.1
Mahlke, C.2
Yuan, J.3
-
159
-
-
9344227302
-
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
-
DOI 10.1038/ng0896-442
-
Goldberg Y. P., Nicholson D. W., Rasper D. M., Kalchman M. A., Koide H. B., Graham R. K., Bromm M., Kazemi-Esfarjani P., Thornberry N. A., Vaillancourt J. P., Hayden M. R., Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract Nature Genetics 1996 13 4 442 449 (Pubitemid 26256618)
-
(1996)
Nature Genetics
, vol.13
, Issue.4
, pp. 442-449
-
-
Goldberg, Y.P.1
Nicholson, D.W.2
Rasper, D.M.3
Kalchman, M.A.4
Koide, H.B.5
Graham, R.K.6
Bromm, M.7
Kazemi-Esfarjani, P.8
Thornberry, N.A.9
Vaillancourt, J.P.10
Hayden, M.R.11
-
160
-
-
0034733607
-
Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells
-
DOI 10.1074/jbc.M001475200
-
Wellington C. L., Singaraja R., Ellerby L., Savill J., Roy S., Leavitt B., Cattaneo E., Hackam A., Sharp A., Thornberry N., Nicholson D. W., Bredesen D. E., Hayden M. R., Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells Journal of Biological Chemistry 2000 275 26 19831 19838 (Pubitemid 30441585)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.26
, pp. 19831-19838
-
-
Wellington, C.L.1
Singaraja, R.2
Ellerby, L.3
Savill, J.4
Roy, S.5
Leavitt, B.6
Cattaneo, E.7
Hackam, A.8
Sharp, A.9
Thornberry, N.10
Nicholson, D.W.11
Bredesen, D.E.12
Hayden, M.R.13
-
161
-
-
0035940412
-
Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpaindependent proteolysis
-
DOI 10.1073/pnas.221451398
-
Kim Y. J., Yi Y., Sapp E., Wang Y., Cuiffo B., Kegel K. B., Qin Z. H., Aronin N., DiFiglia M., Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpaindependent proteolysis Proceedings of the National Academy of Sciences of the United States of America 2001 98 22 12784 12789 (Pubitemid 33020022)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.22
, pp. 12784-12789
-
-
Kim, Y.J.1
Yi, Y.2
Sapp, E.3
Wang, Y.4
Cuiffo, B.5
Kegel, K.B.6
Qin, Z.-H.7
Aronin, N.8
DiFiglia, M.9
-
162
-
-
0036671821
-
Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions
-
DOI 10.1016/S1097-2765(02)00602-0
-
Lunkes A., Lindenberg K. S., Ben-Haem L., Weber C., Devys D., Landwehrmeyer G. B., Mandel J. L., Trottier Y., Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions Molecular Cell 2002 10 2 259 269 (Pubitemid 35007341)
-
(2002)
Molecular Cell
, vol.10
, Issue.2
, pp. 259-269
-
-
Lunkes, A.1
Lindenberg, K.S.2
Ben-Haem, L.3
Weber, C.4
Devys, D.5
Landwehrmeyer G.Bernhard6
Mandel, J.-L.7
Trottier, Y.8
-
163
-
-
22344439156
-
Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: Implications for mutant huntingtin toxicity
-
DOI 10.1083/jcb.200412071
-
Luo S., Vacher C., Davies J. E., Rubinsztein D. C., Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity Journal of Cell Biology 2005 169 4 647 656 (Pubitemid 41002857)
-
(2005)
Journal of Cell Biology
, vol.169
, Issue.4
, pp. 647-656
-
-
Luo, S.1
Vacher, C.2
Davies, J.E.3
Rubinsztein, D.C.4
-
164
-
-
34447130222
-
Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons
-
DOI 10.1523/JNEUROSCI.1831-07.2007
-
Anne S. L., Saudou F., Humbert S., Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons Journal of Neuroscience 2007 27 27 7318 7328 (Pubitemid 47037570)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.27
, pp. 7318-7328
-
-
Anne, S.L.1
Saudou, F.2
Humbert, S.3
-
165
-
-
52049095054
-
Suppression of mutant huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability
-
Kaminosono S., Saito T., Oyama F., Ohshima T., Asada A., Nagai Y., Nukina N., Hisanaga S. I., Suppression of mutant huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability Journal of Neuroscience 2008 28 35 8747 8755
-
(2008)
Journal of Neuroscience
, vol.28
, Issue.35
, pp. 8747-8755
-
-
Kaminosono, S.1
Saito, T.2
Oyama, F.3
Ohshima, T.4
Asada, A.5
Nagai, Y.6
Nukina, N.7
Hisanaga, S.I.8
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