-
1
-
-
33845531563
-
Parkinson's disease: diagnosis and treatment
-
Rao S.S., Hofmann L.A., and Shakil A. Parkinson's disease: diagnosis and treatment. Am Fam Physician 74 (2006) 2046-2054
-
(2006)
Am Fam Physician
, vol.74
, pp. 2046-2054
-
-
Rao, S.S.1
Hofmann, L.A.2
Shakil, A.3
-
2
-
-
33846030132
-
The role of CDK5/P25 formation/inhibition in neurodegeneration
-
Camins A., Verdaguer E., Folch J., Canudas A.M., and Pallas M. The role of CDK5/P25 formation/inhibition in neurodegeneration. Drug News Perspect 19 (2006) 453-460
-
(2006)
Drug News Perspect
, vol.19
, pp. 453-460
-
-
Camins, A.1
Verdaguer, E.2
Folch, J.3
Canudas, A.M.4
Pallas, M.5
-
3
-
-
33747861696
-
Involvement of oxidative stress in Alzheimer disease
-
Nunomura A., Castellani R.J., Zhu X., Moreira P.I., Perry G., and Smith M.A. Involvement of oxidative stress in Alzheimer disease. J Neuropathol Exp Neurol 65 (2006) 631-641
-
(2006)
J Neuropathol Exp Neurol
, vol.65
, pp. 631-641
-
-
Nunomura, A.1
Castellani, R.J.2
Zhu, X.3
Moreira, P.I.4
Perry, G.5
Smith, M.A.6
-
4
-
-
32544441845
-
Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2
-
Smith P.D., Mount M.P., Shree R., Callaghan S., Slack R.S., Anisman H., et al. Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2. J Neurosci 26 (2006) 440-447
-
(2006)
J Neurosci
, vol.26
, pp. 440-447
-
-
Smith, P.D.1
Mount, M.P.2
Shree, R.3
Callaghan, S.4
Slack, R.S.5
Anisman, H.6
-
5
-
-
12944250987
-
Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease
-
Hartmann A., Hunot S., Michel P.P., Muriel M.P., Vyas S., Faucheux B.A., et al. Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. Proc Natl Acad Sci U S A 97 (2000) 2875-2880
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 2875-2880
-
-
Hartmann, A.1
Hunot, S.2
Michel, P.P.3
Muriel, M.P.4
Vyas, S.5
Faucheux, B.A.6
-
6
-
-
0035103294
-
Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease?
-
Hartmann A., Michel P.P., Troadec J.D., Mouatt-Prigent A., Faucheux B.A., Ruberg M., et al. Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease?. J Neurochem 76 (2001) 1785-1793
-
(2001)
J Neurochem
, vol.76
, pp. 1785-1793
-
-
Hartmann, A.1
Michel, P.P.2
Troadec, J.D.3
Mouatt-Prigent, A.4
Faucheux, B.A.5
Ruberg, M.6
-
7
-
-
0029882525
-
Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?
