Cdk5 deregulation in the pathogenesis of Alzheimer's disease

Trends in Molecular Medicine

Volumn 10, Issue 9, 2004, Pages 452-458

  Cruz, Jonathan C ^a   Tsai, Li Huei ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CYCLIN DEPENDENT KINASE 5; PROTEIN P25; PROTEIN P35;

ALZHEIMER DISEASE; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; MOLECULAR BIOLOGY; MOUSE; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; REVIEW;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CYCLIN-DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASES; HUMANS; NERVE TISSUE PROTEINS; SUBSTRATE SPECIFICITY;

EID: 4444262625     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2004.07.001     Document Type: Review

References (71)

1. J. Hardy The relationship between amyloid and tau J. Mol. Neurosci. 20 2003 203 206
2. 2+/calmodulin-dependent protein kinase II and α-actinin-1 in a calcium-dependent manner J. Neurosci. 22 2002 7879 7891
3. J. Ko p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment J. Neurosci. 21 2001 6758 6771
4. L.H. Tsai p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 Nature 371 1994 419 423
5. D. Tang An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator J. Biol. Chem. 270 1995 26897 26903
6. J. Lew A brain-specific activator of cyclin-dependent kinase 5 Nature 371 1994 423 426
7. G.N. Patrick Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration Nature 402 1999 615 622
8. H. Patzke, and L.H. Tsai Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29 J. Biol. Chem. 277 2002 8054 8060
9. G.N. Patrick p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway J. Biol. Chem. 273 1998 24057 24064
10. M.S. Lee Neurotoxicity induces cleavage of p35 to p25 by calpain Nature 405 2000 360 364
11. G. Kusakawa Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25 J. Biol. Chem. 275 2000 17166 17172
12. R. Nath Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells Biochem. Biophys. Res. Commun. 274 2000 16 21
13. P. Kerokoski Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35 Brain Res. Mol. Brain Res. 106 2002 50 56
14. T. Saito Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation J. Neurosci. 23 2003 1189 1197
15. J.H. Weishaupt Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction Mol. Cell. Neurosci. 24 2003 489 502
16. X. Gong Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis Neuron 38 2003 33 46
17. M. Hashiguchi Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau J. Biol. Chem. 277 2002 44525 44530
18. M.K. Ahlijanian Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5 Proc. Natl. Acad. Sci. U.S.A. 97 2000 2910 2915
19. J.C. Cruz Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles Neuron 40 2003 471 483
20. C. Van den Haute Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice Neurobiol. Dis. 8 2001 32 44
21. S. Takahashi Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules J. Biol. Chem. 278 2003 10506 10515
22. J.L. Hallows Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice J. Neurosci. 23 2003 10633 10644
23. T. Chae Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality Neuron 18 1997 29 42
24. K. Iijima Neuron-specific phosphorylation of Alzheimer's β-amyloid precursor protein by cyclin-dependent kinase 5 J. Neurochem. 75 2000 1085 1091
25. F. Liu Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5 FEBS Lett. 547 2003 193 196
26. M. Morabito Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons J. Neurosci. 24 2004 865 876
27. M. Niethammer NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein Neuron 28 2000 697 711
28. S. Sasaki A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system Neuron 28 2000 681 696
29. L. Keshvara Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling J. Neurosci. 22 2002 4869 4877
30. nck5a complex Mol. Cell 8 2001 657 669
31. J. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356
32. K.Y. Lee Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain Neurosci. Res. 34 1999 21 29
33. F. Grynspan Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease Brain Res. 763 1997 145 158
34. H.C. Tseng A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains FEBS Lett. 523 2002 58 62
35. M.D. Nguyen Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions Neuron 30 2001 135 147
36. B. Bu Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model J. Neurosci. 22 2002 6515 6525
37. R. Borghi Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy Neurology 58 2002 589 592
38. P.D. Smith Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease Proc. Natl. Acad. Sci. U. S. A. 100 2003 13650 13655
39. J. Wang Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors Nat. Neurosci. 6 2003 1039 1047
40. A. Takashima Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain Neurosci. Lett. 306 2001 37 40
41. F. Bian Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice J. Comp. Neurol. 446 2002 257 266
42. M. Angelo Improved reversal learning and altered fear conditioning in transgenic mice with regionally restricted p25 expression Eur. J. Neurosci. 18 2003 423 431
43. K. Tomizawa Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles J. Cell Biol. 163 2003 813 824
44. T.C. Tan Cdk5 is essential for synaptic vesicle endocytosis Nat. Cell Biol. 5 2003 701 710
45. A. Fischer Cyclin-dependent kinase 5 is required for associative learning J. Neurosci. 22 2002 3700 3707
46. K. Sobue Interaction of neuronal Cdc2-like protein kinase with microtubule-associated protein tau J. Biol. Chem. 275 2000 16673 16680
47. D.B. Flaherty Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants J. Neurosci. Res. 62 2000 463 472
48. J.C. Augustinack Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles J. Neuropathol. Exp. Neurol. 61 2002 557 564
49. W. Noble Cdk5 is a key factor in tau aggregation and tangle formation in vivo Neuron 38 2003 555 565
50. I. Nishimura PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila Cell 116 2004 671 682
51. A. Sengupta Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5 Mol. Cell. Biochem. 167 1997 99 105
52. G. Morfini A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons EMBO J. 23 2004 2235 2245
53. J.J. Lucas Decreased nuclear β-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice EMBO J. 20 2001 27 39
54. G.R. Jackson Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila Neuron 34 2002 509 519
55. C.W. Wittmann Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles Science 293 2001 711 714
56. Y.C. Liou Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration Nature 424 2003 556 561
57. A. Alvarez Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death FEBS Lett. 459 1999 421 426
58. T. Town p35/Cdk5 pathway mediates soluble amyloid-β peptide-induced tau phosphorylation in vitro J. Neurosci. Res. 69 2002 362 372
59. C. Otth AβPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576 J. Alzheimers Dis. 4 2002 417 430
60. M.S. Lee APP processing is regulated by cytoplasmic phosphorylation J. Cell Biol. 163 2003 83 95
61. T.A. Ramelot, and L.K. Nicholson Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR J. Mol. Biol. 307 2001 871 884
62. K. Ando Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of β-amyloid J. Biol. Chem. 276 2001 40353 40361
63. J. Ryder Divergent roles of GSK3 and CDK5 in APP processing Biochem. Biophys. Res. Commun. 312 2003 922 929
64. K.F. Lau Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability Mol. Cell. Neurosci. 20 2002 13 20
65. B.S. Li Regulation of NMDA receptors by cyclin-dependent kinase-5 Proc. Natl. Acad. Sci. U. S. A. 98 2001 12742 12747
66. D.H. Geschwind Tau phosphorylation, tangles, and neurodegeneration: the chicken or the egg? Neuron 40 2003 457 460
67. T.D. Bird A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L) Brain 122 1999 741 756
68. B. Wolozin The cellular biochemistry of cholesterol and statins: insights into the pathophysiology and therapy of Alzheimer's disease CNS Drug Rev. 10 2004 127 146
69. J.W. Husseman Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases Neurobiol. Aging 21 2000 815 828
70. M.R. D'Andrea Evidence linking neuronal cell death to autoimmunity in Alzheimer's disease Brain Res. 982 2003 19 30
71. A.I. Bush Metals and neuroscience Curr. Opin. Chem. Biol. 4 2000 184 191