-
Mouatt-Prigent A., Karlsson J.O., Agid Y., and Hirsch E.C. Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?. Neuroscience 73 (1996) 979-987
-
(1996)
Neuroscience
, vol.73
, pp. 979-987
-
-
Mouatt-Prigent, A.1
Karlsson, J.O.2
Agid, Y.3
Hirsch, E.C.4
-
8
-
-
33645288896
-
The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target
-
Webber K.M., Casadesus G., Zhu X., Obrenovich M.E., Atwood C.S., Perry G., et al. The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target. Curr Pharm Des 12 (2006) 691-697
-
(2006)
Curr Pharm Des
, vol.12
, pp. 691-697
-
-
Webber, K.M.1
Casadesus, G.2
Zhu, X.3
Obrenovich, M.E.4
Atwood, C.S.5
Perry, G.6
-
9
-
-
0037229278
-
Expression patterns of retinoblastoma protein in Parkinson disease
-
Jordan-Sciutto K.L., Dorsey R., Chalovich E.M., Hammond R.R., and Achim C.L. Expression patterns of retinoblastoma protein in Parkinson disease. J Neuropathol Exp Neurol 62 (2003) 68-74
-
(2003)
J Neuropathol Exp Neurol
, vol.62
, pp. 68-74
-
-
Jordan-Sciutto, K.L.1
Dorsey, R.2
Chalovich, E.M.3
Hammond, R.R.4
Achim, C.L.5
-
10
-
-
24344476294
-
The cell cycle in Alzheimer disease: a unique target for neuropharmacology
-
Webber K.M., Raina A.K., Marlatt M.W., Zhu X., Prat M.I., Morelli L., et al. The cell cycle in Alzheimer disease: a unique target for neuropharmacology. Mech Ageing Dev 126 (2005) 1019-1025
-
(2005)
Mech Ageing Dev
, vol.126
, pp. 1019-1025
-
-
Webber, K.M.1
Raina, A.K.2
Marlatt, M.W.3
Zhu, X.4
Prat, M.I.5
Morelli, L.6
-
11
-
-
33644809553
-
Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease
-
Alvira D., Tajes M., Verdaguer E., Acuna-Castroviejo D., Folch J., Camins A., et al. Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease. J Pineal Res 40 (2006) 251-258
-
(2006)
J Pineal Res
, vol.40
, pp. 251-258
-
-
Alvira, D.1
Tajes, M.2
Verdaguer, E.3
Acuna-Castroviejo, D.4
Folch, J.5
Camins, A.6
-
12
-
-
0344823864
-
Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease
-
Smith P.D., Crocker S.J., Jackson-Lewis V., Jordan-Sciutto K.L., Hayley S., Mount M.P., et al. Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 100 (2003) 13650-13656
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 13650-13656
-
-
Smith, P.D.1
Crocker, S.J.2
Jackson-Lewis, V.3
Jordan-Sciutto, K.L.4
Hayley, S.5
Mount, M.P.6
-
13
-
-
0034682414
-
Neurotoxicity induces cleavage of p35 to p25 by calpain
-
Lee M.S., Kwon Y.T., Li M., Peng J., Friedlander R.M., and Tsai L.H. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405 (2000) 360-364
-
(2000)
Nature
, vol.405
, pp. 360-364
-
-
Lee, M.S.1
Kwon, Y.T.2
Li, M.3
Peng, J.4
Friedlander, R.M.5
Tsai, L.H.6
-
14
-
-
0033540060
-
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
-
Patrick G.N., Zukerberg L., Nikolic M., de la Monte S., Dikkes P., and Tsai L.H. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402 (1999) 615-622
-
(1999)
Nature
, vol.402
, pp. 615-622
-
-
Patrick, G.N.1
Zukerberg, L.2
Nikolic, M.3
de la Monte, S.4
Dikkes, P.5
Tsai, L.H.6
-
15
-
-
4444262625
-
Cdk5 deregulation in the pathogenesis of Alzheimer's disease
-
Cruz J., and Tsai L. Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends Mol Med 10 (2004) 452-458
-
(2004)
Trends Mol Med
, vol.10
, pp. 452-458
-
-
Cruz, J.1
Tsai, L.2
-
16
-
-
0345405447
-
Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
-
Cruz J.C., Tseng H.C., Goldman J.A., Shih H., and Tsai L.H. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40 (2003) 471-483
-
(2003)
Neuron
, vol.40
, pp. 471-483
-
-
Cruz, J.C.1
Tseng, H.C.2
Goldman, J.A.3
Shih, H.4
Tsai, L.H.5
-
17
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
Braak H., Del Tredici K., Rüb U., de Vos R.A., Jansen Steur E.N., and Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24 (2003) 197-211
-
(2003)
Neurobiol Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
Del Tredici, K.2
Rüb, U.3
de Vos, R.A.4
Jansen Steur, E.N.5
Braak, E.6
-
18
-
-
0042886045
-
Cell cycle aberrations by alpha-synuclein over-expression and cyclin B immunoreactivity in Lewy bodies
-
Lee S.S., Kim Y.M., Junn E., Lee G., Park K.H., Tanaka M., et al. Cell cycle aberrations by alpha-synuclein over-expression and cyclin B immunoreactivity in Lewy bodies. Neurobiol Aging 24 (2003) 687-696
-
(2003)
Neurobiol Aging
, vol.24
, pp. 687-696
-
-
Lee, S.S.1
Kim, Y.M.2
Junn, E.3
Lee, G.4
Park, K.H.5
Tanaka, M.6
-
19
-
-
0038380524
-
Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease
-
Crocker S.J., Smith P.D., Jackson-Lewis V., Lamba W.R., Hayley S.P., Grimm E., et al. Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease. J Neurosci 23 (2003) 4081-4091
-
(2003)
J Neurosci
, vol.23
, pp. 4081-4091
-
-
Crocker, S.J.1
Smith, P.D.2
Jackson-Lewis, V.3
Lamba, W.R.4
Hayley, S.P.5
Grimm, E.6
-
20
-
-
0030749732
-
p35nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease
-
Nakamura S., Kawamoto Y., Nakano S., Akiguchi I., and Kimura J. p35nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease. Acta Neuropathol (Berl) 94 (1997) 153-157
-
(1997)
Acta Neuropathol (Berl)
, vol.94
, pp. 153-157
-
-
Nakamura, S.1
Kawamoto, Y.2
Nakano, S.3
Akiguchi, I.4
Kimura, J.5
-
21
-
-
4444285321
-
CDKs: taking on a role as mediators of dopaminergic loss in Parkinson's disease
-
Smith P.D., O'Hare M.J., and Park D.S. CDKs: taking on a role as mediators of dopaminergic loss in Parkinson's disease. Trends Mol Med 10 (2004) 445-451
-
(2004)
Trends Mol Med
, vol.10
, pp. 445-451
-
-
Smith, P.D.1
O'Hare, M.J.2
Park, D.S.3
-
22
-
-
0028828550
-
Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5
-
Brion J.P., and Couck A.M. Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5. Am J Pathol 147 (1995) 1465-1476
-
(1995)
Am J Pathol
, vol.147
, pp. 1465-1476
-
-
Brion, J.P.1
Couck, A.M.2
-
23
-
-
33847610595
-
The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease
-
Hoglinger G.U., Breunig J.J., Depboylu C., Rouaux C., Michel P.P., Alvarez-Fischer D., et al. The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc Natl Acad Sci U S A 104 (2007) 3585-3590
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 3585-3590
-
-
Hoglinger, G.U.1
Breunig, J.J.2
Depboylu, C.3
Rouaux, C.4
Michel, P.P.5
Alvarez-Fischer, D.6
-
24
-
-
33750207744
-
Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases
-
Waldmeier P., Bozyczko-Coyne D., Williams M., and Vaught J.L. Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases. Biochem Pharmacol 72 (2006) 1197-1206
-
(2006)
Biochem Pharmacol
, vol.72
, pp. 1197-1206
-
-
Waldmeier, P.1
Bozyczko-Coyne, D.2
Williams, M.3
Vaught, J.L.4
-
25
-
-
1242274335
-
Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum
-
Chergui K., Svenningsson P., and Greengard P. Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum. Proc Natl Acad Sci U S A 101 (2004) 2191-2196
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 2191-2196
-
-
Chergui, K.1
Svenningsson, P.2
Greengard, P.3
-
26
-
-
0142242238
-
Parkin cleaves intracelular alpha-synuclein inclusions via the activation of calpain
-
Kim S.J., Sung J.Y., Um J.W., Hattori N., Mizuno Y., Tanaka K., et al. Parkin cleaves intracelular alpha-synuclein inclusions via the activation of calpain. J Biol Chem 278 (2003) 41890-41899
-
(2003)
J Biol Chem
, vol.278
, pp. 41890-41899
-
-
Kim, S.J.1
Sung, J.Y.2
Um, J.W.3
Hattori, N.4
Mizuno, Y.5
Tanaka, K.6
|